Silica gel chromatographic stationary phase bonded with CMBZ, its preparation method and application
By modifying the silica gel surface with a 5-chlorobenzimidazole-2-thiol structure, a multi-ligand heterocyclic silica gel chromatographic stationary phase was prepared, which solved the problem of insufficient selectivity for the separation of multiple types of compounds in the prior art, and achieved efficient separation and good peak shape control of flavonoids.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
- Filing Date
- 2025-01-16
- Publication Date
- 2026-07-17
AI Technical Summary
Existing chromatographic stationary phases are insufficient to meet the separation requirements of various types of compounds in the extraction process of traditional Chinese medicine, especially flavonoids, which suffer from dead adsorption and poor selectivity. Reversed-phase chromatography has long separation time, and supercritical fluid chromatography has limited selectivity.
A silica gel chromatographic stationary phase with bonded multi-ligand heterocyclic structures was prepared. By modifying the silica gel surface with a 5-chlorobenzimidazole-2-thiol structure, various interactions such as polar interactions, hydrophobic interactions, π-π interactions, and hydrogen bonding interactions were provided to improve selectivity.
It achieves efficient separation of various types of compounds, especially flavonoids, with normal peak shapes and excellent selectivity. The separation process is simple, the conditions are mild, and it has good reproducibility and stability.
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