A stable liquid crystal emulsion and a method of preparation

Abstract

The application belongs to the field of cosmetics, and relates to a stable liquid crystal emulsion and a preparation method. The liquid crystal emulsion comprises an A phase, a B phase, a C phase, a D phase, an E phase and an F phase; the A phase comprises a solvent, a humectant and a thickening agent; the solvent is water; the B phase comprises an emulsifier, a co-emulsifier, a thickening agent and an emollient; the emulsifier in the B phase comprises at least one of MONTANOV 68MB, BEAUTYDERM K10, BEAUTYDERM HP, Lipomulse Luxe MB, Aminol GDO and Phytocompo-PP; the C phase comprises a thickening agent and water; the D phase comprises a pH regulator; the E phase comprises an active ingredient; and the F phase comprises an antioxidant and a humectant. The liquid crystal emulsion still has good liquid crystal content stability, appearance shape stability and mechanical stability under conditions such as accelerated conditions and low temperature, and has unexpected technical effects.

Description

Technical Field

[0001] This invention relates to the field of cosmetics, and more particularly to a stable liquid crystal emulsion and its preparation method. Background Technology

[0002] With the rapid development of the cosmetics market and the widespread use of the internet, consumers have gained a deeper understanding of cosmetics, and their focus has shifted to the quality of the products themselves. Therefore, cosmetic companies need to gradually shift their focus to technological innovation in cosmetics. Layered liquid crystals, due to their unique oil / liquid / water structure highly similar to the oil / stratum corneum / water structure of human skin, exhibit high skin affinity, improving product stability, enhancing emulsion water retention, and slowing the release of active ingredients, thus contributing to the efficacy of cosmetics and attracting widespread attention in the cosmetics industry. Liquid crystal emulsions form an ordered multilayer structure—the liquid crystal structure—through the alternating arrangement of emulsifier molecules with amphiphilic structures at the oil / water interface. To date, researchers have conducted extensive studies on the factors influencing the formation of liquid crystal structures, but there is very little research on the impact of formulation composition on the stability of liquid crystal structures. The liquid crystal structure of liquid crystal emulsions gradually fades or even disappears completely during storage, thus significantly limiting their widespread application.

[0003] There are various liquid crystal emulsion formulations in the existing technology, but research has found that most of the liquid crystal emulsions prepared by the existing technical solutions have poor stability. After being placed under accelerated conditions (40℃, 75%RH) and low temperature conditions (-8℃) for a period of time, the amount of liquid crystal is significantly reduced.

[0004] Therefore, there is still an urgent need for a liquid crystal emulsion with good stability. Summary of the Invention

[0005] To address the aforementioned technical problems, this invention provides a liquid crystal emulsion and its preparation method.

[0006] In a first aspect, the present invention provides a liquid crystal emulsion.

[0007] A liquid crystal emulsion comprising: phase A, phase B, phase C, phase D, phase E, and phase F;

[0008] Phase A comprises a solvent, a humectant, and a thickener; the solvent is water.

[0009] Phase B includes emulsifiers, co-emulsifiers, thickeners, and emollients;

[0010] The emulsifier in phase B includes at least one of BEAUTYDERM K10, BEAUTYDERM HP, Lipomulse LuxeMB, MONTANOV 68MB, Aminol GDO, and Phytocompo-PP;

[0011] Phase C comprises a thickener and water;

[0012] Phase D includes a pH adjuster;

[0013] Phase E includes active ingredients;

[0014] The F phase includes antioxidants and humectants.

[0015] In some embodiments, the humectant in phase A includes at least one selected from 1,3-propanediol, 1,3-butanediol, dipropylene glycol, and glycerin. In some preferred embodiments, the humectant in phase A is at least one selected from glycerin and 1,3-butanediol. In some more preferred embodiments, the humectant in phase A is glycerin.

[0016] In some embodiments, the thickener in phase A includes carbomer.

[0017] In some embodiments, the thickener in phase A includes at least one selected from carbomer 980, carbomer 981, carbomer U10, carbomer U20, and carbomer U30. In some preferred embodiments, the thickener in phase A is at least one selected from carbomer 980 and carbomer 981. In some more preferred embodiments, the thickener in phase A is carbomer 981.

[0018] In some embodiments, the emulsifier in phase B is preferably at least one of MONTANOX 68MB, BEAUTYDERMK10, and BEAUTYDERM HP. In some more preferred embodiments, the emulsifier in phase B is MONTANOX 68MB. Compared to other emulsifiers, the use of MONTANOX 68MB is more beneficial in improving the stability of liquid crystal content, appearance, and mechanical stability of the resulting liquid crystal emulsion, resulting in unexpected technical effects.

[0019] In some embodiments, the co-emulsifier in phase B includes at least one of hydrogenated lecithin, ARLACEL 170, and AMPHISOL K. In some preferred embodiments, the co-emulsifier in phase B is hydrogenated lecithin.

[0020] In some embodiments, the thickener of phase B includes at least one selected from cetearyl alcohol, behenyl alcohol, and arachidyl alcohol. In some preferred embodiments, the thickener in phase B is cetearyl alcohol.

[0021] In some embodiments, the emollient in phase B comprises oils.

[0022] In some embodiments, the emollient in phase B includes at least one of shea butter, macadamia butter-R, squalane, olive oil, and caprylic / capric triglycerides.

[0023] In some embodiments, the thickener in the C phase includes at least one of SEPIGEL 305, SEPIGEL S, and SEPIGEL 400. In some preferred embodiments, the thickener in the C phase is SEPIGEL 305.

[0024] In some embodiments, the pH adjuster in phase D includes at least one of triethanolamine, L-arginine, and tromethamine.

[0025] In some embodiments, the active ingredients in phase E include at least one of Cordyceps sinensis extract, hyaluronic acid, sodium polyglutamate, and arginine / lysine peptide.

[0026] In some embodiments, the antioxidant in the F phase includes p-hydroxyacetophenone.

[0027] In some embodiments, the humectant in the F phase comprises a polyol.

[0028] In some embodiments, the humectant in the F phase includes at least one selected from 1,3-butanediol, 1,2-hexanediol, pentanediol, and 1,3-propanediol. In some embodiments, the humectant in the F phase is preferably 1,3-butanediol and 1,2-hexanediol.

