Anti-aging composition containing a telomere protective factor and use thereof

Abstract

The present application relates to an anti-aging composition containing a telomere protective factor and its application. The anti-aging composition comprises a telomere factor, a plankton extract and a subarctic overwintering red algae extract, and the mass ratio of the telomere factor, the plankton extract and the subarctic overwintering red algae extract is (0.5-5):(0.5-5):(0.5-5). Compared with the prior art, the anti-aging composition of the present application can significantly improve the anti-aging effect, and can repair the skin barrier and microecology, and is suitable for various anti-aging cosmetics.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to an anti-aging composition containing telomere protective factors and its application. Background Technology

[0002] Skin aging includes endogenous natural aging and exogenous photoaging caused by ultraviolet radiation, environmental pollution, and stress. During the aging process, dermal collagen is lost, elastic fibers break, fibroblast activity decreases, and free radicals accumulate in large quantities, easily forming dry lines, fine lines, and deep wrinkles, while also accompanied by problems such as skin laxity, dullness, roughness, and barrier damage.

[0003] Currently, most anti-wrinkle skincare ingredients on the market are single antioxidants, plant extracts, or oligopeptides. These have limited targets and primarily work only on the skin's surface for hydration and soothing, failing to penetrate the dermis to repair skin structure. Therefore, their effectiveness in improving true wrinkles and facial sagging is limited. Furthermore, existing ingredients generally suffer from low transdermal absorption and poor efficacy utilization. Some highly active ingredients are highly irritating, easily causing redness and sensitivity, and exhibit poor compatibility with cosmetic bases, leading to inactivation and delamination during storage. In addition, existing formulas struggle to achieve dual-pathway anti-aging from both internal and external sources, resulting in insufficient long-lasting firming and anti-wrinkle effects.

[0004] Therefore, developing an anti-wrinkle composition that targets multiple points for synergistic anti-aging, is gentle and low-irritant, has good transdermal absorption, and has a stable formula, while simultaneously promoting collagen regeneration, reducing wrinkles, and firming and repairing, has significant application value. Summary of the Invention

[0005] The purpose of this invention is to overcome the defects of the prior art and provide an anti-aging composition containing telomere protective factors and its application.

[0006] The objective of this invention can be achieved through the following technical solutions: The first aspect of the present invention provides an anti-aging composition containing telomere protective factors, the anti-aging composition comprising telomere factors, planktonic extracts and subarctic overwintering red algae extracts; The mass ratio of the telomere factor, plankton extract, and subarctic overwintering red algae extract is (0.5-5):(0.5-5):(0.5-5), preferably (1-4):(1-2):1.

[0007] Furthermore, the telomere factor is sourced from Ashland Corporation in the United States, and its specific components include water, glycerol, hydrolyzed soy protein, and hydrolyzed yeast protein.

[0008] Furthermore, the core component of the planktonic extract is guanosine tetraphosphate (Gp4G).

[0009] Furthermore, the subarctic overwintering red algae extract is specifically ARCT' ALG P2.

[0010] A second aspect of the present invention provides an application of an anti-aging composition containing telomere protective factors, wherein the anti-aging composition is applied to cosmetics.

[0011] Furthermore, the anti-aging composition has a mass percentage of 1-20% in the cosmetic, preferably 3-18%.

[0012] Furthermore, the telomere factor, plankton extract, and subarctic overwintering red algae extract are present in cosmetics at mass percentages of 0.5-5%, 0.5-5%, and 0.5-5%, respectively, preferably 0.5-4%, 0.5-2%, and 0.5-2%, respectively.

[0013] Furthermore, the cosmetic product is any one of the following: serum, essence lotion, face cream, eye cream, face mask, and dressing.

[0014] Furthermore, the cosmetic product includes conventional excipients.

[0015] Furthermore, the conventional excipients include thickeners, humectants, preservatives, and neutralizers.

[0016] Furthermore, the thickener is one or more of the following: carbomer, ammonium acryloyldimethyl taurate / VP copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, and polyacrylate crosspolymer.

