A moisturizing treatment composition and body care cosmetic products prepared therefrom

Abstract

The present application relates to the technical field of body care daily chemical products, and particularly relates to a moisturizing and repairing composition and a body care daily chemical product prepared by using the composition, wherein the composition is composed of an extract of Saururus chinensis, an extract of Plantago asiatica, glycerol and sodium hyaluronate. The present application further provides a preparation method of the composition, and a body care daily chemical product prepared by using the composition, including but not limited to mouthwash, toothpaste, oral spray, facial cleanser, facial cream, skin care emulsion, moisturizing essence, shower gel, toner and toilet soap. The composition of the present application can significantly improve the moisturizing capacity of oral mucosa and human skin and lock water for a long time, and can repair damaged mucosa and human skin, and has excellent dual effects of moisturizing and repairing.

Description

Technical Field

[0001] This invention relates to the field of body care daily chemical products technology, specifically to a composition with dual functions of moisturizing and repairing, and body care daily chemical products prepared containing the composition. Background Technology

[0002] Both the oral mucosa and skin are part of the body's protective barrier and need to be kept moist in daily care. Maintaining the moisture of the oral mucosa is crucial for oral health. A dry oral environment can cause burning sensations, a foreign body sensation, and difficulty swallowing, and can also lead to a decline in mucosal barrier function, making it prone to micro-injuries and ulcers. Recurrent oral ulcers are a common oral mucosal disease, characterized by significant pain, slow healing, and the risk of secondary infection, leading to local suppuration, spreading redness and swelling, and severely impacting quality of life. Keeping the skin moisturized also helps maintain skin barrier function, preserves skin elasticity and luster, delays skin aging, and reduces dryness, sensitivity, and itching, helping people maintain a healthy lifestyle.

[0003] Most commercially available mouthwashes and oral sprays primarily function to freshen breath, kill bacteria, and eliminate odors. However, the addition of ingredients like alcohol and fragrances can irritate the oral mucosa and worsen dryness. A few oral care products claiming to protect gums or soothe the skin often only contain cooling agents like menthol, failing to truly address dryness and damage to the mucosa. Furthermore, moisturizing products for the skin often use humectants to draw moisture from the environment or the dermis to the stratum corneum, increasing skin hydration, or occlusive agents to reduce transepidermal water evaporation. Few offer both moisturizing and repairing benefits.

[0004] Therefore, researching a composition with moisturizing and repairing effects that can be applied to the oral cavity and skin can help consumers maintain oral and skin health and alleviate the pain of oral ulcers. Summary of the Invention

[0005] This invention provides a moisturizing and repairing composition and a body care daily chemical product prepared containing the composition, which has dual effects of moisturizing and repairing. It can improve dryness, burning and dryness in the mouth, repair damaged oral mucosa, and help consumers maintain oral health and relieve the pain of oral ulcers. In addition, it can also repair the skin barrier, reduce moisture loss and enhance the skin's ability to retain moisture.

[0006] To achieve the above objectives, the technical solution of the present invention is as follows:

[0007] The first aspect of the present invention provides a moisturizing and repairing composition, which is composed of the following components in parts by weight: 1-20 parts of Hedyotis diffusa extract and 1-20 parts of Plantago asiatica extract.

[0008] Preferably, it also includes 1 to 10 parts of glycerin and 0.1 to 4 parts of sodium hyaluronate.

[0009] Preferably, it is composed of the following components in parts by weight: 10 parts of Hedyotis diffusa extract, 10 parts of Plantago asiatica extract, 5 parts of glycerin, and 0.5 parts of sodium hyaluronate.

[0010] Preferably, the extract of Hedyotis diffusa is an aqueous extract or an alcoholic extract of Hedyotis diffusa.

[0011] And / or, the plantain extract is an aqueous or alcoholic extract of plantain.

