A material analysis method for screening a diabetic core flora

CN122409757APending Publication Date: 2026-07-17SHANXI MEDICAL UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANXI MEDICAL UNIV
Filing Date
2026-04-23
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies struggle to effectively extract the specific dielectric relaxation characteristics of target bacterial communities in strong electrolyte environments, resulting in analytical results that are limited by the charge fluctuations of the background environment, leading to baseline drift and false positives.

Method used

A dielectric gradient thin film is deposited on the substrate surface to construct a non-equilibrium analytical surface with a gradient distribution of polarization response time constant. By overlapping the polarization frequency window with the dielectric loss peak of the target analyte particles, the mismatch between the polarization response time constant and the migration rate of ions is utilized to trigger a cooperative polarization response to shield background interference signals. The imaginary part change characteristics of the complex impedance are extracted synchronously through the measurement channel and the reference channel. The quantization parameters are calculated by combining the multidimensional parameter correlation between the phase offset and the complex impedance.

Benefits of technology

It achieves a highly deterministic response to the target analyte in a strong electrolyte environment, shields against background noise interference, ensures logical consistency and high signal-to-noise ratio of the analytical results, and can accurately extract the target signal under low abundance sample conditions.

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Abstract

本发明涉及材料分析技术领域,公开了一种糖尿病核心菌群筛选的材料分析方法,包括:在分析基底表面沉积具有介电弛豫时间梯度的介电梯度薄膜,构建非平衡态分析面;将待测复杂生物介质样本置于该分析面并施加扫频交流电信号;利用该薄膜极化响应时间常数与该样本离子迁移速率的失配关系,触发分析基底深层极化子的协同极化响应,屏蔽背景干扰信号;根据复数阻抗虚部变化特征提取目标分析物微粒产生的极化信号;基于相位偏移量与复数阻抗的关联关系计算量化参数,本发明实现目标信号与高电导率背景噪声的物理级分离,确保在低丰度条件下获得确定的物理响应特征,提升肠道微生态物理状态表征精度。
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