[0029] In some embodiments, the content of the humectant in phase A is 3.00 wt% to 8.00 wt% based on the total mass of the liquid crystal emulsion. In some embodiments, the content of the humectant in phase A is 3.00 wt%, 4.00 wt%, 5.00 wt%, 6.00 wt%, 7.00 wt%, or 8.00 wt% based on the total mass of the liquid crystal emulsion.

[0030] In some embodiments, the content of the thickener in phase A, calculated based on the total mass of the liquid crystal emulsion, is 0.05 wt% to 0.30 wt%. In some embodiments, the content of the thickener in phase A, calculated based on the total mass of the liquid crystal emulsion, is 0.05 wt%, 0.10 wt%, 0.15 wt%, 0.20 wt%, 0.25 wt%, or 0.30 wt%.

[0031] In some embodiments, the content of the emulsifier in phase B, calculated based on the total mass of the liquid crystal emulsion, is 2.00 wt% to 5.00 wt%. In some embodiments, the content of the emulsifier in phase B, calculated based on the total mass of the liquid crystal emulsion, is 2.00 wt%, 3.00 wt%, 4.00 wt%, or 5.00 wt%.

[0032] In some embodiments, the content of the co-emulsifier in phase B, calculated based on the total mass of the liquid crystal emulsion, is 0.05 wt% to 0.30 wt%. In some embodiments, the content of the co-emulsifier in phase B, calculated based on the total mass of the liquid crystal emulsion, is 0.05 wt%, 0.10 wt%, 0.15 wt%, 0.20 wt%, 0.25 wt%, or 0.30 wt%.

[0033] In some embodiments, the content of the thickener in phase B, calculated based on the total mass of the liquid crystal emulsion, is 2.00 wt% to 5.00 wt%. In some embodiments, the content of the thickener in phase B, calculated based on the total mass of the liquid crystal emulsion, is 2.00 wt%, 3.00 wt%, 4.00 wt%, or 5.00 wt%.

[0034] In some embodiments, the content of the emollient in phase B, calculated based on the total mass of the liquid crystal emulsion, is 9.00 wt% to 12.00 wt%. In some embodiments, the content of the emollient in phase B, calculated based on the total mass of the liquid crystal emulsion, is 9.00 wt%, 10.00 wt%, 10.50 wt%, 11.00 wt%, or 12.00 wt%.

[0035] In some embodiments, the content of the thickener in the C phase, calculated based on the total mass of the liquid crystal emulsion, is 0.30 wt% to 1.00 wt%. In some embodiments, the content of the thickener in the C phase, calculated based on the total mass of the liquid crystal emulsion, is 0.30 wt%, 0.40 wt%, 0.50 wt%, 0.60 wt%, 0.70 wt%, 0.80 wt%, 0.90 wt%, or 1.00 wt%.

[0036] In some embodiments, the water content of the C phase, calculated based on the total mass of the liquid crystal emulsion, is 15.00 wt% to 25.00 wt%. In some embodiments, the water content of the C phase, calculated based on the total mass of the liquid crystal emulsion, is 15.00 wt%, 16.00 wt%, 17.00 wt%, 18.00 wt%, 19.00 wt%, 20.00 wt%, 21.00 wt%, 22.00 wt%, 23.00 wt%, 24.00 wt%, or 25.00 wt%.

[0037] In some embodiments, the content of the pH adjuster in the D phase, calculated based on the total mass of the liquid crystal emulsion, is 0.05 wt% to 0.50 wt%. In some embodiments, the content of the pH adjuster in the D phase, calculated based on the total mass of the liquid crystal emulsion, is 0.05 wt%, 0.10 wt%, 0.15 wt%, 0.20 wt%, 0.25 wt%, 0.30 wt%, 0.35 wt%, 0.40 wt%, 0.45 wt%, or 0.50 wt%.

[0038] In some embodiments, the amount of pH adjuster added to the D phase is such that the pH of the liquid crystal emulsion is 5.5-6.50. In some embodiments, the amount of pH adjuster added to the D phase is such that the pH of the liquid crystal emulsion is 5.5, 6.0, or 6.5.

[0039] In some embodiments, the content of the active material in the E phase is 1.00 wt% to 5.00 wt% based on the total mass of the liquid crystal emulsion. In some embodiments, the content of the active material in the E phase is 1.00 wt%, 2.00 wt%, 3.00 wt%, 4.00 wt%, or 5.00 wt% based on the total mass of the liquid crystal emulsion.

[0040] In some embodiments, the content of the humectant in the F phase is 1.50 wt% to 3.80 wt% based on the total mass of the liquid crystal emulsion. In some embodiments, the content of the humectant in the F phase is 1.50 wt%, 2.00 wt%, 2.50 wt%, 3.00 wt%, 3.50 wt%, or 3.80 wt% based on the total mass of the liquid crystal emulsion.

[0041] In some embodiments, the antioxidant content of the F phase is 0.50 wt% to 0.80 wt% based on the total mass of the liquid crystal emulsion. In some embodiments, the antioxidant content of the F phase is 0.50 wt%, 0.55 wt%, 0.60 wt%, 0.65 wt%, 0.70 wt%, 0.75 wt%, or 0.80 wt% based on the total mass of the liquid crystal emulsion.

[0042] In some embodiments, based on the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 3.00 wt%-8.00 wt%; the content of the thickener in phase A is 0.05 wt%-0.30 wt%; the content of the emulsifier in phase B is 2.00 wt%-5.00 wt%; the content of the co-emulsifier in phase B is 0.05 wt%-0.30 wt%; the content of the thickener in phase B is 2.00 wt%-5.00 wt%; the content of the emollient in phase B is 9.00 wt%-12.00 wt%; and the content of the thickener in phase C is 0. The liquid crystal emulsion contains 0.30wt%-1.00wt% of water in phase C, 15.00wt%-25.00wt% of water, 0.05wt%-0.50wt% of pH adjuster in phase D, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the active substance content in phase E is 1.00wt%-5.00wt% of active ingredient; the humectant content in phase F is 1.50wt%-3.80wt% of humectant; the antioxidant content in phase F is 0.50wt%-0.80wt% of antioxidant; and the balance is the solvent.