[0012] A second aspect of the present invention provides a method for preparing the above-described moisturizing and repairing composition, comprising the following steps:

[0013] (1) Preparation of Hedyotis diffusa extract: Take Hedyotis diffusa herb, crush it, add extraction solvent, the extraction solvent is 1 to 20 times the weight of water or 30% vol to 90% vol ethanol, reflux extract for 1 to 3 hours, filter, repeat the water or ethanol reflux extraction step 1 to 2 times, combine the filtrates, concentrate under reduced pressure to 1 / 3 to 1.5 times the weight of Hedyotis diffusa herb, to obtain Hedyotis diffusa extract;

[0014] Preparation of plantain extract: Take plantain herb, crush it, add extraction solvent, the extraction solvent is 1 to 20 times the weight of water or 30% vol to 70% vol ethanol, reflux extract for 0.5 to 3 hours, filter, repeat the water or ethanol reflux extraction step 1 to 2 times, combine the filtrates, concentrate under reduced pressure to 1 / 3 to 1.5 times the weight of plantain herb, to obtain plantain extract;

[0015] (2) Weigh out the extracts of Hedyotis diffusa and Plantago asiatica according to the ratio, stir them evenly, and the moisturizing and repairing composition is obtained.

[0016] Preferably, in step (1), before the first reflux extraction, a 1wt% to 10wt% weak alkaline salt solution of 1 to 5 times the weight of the white flower snake tongue herb / plantain herb is added in advance and soaked for 20 to 150 minutes;

[0017] And / or, in step (1), after adding the extraction solvent, add an antioxidant of 0.01%~0.1% of the total weight of the extraction solvent and the herbal medicine of Hedyotis diffusa / Plantago asiatica.

[0018] The weakly basic salts include, but are not limited to, sodium bicarbonate, sodium carbonate, potassium bicarbonate, and potassium carbonate.

[0019] The antioxidants include, but are not limited to, 2,6-di-tert-butyl-p-methylphenol and butylated hydroxyanisole.

[0020] Preferably, in step (1), the herbal medicine of Hedyotis diffusa is ultra-finely pulverized to 50nm~800μm.

[0021] Preferably, in step (1), the plantain herb is ultra-finely pulverized to 60nm~900μm.

[0022] A third aspect of the present invention provides a body care daily chemical product, wherein the moisturizing and repairing composition described above or the moisturizing and repairing composition prepared by the preparation method described above is used as the active ingredient for moisturizing and repairing.

[0023] Preferably, the personal care product is one of the following: mouthwash, toothpaste, oral spray, facial cleanser, face cream, skin lotion, moisturizing essence, shower gel, toner, and soap.

[0024] Preferably, the amount of the moisturizing and repairing composition added to the body care daily chemical product is 0.1wt% to 10wt%, calculated by weight percentage.

[0025] Preferably, the mouthwash / toothpaste / oral spray further comprises orally acceptable excipients;

[0026] The oral-acceptable excipients are selected from at least one of abrasives, foaming agents, humectants, surfactants, adhesives, and dispersants.

[0027] Preferably, the body care daily chemical products may also contain, but are not limited to, anti-wrinkle ingredients, acne-reducing ingredients, sun protection ingredients, firming ingredients, anti-inflammatory ingredients, soothing ingredients, antibacterial ingredients, whitening ingredients, and analgesic ingredients.

[0028] In the moisturizing and repairing composition of the present invention, each component has the following functions:

[0029] Hedyotis diffusa extract: The dried whole herb extract of Hedyotis diffusa Willd., a plant of the Rubiaceae family; its extract is rich in active ingredients such as flavonoids, iridoids, and polysaccharides, and has the effects of clearing heat and detoxifying, and promoting tissue repair.

[0030] Plantain extract: This is the dried whole herb extract of Plantago asiatica L. or Plantago depressa Willd., plants of the Plantaginaceae family. The extract is rich in plantain glycoside, aucubin, phenylethyl glycosides and polysaccharide components, and has the effects of clearing heat and dampness and promoting mucosal healing.

