An adjustable release container capsule system with a silica support

Abstract

The application discloses a kind of adjustable release container capsule systems with silica support, including bottle body, two chambers that are communicated with each other are equipped in the bottle body, one of the chambers is equipped with capsule storehouse, and press pump assembly is equipped in the other chamber;The capsule storehouse is equipped with silica capsule for loading active ingredient and realizing first fast release, then slow release, by waterproof locking mechanism between capsule storehouse and support frame, the alignment conduction or misalignment sealing of first water inlet and second water inlet are matched, the activation or non-activation state of quick switching device can be switched;In the activated state, the internal space of capsule storehouse is contacted with liquid medium, realizes the dilution release of pre-concentrated liquid, in the non-activated state, the internal space of capsule storehouse is sealed from liquid medium, silica capsule in storehouse and liquid medium form pre-concentrated liquid, so that reusable is realized, and each use reaches approximately same amount of ingredient.

Description

Technical Field

[0001] This application relates to the field of healthcare technology, and more specifically to an adjustable release container capsule system with a silica support. Background Technology

[0002] In the fields of hygiene and personal care, and liquid functional products, the control of active ingredient delivery and release is a crucial technological direction for related products. To meet the ingredient supply needs of different usage scenarios, the industry has developed various active ingredient delivery containers and release structures to adapt to the storage, transportation, and ingredient release applications of various liquid media.

[0003] With the diversification of usage scenarios, the demand for adjustability in the timing and rate of active ingredient release continues to increase. Traditional liquid hygiene products, such as hand sanitizers and disinfectants, typically contain 70%–80% water. This high water content significantly increases product volume, transportation weight, and single-use plastic waste. To further optimize ingredient release management and improve system flexibility and longevity, a new type of container capsule system is needed that can achieve sealed isolation and on-demand conduction switching, and is compatible with gradient release functions, to better meet diverse usage needs. Summary of the Invention

[0004] This application provides an adjustable release container capsule system with a silica support to achieve controllable mechanical start-stop and gradient chemical release of hygienic active ingredients.

[0005] To achieve the above objectives, this application provides an adjustable release container capsule system with a silica support, comprising a bottle body, wherein the bottle body has two interconnected chambers, one chamber containing a capsule compartment and the other chamber containing a press pump assembly; The capsule chamber contains silica capsules for encapsulating hygienic active ingredients and achieving initial rapid release followed by sustained slow release. The bottle body contains a support frame for supporting the capsule chamber, and a waterproof locking mechanism is provided between the capsule chamber and the support frame. The waterproof locking mechanism has two usage states: an activated state and an inactivated state. In the non-activated state, the internal space of the capsule compartment is sealed and isolated from the chamber by a waterproof locking mechanism, and the silica capsule inside the capsule compartment and the reserved liquid medium form a pre-concentrated liquid.

[0006] In the activated state, the internal space of the capsule compartment is connected to the chamber through a waterproof locking mechanism, enabling the dilution and release of the pre-concentrated liquid within the chamber; This application proposes some specific embodiments, wherein the capsule compartment is provided with a first water inlet and the support frame is provided with a second water inlet; The waterproof locking mechanism is activated by aligning and connecting the first water inlet and the second water inlet; The waterproof locking mechanism is inactive by sealing the first water inlet and the second water inlet by misalignment.

[0007] This application proposes some specific embodiments in which the waterproof locking mechanism adopts a rotary valve mechanism: By rotating the capsule chamber cover, the capsule chamber rotates, aligning or misaligning the first water inlet with the second water inlet, thus switching between the activated and inactive states. The rotary valve mechanism switches between active and inactive states by rotating 90°. The bottle body is provided with a fastening cap at the bottle opening for axially limiting and fixing the capsule compartment and the support frame; A second sealing ring is provided between the support frame and the bottle body.

[0008] This application proposes some specific embodiments, wherein the bottom opening of the bottle body, the capsule compartment and the support frame are disposed at the bottom opening of the bottle body, the rotating capsule compartment cover is rotatably sleeved on the bottom outside of the bottle body, the first water inlet is opened at the top of the capsule compartment, the second water inlet is opened at the upper part of the support frame, the capsule compartment and the support frame are connected by an inner and outer threaded connection, when the capsule compartment rotates through the thread of the support frame, the first water inlet and the support frame undergo axial misalignment displacement, at which time the first water inlet and the second water inlet are connected to each other.

