Use of regulatory t cell exosome in preparation of medicine for promoting repair of nerve injury

By covering the nerve stump with a gel containing short peptides of regulatory T cell extracellular vesicles, the pro-inflammatory activation of macrophages is inhibited, while Schwann cell proliferation and migration are promoted. This solves the problem of inflammatory cascade amplification of the immune response after peripheral nerve injury, and achieves effective repair and regeneration of nerve damage.

CN122399014APending Publication Date: 2026-07-17NANTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANTONG UNIV
Filing Date
2026-03-30
Publication Date
2026-07-17

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Abstract

本发明公开了调节性T细胞外囊泡在制备促进神经损伤修复的药物中的应用，属于生物医药技术领域。本发明提供了调节性T细胞外囊泡在制备促进神经损伤修复特别是周围神经损伤的药物中的应用。本发明所述Treg细胞外囊泡可以有效促进神经损伤修复，抑制巨噬细胞促炎活化，增加Treg细胞外囊泡的医药用途。
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