[0031] Glycerin: A triol humectant with strong hygroscopic properties; it can absorb moisture from the air and lock in water molecules on the surface of the oral mucosa, preventing moisture loss and prolonging the duration of hydration, thus playing a synergistic moisturizing role. At the same time, glycerin has good lubrication properties, which can relieve the friction and discomfort caused by dry mouth.

[0032] Sodium hyaluronate: a natural mucopolysaccharide, is an important component of the human extracellular matrix; it can form a breathable moisturizing film on the surface of the oral mucosa, absorbing and retaining hundreds of times its own weight in water, achieving deep and long-lasting hydration; in addition, sodium hyaluronate can also provide a suitable moist microenvironment for the migration and proliferation of oral mucosal cells, indirectly promoting the repair of ulcers and damage.

[0033] Compared with existing moisturizing and repairing products, this invention has the following beneficial effects:

[0034] (1) The composition of the present invention can work synergistically to help replenish oral mucosal moisture, improve oral dryness, burning and dryness, repair damaged oral mucosa, and relieve oral mucosal redness, minor damage and sensitivity; at the same time, it forms a breathable and water-locking protective film on the surface of oral mucosa, reduces oral moisture evaporation, achieves long-lasting moisturization, maintains the normal physiological barrier function of oral mucosa, and promotes the development of oral environment towards health.

[0035] (2) The composition of the present invention can achieve dual effects of repair and moisturization. The repair and moisturizing effects can work synergistically. It can quickly replenish the moisture of the oral mucosa, relieve discomfort such as dryness and burning, and repair the damaged mucosa in a targeted manner, promote the repair of the mucosal barrier, and form a breathable and water-locking protective film. It achieves the integration of "hydration-repair-locking", maintains the moist state of the oral mucosa for a long time, solves the problem of the existing products' lack of lasting moisturization and limited repair effect. It is different from the limitations of existing products that only moisturize or repair. It is conducive to better regulating the microecological balance of the oral mucosa, enhancing the resistance of the oral mucosa itself, preventing derivative problems such as halitosis and mucosal peeling, and improving the user experience of consumers.

[0036] (3) The composition of the present invention has been verified by zebrafish embryo tail-related experiments. It can repair the skin barrier, reduce water loss, enhance the skin's ability to retain moisture, and promote the skin's self-repair effect. Therefore, in addition to oral care products such as mouthwash, toothpaste, and oral spray, it can also be applied to other body care daily chemical products related to human skin, such as facial cleanser, face cream, skin lotion, moisturizing essence, shower gel, and soap, so as to exert its dual effects of moisturizing and repairing and improve the skin condition of consumers.

[0037] (4) The components of this invention are mild and non-irritating, with no adverse sensory experience. They can be gently adapted to the oral environment and are suitable for use by all types of oral populations, especially those with sensitive oral cavities, and have stronger compatibility.

[0038] (5) The composition of the present invention can be added to body care daily chemical products, which are products for daily use by consumers. There is no need to add other special products, making it more convenient to use.

[0039] (6) The preparation method of the present invention is simple and controllable, the raw materials are widely available and safe, and there are no harmful additives. It is suitable for industrial mass production. Compared with some existing products with complex processes and scarce raw materials, the production cost is lower and it is easy to achieve large-scale promotion. At the same time, it is compatible with a variety of oral care product forms, which can meet the needs of different groups of people and different usage scenarios, and has a wider range of applications. Detailed Implementation

[0040] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below in conjunction with the embodiments of this invention. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0041] The first aspect of the present invention provides a moisturizing and repairing composition comprising the following components in parts by weight: 1-20 parts of Hedyotis diffusa extract and 1-20 parts of Plantago asiatica extract (e.g., 1 part of Hedyotis diffusa extract and 1 part of Plantago asiatica extract, 10 parts of Hedyotis diffusa extract and 1 part of Plantago asiatica extract, 1 part of Hedyotis diffusa extract and 10 parts of Plantago asiatica extract, 20 parts of Hedyotis diffusa extract and 1 part of Plantago asiatica extract, or 1 part of Hedyotis diffusa extract and 20 parts of Plantago asiatica extract).