[0009] This application proposes some specific embodiments in which the waterproof locking mechanism adopts a vertical sliding mechanism: By pulling the capsule upwards, the first water inlet and the second water inlet are aligned and connected; By pushing the capsule downwards, the first water inlet and the second water inlet are misaligned and sealed.

[0010] The support frame is equipped with a lower sealing plug located at the bottom of the chamber. The second water inlet is located on the lower sealing plug, and the first water inlet is located on the lower side of the capsule chamber. When the capsule chamber is pushed down to the lowest position, the lower sealing plug seals the first water inlet on the lower side of the capsule chamber.

[0011] A third sealing ring is provided between the capsule compartment and the support frame.

[0012] This application proposes some specific embodiments in which a first sealing ring is provided between the capsule compartment cover and the capsule compartment.

[0013] This application proposes some specific embodiments, wherein the lower part of the capsule compartment is provided with a mesh frame for supporting the silica capsules, and the capsule compartment and the outer wall of the bottle are made of transparent material for real-time observation of the remaining amount and usage status of the silica capsules.

[0014] This application proposes some specific embodiments in which the silica capsule includes silica, an active disinfectant, and a surfactant.

[0015] This application proposes some specific embodiments in which the silica capsule is prepared by a sol-gel process containing surfactants to form a solid porous material for storing active ingredients. The active disinfectant is a quaternary ammonium compound, including but not limited to benzalkonium chloride. The surfactant is anionic surfactant, cationic surfactant, nonionic surfactant or amphoteric surfactant.

[0016] This application proposes some specific embodiments, wherein the anionic surfactants include, but are not limited to, sodium lauryl ether sulfate and sodium dodecyl sulfate; the cationic surfactants include, but are not limited to, benzalkonium chloride and hexadecyltrimethylammonium bromide; the nonionic surfactants include, but are not limited to, Pluronic F127; and the amphoteric surfactants include, but are not limited to, cocamidopropyl betaine.

[0017] The beneficial effects are: 1. Through the waterproof locking mechanism between the capsule chamber and the support frame, and with the alignment and conduction or staggered sealing of the first and second water inlets, the active or inactive state of the device can be quickly switched. In the active state, the internal space of the capsule chamber is in contact with the liquid medium, realizing the dilution and release of the pre-concentrated liquid. In the inactive state, the internal space of the capsule chamber is sealed and isolated from the liquid medium, and the silica capsules inside the chamber form a pre-concentrated liquid with the liquid medium. This enables reusability, and each use achieves approximately the same amount of ingredients.

[0018] 2. When the waterproof locking mechanism is not activated, a pre-placed quantitative liquid medium is placed in the capsule compartment to keep it in continuous contact with the silica capsule; the active ingredients in the silica capsule slowly dissolve and reach concentration equilibrium in the confined space of the capsule compartment, forming a stable pre-concentrated solution, which can avoid excessive release of active ingredients and ensure stable effect with each use.

[0019] 3. After the user operates to open the waterproof locking mechanism, the isolation state is released, and the pre-dissolved concentrate is quickly released and mixed with the diluent in the main container to form a ready-to-use sanitary solution that meets the standards. This structure separates the slow chemical diffusion and rapid release process into two stages, solving the problem of delayed solid agent delivery and allowing for the rapid preparation of ready-to-use sanitary solutions at any time.

[0020] 4. The dual-chamber design eliminates the need for pre-loading and transporting large amounts of water, significantly reducing product volume, transportation costs, and single-use plastic waste, thus achieving reusability and lightweight design.

