Method and system for dynamic stimulation parameter optimization in closed-loop neuromodulation systems

By using individualized stimulus-response prediction models and electrode channel impedance estimation, the electrical stimulation parameters of the neural modulation system are optimized, solving the problems of individual differences and changes in neural state, and improving the stability and adaptability of the system.

CN122399237APending Publication Date: 2026-07-17FANSKY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FANSKY CO LTD
Filing Date
2026-03-31
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing closed-loop neural modulation systems struggle to achieve stable and safe adjustment of electrical stimulation parameters in the face of individual differences and dynamic changes in neural states, leading to unreliable response judgments and lagging control strategies.

Method used

By establishing an individualized stimulus-response prediction model, combined with electrode channel impedance estimation, the combination of stimulus parameters is optimized and adjusted in real time in practical applications to adapt to changes in neural state, including model retraining and parameter switching mechanisms.

Benefits of technology

It improves the stability and adaptability of the neural regulation system in complex environments, ensures the clarity and engineering feasibility of the control logic, and avoids problems such as slow parameter adjustment and unreliable response judgment.

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Abstract

本发明提出闭环神经调节系统中的动态刺激参数优化方法及系统,方法包括:基于个体实际采集的刺激参数与神经响应延迟数据训练个体化的刺激-响应预测模型;在预设刺激参数空间中生成全部有效刺激参数组合,并结合电极通道阻抗估计值对所述全部有效刺激参数组合进行综合评分,选取评分最优组合作为当前刺激指令;执行刺激并同步采集神经响应延迟与阻抗,形成生理响应状态向量;将实际响应延迟与模型预测延迟对比,偏差超阈值时触发控制策略更新;根据更新结果输出新刺激指令,实现闭环自适应调节。本发明提升刺激效率与个体适配性,增强闭环神经调控系统的稳定性与长期有效性。
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