[0042] Preferably, it also includes 1-10 parts of glycerin and 0.1-4 parts of sodium hyaluronate (e.g., 1 part of Hedyotis diffusa extract, 1 part of Plantago asiatica extract, 1 part of glycerin, 0.1 part of sodium hyaluronate; 10 parts of Hedyotis diffusa extract, 1 part of Plantago asiatica extract, 5 parts of glycerin, 2 parts of sodium hyaluronate; 1 part of Hedyotis diffusa extract, 10 parts of Plantago asiatica extract, 4 parts of glycerin, 0.5 parts of sodium hyaluronate; 20 parts of Hedyotis diffusa extract, 1 part of Plantago asiatica extract, 10 parts of glycerin, 0.2 parts of sodium hyaluronate; or 1 part of Hedyotis diffusa extract, 20 parts of Plantago asiatica extract, 1 part of glycerin, 4 parts of sodium hyaluronate).

[0043] Preferably, it is composed of the following components in parts by weight: 10 parts of Hedyotis diffusa extract, 10 parts of Plantago asiatica extract, 5 parts of glycerin, and 0.5 parts of sodium hyaluronate.

[0044] Preferably, the extract of Hedyotis diffusa is an aqueous extract or an alcoholic extract of Hedyotis diffusa.

[0045] And / or, the plantain extract is an aqueous or alcoholic extract of plantain.

[0046] A second aspect of the present invention provides a method for preparing the above-described moisturizing and repairing composition, comprising the following steps:

[0047] (1) Preparation of Hedyotis diffusa extract: Take Hedyotis diffusa herb, crush it, add extraction solvent, the extraction solvent is 1 to 20 times (e.g. 1, 5, 15, 18 or 20 times) of water or 30% vol to 70% vol (e.g. 30% vol, 50% vol, 75% vol, 80% vol or 90% vol) of ethanol, then reflux extract for 0.5 to 3 hours (e.g. 0.5 hours, 1 hour, 1.5 hours, 2 hours or 3 hours), filter, repeat the water or ethanol reflux extraction step 1 to 2 times, combine the filtrates, concentrate under reduced pressure to 1 / 3 to 1.5 times the weight of Hedyotis diffusa herb, to obtain Hedyotis diffusa extract;

[0048] Preparation of plantain extract: Take plantain herb, crush it, add extraction solvent, the extraction solvent is 1 to 20 times the weight of water or 30% vol to 70% vol ethanol, reflux extract for 1 to 3 hours, filter, repeat the water or ethanol reflux extraction step 1 to 2 times, combine the filtrates, concentrate under reduced pressure to 1 / 3 to 1.5 times the weight of plantain herb, to obtain plantain extract.

[0049] (2) Weigh out the extracts of Hedyotis diffusa and Plantago asiatica according to the ratio, stir them evenly, and the moisturizing and repairing composition is obtained.

[0050] Preferably, in step (1), before the first reflux extraction, a weakly alkaline salt solution with a concentration of 1wt% to 10wt% (e.g., 1wt%, 3wt%, 5wt%, 6wt% or 10wt%) is added at 1 to 5 times (e.g., 1, 3, 4 or 5 times) the weight of the herb *Hedyotis diffusa* / *Plantago asiatica*, and soaked for 20 to 150 minutes (e.g., 20 minutes, 30 minutes, 60 minutes, 120 minutes or 150 minutes).

[0051] And / or, in step (1), after adding the extraction solvent, add an antioxidant of 0.01% to 0.1% (e.g., 0.01%, 0.02%, 0.05%, 0.08% or 0.1%) of the total weight of the extraction solvent and the plant extract.