[0021] 5. Through a dual-layer control of mechanical on / off and chemical slow release, the macroscopic valve controls the contact timing, while the microscopic porous silica controls the release rate, providing dual protection for stable release, no leakage, and no risk of sudden over-release. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0023] Figure 1 This is a schematic diagram of the structure of Embodiment 1 of this application; Figure 2 This application Figure 1 A magnified view of part A; Figure 3 This application Figure 1 A magnified view of section B; Figure 4 This is a schematic diagram of the structure of Embodiment 2 of this application; Figure 5 This application Figure 4 A magnified view of a portion at point C; Figure 6 This application Figure 1 A magnified view of section B; Figure 7 This is a schematic diagram of the structure of Embodiment 2 of this application; Figure 8 This application Figure 4 A magnified view of a portion at point C; Figure 9 The results are FTIR values ​​of the active ingredients released from the silica capsules after 3 days of exposure and the 1st / 2nd / 3rd dilution. Figure 10 The UV-Vis absorption results are those of the active ingredient (sample 1-chloroxylenol) released from the silica capsules after different contact times and the 1st / 2nd / 3rd dilution. Figure 11 The results show the concentration of the active ingredient (sample 1-chloroxylenol) released from the silica capsules at different contact times; Figure 12 The UV-Vis absorption results of the active ingredient (sample 2-benzalkonium chloride) released from the silica capsules after different contact times and the 1st / 2nd / 3rd dilution are shown. Figure 13 The results show the concentration of the active ingredient (sample 2-benzalkonium chloride) released from the silica capsules at different contact times; Figure 14The UV-Vis absorption results are those of the active ingredient (sample 3-benzalkonium chloride) released from the silica capsules after different contact times and the 1st / 2nd / 3rd dilution. Figure 15 The results show the concentration of the active ingredient (sample 3-benzalkonium chloride) released from the silica capsules at different contact times.

[0024] The following are the annotations in the attached diagram: 1. Capsule compartment cover; 2. Capsule compartment; 201. First water inlet; 3. Support frame; 301. Second water inlet; 302. Lower sealing plug; 4. Fastening cap; 5. Silica capsule; 6. Mesh frame; 7. Bottle body; 701. Chamber; 8. First sealing ring; 9. Second sealing ring; 10. Third sealing ring; 11. Soft rubber stopper; 12. Press pump assembly; 13. Bottom stopper. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions of this application will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. Based on the embodiments in this application, all other implementation methods obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0026] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of this disclosure. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following drawings denote similar items; therefore, once an item is defined in one drawing, it need not be further discussed in subsequent drawings.

[0027] See Figures 1-12 As shown, this application provides an adjustable release container capsule system with a silica support, including a bottle body 7. The bottle body 7 has two interconnected chambers 701, which provide space for the flow of liquid media, release of active ingredients and pumping out. One chamber 701 is equipped with a capsule chamber 2, and the other chamber 701 is equipped with a pump assembly 12 to provide suction power to pump out the liquid media mixed with active ingredients for use.

[0028] The capsule chamber 2 contains silica capsules 5 that can encapsulate hygienic active ingredients and achieve initial rapid release followed by sustained slow release. Simultaneously, the bottle body 7 contains a support frame 3, which supports the capsule chamber 2, providing a fixed installation base and ensuring the relative positional stability of the capsule chamber 2 and the bottle body 7. To achieve controllable release of the active ingredients, a waterproof locking mechanism is installed between the capsule chamber 2 and the support frame 3. This mechanism has two operating states: activated and deactivated, as detailed below: In the non-activated state, the internal space of capsule chamber 2 is sealed and isolated from chamber 701 by a waterproof locking mechanism, and the silica capsule 5 inside capsule chamber 2 and the reserved liquid medium inside form a pre-concentrated liquid.

[0029] In the activated state, the internal space of capsule chamber 2 is connected to the chamber 701 through a waterproof locking mechanism, so as to realize the dilution and release of pre-concentrated liquid in chamber 701; The above describes a dual-chamber structure, with one chamber containing silica capsules 5 and the other containing the liquid medium. The two chambers are separated by a waterproof locking mechanism, allowing for selective initiation or termination of contact between the silica capsules 5 and the liquid medium. This supports user-controlled mixing, eliminates the need for packaging and water transportation, and enables multiple repeated activation cycles while maintaining a consistent composition. Furthermore, the pre-concentrated liquid allows users to use the product immediately after each activation without waiting.

[0030] To achieve the switching between the two states, a first water inlet 201 is provided on the capsule chamber 2, which is the channel for the liquid medium to enter the interior of the capsule chamber 2. A second water inlet 301 is provided on the support frame 3, which is the channel for the liquid medium to enter the inner side of the support frame 3 from the chamber 701. The waterproof locking mechanism is activated by the alignment and conduction of the first water inlet 201 and the second water inlet 301, and is deactivated by the misalignment and sealing of the two.