[0017] Furthermore, the moisturizer is one or more of the following: glycerin, butylene glycol, propylene glycol, dipropylene glycol, panthenol, glyceryl polyether-26, diglycerin, sorbitol, erythritol, PEG-8, PEG-32, PEG-6, and PEG-15.

[0018] Furthermore, the preservative is one or more of the following: 1,2-pentanediol, 1,2-hexanediol, p-hydroxyacetophenone, phenoxyethanol, ethylhexylglycerin, p-hydroxybenzoate, sodium benzoate, and capryloyl hydroxamic acid.

[0019] Furthermore, the neutralizing agent is one or more of the following: tromethorphan, sodium hydroxide, potassium hydroxide, arginine, citric acid, sodium citrate, and sodium bicarbonate.

[0020] Furthermore, the cosmetic is an essence, which comprises the following components in weight percentage: telomere factor 0.5-5%, plankton extract 0.5-5%, subarctic overwintering red algae extract 0.5-5%, thickener 0.05-1%, moisturizer 5-15%, preservative 0.1-3%, and neutralizer 0.01-1%.

[0021] Compared with the prior art, the present invention has the following technical advantages: (1) This invention, through the successful compounding of telomere factors, plankton extracts, and subarctic overwintering red algae extracts, yields a novel anti-aging composition with multiple active ingredients possessing different anti-wrinkle mechanisms. Experimental tests show that serum cosmetics containing this anti-aging composition exhibit excellent effects in wrinkle reduction, skin hydration, reduction of transepidermal water loss, inhibition of H reactive oxygen species, and promotion of collagen regeneration. The composition of this invention is highly safe and effective, significantly enhancing anti-aging efficacy and repairing the skin barrier and microecology.

[0022] (2) The active ingredients in the anti-aging composition of the present invention are less irritating, less likely to cause redness and sensitivity, have better compatibility with cosmetic matrix, and are less likely to be deactivated and separated during storage.

[0023] (3) The anti-aging composition of the present invention has the advantages of multi-target synergistic anti-aging, mild and low irritation, good transdermal absorption and stable formula. It can simultaneously promote the regeneration of type I collagen and type III collagen, reduce wrinkles and tighten and repair, and can be widely used in anti-wrinkle, anti-aging and skin barrier repair products. Attached Figure Description

[0024] Figure 1 This is a diagram showing the results of the cell proliferation assay of this invention.

[0025] Figure 2 The image shows the test results of type III collagen content in this invention.

[0026] Figure 3 This is a graph showing the test results of type I collagen content in this invention.

[0027] Figure 4 The graph shows the ROS inhibition rate test results of this invention.

[0028] Figure 5 Comparison of eye wrinkles before and after using the anti-aging composition of this invention in skin efficacy testing. Detailed Implementation

[0029] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments. These embodiments are based on the technical solution of the present invention and provide detailed implementation methods and specific operating procedures. However, the scope of protection of the present invention is not limited to the following embodiments.

[0030] Unless otherwise specified, the reagents, methods, instruments, and equipment used in this invention are conventional in the art. Unless otherwise specified, the reagents and materials used in the following examples are all commercially available.

[0031] The anti-aging composition containing telomere protective factors provided by this invention is compounded with a variety of active ingredients with different anti-wrinkle mechanisms, specifically containing three core active ingredients: telomere factors, plankton extract, and subarctic overwintering red algae extract.

[0032] Telomere factor: Telosense TM Biofunctional is a patented anti-aging cosmetic active ingredient developed by Ashland, Inc. in the United States. Its core function is to delay skin aging by protecting cell telomeres. It belongs to the high-end cell-level anti-aging raw materials. It significantly enhances the expression of TRF2 protein (the core protein for telomere protection), stabilizes the T-loop structure of telomeres, prevents chromosome ends from fusing or being misidentified as damaged DNA, protects lamin A, maintains cell nucleus morphology and DNA replication stability, reduces DNA damage caused by external factors such as UVB, inhibits the accumulation of aging markers (β-galactosidase), prolongs the healthy lifespan of skin cells, and slows down the aging process. It is purchased from Ashland China.