[0052] The weakly basic salts include, but are not limited to, sodium bicarbonate, sodium carbonate, potassium bicarbonate, and potassium carbonate.

[0053] The antioxidants include, but are not limited to, 2,6-di-tert-butyl-p-methylphenol and butylated hydroxyanisole.

[0054] Preferably, in step (1), the herbal medicine of Hedyotis diffusa is ultra-finely pulverized to 50nm~800μm (e.g. 50nm, 100nm, 60μm or 800μm).

[0055] Preferably, in step (1), the plantain herb is ultra-finely pulverized to 60nm~900μm (e.g., 60nm, 200nm, 70μm or 900μm).

[0056] A third aspect of the present invention provides a body care daily chemical product, wherein the moisturizing and repairing composition described above or the moisturizing and repairing composition prepared by the preparation method described above is used as the active ingredient for moisturizing and repairing.

[0057] Preferably, the personal care product is one of the following: mouthwash, toothpaste, oral spray, facial cleanser, face cream, skin lotion, moisturizing essence, shower gel, toner, and soap.

[0058] Preferably, the amount of the moisturizing and repairing composition added to the body care daily chemical product is 0.1wt% to 10wt% (e.g., 0.1wt%, 1wt%, 2wt%, 2.5wt%, 5wt% or 10wt%), calculated by weight percentage.

[0059] Preferably, the mouthwash / toothpaste / oral spray further comprises orally acceptable excipients;

[0060] The oral-acceptable excipients are selected from at least one of abrasives, foaming agents, humectants, surfactants, adhesives, and dispersants.

[0061] Preferably, the body care daily chemical products may also contain, but are not limited to, anti-wrinkle ingredients, acne-reducing ingredients, sun protection ingredients, firming ingredients, anti-inflammatory ingredients, soothing ingredients, antibacterial ingredients, whitening ingredients, and analgesic ingredients.

[0062] The present invention will be further described below by way of examples, but the scope of protection of the present invention is not limited to these embodiments.

[0063] I. Preparation of extracts from Hedyotis diffusa and Plantago asiatica

[0064] The preparation method of Hedyotis diffusa extract includes the following steps: A1. The Hedyotis diffusa herb is pulverized to 50-600 nm using a pulverizer; A2. The herb is soaked in 5wt% sodium carbonate solution (3 times its weight) for 60 min, then 80% vol ethanol (15 times its weight) and 2,6-di-tert-butyl-p-methylphenol (0.05% of the total weight) are added. The mixture is then refluxed at 72-75℃ for 3 hours to separate the Hedyotis diffusa extract; A3. The ethanol reflux extraction step is repeated once (ethanol and 2,6-di-tert-butyl-p-methylphenol are added, and reflux is performed) to separate the Hedyotis diffusa extract; A4. The Hedyotis diffusa extracts from steps A2 and A3 are combined and concentrated under reduced pressure to 1 / 3 of the weight of the mixed herbs to obtain the Hedyotis diffusa extract.

[0065] The preparation method of plantain extract includes the following steps: B1. Pulverize the plantain herb to 60-700 nm using a pulverizer; B2. Soak the plantain herb in a 6wt% sodium bicarbonate solution (3 times its weight) for 60 min to obtain a plantain herb soaking solution; then add 85% vol. ethanol (15 times its weight), and 2,6-di-tert-butyl-p-methylphenol (0.06% of the total weight), and reflux extract at 75-78℃ for 2.5 hours to separate the plantain extract; B3. Repeat the above ethanol reflux extraction step once (adding ethanol and 2,6-di-tert-butyl-p-methylphenol, reflux) to separate the plantain extract; B4. Combine the plantain extracts from steps B2 and B3, and concentrate under reduced pressure to 1 / 2 times the weight of the plantain herb to obtain the plantain extract.

