A medicine combination for preventing and treating osteoporosis syndrome and its preparation method

By employing specific ratios of tortoise shell, deer antler, psoralea corylifolia, drynaria fortunei, and dipsacus asper in traditional Chinese medicine compound formulas, along with polarity-based fractional extraction and a step-by-step liquid-phase co-grinding process, the problem of low absorption rates of poorly soluble active ingredients and inorganic calcium salts was solved, thereby improving the solubility and absorption rate of the drugs and enhancing their therapeutic effects.

CN122398884APending Publication Date: 2026-07-17ZHONG YAN PHARM CO LTD OF JILIN PROVINCE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHONG YAN PHARM CO LTD OF JILIN PROVINCE
Filing Date
2026-06-01
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In existing traditional Chinese medicine compound preparations for the prevention and treatment of osteoporosis syndrome, the apparent solubility and dissolution rate of poorly soluble active ingredients (such as psoralen) are low, and middle-aged and elderly patients have low absorption and conversion rates of inorganic calcium salts in animal bone matrix that are conventionally physically pulverized for medicinal use due to insufficient gastric acid secretion.

Method used

Using tortoise shell to provide calcium carbonate and collagen network framework, and deer antler to provide hydroxyapatite and keratin hydrophobic microenvironment, combined with lipophilic coumarin active components in psoralea corylifolia, and flavonoid polyphenols and plant organic acids in drynaria fortunei and dipsacus asper, a pharmacological synergistic effect is produced through a specific ratio. Furthermore, the crystallization thermodynamic state of the insoluble organic components and the surface organic modification of the inorganic calcium source are changed through polar fractional extraction and step-by-step liquid-phase assisted co-grinding process.

Benefits of technology

It improved the in vitro dissolution rate of poorly soluble active ingredients and the solubility and absorption of inorganic calcium sources in a neutral intestinal environment, enhanced the bioavailability of the drug, and improved the symptoms of osteoporosis syndrome.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application relates to the field of medicines, and discloses a medicine combination for preventing and treating osteoporosis syndrome and a preparation method, wherein the medicine combination is made of tortoise shell, deer horn, psoralea, drynaria and rhizoma curculiginis. A stepwise liquid-phase assisted co-grinding technology is adopted, that is, psoralen extract, deer horn coarse powder and part of tortoise shell coarse powder are ground at low temperature of 0-5 DEG C, psoralen is locked in an amorphous solid dispersion state by using the keratin network of the deer horn; then the remaining tortoise shell coarse powder and drynaria-rhizoma curculiginis water extraction thick paste are added and ground at normal temperature, so that in-situ complexation reaction of plant organic acid and tortoise shell calcium carbonate is caused. The original components in the prescription are used as natural carriers and complexing agents, and the amorphous state of the difficult-to-dissolve components and the organic modification of inorganic calcium are realized without adding synthetic auxiliary materials. The medicine combination significantly improves the dissolution rate of psoralen and the calcium release amount in a neutral environment, and has excellent osteogenic activity.
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