[0031] When the waterproof locking mechanism is inactive, a certain amount of liquid medium is confined and pre-filled within capsule 2 as a water diluent, completely isolating it within capsule 2. This physical confinement is crucial; it forces the isolated water diluent to maintain continuous and localized contact with the silica capsule 5. The active hygiene ingredient migrates from the silica capsule 5 into this confined area. Because the isolated diluent dose is small and fixed, the diffusion gradient naturally weakens as the concentration of the active ingredient increases, eventually reaching a dynamic equilibrium. Through this independent incubation process, the confined aqueous solvent is transformed into a highly effective, chemically stable pre-concentrated liquid. This structural confinement mechanism fundamentally prevents the over-release of the active ingredient, thus ensuring consistent quality with each release.

[0032] During user operation, the waterproof locking mechanism opens, breaking the fluid isolation. The pre-concentrated liquid, having undergone a time-consuming dissolution phase during its entrapment, is then rapidly released and uniformly mixed into the bulk liquid medium within the main container. This instantly transforms the bulk fluid into a final, medical-grade Ready-To-Use (RTU) hygiene solution. By structurally separating the slow chemical diffusion phase (Phase I) from the rapid delivery phase (Phase II), the capsule chamber overcomes the inherent time lag limitations of solid-state chemical delivery, enabling the provision of an immediate RTU solution to the user on demand.

[0033] Example 1: In this embodiment, the waterproof locking mechanism adopts a rotary valve mechanism. The rotary valve mechanism achieves on / off switching through rotation.

[0034] Specifically, by rotating the capsule cover 1 and the capsule chamber 2 synchronously, the first water inlet 201 and the second water inlet 301 are aligned or misaligned, thus completing the switching between the active and inactive states. Specifically, this rotary valve mechanism can achieve state switching by rotating it 90°.

[0035] To ensure structural stability, a fastening cap 4 is provided at the bottle mouth of the bottle body 7, which is used to axially limit and fix the capsule chamber 2 and the support frame 3 to prevent the parts from loosening, falling off or moving during use.

[0036] Meanwhile, to improve sealing performance, a second sealing ring 9 is provided between the support frame 3 and the bottle body 7, and a first sealing ring 8 is provided between the capsule compartment cover 1 and the capsule compartment 2.

[0037] In addition, a mesh frame 6 is provided in the lower part of the capsule compartment 2 to stably support the silica capsule 5.

[0038] The rotary valve mechanism can also adopt the following structure, see the attached instruction manual. Figure 6 , Figure 7 and Figure 8 As shown, the bottom opening of the bottle body 7, the capsule compartment 2 and the support frame 3 are located at the bottom opening of the bottle body 7, the rotating capsule compartment cover 1 is rotated and sleeved on the outside of the bottom of the bottle body 7, the first water inlet 201 is opened at the top of the capsule compartment 2, and the second water inlet 301 is opened at the upper part of the support frame 3. The capsule compartment 2 and the support frame 3 are connected by an inner and outer threaded connection. When the capsule compartment 2 rotates through the thread of the support frame 3, the first water inlet 201 and the support frame 3 undergo axial displacement, at which time the first water inlet 201 and the second water inlet 301 are connected to each other.

[0039] Example 2: In this embodiment, the waterproof locking mechanism adopts a vertical sliding mechanism.

[0040] The specific operation method is as follows: pull the capsule chamber 2 upward to align and connect the first water inlet 201 and the second water inlet 301, and the system enters the activated state; push the capsule chamber 2 downward to misalign and seal the first water inlet 201 and the second water inlet 301, and the system switches to the inactive state.

[0041] Specifically, the support frame 3 is provided with a lower sealing plug 302 located at the bottom of the chamber, the second water inlet 301 is opened on the lower sealing plug 302, and the first water inlet 201 is opened on the lower side of the capsule chamber 2; when the capsule chamber 2 is pushed to the lowest position, the lower sealing plug 302 can directly seal the first water inlet 201, further blocking the liquid from entering.

[0042] To prevent liquid leakage during sliding, a third sealing ring 10 is provided between the capsule compartment 2 and the support frame 3; a first sealing ring 8 is also provided between the capsule compartment cover 1 and the capsule compartment 2.

[0043] Similar to Example 1, the lower part of the capsule compartment 2 in this example is also provided with a mesh frame 6 to support the silica capsule 5.

[0044] The capsule compartment (2) and the outer wall of the bottle (7) can be made of transparent material to monitor the remaining amount and usage status of the silica capsule (5) in real time.

[0045] Example 3: In this embodiment, the silica capsule (5) includes silica, water, active disinfectant, phenoxyethanol, surfactant, Allura Red AC, and essential oil compound.