[0043] In some embodiments, the emollient is shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides; based on the total mass of the liquid crystal emulsion, the content of shea butter is 0.50 wt%-2.00 wt%, the content of macadamia nut butter-R is 1.00 wt%-3.00 wt%, the content of squalane is 1.00 wt%-4.00 wt%, the content of olive oil is 1.00 wt%-4.00 wt% or 1.00 wt%-2.00 wt%, and the content of caprylic / capric triglycerides is 2.00 wt%-5.00 wt%.

[0044] In some embodiments, the content of avocado oil, calculated based on the total mass of the liquid crystal emulsion, is 0.50 wt% to 2.00 wt%. In some embodiments, the content of avocado oil, calculated based on the total mass of the liquid crystal emulsion, is 0.50 wt%, 1.00 wt%, 1.50 wt%, or 2.00 wt%.

[0045] In some embodiments, the content of macadamia nut oil-R, calculated based on the total mass of the liquid crystal emulsion, is 1.00 wt% to 3.00 wt%. In some embodiments, the content of macadamia nut oil-R, calculated based on the total mass of the liquid crystal emulsion, is 1.00 wt%, 1.50 wt%, 2.00 wt%, 2.50 wt%, or 3.00 wt%.

[0046] In some embodiments, the squalane content is 1.00 wt% to 4.00 wt% based on the total mass of the liquid crystal emulsion. In some embodiments, the squalane content is 1.00 wt%, 1.50 wt%, 2.00 wt%, 2.50 wt%, 3.00 wt%, 3.50 wt%, or 4.00 wt% based on the total mass of the liquid crystal emulsion.

[0047] In some embodiments, the content of olive fruit oil, calculated based on the total mass of the liquid crystal emulsion, is 1.00 wt% to 4.00 wt%. In some embodiments, the content of olive fruit oil, calculated based on the total mass of the liquid crystal emulsion, is 1.00 wt%, 1.50 wt%, 2.00 wt%, 2.50 wt%, 3.00 wt%, 3.50 wt%, or 4.00 wt%. In some embodiments, the content of olive fruit oil, calculated based on the total mass of the liquid crystal emulsion, is 1.00 wt% to 2.00 wt%.

[0048] In some embodiments, the content of caprylic / capric triglycerides is 2.00 wt% to 5.00 wt% based on the total mass of the liquid crystal emulsion. In some embodiments, the content of caprylic / capric triglycerides is 2.00 wt%, 2.50 wt%, 3.00 wt%, 3.50 wt%, 4.00 wt%, 4.50 wt%, or 5.00 wt% based on the total mass of the liquid crystal emulsion.

[0049] In some embodiments, the humectant is 1,3-butanediol and 1,2-hexanediol; the content of 1,3-butanediol is 1.00wt%-3.00wt% (e.g., 1.00wt%, 1.50wt%, 2.00wt%, 2.50wt%, or 3.00wt%) based on the total mass of the liquid crystal emulsion, and the content of 1,2-hexanediol is 0.50wt%-0.80wt% (e.g., 0.50wt%, 0.60wt%, 0.70wt%, or 0.80wt%).

[0050] In some embodiments, the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollients in phase B are shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectants in phase F are 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone.

[0051] In some embodiments, the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollient in phase B is shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone;

[0052] Based on the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 3.00 wt%-8.00 wt%; the content of the thickener in phase A is 0.05 wt%-0.30 wt%; the content of the emulsifier in phase B is 2.00 wt%-5.00 wt%; the content of the co-emulsifier in phase B is 0.05 wt%-0.30 wt%; the content of the thickener in phase B is 2.00 wt%-5.00 wt%; the content of the emollient in phase B is 9.00 wt%-12.00 wt%; and the content of the thickener in phase C is 0.30 wt%. The liquid crystal emulsion contains 15.00 wt% to 1.00 wt% water in phase C, 0.05 wt% to 25.00 wt% water in phase D, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5 to 6.5; the active substance content of phase E is 1.00 wt% to 5.00 wt% active ingredient; the humectant content of phase F is 1.50 wt% to 3.80 wt% humectant; the antioxidant content of phase F is 0.50 wt% to 0.80 wt% antioxidant; and the balance is the solvent.

[0053] In some embodiments, the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollient in phase B is shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone;

[0054] Based on the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 5.00 wt%; the content of the thickener in phase A is 0.15 wt%; the content of the emulsifier in phase B is 3.50 wt%; the content of the co-emulsifier in phase B is 0.15 wt%; the content of the thickener in phase B is 3.50 wt%; the content of shea butter is 1.00 wt%; the content of macadamia nut butter-R is 1.50 wt%; the content of squalane is 2.00 wt%; the content of olive oil is 1.50 wt%; and the content of caprylic / capric triglycerides is... The amount is 3.00 wt%; the content of the thickener in phase C is 0.50 wt%; the content of water in phase C is 20.00 wt%; the content of the pH adjuster in phase D is 0.10 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of the active substance in phase E is 2.00 wt%; the content of 1,3-butanediol in phase F is 2.00 wt%; the content of 1,2-hexanediol in phase F is 0.60 wt%; the content of antioxidant in phase F is 0.60 wt%; the balance is the solvent.

[0055] In some embodiments, the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollient in phase B is shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone;

[0056] Based on the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 3.00 wt%; the content of the thickener in phase A is 0.20 wt%; the content of the emulsifier in phase B is 2.00 wt%; the content of the co-emulsifier in phase B is 0.30 wt%; the content of the thickener in phase B is 3.00 wt%; the content of shea butter is 0.50 wt%; the content of macadamia nut butter-R is 1.00 wt%; the content of squalane is 3.00 wt%; the content of olive oil is 1.00 wt%; and the content of caprylic / capric triglycerides is... The amount is 5.00 wt%; the content of the thickener in phase C is 1.00 wt%; the content of water in phase C is 25.00 wt%; the content of the pH adjuster in phase D is 0.15 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of the active substance in phase E is 3.00 wt%; the content of 1,3-butanediol in phase F is 1.50 wt%; the content of 1,2-hexanediol in phase F is 0.80 wt%; the content of antioxidant in phase F is 0.50 wt%; the balance is the solvent.

