A nitrile glycoside compound, a preparation method and application thereof
By extracting and purifying nitrile glycosides from Moringa seeds, the problem of poor efficacy of existing treatments has been solved, achieving effective treatment for diabetic nephropathy. By reducing reactive oxygen species and pro-inflammatory factors, the decline in mitochondrial membrane potential is alleviated, and the expression of renal fibrosis-related proteins is significantly reduced.
CN122444798APending Publication Date: 2026-07-24XIANGYA HOSPITAL CENT SOUTH UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- XIANGYA HOSPITAL CENT SOUTH UNIV
- Filing Date
- 2025-01-23
- Publication Date
- 2026-07-24
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Figure CN122444798A_ABST
Abstract
The present application relates to the technical field of biological medicine, and particularly relates to a nitrile glycoside compound, a preparation method thereof and application of the nitrile glycoside compound in preventing and / or treating kidney disease. A structural formula of the nitrile glycoside compound is shown as follows: wherein R is selected from hydrogen, substituted rhamnose, glucose, substituted glucose, mannose and substituted mannose; the substituents on the substituted rhamnose, the substituted glucose and the substituted mannose are independently selected from formyl, acetyl, propionyl, butyryl, C1-C6 alkyl, C1-C6 alkoxy, halogen, sulfonic acid group or amino; and the substituents on the substituted rhamnose, the substituted glucose and the substituted mannose are located at 2 and 4 positions of a monosaccharide cyclic structure. The present application shows that the nitrile glycoside compound can relieve diabetic nephropathy by driving metabolic reprogramming and a PFKFB3 / TGF-beta / Smads pathway, and has a good treatment effect.
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Citation Information
Patent Citations
CN109160928B