[0046] Silica capsules (5) are solid porous materials used to store active ingredients, prepared by a sol-gel process containing surfactants.

[0047] The preparation method of the silica capsules is as follows: Example 1: The synthesis involves a combination of tetraethyl orthosilicate (TEOS), an acid catalyst, essential oils, active ingredients, and anionic surfactants. TEOS is used as the primary precursor for the silica capsules. In a typical synthesis, 50 ml of TEOS is hydrolyzed in an acidic aqueous solution (0.1 mol / L hydrochloric acid) at room temperature with uniform stirring. Sodium dodecyl sulfate is then added as a surfactant at a concentration higher than its critical micelle concentration to form a porous template. Quaternary ammonium compounds, essential oils, preservatives, and dyes are subsequently added. The resulting sol gradually transforms into a rigid gel network. Before solidification, these liquid silica capsules are poured into cylindrical containers to form granules weighing approximately 15 g. Fourier transform infrared spectroscopy confirms that all organic active ingredients are uniformly encapsulated within intact silica capsules; the vibrational frequency of the Si–O–Si bonds in the silica capsules is approximately 1100 cm⁻¹. This result further proves that both water-soluble and lipophilic active ingredients were successfully encapsulated in a silica matrix.

[0048] Example 2: A combination of TEOS, an acid catalyst, essential oils, active ingredients, and cationic surfactants was used to prepare silica capsules by hydrolyzing 50 ml of TEOS in an acidic aqueous solution (0.1 mol / L nitric acid) at room temperature and reacting under uniform stirring. Subsequently, benzalkonium chloride, a cationic antibacterial surfactant, was added at a concentration exceeding its critical micelle concentration, thus enabling it to simultaneously act as a template for forming porous structures and possess antibacterial activity. Tea tree oil, an essential oil, was then added as an auxiliary ingredient, along with preservatives and dyes. The resulting solution was poured into a cylindrical mold to induce a gelation reaction, ultimately yielding granular products weighing approximately 15 g. Fourier transform infrared spectroscopy confirmed that all organic active ingredients were indeed present within the intact silica matrix.

[0049] Example 3 A combination of TEOS, an acid catalyst, essential oils, active ingredients, and nonionic surfactants was used to prepare silica capsules by hydrolyzing 50 ml of TEOS in an acidic aqueous solution (0.1 mol / L nitric acid) at room temperature and reacting under uniform stirring. Pluronic F127 (EO) 106 PO 70 EO 106A certain component was used as a structure-directing agent in the nonionic triblock copolymer to form an ordered mesoporous structure. Lavender essential oil, quaternary ammonium compounds, preservatives, and fluorescent whitening agents were then added as active ingredients. The resulting solution was cast and aged to form a hard gel, ultimately yielding cylindrical particles weighing 15g. Fourier transform infrared spectroscopy confirmed that all organic active ingredients were uniformly distributed within the silica matrix.

[0050] Example 4 A combination of TEOS, acid catalyst, essential oils, active ingredients, and amphoteric surfactants was used to synthesize silica capsules under acidic catalytic conditions (0.1 mol / L nitric acid), with cocamidopropyl betaine as the amphoteric structure-directing surfactant, exceeding its critical micelle concentration. This resulted in the synthesis of silica capsules using 50 ml of TEOS. Furthermore, aromatic essential oils, quaternary ammonium compounds, preservatives, and brighteners were added. The resulting solution was cast into cylindrical particles (approximately 15 g), followed by aging treatment to ultimately form a rigid mesoporous gel. Fourier transform infrared spectroscopy confirmed that all organic active ingredients were uniformly distributed within the silica framework.

[0051] Example 5 A combination of TEOS, an alkaline catalyst, essential oils, active ingredients, and cationic surfactants was used to prepare silica capsules, with TEOS as the main precursor. In a typical synthesis, 50 ml of TEOS was hydrolyzed in an alkaline aqueous solution (0.1 mol / L ammonium hydroxide) under stirring. Hexadecyltrimethylammonium bromide was added to this mixture as a cationic surfactant at a concentration higher than its critical micelle concentration to form a porous structure; subsequently, essential oils, preservatives, and optical brighteners were added. After treatment, the solution transformed into a rigid gel network. Before solidification, the liquid silica framework was poured into a cylindrical particle weighing approximately 15 g. Fourier transform infrared spectroscopy confirmed that all organic active ingredients were indeed present within the intact silica matrix.