[0033] Plankton extract: Anisotropic plankton acclimated to stress environments, containing nucleotide-based active compounds. With plankton-derived nucleotides as the core, it enhances cellular stress resistance and repair capabilities, synergistically protects DNA and organelles, and reduces aging symptoms caused by environmental stress. The plankton extract used in the following examples and comparative examples is specifically gp4g™ cnbiofunctional, purchased from Ashland China.

[0034] Subarctic overwintering red algae extract: Antioxidant, moisturizing and protective. This polar red algae extract is rich in antioxidants, resisting external stress and enhancing the skin's moisture retention capacity. The subarctic overwintering red algae extract used in the following examples and comparative examples is specifically ARCT' ALG P2, purchased from Shanghai Baihaobo Biotechnology Co., Ltd.

[0035] In the anti-aging composition of the present invention, the mass ratio of telomere factor, plankton extract and subarctic overwintering red algae extract is (0.5-5):(0.5-5):(0.5-5), preferably (1-4):(1-2):1.

[0036] The anti-aging composition containing telomere protective factors of the present invention can be used in cosmetics, for example, it can be formulated into dosage forms such as serums, lotions, creams, eye creams, dressings, etc.

[0037] In the aforementioned cosmetics, the mass percentages of telomere factor, plankton extract, and subarctic overwintering red algae extract are 0.5-5%, 0.5-5%, and 0.5-5%, respectively, and preferably 0.5-4%, 0.5-2%, and 0.5-2%, respectively.

[0038] The following examples and comparative examples illustrate the preparation of an anti-aging serum.

[0039] The specific preparation steps of Examples 1 to 4 are as follows: (1) Phase A is an aqueous phase. The acrylic (ester) / C10-30 alkanol acrylate cross-linked polymer in Phase A is dispersed in deionized water and stirred evenly before adding other components of Phase A one by one.

[0040] (2) Phase B is an oil phase. Add the components of phase B one by one to phase A and stir until homogeneous.

[0041] (3) Phase C is a neutralizing agent. Add the components of phase C one by one to phase A and stir until homogeneous.

[0042] (4) D phase active composition: add the middle D phase to the A phase and stir evenly.

[0043] (5) Phase E is deionized water, replenished to 100%.

[0044] The specific formulations of the anti-aging serums in Examples 1-4 are shown in Table 1.

[0045] Table 1. Specific formulations of the anti-aging serums in Examples 1-4 Comparative Example 1: The only difference between this comparative serum and Example 1 is that only telomere factors are added to phase D, meaning that the mass percentage of telomere factors in the entire serum is 3 wt%.

[0046] Comparative Example 2: The only difference between this comparative serum and Example 1 is that only planktonic extract was added to phase D, meaning that the planktonic extract accounted for 3 wt% of the total serum.

[0047] Comparative Example 3: The only difference between this comparative serum and Example 1 is that only sub-Arctic overwintering red algae extract was added to phase D, meaning that the sub-Arctic overwintering red algae extract accounted for 3 wt% of the total serum.

[0048] Comparative Example 4: The only difference between the serum in this comparative example and that in Example 1 is that only telomere factor and plankton extract were added to phase D, with the two accounting for 1.5 wt% and 1.5 wt% of the total serum, respectively.

[0049] Comparative Example 5: The only difference between this comparative serum and Example 1 is that only telomere factor and subarctic overwintering red algae extract were added to phase D, with the two accounting for 1.5 wt% and 1.5 wt% of the total serum, respectively.

[0050] Comparative Example 6: The only difference between this comparative example serum and Example 1 is that only plankton extract and subarctic overwintering red algae extract were added to phase D, with the two accounting for 1.5 wt% and 1.5 wt% of the total serum, respectively.

