Intermediates of talazoparib or salts thereof and methods of making the same
By optimizing the preparation method of tapolaparib intermediate, using mild reaction conditions and environmentally friendly reagents, the problems of harsh reaction and low yield in the existing technology have been solved, and efficient intermediate preparation and industrial production have been achieved.
CN122444701APending Publication Date: 2026-07-24HANGZHOU QINGYUE MEDICAL TECH CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HANGZHOU QINGYUE MEDICAL TECH CO LTD
- Filing Date
- 2025-01-24
- Publication Date
- 2026-07-24
AI Technical Summary
Technical Problem
Existing methods for synthesizing key intermediates of tapolaparib involve harsh reaction conditions, low yields, and are unsuitable for industrial production.
Method used
The preparation method of intermediates is optimized by using a combination of reactions involving condensation, reduction, substitution and elimination, with mild reaction conditions and environmentally friendly reagents.
Benefits of technology
It improves the overall yield of intermediates to over 64%, making it suitable for large-scale industrial production. It is also easy to operate and environmentally friendly with no pollution.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN122444701A_ABST
Abstract
The present application relates to a kind of intermediate of talazoparib or its salt and its preparation method, which can avoid using reagent harmful to environment under mild condensation reaction conditions;It eliminates product one-pot method to obtain key intermediate, easy to operate, high yield and purity, suitable for large-scale industrial production.
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