[0066] II. Moisturizing and Repairing Efficacy Testing of the Moisturizing and Repairing Composition

[0067] Experimental method: The extracts of Hedyotis diffusa and Plantago asiatica obtained in Experiment 1 were used to prepare a moisturizing and repairing composition according to the proportions in Table 1, as follows:

[0068] Table 1. Composition of the moisturizing and repairing composition

[0069]

[0070] 2.1 Composition Moisturizing Test: Inhibition of Water Loss in Zebrafish Embryo Caudal Fin

[0071] The skin structure, epidermal barrier function, and water metabolism mechanism of zebrafish embryos are highly homologous to human skin. Their surface mucus layer (corresponding to the stratum corneum of human skin) is a key structure for maintaining skin moisture and resisting water loss, directly reflecting the skin's moisturizing ability and barrier integrity, making it an ideal model for evaluating moisturizing efficacy. Rapid skin moisture loss and impaired barrier function are the main causes of dry and rough skin. The core of moisturizing efficacy lies in repairing the skin barrier, reducing moisture loss, and enhancing the skin's ability to retain moisture. High concentrations of sodium chloride can damage the surface mucus layer structure of zebrafish embryos, leading to skin barrier damage and rapid moisture loss, thus allowing for the construction of a stable model for evaluating moisturizing efficacy.

[0072] A model of skin barrier damage and water loss in zebrafish embryos induced by sodium chloride was used for testing. Twenty embryos from each treatment group were tested. The embryos were exposed to 150 mM sodium chloride, different concentrations (0.5%, 1.0%, 1.5%, 2.0%, 2.5%) of different moisturizing compositions (1#, 2#, 3#, 4#, and 5# moisturizing and repairing compositions), and a blank control group (normal rearing environment, no sodium chloride) and a positive control group (0.05% glycerol). After 72 hours of exposure, the relative caudal fin area was measured using an image analysis system and statistically analyzed. A higher caudal fin water loss inhibition rate indicated a better moisturizing effect. The experimental results are shown in Table 2.

[0073] Table 2. Moisturizing effect test of the four components and mixed components (tail fin water loss inhibition rate, %)

[0074]

[0075] 2.2 Composite Repair Test: Inhibition of Water Loss in Zebrafish Embryo Caudal Fin

[0076] When injured, the skin must regenerate rapidly to repair the skin barrier. In the embryonic stage, wound healing is very rapid and leaves no scar; however, after the embryonic stage, wound healing involves steps such as coagulation, inflammation, skin regeneration, blood vessel regeneration, and the formation of granulation tissue, ultimately resulting in a scar. In zebrafish, the wound repair process follows the same steps as in humans, except for the absence of coagulation. Zebrafish wounds heal very quickly, followed by the migration of inflammatory cells to the wound to form granulation tissue composed of macrophages, fibroblasts, blood vessels, and collagen. Therefore, the main steps and principles of wound healing in zebrafish and humans are very similar, making zebrafish a suitable model for screening and evaluating the effectiveness of human skin repair.

[0077] A zebrafish embryo caudal fin injury model was established using the artificial tail amputation method for testing. Twenty embryos were collected from each treatment group. The zebrafish embryos were first anesthetized with tricaine solution, and the caudal fins were removed under a microscope using a scalpel (the distal 1 / 3 of the caudal fin was uniformly removed to ensure consistent damage). The treated embryos were then exposed to different repair compositions (1#, 2#, 3#, 4#, and 5# moisturizing repair compositions) at different concentrations (0.05%, 0.1%, 0.3%, 0.6%, and 1%). A blank control group and a positive control group (0.5% asiaticoside) were also included. After 72 hours of exposure, the embryos were fixed, and the caudal fin regeneration morphology was observed under a microscope. The regenerated caudal fin length was measured using an image analysis system, and statistical analysis was performed. A higher caudal fin repair rate indicated a better repair effect (see Table 3).