[0057] In some embodiments, the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollient in phase B is shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone;

[0058] Based on the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 8.00 wt%; the content of the thickener in phase A is 0.30 wt%; the content of the emulsifier in phase B is 3.00 wt%; the content of the co-emulsifier in phase B is 0.20 wt%; the content of the thickener in phase B is 2.00 wt%; the content of shea butter is 1.50 wt%; the content of macadamia nut butter-R is 2.00 wt%; the content of squalane is 4.00 wt%; the content of olive oil is 1.00 wt%; and the content of caprylic / capric triglycerides is... The amount is 2.00 wt%; the content of the thickener in phase C is 0.30 wt%; the content of water in phase C is 15.00 wt%; the content of the pH adjuster in phase D is 0.20 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of the active substance in phase E is 4.00 wt%; the content of 1,3-butanediol in phase F is 2.50 wt%; the content of 1,2-hexanediol in phase F is 0.70 wt%; the content of antioxidant in phase F is 0.70 wt%; the balance is the solvent.

[0059] In some embodiments, the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollient in phase B is shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone;

[0060] Based on the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 6.00 wt%; the content of the thickener in phase A is 0.05 wt%; the content of the emulsifier in phase B is 5.00 wt%; the content of the co-emulsifier in phase B is 0.05 wt%; the content of the thickener in phase B is 5.00 wt%; the content of shea butter is 2.00 wt%; the content of macadamia nut butter-R is 3.00 wt%; the content of squalane is 1.00 wt%; the content of olive oil is 2.00 wt%; and the content of caprylic / capric triglycerides is... The amount is 4.00 wt%; the content of the thickener in phase C is 0.60 wt%; the content of water in phase C is 22.00 wt%; the content of the pH adjuster in phase D is 0.05 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of the active substance in phase E is 5.00 wt%; the content of 1,3-butanediol in phase F is 3.00 wt%; the content of 1,2-hexanediol in phase F is 0.50 wt%; the content of antioxidant in phase F is 0.80 wt%; the balance is the solvent.

[0061] In some embodiments, the preparation method of the Cordyceps sinensis extract includes:

[0062] (1) Mix Cordyceps sinensis or Cordyceps mycelium powder with water at a mass ratio of 1:20 to 1:30, and extract by stirring in a water bath at 20 to 100°C for 30 to 100 minutes, then filter.

[0063] (2) After filtration, the solid is added to a mixture of glycerol and water of the same mass as the water in step (1) for extraction. The mixture is stirred at a constant temperature in a water bath at 20-100℃ for 30-100 minutes and then filtered. The filtrates from the two extractions are combined, and the volume ratio of glycerol to water is 1:20-50.

[0064] (3) The filtrate obtained in (2) is concentrated under vacuum to 10 to 50 times the mass of Cordyceps or mycelium powder, centrifuged and filtered, and the filtrate is mixed with glycerol at a mass ratio of 1:0.5 to 3 to obtain the Cordyceps extract.

[0065] In some embodiments, the preparation method of the Cordyceps sinensis extract includes:

[0066] (1) Weigh 20.0g of dried Cordyceps sinensis and grind it to 40 mesh. Mix the powder with water at a mass ratio of 1:20. Extract the powder by stirring in a 20℃ water bath for 30 minutes and then filter.

[0067] (2) After filtration, add the same mass of glycerol and water mixture as in step (1) to the solid. Stir and extract in a 20°C water bath for 30 minutes, then filter. Combine the filtrates from the two extractions, where the volume ratio of glycerol to water is 1:20.

[0068] (3) The filtrate obtained in (2) was concentrated under vacuum to 10 times the mass of Cordyceps sinensis powder, and then centrifuged at 6000 r / min for 20 minutes and filtered through a 0.22 μm filter membrane. The filtrate was mixed with glycerol at a mass ratio of 1:0.5 to obtain the Cordyceps sinensis extract.

[0069] Secondly, the present invention provides a method for preparing the aforementioned liquid crystal emulsion.

[0070] A method for preparing the liquid crystal emulsion according to any one of claims 1-8, characterized in that it comprises:

[0071] (1) Mix the components in phase A, heat and dissolve to obtain phase A mixture; mix the components in phase B, heat and dissolve to obtain phase B mixture; then add phase B mixture to phase A mixture, homogenize and emulsify to obtain AB mixture;

[0072] (2) Mix the C phase to obtain a C phase mixture, then add the C phase mixture to the AB phase mixture, homogenize, stir and cool to obtain the ABC phase mixture;

[0073] (3) Add phase D to the ABC mixed phase, stir and cool to obtain the ABCD mixed phase;

[0074] (4) Add phase E to the ABCD mixed phase and stir to obtain the ABCDE mixed phase;

[0075] (5) Mix the components in phase F, heat to dissolve, and obtain phase F mixture. Then add it to phase ABCDE mixture, stir, and cool to room temperature to obtain liquid crystal emulsion.

[0076] In some embodiments, the heating and dissolution temperature of each component in phase A in step (1) is 80°C-95°C. In some embodiments, the heating and dissolution temperature of each component in phase A in step (1) is 80°C, 85°C, 90°C, or 95°C. In some embodiments, the heating and dissolution temperature of each component in phase A in step (1) is 85°C.

[0077] In some embodiments, the heating and dissolution temperature of each component in phase B in step (1) is 80°C-95°C. In some embodiments, the heating and dissolution temperature of each component in phase B in step (1) is 80°C, 85°C, 90°C, or 95°C. In some embodiments, the heating and dissolution temperature of each component in phase B in step (1) is 85°C.

[0078] In some embodiments, the stirring and cooling in step (2) is to cool to 70°C-60°C while stirring. In some embodiments, the stirring and cooling in step (2) is to cool to 70°C, 65°C, 64°C, 63°C, 62°C, 61°C, or 60°C while stirring. In some embodiments, the stirring and cooling in step (2) is to cool to 65°C while stirring.