[0052] Example 6 A silica capsule was prepared using a combination of TMOS, an acid catalyst, essential oils, active ingredients, and anionic surfactants, with tetramethyl orthosilicate (TMOS) as the main precursor. 50 ml of TMOS was hydrolyzed in an acidic aqueous solution (0.1 mol / L hydrochloric acid). Sodium dodecyl sulfate (SDS) was then added as an anionic surfactant, followed by lemon essential oil, a chelating agent, a water softener, a preservative, and a brightener. The resulting solution was cast into 15 g cylindrical granules. Since TMOS releases methanol, not ethanol, during hydrolysis, the granules were dried under a gentle vacuum to remove residual solvent.

[0053] Example 7 A combination of TMOS, an alkaline catalyst, essential oil, active ingredients, and anionic surfactants was prepared by hydrolyzing 50 ml of tetramethyl orthosilicate (TMOS) in an alkaline aqueous solution (0.1 mol / L ammonium hydroxide, pH approximately 10) at room temperature. Sodium lauryl ether sulfate was added first as an anionic structure-directing agent, followed by peppermint oil, preservatives, and brighteners. Compared to the product prepared by the acid-catalyzed method, the product prepared by the alkaline-catalyzed method exhibited a more compact particle structure and smaller mesopore size. The final particle weight was approximately 15 g, and Fourier transform infrared spectroscopy analysis revealed absorption peaks for Si–O–Si bonds in the 1000–1100 cm⁻¹ band; absorption peaks for C–O–C bonds from the ethoxylated chain were located around 1100 cm⁻¹; and absorption peaks for S=O bonds of sulfate ions were located between 1200–1250 cm⁻¹.

[0054] The active disinfectant uses quaternary ammonium compounds or phenolic compounds. Quaternary ammonium compounds include benzalkonium chloride, phenolic compounds include chlorooxybenzyl alcohol, and essential oil blends include frankincense oil, sandalwood oil, cedarwood oil, chamomile oil, and lavender oil.

[0055] The surfactants used are anionic surfactants, cationic surfactants, nonionic surfactants, or amphoteric surfactants.

[0056] Anionic surfactants include, but are not limited to, sodium lauryl ether sulfate or sodium dodecyl sulfate; cationic surfactants include, but are not limited to, benzalkonium chloride or hexadecyltrimethylammonium bromide; nonionic surfactants include, but are not limited to, Pluronic F127; and amphoteric surfactants include, but are not limited to, cocamidopropyl betaine.

[0057] Ingredients list for silica capsules: Silica capsules can support multiple activation cycles, 3-5 times. During testing, the silica capsules are placed in contact with water diluent in the capsule cavity for a set duration: 1 day, 3 days, 1 week, or 2 weeks.

[0058] Short-term exposure (1 day, 3 days): Evaluate the matrix's ability to rapidly release active ingredients on demand and formulate the final disinfectant, testing the 1st, 2nd, and 3rd activation cycles.

[0059] Long-term immersion (1 week, 2 weeks): Simulates long-term contact with diluent, assesses matrix structural integrity, and verifies that the matrix can prevent excessive or one-time release of active ingredients.

[0060] The tested silica capsule formulation included: silica, water, benzalkonium chloride, phenoxyethanol, sodium lauroyl sarcosinate, Allura Red AC, frankincense, sandalwood, cedarwood, chamomile, and lavender. FTIR spectroscopy was used to analyze the organic matter and active ingredients in the "concentrate" under different dilution cycles and contact times.

[0061] Reference absorbance values ​​for each component inside the silica capsule: The spectral analysis of the undiluted concentrate confirmed significant signals for the following components: 1. Silica framework (~1100cm) -1 The peaks at α represent the characteristic peaks of Si-O-Si asymmetric stretching, confirming the existence of the silica capsule structure.

[0062] 2. Benzalkonium chloride and phenoxyethanol aromatic ring (~1600cm) -1 Peak, ~1510cm -1 acromion, ~830-700cm -1 The C=C aromatic ring vibration indicates that benzalkonium chloride contains benzyl groups and phenoxyethanol contains aromatic ethers. Combined with the C=O peak of the essential oil, this confirms that the essential oil is co-encapsulated with aromatic preservatives / active ingredients.