[0078] Table 3. Repair effect test of four components and mixed components (tail fin damage repair rate, %)

[0079]

[0080] III. Moisturizing and Repairing Tests of Toothpaste, Mouthwash, and Oral Spray

[0081] 3.1 Preparation of moisturizing and repairing toothpaste: The above-mentioned No. 4 moisturizing and repairing composition was applied to toothpaste.

[0082] Examples 1 to 6 show the ingredients and their weight percentages used to formulate the toothpaste, as shown in Table 4:

[0083] Table 4 Moisturizing and Repairing Toothpaste Formula

[0084]

[0085] 3.2 Preparation of moisturizing and repairing mouthwash: The above-mentioned No. 4 moisturizing and repairing composition was applied to mouthwash.

[0086] Examples 7 to 12 show the ingredients and their weight percentages in the formulation of the moisturizing and repairing mouthwash, as shown in Table 5:

[0087] Table 5 Moisturizing and Repairing Mouthwash Formula

[0088]

[0089] 3.3 Preparation of moisturizing and repairing oral spray: The above-mentioned No. 4 moisturizing and repairing composition was applied to the oral spray.

[0090] Examples 13 to 18 show the raw materials and their weight percentage content in the formulation of moisturizing and repairing oral spray, as shown in Table 6:

[0091] Table 6 Moisturizing and Repairing Oral Spray Formula

[0092]

[0093] 3.4 Moisturizing and Repairing Tests of Toothpaste, Mouthwash, and Oral Spray

[0094] Moisturizing test: A zebrafish embryo skin barrier damage and water loss model induced by sodium chloride was used for testing. Twenty embryos were taken from each treatment group for testing. The embryos were exposed to 150mM sodium chloride, with Examples 1, 7, and 13 serving as the blank group (without the 4# moisturizing and repairing composition), and Examples 2-6, 8-12, and 14-18 serving as toothpaste, mouthwash, or oral spray containing the 4# moisturizing and repairing composition (toothpaste: 4# moisturizing and repairing composition concentration 1.0%, 2.0%, 3.0%, 4.0%, 5.0%; mouthwash: 4# moisturizing and repairing composition concentration 1.0%, 2.0%, 3.0%, 4.0%, 5.0%; oral spray: 4# moisturizing and repairing composition concentration 0.5%, 1.0%, 1.5%, 2.0%, 2.5%). After 72 hours of exposure, the relative caudal fin area was measured using an image analysis system and statistically analyzed. A higher caudal fin water loss inhibition rate indicated a better moisturizing effect.

[0095] Repair Experiment: A zebrafish embryo tail fin injury model was established using the artificial tail amputation method for testing. Twenty embryos were taken from each treatment group. The zebrafish embryos were first anesthetized with tricaine solution, and the tail fins were removed under a microscope using a scalpel (the distal 1 / 3 of the tail fin was uniformly removed to ensure consistent damage). Examples 1, 7, and 13 served as the control group (without the 4# moisturizing repair composition). Examples 2-6, 8-12, and 14-18 were toothpaste, mouthwash, or oral spray containing the 4# moisturizing repair composition (toothpaste: 4# moisturizing repair composition concentration 1.0%, 2.0%). %, 3.0%, 4.0%, 5.0%; mouthwash: 1.0%, 2.0%, 3.0%, 4.0%, 5.0% of the No. 4 moisturizing and repairing composition; oral spray: 0.5%, 1.0%, 1.5%, 2.0%, 2.5% of the No. 4 moisturizing and repairing composition. After exposure for 72 hours, the fish embryos were fixed, and the morphology of the regenerated tail fin was observed under a microscope. The length of the regenerated tail fin was measured using an image analysis system, and statistical analysis was performed. The higher the tail fin repair rate, the better the repair effect.

