A method for synthesizing difluoromethyl compounds
By activating the CF bond using BPh4Na as an activator in the photocatalytic reaction of aryl trifluoromethyl compounds with aryl olefins, the problems of substrate adaptability and mild conditions in the synthesis of difluoromethyl compounds in the prior art have been solved, and efficient and inexpensive synthesis of difluoromethyl compounds has been achieved.
Patent Information
- Application Number
- CN202610560090.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies struggle to synthesize difluoromethyl compounds efficiently under mild conditions, especially due to the high bond energy of the carbon-fluorine bond in trifluoromethyl groups and the waste associated with metal catalysis. Furthermore, photocatalysis methods are only applicable to specific substrates and lack broad substrate adaptability and functional group compatibility.
Aryl trifluoromethyl compounds were used to carry out aryl difluoromethylation reactions with aryl olefins in organic solvents under light conditions. The CF bond was activated with the activator BPh4Na to form a B–F radical complex. The CF bond was then activated through the coordination bond between boron and fluorine to generate aryl difluoromethyl radicals, which were then reduced to the target product through the HAT process.
The synthesis of difluoromethyl compounds in high yield was achieved under mild conditions, broadening the synthetic reaction system. All reagents were inexpensive and readily available, making it valuable for industrial applications.
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Abstract
Citation Information
Patent Citations
Method for defluorination alkylation of trifluoromethyl compound
CN119954671A