[0079] In some embodiments, the stirring and cooling in step (3) is to cool to 60°C-50°C while stirring. In some embodiments, the stirring and cooling in step (3) is to cool to 60°C, 55°C, 54°C, 53°C, 52°C, 51°C, or 50°C while stirring. In some embodiments, the stirring and cooling in step (3) is to cool to 55°C while stirring.

[0080] In some embodiments, the heating and dissolving temperature in step (5) is 65°C-70°C. In some embodiments, the heating and dissolving temperature in step (5) is 65°C, 66°C, 67°C, 68°C, 69°C, or 70°C.

[0081] Beneficial effects

[0082] Compared with the prior art, the present invention has at least one of the following technical effects:

[0083] (1) The liquid crystal emulsion provided by the present invention has good stability. It still has good stability of liquid crystal content, appearance and shape and mechanical stability under accelerated conditions and low temperature conditions, and has unexpected technical effects.

[0084] (2) Compared with other emulsifiers, the emulsifier provided by the present invention, especially MONTANOV 68MB, is more conducive to improving the stability of liquid crystal content, appearance and shape and mechanical stability of the obtained liquid crystal emulsion, and has unexpected technical effects.

[0085] (3) Compared with other co-emulsifiers, the co-emulsifier provided by the present invention, especially hydrogenated lecithin, is more conducive to improving the stability of liquid crystal content, appearance and shape and mechanical stability of the obtained liquid crystal emulsion, and has unexpected technical effects.

[0086] (4) Compared with other thickeners, the thickener provided by the present invention, especially cetearyl alcohol, is more conducive to improving the stability of liquid crystal content, appearance and shape and mechanical stability of the obtained liquid crystal emulsion, and has unexpected technical effects.

[0087] (5) Compared with other emollients or single emollients, the present invention preferably uses avocado fruit oil, macadamia fruit oil-R, squalane, olive fruit oil and caprylic / capric triglyceride as emollients, which is more conducive to improving the stability of liquid crystal content, appearance and shape and mechanical stability of the obtained liquid crystal emulsion, and has unexpected technical effects.

[0088] Terminology Explanation:

[0089] The term "room temperature" refers to the ambient temperature, which can be 15℃-40℃, 20℃-35℃, or 20℃-30℃.

[0090] The term "wt%" indicates a weight percentage.

[0091] The term "rpm" means "revolutions per minute".

[0092] In the description of this invention, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0093] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples. Detailed Implementation

[0094] To enable those skilled in the art to better understand the technical solutions of the present invention, some non-limiting embodiments are further disclosed below to provide a more detailed description of the present invention.

[0095] All reagents used in this invention can be purchased from the market, prepared according to conventional methods in the art, or prepared by the methods described in this invention.

[0096] I. Names and manufacturers of each reagent:

[0097]

[0098]

[0099] Cordyceps sinensis extract: Prepared according to the preparation method with added glycerin in Example 1 of CN104546657A; details are as follows:

[0100] (1) Weigh 20.0g of dried Cordyceps sinensis and grind it to 40 mesh. Mix the powder with water at a mass ratio of 1:20. Extract the powder by stirring in a 20℃ water bath for 30 minutes and then filter.

[0101] (2) After filtration, add the same mass of glycerol and water mixture as in step (1) to the solid. Stir and extract in a 20°C water bath for 30 minutes, then filter. Combine the filtrates from the two extractions, where the volume ratio of glycerol to water is 1:20.

[0102] (3) The filtrate obtained in (2) was concentrated under vacuum to 10 times the mass of the Cordyceps sinensis powder, then centrifuged at 6000 r / min for 20 minutes and filtered through a 0.22 μm filter membrane. The filtrate was then mixed with glycerol at a mass ratio of 1:0.5 to obtain the Cordyceps sinensis extract.

[0103] II. Methods for Detecting Liquid Crystal Content

[0104] The liquid crystal structure of the liquid crystal emulsion was observed using a microscope (Ci-POL polarizing microscope), and the pixels in the image were analyzed using Photoshop software to calculate the number of pixels in the liquid crystal portion.

[0105] The formula for calculating the liquid crystal content is as follows:

[0106] L = (Pc / Pg) × 100%;

[0107] Where L represents the liquid crystal content;

[0108] Pc represents the pixels of a liquid crystal image;

[0109] Pg represents the pixels of the image.

[0110] To minimize human error in the calculations, all sample image processing and calculations were performed by the same person.

[0111] III. Mechanical Stability Test

[0112] Place the test sample in a centrifuge, set the speed to 3000 rpm, and observe the condition of the sample after 30 minutes.

[0113] Examples 1-4: Liquid Crystal Emulsions

[0114] Formula: See Table 1.

[0115] Table 1: Liquid Crystal Emulsion Formulations

[0116]

[0117]

[0118] Preparation method:

[0119] (1) Mix the components in phase A and heat to dissolve (85°C) to obtain phase A mixture; mix the components in phase B and heat to dissolve (85°C) to obtain phase B mixture; then add phase B mixture to phase A mixture and homogenize and emulsify to obtain AB mixture phase;

[0120] (2) Mix the C phase to obtain the C phase mixture, then add the C phase mixture to the AB phase mixture, homogenize (homogenization rate is 5000 rpm, homogenization time is 60 seconds), stir and cool to 50℃ to obtain the ABC phase mixture;

[0121] (3) Add phase D to the ABC mixed phase, stir and cool to 45℃ (stirring speed is 300 rpm) to obtain the ABCD mixed phase;

[0122] (4) Add phase E to the ABCD mixed phase and stir to obtain the ABCDE mixed phase;

[0123] (5) Mix the components in phase F, heat to dissolve (65°C) to obtain phase F mixture, then add to phase ABCDE mixture, stir, cool to room temperature to obtain liquid crystal emulsion (the liquid crystal emulsion obtained in Example 1 has a pH of 5.80, the liquid crystal emulsion obtained in Example 2 has a pH of 6.0, the liquid crystal emulsion obtained in Example 3 has a pH of 5.7, and the liquid crystal emulsion obtained in Example 4 has a pH of 6.3).