[0063] 3. Essential oil esters / ketones (~1735cm) -1 ~1710cm -1 ): Corresponding to the C=O stretching of esters and ketones, essential oils are rich in esters (such as linalyl acetate of lavender) and ketones, which are key markers for the presence of essential oil complexes; 2950–2850 cm -1 Strong CH stretching (alkyl chain), ~1455cm -1 With ~1375cm -1 The bending of the CH symbol confirms the hydrocarbon properties of the essential oil.

[0064] 4. Sodium lauroyl sarcosinate / surfactant (~1610cm) -1 ~1400cm -1 ): ~1610cm -1 Overlaps with aromatic ring stretching peak, ~1400cm -1 The broad peak represents the stretching of the carboxylate group in the surfactant, which can stabilize emulsions or capsule dispersions.

[0065] The spectral characteristics of the first, second, and third activations are completely consistent; the peak ratios (e.g., silica peak ~ 1100 cm⁻¹) are identical. -1 With essential oil / C=O peak ~1735cm -1 The ratio of the two values ​​is highly stable, indicating that the encapsulation efficiency and release behavior are repeatable under multiple user activations.

[0066] The samples diluted for the third time after contact times of 1 day, 3 days, 1 week, and 2 weeks showed highly consistent spectral shapes and relative band intensities, with no missing bands, proving that the formulation does not degrade after 14 days of immersion in water; all samples had consistent peak positions (wavenumber shift <2cm). -1 (within the instrument tolerance).

[0067] The relative peak ratio is stable: aromatic peak ~1600cm -1 With silica peak ~1100cm -1 The ratio is approximately 0.35, and the carbonyl peak is around 1735 cm⁻¹. -1 With aliphatic CH peak ~2925cm -1 The ratio is approximately 0.40-0.42.

[0068] The dilution factor does not affect the detection. The spectrum is mainly composed of silica capsule wall and water, but organic components can be clearly observed.

[0069] The above reference absorbance values ​​are used to compare and determine the presence of each component in the diluted concentrate.

[0070] To verify the practical application value of the system, an antibacterial contact sterilization test was conducted on the final mixture, and the results are shown in the table below.

[0071] Table of antibacterial test results for silica capsules releasing concentrated diluted solution: Test strains: Escherichia coli (Gram-negative), Staphylococcus aureus (Gram-positive), microbial load approximately 10. 5 -10 6 CFU / mL. Testing verified its effectiveness. A key finding from the 1-week and 2-week contact experiments was the stable release curves. If the silica matrix formulation is poor, prolonged immersion can lead to a surge in the concentration of active ingredients, forming a toxic or highly concentrated liquid, with no effective components remaining in subsequent cycles.

[0072] FTIR and UV-Vis data confirm that benzalkonium chloride and essential oil concentrations achieve functional balance; even after 14 days of contact with liquid, the matrix can still retain reserve components in its porous structure for use in the 2nd, 3rd, and 4th activation cycles.

[0073] Low molecular weight active ingredients (such as chloroxylenol): suitable for medium-level disinfection scenarios requiring multiple cycles and continuous stability; High molecular weight active ingredients (such as benzalkonium chloride): suitable for high-intensity instant disinfection, with a rapid initial release to achieve strong sterilization, followed by a gradual and stable release.

[0074] In summary, it is particularly important to note that this application provides an adjustable release container capsule system with a silica support, which achieves controllable start-up and gradient release of hygienic active ingredients by combining the synergistic effect of mechanical control structure and chemical sustained-release carrier, integrating physical on / off regulation mechanism and material sustained-release characteristics. This improves the sealing stability, ease of operation and reusability of the container system, and meets the usage needs of efficient carrying, precise regulation and long-lasting effect of active ingredients in diverse scenarios.

Claims

1. An adjustable release container capsule system with a silica support, characterized in that: Includes a bottle body (7), which has two interconnected chambers (701), one of which has a capsule compartment (2) and the other has a pump assembly (12). The capsule compartment (2) contains a silica capsule (5) for encapsulating hygienic active ingredients and achieving rapid release followed by sustained slow release. The bottle body (7) contains a support frame (3) for supporting the capsule compartment (2). A waterproof locking mechanism is provided between the capsule compartment (2) and the support frame (3). The waterproof locking mechanism has two usage states: an activated state and an inactive state. In the non-activated state, the internal space of the capsule compartment (2) is sealed and isolated from the chamber (701) by a waterproof locking mechanism, and the silica capsule (5) inside the capsule compartment (2) and the reserved liquid medium inside form a pre-concentrated liquid. In the activated state, the internal space of the capsule compartment (2) is connected to the chamber (701) through a waterproof locking mechanism, so as to realize the dilution and release of the pre-concentrated liquid in the chamber (701).