[0051] Comparative Example 7: The only difference between this comparative example and Example 1 is that it is an essence base without any active substances, and serves as a blank control group.

[0052] Table 2. Specific formulas of the serums in Comparative Examples 1-7 Based on the successful formulation of the serums in the above embodiments and comparative examples, the present invention conducts the following tests on the prepared serums: I. In vitro testing (1) Cell proliferation assay The experimental sample groups were: Examples 1-4, Comparative Examples 1-7, and a blank control group of culture medium. The concentration of the sample groups was adjusted to 0.05% (all samples at this concentration were non-cytotoxic).

[0053] The specific experimental steps were as follows: Human dermal fibroblasts in the logarithmic growth phase (purchased from Stemer (Shanghai) Biotechnology Co., Ltd., catalog number: 241008) were collected, the culture medium was discarded, and the cells were washed once with PBS. They were then digested with 0.25% trypsin. During digestion, the cells were observed under a microscope; once most cells floated, digestion was immediately stopped with complete culture medium. The cells were centrifuged at 1000 rpm for 3 min, resuspended in complete DMEM medium (DMEM medium containing 10% FBS), counted, and the cell concentration was adjusted to 1.0 × 10⁶ cells / cm². 5Cells / ml, 100 μL per well, were added to a 96-well plate and incubated at 37 ℃ with 5% CO2 for 24 h ± 2 h. Then, 100 μL of serum-free culture medium or 100 μL of sample solution was added, and incubation continued for another 24 h. After another 24 h of incubation, the culture medium was discarded, and 100 μL of CCK8 (purchased from Beyotime) diluted 10-fold with serum-free culture medium was added to each well. The plate was then incubated at 37 ℃ with 5% CO2 for another 2 h. The absorbance of the 96-well plate at 450 nm was read using a microplate reader, and the results were recorded. Relative cell proliferation rate (%) = 1 + (sample OD, blank control OD) / blank control OD.

[0054] The results of the cell proliferation assay are shown in Table 3 and Figure 1 The results showed that, under the conditions of this experiment, all the sample groups in the examples had significant cell proliferation effects compared with the comparative examples and the blank control group, and the component ratios in Examples 1, 3, and 4 had the most significant effects.

[0055] Table 3 Results of cell proliferation experiment (2) Experiments to promote collagen expression in fibroblasts Immortalized human skin fibroblasts (HSF) can serve as a cell model for studying the enhancement of type I and type III collagen content in cosmetics. By measuring the upregulation rate of type III collagen content after administration of the test substance, compared with the blank control and the test substance, the efficacy of the test substance in promoting collagen synthesis can be evaluated.

[0056] The content of type I and type III collagen was determined using enzyme-linked immunosorbent assay (ELISA). The principle is as follows: type I and type III collagen specifically bind to collagen antibodies coated on an ELISA plate, which then bind to substrate-labeled antibodies. The substrate is catalyzed by the enzyme to produce a colored product. The content of type I and type III collagen is positively correlated with the intensity of the colored product. The optical density (OD value) was measured at a wavelength of 450 nm using an ELISA reader to calculate the content of type I and type III collagen.

[0057] This experiment used immortalized human skin fibroblasts (HSF, purchased from Stemer (Shanghai) Biotechnology Co., Ltd.) as the research subject, and cultured them in DMEM containing 10% fetal bovine serum at 37 ℃ and 5% CO2 saturated humidity. The experiment included a blank control (DMEM medium) and a test sample group (samples diluted to 10 μg / mL with medium). The content of type I and type III collagen was determined using an ELISA kit purchased from Enzyme-Linked Biotechnology Co., Ltd.