[0124] Comparative Examples 1-5: Investigation of Emulsifiers

[0125] The emulsifier was investigated based on the formulation of Example 1. The MONTANOV 68MB with a content of 3.5 wt% in Example 1 was replaced with the emulsifier in Table 2 with a content of 3.5 wt%. The other components, their contents, and the preparation method were the same as in Example 1.

[0126] Table 2: Emulsifier Evaluation

[0127] test emulsifier Comparative Example 1 BEAUTYDERM K10 Comparative Example 2 BEAUTYDERM HP Comparative Example 3 Lipomulse Luxe MB Comparative Example 4 Aminol GDO Comparative Example 5 Phytocompo-PP Comparative Example 6 MONTANOV 202

[0128] Comparative Examples 7-8: Investigation of Co-emulsifiers

[0129] Based on the formulation of Example 1, the co-emulsifier was investigated. The hydrogenated lecithin in the formulation of Example 1, which had a content of 0.15 wt%, was replaced with the co-emulsifier in Table 3, which had a content of 0.15 wt%. The other components, their contents, and the preparation methods were the same as in Example 1.

[0130] Table 3: Evaluation of Emulsifiers

[0131] test co-emulsifier Comparative Example 7 ARLACEL 170 Comparative Example 8 AMPHISOL K

[0132] Comparative Examples 9-11: Investigation of Thickeners

[0133] Thickeners were investigated based on the formulation of Example 1. The SEPIGEL 305 in Example 1, with a content of 0.50 wt%, was replaced with the thickener in Table 4, with a content of 0.50 wt%. The other components, their contents, and the preparation method were the same as in Example 1.

[0134] Table 4: Thickener Investigation

[0135] test Thickener Comparative Example 9 SEPINOV EMT 10 Comparative Example 10 Aristoflex AVC Comparative Example 11 Carbomer 940

[0136] Comparative Examples 12-16: Investigation of Emollients

[0137] Thickeners were investigated based on the formulation of Example 1. All emollients in Example 1 were replaced with emollients in Table 5. The total content of emollients remained unchanged, while the content of other components and preparation methods were the same as in Example 1.

[0138] Table 5: Analysis of Emollients

[0139]

[0140]

[0141] Experimental Example 1: Stability of Liquid Crystal Content and Appearance

[0142] The liquid crystal emulsions obtained in the above examples and comparative examples were placed under accelerated conditions (40°C, 75% RH) and low temperature conditions (-8°C) for 0 days and 9 months, respectively. The appearance and shape were observed, and the liquid crystal content was tested (the liquid crystal content was stirred evenly before testing). The results are shown in Table 6.

[0143] Table 6: Results of Liquid Crystal Content Stability Study

[0144]

[0145]

[0146] in conclusion:

[0147] (1) Compared with other emulsifiers, using MONTANOV 68MB provided by the present invention as an emulsifier is more conducive to improving the stability of liquid crystal content and appearance properties of liquid crystal emulsion, and has unexpected technical effects.

[0148] (2) Compared with other co-emulsifiers, the hydrogenated lecithin provided by the present invention is more conducive to improving the stability of liquid crystal content and appearance of liquid crystal emulsion, and has unexpected technical effects.

[0149] (3) Compared with other thickeners, the use of cetearyl alcohol provided by the present invention as a thickener in phase B is more conducive to improving the stability of liquid crystal content and appearance of liquid crystal emulsion, and has unexpected technical effects.

[0150] (4) Compared with a single emollient, the present invention uses avocado fruit oil, macadamia fruit oil-R, squalane, olive fruit oil and caprylic / capric triglyceride as emollients, which is more conducive to improving the stability of liquid crystal content and appearance of liquid crystal emulsion, and has unexpected technical effects.

[0151] Experimental Example 2: Investigation of Mechanical Stability

[0152] The liquid crystal emulsions obtained in the above examples and comparative examples were placed under accelerated conditions (40°C, 75% RH) and low temperature conditions (-8°C) for 0 days and 9 months, respectively, and their mechanical stability was tested. The results are shown in Table 7.

[0153] Table 7: Results of Mechanical Stability Test

[0154]

[0155] in conclusion:

[0156] (1) Compared with other emulsifiers, using MONTANOV 68MB provided by the present invention as an emulsifier is more conducive to improving the mechanical stability of liquid crystal emulsions and has unexpected technical effects.

[0157] (2) Compared with other co-emulsifiers, the hydrogenated lecithin provided by the present invention is more conducive to improving the mechanical stability of liquid crystal emulsions and has unexpected technical effects.

[0158] (3) Compared with other thickeners, the use of cetearyl alcohol provided by the present invention as a thickener in phase B is more conducive to improving the mechanical stability of liquid crystal emulsion and has unexpected technical effects.

[0159] (4) Compared with a single emollient, the present invention uses avocado fruit oil, macadamia fruit oil-R, squalane, olive fruit oil and caprylic / capric triglyceride as emollients, which is more conducive to improving the mechanical stability of liquid crystal emulsion and has unexpected technical effects.

[0160] The method of this invention has been described through preferred embodiments. Those skilled in the art will readily be able to modify or appropriately alter and combine the methods and applications described herein within the scope, spirit, and context of this invention to implement and apply the technology of this invention. Those skilled in the art can refer to the content herein to appropriately improve process parameters. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are considered to be included within the scope of this invention.

Claims

1. A liquid crystal emulsion, characterized in that, include: Phase A, Phase B, Phase C, Phase D, Phase E, and Phase F; Phase A comprises a solvent, a humectant, and a thickener; the solvent is water. Phase B includes emulsifiers, co-emulsifiers, thickeners, and emollients; The emulsifier in phase B includes at least one of MONTANOV 68MB, BEAUTYDERM K10, BEAUTYDERM HP, Lipomulse Luxe MB, Aminol GDO, and Phytocompo-PP; Phase C comprises a thickener and water; Phase D includes a pH adjuster; Phase E includes active ingredients; The F phase includes antioxidants and humectants.

2. The liquid crystal emulsion according to claim 1, wherein the humectant in phase A comprises at least one selected from 1,3-propanediol, 1,3-butanediol, dipropylene glycol, and glycerin; preferably at least one selected from glycerin and 1,3-butanediol; and / or The thickener in phase A includes carbomer; and / or The thickener in phase A includes at least one of carbomer 980, carbomer 981, carbomer U10, carbomer U20 and carbomer U30; preferably at least one of carbomer 980 and carbomer 981; more preferably carbomer 981.

