Preparation method of paris polyphylla fresh product neutral polysaccharide and application thereof in preparation of antitumor drugs
Neutral polysaccharides from fresh Paris polyphylla were prepared by water bath extraction and column chromatography purification, solving the problem of lack of targeted preparation in existing technologies. This enabled the precise development and high-value utilization of highly active polysaccharides, which significantly inhibited the proliferation of lung cancer and breast cancer cells.
CN122404585APending Publication Date: 2026-07-17ZUNYI MEDICAL UNIVERSITY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZUNYI MEDICAL UNIVERSITY
- Filing Date
- 2026-04-21
- Publication Date
- 2026-07-17
Smart Images
Figure CN122404585A_ABST
Abstract
本发明涉及医药技术领域，公开了一种重楼鲜品中性多糖的制备方法及其在制备抗肿瘤药物中的应用，以重楼鲜品根茎为原料，经原料预处理、水浴提取、浓缩醇沉制备重楼鲜品总多糖，再经DEAE‑FF阴离子凝胶色谱柱分离，以纯化水洗脱得到重楼鲜品中性多糖。本发明方法操作简单、条件温和，可定向制备结构稳定的重楼鲜品中性多糖；同时明确了重楼不同来源、不同组分多糖的活性差异，本发明制得的鲜品中性多糖对肺癌、乳腺癌肿瘤细胞具有显著的浓度依赖性增殖抑制作用，干燥重楼来源中性多糖的抑制活性显著弱于鲜品中性多糖。本发明为重楼鲜品多糖的精准开发提供了技术支撑，也为天然抗肿瘤药物研发提供了新的活性物质基础。
Need to check novelty before this filing date? Find Prior Art