[0058] The specific procedure is as follows: HSF cells in the logarithmic growth phase are introduced into each well at a density of 5 × 10⁶ cells / well. 4 Cells were seeded at a density of [number] cells / mL in 12-well plates and cultured for 18–24 h to allow cell adhesion. Subsequently, 1 mL of the corresponding sample solution (blank control or test sample) was added to each well according to the experimental group, and the plates were incubated in a CO2 incubator for another 48 h. After incubation, the supernatant from each well was collected, and the results were analyzed according to the instructions for the type I and type III collagen ELISA kits. Finally, the absorbance of each well was measured at 450 nm using a microplate reader. The relative collagen content was calculated using the following formula: Relative content (%) = (Absorbance of sample group / Absorbance of blank control) × 100%.

[0059] The results of the assay that promoted collagen expression in fibroblasts are shown in Table 4 and Figure 2 , 3 The results showed that, under the experimental conditions, the serum samples from all example groups and comparative groups showed a certain increase in both type I and type III collagen levels compared to the blank control group. The proportions of components used in Examples 1, 3, and 4 showed a significant increase compared to other groups. TGF-β in the positive control group is the main collagen-promoting growth factor and is the most commonly used positive control for collagen expression. The collagen-promoting effect of this example has reached or exceeded the collagen-promoting effect of this concentration of TGF-β.

[0060] Table 4. Results of experiments promoting collagen expression in fibroblasts (3) Cell ROS content test (photoaging) This experiment employed a UVA-damaged human keratinocyte model. The antioxidant effect of cosmetics was investigated by detecting reactive oxygen species (ROS) levels in human keratinocytes (National Model and Special Cell Bank, Chinese Academy of Sciences (Shanghai), catalog number: SCSP-5091). 2',7'-Dichlorofluorescein diacetate (DCFH-DA) is non-fluorescent and can freely cross the cell membrane. Once inside the cell, it is hydrolyzed by esterases to generate DCFH, which, unable to penetrate the cell membrane, accumulates intracellularly. Intracellular ROS oxidize the non-fluorescent DCFH to generate fluorescent DCF. The intensity of green fluorescence is directly proportional to the level of intracellular ROS. Hydrogen peroxide (H2O2), ultraviolet light, and blue light, as exogenous oxidants, can induce an increase in ROS content within human keratinocytes. The ROS inhibition rate was calculated by comparing the changes in intracellular fluorescence intensity of the fluorescent dye DCFH-DA after administration of the negative control and the test substance.

[0061] The specific testing steps are as follows: ① ROS detection plate loading and sample addition: Prepare a single-cell suspension of human keratinocytes (transfer cell culture medium to centrifuge tubes, centrifuge at 1000 rpm for 5 min, discard the supernatant, resuspend the pellet in DMEM medium, gently disperse the cells by pipetting, and count the cells). Use a cell counter to count the cells and adjust the cell concentration to 5.0 × 10⁻⁶. 4 Cells / mL were seeded into 96-well cell culture plates at 100 μL per well and cultured at 37°C with 5% CO2 for 24 h.

[0062] ②ROS detection of photodamaged cell model induction: After incubation, do not discard the solution. Except for the negative control and naked cell wells, all other wells should be induced with UVA at a UVA light damage intensity of 9-15 J / cm². 2 Irradiate for 120 seconds.

[0063] ③ ROS detection probe loading: Except for the wells containing naked cells, discard the culture medium in the remaining wells. Wash three times with PBS, then add 200 μL of DCFH-DA working solution to each well and incubate at 37°C for 30 min in a 5% CO2 cell culture incubator. After the operation, place the 96-well plate on the detection stage of a fluorescence microplate reader, set the incident light wavelength to 525 nm and the excitation light wavelength to 488 nm, read the values, and calculate the ROS inhibition rate.

[0064] ROS inhibition rate % = [(absorbance of model group - absorbance of sample group) / (absorbance of model group - absorbance of blank group)] × 100%.