3. The liquid crystal emulsion according to any one of claims 1-2, wherein the emulsifier in the B phase is at least one selected from MONTANOX 68MB, BEAUTYDERM K10, and BEAUTYDERM HP; preferably, the emulsifier in the B phase is MONTANOX 68MB; and / or The co-emulsifier in phase B includes at least one of hydrogenated lecithin, ARLACEL 170, and AMPHISOL K; preferably hydrogenated lecithin; and / or The thickener in phase B includes cetearyl alcohol; and / or The emollient in phase B includes oils; and / or The emollient in phase B includes at least one of shea butter, macadamia nut butter-R, squalane, olive oil, and caprylic / capric triglycerides.

4. The liquid crystal emulsion according to any one of claims 1-3, wherein the thickener in the C phase comprises at least one selected from SEPIGEL 305, SEPIGEL S, and SEPIGEL 400; preferably SEPIGEL 305; and / or The pH adjuster in phase D includes at least one of triethanolamine, L-arginine, and tromethamine; and / or The active ingredients in phase E include at least one of Cordyceps sinensis extract, hyaluronic acid, sodium polyglutamate, and arginine / lysine peptides; and / or The antioxidants in phase F include p-hydroxyacetophenone; and / or The humectant in phase F includes polyols; and / or The humectant in phase F includes at least one of 1,3-butanediol, 1,2-hexanediol, pentanediol, and 1,3-propanediol; preferably 1,3-butanediol and 1,2-hexanediol.

5. The liquid crystal emulsion according to any one of claims 1-4, wherein the content of the humectant in phase A is 3.00 wt%-8.00 wt% based on the total mass of the liquid crystal emulsion; and / or Based on the total mass of the liquid crystal emulsion, the content of the thickener in phase A is 0.05 wt% - 0.30 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the emulsifier in phase B is 2.00 wt% - 5.00 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the co-emulsifier in phase B is 0.05 wt% - 0.30 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the thickener in phase B is 2.00 wt% - 5.00 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the emollient in phase B is 9.00 wt% - 12.00 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the thickener in the C phase is 0.30 wt% - 1.00 wt%; and / or Based on the total mass of the liquid crystal emulsion, the water content of the C phase is 15.00 wt% - 25.00 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the pH adjuster in phase D is 0.05wt%-0.50wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; and / or Based on the total mass of the liquid crystal emulsion, the content of active material in the E phase is 1.00 wt% - 5.00 wt%; and / or Based on the total mass of the liquid crystal emulsion, the content of the humectant in the F phase is 1.50 wt% - 3.80 wt%; and / or Based on the total mass of the liquid crystal emulsion, the antioxidant content of the F phase is 0.50wt%-0.80wt%.

6. The liquid crystal emulsion according to any one of claims 1-5, wherein, calculated by the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 3.00 wt%-8.00 wt%; the content of the thickener in phase A is 0.05 wt%-0.30 wt%; the content of the emulsifier in phase B is 2.00 wt%-5.00 wt%; the content of the co-emulsifier in phase B is 0.05 wt%-0.30 wt%; the content of the thickener in phase B is 2.00 wt%-5.00 wt%; the content of the emulsifier in phase B is 9.00 wt%-12.00 wt%; and the content of the emulsifier in phase C is... The thickener content is 0.30wt%-1.00wt%; the water content of phase C is 15.00wt%-25.00wt%; the pH adjuster content of phase D is 0.05wt%-0.50wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the active substance content of phase E is 1.00wt%-5.00wt%; the humectant content of phase F is 1.50wt%-3.80wt%; the antioxidant content of phase F is 0.50wt%-0.80wt%; and the balance is the solvent.

7. The liquid crystal emulsion according to any one of claims 1-6, wherein the emollient is shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides; and, based on the total mass of the liquid crystal emulsion, the content of shea butter is 0.50 wt%-2.00 wt%, the content of macadamia nut butter-R is 1.00 wt%-3.00 wt%, the content of squalane is 1.00 wt%-4.00 wt%, the content of olive fruit oil is 1.00 wt%-4.00 wt% or 1.00 wt%-2.00 wt%, and the content of caprylic / capric triglycerides is 2.00 wt%-5.00 wt%; and / or The humectant is 1,3-butanediol and 1,2-hexanediol; based on the total mass of the liquid crystal emulsion, the content of 1,3-butanediol is 1.00wt%-3.00wt%, and the content of 1,2-hexanediol is 0.50wt%-0.80wt%.

