Self-assembled nanoparticles enriched in chicory sesquiterpenes, process for their preparation and use
By self-assembling chicory sesquiterpene nanoparticles using differential centrifugation and sucrose density gradient centrifugation, the limitations of poor water solubility of chicory sesquiterpene and existing nanodelivery systems have been overcome, achieving efficient delivery and liver protection effects, and providing a new drug solution for alcoholic fatty liver disease.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
- Filing Date
- 2026-06-03
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies fail to effectively utilize the amphiphilic molecular structure of chicory sesquiterpenes, resulting in poor water solubility and low oral bioavailability. Furthermore, existing nanodelivery systems suffer from immunogenicity and low drug loading, failing to meet the precision treatment needs of alcoholic fatty liver disease.
By using differential centrifugation and sucrose density gradient centrifugation, nanoparticles rich in chicory sesquiterpenes were extracted from chicory juice and self-assembled, forming nanoparticles with a phospholipid bilayer membrane structure. This method requires no exogenous carrier material, resulting in high drug loading and clearly defined components.
This study achieved efficient delivery of chicory sesquiterpenes, significantly reduced hepatic lipid accumulation, lowered serum transaminase levels, regulated lipid metabolism disorders, and inhibited the release of pro-inflammatory factors, demonstrating comprehensive hepatoprotective and anti-inflammatory effects. It provides a novel drug candidate for the treatment of AFLD with clear components, safety, and high efficacy.
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