[0065] The results of the cell proliferation assay are shown in Table 5 and Figure 4 The results showed that, under the experimental conditions, the ROS inhibition rates of all example groups and comparative groups were significantly different from those of the blank control group. The component ratios used in Examples 1, 3, and 4 were significantly higher than those in other groups. In the anti-aging composition of this invention, telomere factors (endogenous pathway + DNA / mitochondrial source regulation), plankton extract (rapid free radical scavenging), and subarctic red algae extract (blocking the oxidative inflammation cycle) have completely complementary targets, pathways, and intracellular distributions. When used together, they simultaneously inhibit ROS generation, immediately scavenge reactive oxygen species, block the oxidative chain reaction, activate the long-lasting endogenous antioxidant system, and break the vicious cycle of oxidation and inflammation, constructing a complete and multi-layered antioxidant closed loop. Therefore, the ROS scavenging ability of the ternary compound composition of this invention is significantly better than that of single components and any binary compound, exhibiting a significant synergistic antioxidant effect.

[0066] Table 5. Results of ROS Inhibition Experiment II. Facial Adverse Reactions and Skin Efficacy Tests (1) Adverse reaction test Test method: 110 female volunteers aged 40-55 were selected and randomly divided into 11 groups of 10 people each. After cleansing their faces with water, the volunteers applied the essence prepared by Examples 1-4 and Comparative Examples 1-7.

[0067] Test environment: Volunteers cleansed their faces before the test and waited 30 minutes in an environment with a temperature of 25±4 ℃ and a relative humidity of 48±5% before the test.

[0068] Doctors evaluated the adverse reactions such as itching, stinging, and erythema experienced by volunteers after using the samples. The specific results are shown in Table 6 below. As can be seen from the table, no adverse reactions such as itching, stinging, or erythema occurred after using any of the serums in Example 1; however, in Comparative Examples 2, 3, and 6, which did not contain telomere factors, a small number of participants experienced itching and erythema. This indicates that the introduction of telomere factors into the serums in this invention has a certain soothing effect.

[0069] Table 6 Adverse reaction test results (2) Facial skin efficacy test The test product was evaluated by recruiting 10 healthy female subjects (groups) with loose skin, fine lines, and crow's feet. The efficacy of the cosmetic in moisturizing and firming was assessed using instrument detection and image analysis.

[0070] Subject selection: Qualified subjects were selected according to the inclusion and exclusion criteria. Subjects voluntarily signed a written informed consent form, understood the trial process, and voluntarily participated in the trial, ensuring that the number of valid cases completed was no less than 10 per group.

[0071] Instructions for use: All samples were applied to the entire face twice a day, once in the morning and once in the evening.

[0072] The testing methods referenced relevant domestic and international industry / academic organizations and literature. (1) T / CAB 0152-2022 Test methods for seven effects of cosmetics: anti-wrinkle, firming, moisturizing, oil control, repair, nourishing and soothing.

[0073] (2) Cosmetic Safety Technical Specifications (2015 Edition).

[0074] The various efficacy testing indicators are shown in Table 7 below.

[0075] Table 7 Efficacy Testing Indicators The results of the skin firmness R0 value, skin stratum corneum moisture content, and transepidermal water loss are shown in Tables 8-10.

[0076] Table 8 Results of Skin Tightness R0 Value Test As shown in Table 8, after 28 days, the change rate of R0 values ​​in Examples 1-4 was not only far superior to that of the blank essence group, but also superior to the combination of other single active components and dual active components, indicating that the telomere factor, planktonic extract and subarctic overwintering red algae extract of the present invention have a significant synergistic effect on skin firmness.

[0077] Table 9 Results of skin stratum corneum moisture content detection As shown in Table 9, after 28 days, the rate of change in skin stratum corneum moisture content in Examples 1-4 was not only far superior to that of the blank essence group, but also superior to the combination of other single and dual active components, indicating that the telomere factor, plankton extract and subarctic overwintering red algae extract of the present invention have a significant synergistic effect in improving skin stratum corneum moisture.

[0078] Table 10 Results of transdermal water loss detection As shown in Table 10, after using the anti-aging serums of Examples 1-4 of the present invention for 28 days, the amount of water lost through the skin was much less than that in the blank serum group, the single active component group, and the dual active component group. This indicates that the telomere factor, plankton extract, and subarctic overwintering red algae extract of the present invention have a significant synergistic effect in improving the skin barrier function.