8. The liquid crystal emulsion according to any one of claims 1-7, wherein the humectant in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollient in phase B is shea butter, macadamia butter-R, squalane, olive oil and caprylic / capric triglyceride, the thickener in phase C is SEPIGEL 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone; or The moisturizer in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollients in phase B are shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides, and the thickener in phase C is SEPIGEL. 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone; calculated by the total mass of the liquid crystal emulsion, the humectant content in phase A is 3.00wt%-8.00wt%; the thickener content in phase A is 0.05wt%-0.30wt%; the emulsifier content in phase B is 2.00wt%-5.00wt%; and the co-emulsifier content in phase B is 0.05wt%-0.30wt%. The content of the thickener in phase B is 2.00 wt%-5.00 wt%; the content of the emollient in phase B is 9.00 wt%-12.00 wt%; the content of the thickener in phase C is 0.30 wt%-1.00 wt%; the content of water in phase C is 15.00 wt%-25.00 wt%; the content of the pH adjuster in phase D is 0.05 wt%-0.50 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of the active substance in phase E is 1.00 wt%-5.00 wt%. The content of the humectant in phase F is 1.50wt%-3.80wt%; the content of the antioxidant in phase F is 0.50wt%-0.80wt%. The remainder is the solvent; or The moisturizer in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollients in phase B are shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides, and the thickener in phase C is SEPIGEL. 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone; calculated by the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 5.00 wt%; the content of the thickener in phase A is 0.15 wt%; the content of the emulsifier in phase B is 3.50 wt%; the content of the co-emulsifier in phase B is 0.15 wt%; the content of the thickener in phase B is 3.50 wt%; the content of the shea butter is 1.00 wt%; the content of macadamia nut butter-R is 1.50 wt%; the content of squalane is... The content of the following components is as follows: 2.00 wt%; the content of olive fruit oil is 1.50 wt%; the content of caprylic / capric triglyceride is 3.00 wt%; the content of the thickener in phase C is 0.50 wt%; the content of water in phase C is 20.00 wt%; the content of pH adjuster in phase D is 0.10 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of active substance in phase E is 2.00 wt%; the content of 1,3-butanediol in phase F is 2.00 wt%; the content of 1,2-hexanediol in phase F is 0.60 wt%; the content of antioxidant in phase F is 0.60 wt%; the balance is the solvent; or The moisturizer in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollients in phase B are shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides, and the thickener in phase C is SEPIGEL. 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectants in phase F are 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone; calculated by the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 3.00 wt%; the content of the thickener in phase A is 0.20 wt%; the content of the emulsifier in phase B is 2.00 wt%; the content of the co-emulsifier in phase B is 0.30 wt%; the content of the thickener in phase B is 3.00 wt%; the content of shea butter is 0.50 wt%; the content of macadamia nut butter-R is 1.00 wt%; the content of squalane is... The content of the following components is as follows: 3.00 wt%; the content of olive fruit oil is 1.00 wt%; the content of caprylic / capric triglyceride is 5.00 wt%; the content of the thickener in phase C is 1.00 wt%; the content of water in phase C is 25.00 wt%; the content of pH adjuster in phase D is 0.15 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of active substance in phase E is 3.00 wt%; the content of 1,3-butanediol in phase F is 1.50 wt%; the content of 1,2-hexanediol in phase F is 0.80 wt%; the content of antioxidant in phase F is 0.50 wt%; the balance is the solvent; or The moisturizer in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollients in phase B are shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides, and the thickener in phase C is SEPIGEL. 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone; calculated by the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 8.00 wt%; the content of the thickener in phase A is 0.30 wt%; the content of the emulsifier in phase B is 3.00 wt%; the content of the co-emulsifier in phase B is 0.20 wt%; the content of the thickener in phase B is 2.00 wt%; the content of the shea butter is 1.50 wt%; the content of the avocado fruit oil is... The content of argan oil-R is 2.00 wt%; the content of squalane is 4.00 wt%; the content of olive oil is 1.00 wt%; the content of caprylic / capric triglyceride is 2.00 wt%; the content of thickener in phase C is 0.30 wt%; the content of water in phase C is 15.00 wt%; the content of pH adjuster in phase D is 0.20 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of active substance in phase E is 4.00 wt%; and the content of 1,3-butanediol in phase F is 2.50 wt%. The 1,2-hexanediol content of the F phase is 0.70 wt%; the antioxidant content of the F phase is 0.70 wt%; the balance is the solvent; or The moisturizer in phase A is glycerin, the thickener in phase A is carbomer 981, the emulsifier in phase B is MONTANOV 68MB, the co-emulsifier in phase B is hydrogenated lecithin, the thickener in phase B is cetearyl alcohol, the emollients in phase B are shea butter, macadamia nut butter-R, squalane, olive fruit oil, and caprylic / capric triglycerides, and the thickener in phase C is SEPIGEL. 305, the pH adjuster in phase D is triethanolamine, the active ingredient in phase E is Cordyceps sinensis extract, the humectant in phase F is 1,3-butanediol and 1,2-hexanediol, and the antioxidant in phase F is p-hydroxyacetophenone; calculated by the total mass of the liquid crystal emulsion, the content of the humectant in phase A is 6.00 wt%; the content of the thickener in phase A is 0.05 wt%; the content of the emulsifier in phase B is 5.00 wt%; the content of the co-emulsifier in phase B is 0.05 wt%; the content of the thickener in phase B is 5.00 wt%; the content of the shea butter is 2.00 wt%; the content of the macadamia nut butter-R is 3.00 wt%; the content of the squalane is... The amount is 1.00 wt%; the content of olive fruit oil is 2.00 wt%; the content of caprylic / capric triglyceride is 4.00 wt%; the content of the thickener in phase C is 0.60 wt%; the content of water in phase C is 22.00 wt%; the content of pH adjuster in phase D is 0.05 wt%, or the amount of pH adjuster added to phase D is such that the pH of the liquid crystal emulsion is 5.5-6.5; the content of active substance in phase E is 5.00 wt%; the content of 1,3-butanediol in phase F is 3.00 wt%; the content of 1,2-hexanediol in phase F is 0.50 wt%; the content of antioxidant in phase F is 0.80 wt%; the balance is the solvent.

9. A method for preparing the liquid crystal emulsion according to any one of claims 1-8, characterized in that, include: (1) Mix the components in phase A, heat to dissolve, and obtain a phase A mixture; The components in phase B are mixed and heated to dissolve, resulting in a phase B mixture. Then, add the B-phase mixture to the A-phase mixture, homogenize and emulsify to obtain the AB-phase mixture; (2) Mix the C phase to obtain a C phase mixture, then add the C phase mixture to the AB phase mixture, homogenize, stir and cool to obtain the ABC phase mixture; (3) Add phase D to the ABC mixed phase, stir and cool to obtain the ABCD mixed phase; (4) Add phase E to the ABCD mixed phase and stir to obtain the ABCDE mixed phase; (5) Mix the components in phase F, heat to dissolve, and obtain phase F mixture. Then add it to phase ABCDE mixture, stir, and cool to room temperature to obtain liquid crystal emulsion.

10. The preparation method according to claim 9, wherein the heating and dissolution temperature of each component in phase A in step (1) is 80℃-95℃, or 85℃; and / or In step (1), the heating and dissolution temperature of each component in phase B is 80℃-95℃, or 85℃; and / or The stirring and cooling in step (2) involves stirring while cooling to 70°C-60°C, or 65°C; and / or The stirring and cooling in step (3) involves stirring while cooling to 60°C-50°C or 55°C; and / or The heating and melting temperature in step (5) is 65℃-70℃.

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