Piezoelectric-driven layered bionic stent for diabetic bone defect repair and preparation method and application of piezoelectric-driven layered bionic stent

By designing a piezoelectrically driven layered biomimetic scaffold, the problems of limited electrical signal conduction and abnormal microenvironment in diabetic bone defects were solved, realizing bone regeneration and microenvironment remodeling, and exhibiting excellent mechanical properties and drug release control.

CN122440903APending Publication Date: 2026-07-24LIANYUNGANG SECOND PEOPLES HOSPITAL (LIANYUNGANG CLINICAL TUMOR RES INST)
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Patent Information

Application Number
CN202610805662.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-05
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing biomaterials are insufficient to achieve spatial gradation and multi-effect coordination in the repair of bone defects in diabetic patients. The electrical signals of piezoelectric materials cannot penetrate deep into the core area of ​​the defect, and conventional materials are insufficient to correct the immune-metabolic abnormalities in the diabetic microenvironment.

Method used

A piezoelectrically driven layered biomimetic scaffold is designed, comprising an upper piezoelectric biomimetic periosteum simulating the periosteum and a lower conductive filling hydrogel simulating the defect filling matrix. Electrical signals are conducted to the defect core area through a continuous conductive network, and excess reactive oxygen species are cleared by Ce-MOF nanozymes, releasing metabolic reprogramming factors.

Benefits of technology

It achieves deep conduction of electrical signals, promotes bone regeneration and microenvironment remodeling, reverses diabetic inflammation, and has excellent mechanical properties and drug release control, making it suitable for the bone tissue healing cycle.

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Abstract

The invention relates to the technical field of orthopedic clinical repair, and particularly discloses a piezoelectric driving layered bionic stent for diabetic bone defect repair and a preparation method and application of the piezoelectric driving layered bionic stent. The stent comprises an upper-layer piezoelectric bionic periosteum for simulating a periosteum and a lower-layer conductive filling hydrogel for simulating a defect filling matrix, the upper-layer piezoelectric bionic periosteum is a nanofiber membrane, and the lower-layer conductive filling hydrogel is composite three-dimensional porous hydrogel. According to the scheme, the composite bionic stent capable of simulating a physical hierarchical structure of bone tissue, conducting surface electric signals to a defect deep part and cooperatively regulating and controlling local immune metabolism and angiogenesis is designed. The physical hierarchical structure material of the stent shows excellent mechanical compressive strength, low impedance conductivity and ultrasonic response on-demand degradation and drug release behaviors adaptive to the bone tissue healing period, and has extremely high clinical transformation potential.
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