2. The adjustable release container capsule system with a silica support according to claim 1, characterized in that: The capsule compartment (2) is provided with a first water inlet (201), and the support frame (3) is provided with a second water inlet (301). The waterproof locking mechanism is activated by aligning and connecting the first water inlet (201) and the second water inlet (301); The waterproof locking mechanism is inactive by the misalignment and sealing of the first inlet (201) and the second inlet (301).

3. The adjustable release container capsule system with a silica support according to claim 2, characterized in that: The waterproof locking mechanism adopts a rotary valve mechanism: By rotating the capsule chamber cover (1), the capsule chamber (2) is driven to rotate, so that the first water inlet (201) and the second water inlet (301) are aligned or misaligned, thereby achieving the switching between the active and inactive states. The rotary valve mechanism switches between active and inactive states by rotating 90°. The bottle body (7) is provided with a fastening cap (4) at the bottle mouth for axially limiting and fixing the capsule compartment (2) and the support frame (3). A second sealing ring (9) is provided between the support frame (3) and the bottle body (7).

4. The adjustable release container capsule system with a silica support according to claim 2, characterized in that: The bottom opening of the bottle body (7) is provided. The capsule compartment (2) and the support frame (3) are located at the bottom opening of the bottle body (7). The rotating capsule compartment cover (1) is rotated and sleeved on the bottom outside of the bottle body (7). The first water inlet (201) is opened at the top of the capsule compartment (2). The second water inlet (301) is opened at the upper part of the support frame (3). The capsule compartment (2) and the support frame (3) are connected by an inner and outer threaded connection. When the capsule compartment (2) rotates through the thread of the support frame (3), the first water inlet (201) and the support frame (3) undergo axial displacement. At this time, the first water inlet (201) and the second water inlet (301) are connected to each other.

5. The adjustable release container capsule system with a silica support according to claim 2, characterized in that: The waterproof locking mechanism adopts a vertical sliding mechanism: By pulling the capsule chamber (2) upward, the first water inlet (201) and the second water inlet (301) are aligned and connected; By pushing the capsule chamber (2) downwards, the first water inlet (201) and the second water inlet (301) are misaligned and sealed. The support frame (3) is provided with a lower sealing plug (302) located at the bottom of the chamber. The second water inlet (301) is located on the lower sealing plug (302). The first water inlet (201) is located on the lower side of the capsule chamber (2). When the capsule chamber (2) is pushed down to the lowest position, the lower sealing plug (302) seals the first water inlet (201) on the lower side of the capsule chamber (2). A third sealing ring (10) is provided between the capsule compartment (2) and the support frame (3).

6. The adjustable release container capsule system with a silica support according to claim 3 or 5, characterized in that: A first sealing ring (8) is provided between the capsule compartment cover (1) and the capsule compartment (2).

7. The adjustable release container capsule system with a silica support according to claim 3 or 5, characterized in that: The lower part of the capsule compartment (2) is provided with a mesh frame (6) for supporting the silica capsules (5). The outer walls of the capsule compartment (2) and the bottle body (7) are made of transparent material for real-time observation of the remaining amount and usage status of the silica capsules (5).

8. The adjustable release container capsule system with a silica support according to claim 3 or 7, characterized in that: The silica capsule (5) comprises silica, an active disinfectant, and a surfactant.

9. The adjustable release container capsule system with a silica support according to claim 8, characterized in that, The silica capsule (5) is a solid porous material used to store active ingredients, prepared by a sol-gel process containing surfactants. The active disinfectant is a quaternary ammonium compound, including but not limited to benzalkonium chloride. The surfactant is anionic, cationic, nonionic, or amphoteric surfactant.

10. The adjustable release container capsule system with a silica support according to claim 9, characterized in that: The anionic surfactants include, but are not limited to, sodium lauryl ether sulfate and sodium dodecyl sulfate; the cationic surfactants include, but are not limited to, benzalkonium chloride and hexadecyltrimethylammonium bromide; the nonionic surfactants include, but are not limited to, Pluronic F127; and the amphoteric surfactants include, but are not limited to, cocamidopropyl betaine.

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