Memory t cells against hpv virus and preparation method and application thereof
By isolating PBMCs from the peripheral blood of HPV-positive patients and stimulating them with interferon, anti-CD3 monoclonal antibody and IL-2 in combination with HPV virus antigen, anti-HPV memory T cells were prepared, solving the problems of complexity and safety in the preparation of existing technologies and achieving efficient and safe T cell preparation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN ANXINGYUAN BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-12-12
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for preparing anti-HPV memory T cells are complex and prone to triggering strong immune responses and inflammation. The use of replicating adeno-associated virus may lead to tumorigenesis and viral contamination.
By isolating PBMCs from the peripheral blood of HPV-positive patients or their haploidentical relatives, culturing them in a medium containing interferon, and adding anti-CD3 monoclonal antibody and IL-2, combined with HPV virus antigen stimulation, anti-HPV memory T cells were prepared, avoiding the use of adeno-associated virus to infect DC cells.
The preparation process was simplified, the number and killing effect of anti-HPV memory T cells were increased, the risk of strong immune response and tumor development was reduced, and biosafety was ensured.
Smart Images
Figure CN122405545A_ABST