Method for inducing bacillus to synthesize antibacterial lipopeptide efficiently and application thereof

By co-culturing Bacillus belye and Tobacco Star Bacterium, and utilizing metabolite exchange to promote the synthesis of antimicrobial lipopeptides, the problem of low yield of antimicrobial lipopeptides synthesized by Bacillus belye was solved, and efficient and stable preparation of antimicrobial lipopeptides was achieved.

CN122428008APending Publication Date: 2026-07-21TOBACCO RESEARCH INSTITUTE OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES (QINGZHOU TOBACCO RESEARCH INSTITUTE OF CHINA NATIONAL TOBACCO COMPANY)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TOBACCO RESEARCH INSTITUTE OF CHINESE ACADEMY OF AGRICULTURAL SCIENCES (QINGZHOU TOBACCO RESEARCH INSTITUTE OF CHINA NATIONAL TOBACCO COMPANY)
Filing Date
2026-04-24
Publication Date
2026-07-21

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Abstract

The present application relates to the technical field of microbial culture and biological control, and particularly relates to a method for inducing high-efficiency synthesis of antibacterial lipopeptide by bacillus, wherein the high-efficiency synthesis of antibacterial lipopeptide is promoted by co-culture induction through always contacting metabolites of pathogenic fungi during the culture of bacillus; the bacillus is bacillus velezensis EM-1, and the preservation number is CGMCC No.21131; the pathogenic fungi is alternaria alternata XN01, and the preservation number is CGMCC No.42504. Through the physical isolation of bacillus velezensis EM-1 and alternaria alternata XN01, pure chemical communication between microorganisms is realized, the synthesis amount of lipopeptide antibacterial substances such as fengycin in bacillus velezensis EM-1 is significantly improved, and a new way for developing efficient and stable microbial biocontrol agents is provided.
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