A composite material containing umbilical cord mesenchymal stromal cell exosome combined with ECM and a preparation method and application thereof
By optimizing the ratio and preparation process of umbilical cord mesenchymal matrix cell exosomes and ECM, a composite material of umbilical cord mesenchymal matrix cell exosomes combined with ECM was prepared, which solved the problems of insufficient exosome repair factor content and short retention time in the existing technology, and achieved efficient healing and low scar formation of chronic wounds.
Patent Information
- Application Number
- CN202610769519.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-29
- Publication Date
- 2026-07-24
AI Technical Summary
Existing technologies have limited content of repair-related factors in umbilical cord mesenchymal matrix cell exosomes, short retention time, and low bioavailability. The ratio of exosomes to ECM composite materials and the preparation process lack systematic optimization, making it difficult to meet the repair needs of chronic wounds.
By inducing and culturing umbilical cord mesenchymal matrix cell exosomes, optimizing their ratio with ECM and the preparation process, a composite material of umbilical cord mesenchymal matrix cell exosomes combined with ECM was prepared, which promoted the transformation of wound from the inflammatory phase to the proliferative phase and accelerated angiogenesis and granulation tissue formation.
It significantly shortens healing time and reduces scar formation rate, and is particularly suitable for chronic wounds such as diabetic foot ulcers, venous ulcers and pressure injuries. It has good bioactivity and carrier support.