[0079] at last, Figure 5 The study demonstrated the wrinkle repair effect on the skin around the eyes 28 days after using the anti-aging serum of Example 1, proving that the anti-aging composition of the present invention has excellent wrinkle removal effect.

[0080] In summary, this invention, through the successful compounding of telomere factors, plankton extracts, and subarctic overwintering red algae extracts, yields a novel anti-aging composition with multiple active ingredients possessing different anti-wrinkle mechanisms. Experimental tests demonstrate that serums containing this anti-aging composition exhibit excellent efficacy in improving wrinkles, moisturizing the skin, and reducing transepidermal water loss. Furthermore, the composition of this invention is highly safe and significantly effective, capable of significantly enhancing anti-aging efficacy, repairing the skin barrier and microecology, and can be widely applied in anti-wrinkle, anti-aging, and skin barrier repair products.

[0081] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. An anti-aging composition containing telomere protective factors, characterized in that, Including telomere factors, plankton extracts, and subarctic overwintering red algae extracts; The mass ratio of telomere factor, plankton extract, and subarctic overwintering red algae extract is (0.5-5):(0.5-5):(0.5-5).

2. The anti-aging composition containing telomere protective factors according to claim 1, characterized in that, The telomere factor is sourced from Ashland Corporation in the United States, and its specific components include water, glycerol, hydrolyzed soy protein, and hydrolyzed yeast protein.

3. The anti-aging composition containing telomere protective factors according to claim 1, characterized in that, The core component of the plankton extract is guanosine tetraphosphate (Gp4G).

4. The anti-aging composition containing telomere protective factors according to claim 1, characterized in that, The subarctic overwintering red algae extract is specifically ARCT' ALG P2.

5. The application of an anti-aging composition containing telomere protective factors as described in any one of claims 1-4, characterized in that, The anti-aging composition is applied to cosmetics; The anti-aging composition accounts for 1-20% by mass in the cosmetic.

6. The application of the anti-aging composition containing telomere protective factors according to claim 5, characterized in that, The telomere factor, plankton extract, and subarctic overwintering red algae extract are present in cosmetics at mass percentages of 0.5-5%, 0.5-5%, and 0.5-5%, respectively.

7. The application of the anti-aging composition containing telomere protective factors according to claim 5, characterized in that, The cosmetic product is any one of the following: serum, essence lotion, face cream, eye cream, face mask, or dressing.

8. The application of the anti-aging composition containing telomere protective factors according to claim 5, characterized in that, The cosmetics include conventional excipients; The conventional excipients include thickeners, humectants, preservatives, and neutralizers.

9. The application of the anti-aging composition containing telomere protective factors according to claim 8, characterized in that, The thickener is one or more of the following: carbomer, ammonium acryloyldimethyl taurate / VP copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, and polyacrylate crosspolymer. The moisturizer is one or more of the following: glycerin, butylene glycol, propylene glycol, dipropylene glycol, panthenol, glyceryl polyether-26, diglycerin, sorbitol, erythritol, PEG-8, PEG-32, PEG-6, and PEG-15. The preservative is one or more of the following: 1,2-pentanediol, 1,2-hexanediol, p-hydroxyacetophenone, phenoxyethanol, ethylhexylglycerin, p-hydroxybenzoate, sodium benzoate, and capryloyl hydroxamic acid. The neutralizing agent is one or more of the following: tromethamine, sodium hydroxide, potassium hydroxide, arginine, citric acid, sodium citrate, and sodium bicarbonate.

10. The application of the anti-aging composition containing telomere protective factors according to claim 5, characterized in that, The cosmetic is an essence, which includes the following components by weight percentage: telomere factor 0.5-5%, plankton extract 0.5-5%, subarctic overwintering red algae extract 0.5-5%, thickener 0.05-1%, moisturizer 5-15%, preservative 0.1-3%, and neutralizer 0.01-1%.

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