Method for the preparation of a biosensor based on a selective membrane modification and biosensor

By using a flexible substrate and a modified solution to prepare a modified ion-selective film layer in a sweat monitoring biosensor, the problem of sensor functional characteristics being impaired under the influence of external environmental factors is solved, and the sensitivity, stability and wearing comfort are improved.

CN122409795APending Publication Date: 2026-07-17SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Filing Date
2025-01-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing sweat monitoring biosensors suffer functional impairments due to external environmental factors, resulting in insufficient sensitivity and stability. Furthermore, their performance fluctuates significantly in variable environments, making them difficult to integrate with flexible textiles and causing discomfort when worn.

Method used

A modified ion-selective film was prepared using a flexible substrate and a modified solution containing hydrophobic substances and fast ion diffusion nanomaterials to enhance the adhesion between the PEDOT:PSS polymer layer and the modified ion-selective film, thereby improving the sensitivity and stability of the biosensor.

Benefits of technology

The sensitivity and stability of the biosensor have been enhanced, its resistance to washing and mechanical damage has been improved, and its wearing comfort has been increased, making it suitable for monitoring needs under varying environmental conditions.

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Abstract

本发明公开了一种基于选择膜改性的生物传感器的制备方法和基于选择膜改性的生物传感器。制备方法包括:提供柔性衬底;在柔性衬底上制备第一银电极层和第二银电极层;在第一银电极层上制备树枝状金层;在树枝状金层上制备PEDOT:PSS聚合物层;提供改性溶液,并使用改性溶液在PEDOT:PSS聚合物层上制备改性离子选择性膜层,改性溶液包括疏水性物质和具有快速离子扩散特性的纳米材料的其中至少一种;将第二银电极层转换为银 / 氯化银电极层,并在银 / 氯化银电极层上制备PVB膜层。生物传感器的功能特性包括生物传感器的灵敏度和稳定性等。包括疏水性物质的改性溶液或包括快速离子扩散特性的纳米材料的改性溶液可以提高生物传感器的灵敏度或稳定性等功能特性。
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