[0096] The results of the moisturizing and repair tests on toothpaste, mouthwash, and oral spray are shown in Tables 7-9:

[0097] Table 7 Results of the toothpaste moisturizing and repairing experiment

[0098]

[0099] Table 8 Results of the Mouthwash Moisturizing and Repairing Experiment

[0100]

[0101] Table 9 Results of the oral spray moisturizing and repairing experiment

[0102]

[0103] The experimental results show that the toothpaste, mouthwash or oral spray of this embodiment can significantly inhibit the loss of water in the tail fin of zebrafish embryos, promote tail fin repair, and have a moisturizing and repairing effect.

[0104] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in the present invention should be included within the scope of protection of the present invention.

Claims

1. A moisturizing and repairing composition, characterized in that, It consists of the following components in parts by weight: 1-20 parts of Hedyotis diffusa extract and 1-20 parts of Plantago asiatica extract.

2. The moisturizing and repairing composition according to claim 1, characterized in that, It also includes 1 to 10 parts of glycerin and 0.1 to 4 parts of sodium hyaluronate.

3. The moisturizing and repairing composition according to claim 1, characterized in that, It consists of the following components in parts by weight: 10 parts of Hedyotis diffusa extract, 10 parts of Plantago asiatica extract, 5 parts of glycerin, and 0.5 parts of sodium hyaluronate.

4. The moisturizing and repairing composition according to claim 1, characterized in that, The extract of Hedyotis diffusa is an aqueous or alcoholic extract of Hedyotis diffusa. And / or, the plantain extract is an aqueous or alcoholic extract of plantain.

5. A method for preparing the moisturizing and repairing composition according to any one of claims 1 to 4, characterized in that, Includes the following steps: (1) Preparation of Hedyotis diffusa extract: Take Hedyotis diffusa herb, crush it, add extraction solvent, the extraction solvent is 1 to 20 times the weight of water or 30% vol to 70% vol ethanol, then reflux extract for 0.5 to 3 hours, filter, repeat the water or ethanol reflux extraction step 1 to 2 times, combine the filtrates, concentrate under reduced pressure to 1 / 3 to 1.5 times the weight of Hedyotis diffusa herb, to obtain Hedyotis diffusa extract; Preparation of plantain extract: Take plantain herb, crush it, add extraction solvent, the extraction solvent is 1 to 20 times the weight of water or 30% vol to 90% vol ethanol, reflux extract for 1 to 3 hours, filter, repeat the water or ethanol reflux extraction step 1 to 2 times, combine the filtrates, concentrate under reduced pressure to 1 / 3 to 1.5 times the weight of plantain herb, to obtain plantain extract. (2) Weigh out the extracts of Hedyotis diffusa and Plantago asiatica according to the ratio, stir them evenly, and the moisturizing and repairing composition is obtained.

6. The method for preparing the moisturizing and repairing composition according to claim 5, characterized in that, In step (1), before the first reflux extraction, add a 1wt% to 10wt% weak alkaline salt solution of 1 to 5 times the weight of the white flower snake tongue herb / plantain herb, and soak for 20 to 150 minutes; And / or, in step (1), after adding the extraction solvent, add an antioxidant of 0.01%~0.1% of the total weight of the extraction solvent and the herbal medicine of Hedyotis diffusa / Plantago asiatica.

7. A personal care product, characterized in that, The moisturizing and repairing composition prepared by any one of claims 1 to 4 or by the preparation method described in claim 5 or 6 shall be used as the active ingredient for moisturizing and repairing.

8. The body care daily chemical product according to claim 7, characterized in that, The personal care products mentioned are one of the following: mouthwash, toothpaste, oral spray, facial cleanser, face cream, skin lotion, moisturizing essence, shower gel, toner, and soap.

9. The body care daily chemical product according to claim 7, characterized in that, The amount of the moisturizing and repairing composition added to daily chemical products is 0.1wt% to 10wt% by weight.

10. The body care daily chemical product according to claim 8, characterized in that, The mouthwash / toothpaste / oral spray also contains oral-acceptable excipients; The oral-acceptable excipients are selected from at least one of abrasives, foaming agents, humectants, surfactants, adhesives, and dispersants.

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