A wet wipe solution for perianal eczema care, a sanitary wet wipe, and a preparation method and application thereof

Abstract

The present application belongs to the technical field of cosmetics, and specifically discloses a wet wipe liquid for perianal eczema care, a sanitary wet wipe, and a preparation method and application thereof. The wet wipe liquid is prepared from the following raw materials in a total amount of 100% by mass fraction: 0.05-0.20% ice flakes, 0.05-0.20% purple grass extract, 0.50-1.50% hydroxypropyl-beta-cyclodextrin, 0.20-1.00% lactobacillus fermentation lysate, 0.10-0.50% alpha-glucan oligosaccharide, 0.10-0.30% dipotassium glycyrrhizinate, 0.10-0.40% sophora extract, 0.10-0.40% cortex phellodendri extract, 0.10-0.40% hamamelis virginiana extract, 0.03-0.08% chlorhexidine gluconate, 1.50-3.00% propylene glycol, 0.10-0.30% octisalate, 0.05-0.15% ethylhexylglycerin, 0.20-0.50% phenoxyethanol, and the balance being purified water. The sanitary wet wipe prepared from the wet wipe liquid provided by the present application can effectively relieve perianal eczema itching, swelling, and exudation symptoms, reduce the risk of recurrence, and is suitable for long-term repeated use on the thin and tender parts around the anus.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a wet wipe liquid for perianal eczema care, sanitary wet wipes, their preparation method and application. Background Technology

[0002] Perianal eczema is a common inflammatory skin disease of the perianal region, clinically manifested as perianal maculopapular rashes, intense itching, exudation, crusting, and a prolonged course with a high recurrence rate. The perianal region is a unique area at the transition between skin and mucous membranes, characterized by a closed, moist environment and a complex local microbiota. The pathogenesis of perianal eczema involves three core pathological mechanisms: damage to the epidermal barrier structure; imbalance of Th1 / Th2 and Th17 / Treg immune cell subsets; and dysregulation of the perianal skin microbiota homeostasis. At the immune pathway level, the NF-κB signaling pathway mediates the release of large amounts of pro-inflammatory factors, while the JAK-STAT signaling pathway continuously amplifies the inflammatory cascade response; both pathways jointly promote the occurrence and development of perianal eczema.

[0003] Existing commercially available wet toilet paper and perianal care wipes have significant technical deficiencies: First, most products only achieve basic physical cleaning and do not have functional components designed to target the pathological targets of perianal eczema, thus failing to intervene in inflammatory pathways and local immune imbalances; Second, a few care products containing antibacterial components use a broad-spectrum bactericidal mode, killing pathogens while indiscriminately destroying the inherent beneficial symbiotic flora of the perianal skin, further exacerbating microecological dysbiosis and increasing the probability of eczema recurrence; Third, some care products add single anti-inflammatory traditional Chinese medicine components, which can only achieve weak anti-inflammatory effects on a single pathway, lacking a multi-target synergistic intervention plan; Among the currently disclosed technologies, there are no perianal care wipes that combine comfrey extract and dipotassium glycyrrhizate in a specific ratio to simultaneously target and inhibit the NF-κB and JAK-STAT inflammatory signaling pathways; most existing traditional Chinese medicine compound wipes are based on empirical formulations and lack "pathway anti-inflammatory barrier repair and selective flora regulation". The three-in-one system technical solution; fourth, some products contain hormones, strong irritant preservatives, alcohol, and fragrances. The perianal skin and mucous membranes are thin and delicate, and long-term use can easily cause irritation and hormone dependence, thus limiting their application.

[0004] In view of this, the present invention is proposed. Summary of the Invention

[0005] To address the aforementioned technical problems, the present invention aims to provide a wet wipe solution, sanitary wipes, and their preparation method and application for perianal eczema care, which can effectively relieve symptoms of itching, redness, swelling, and exudation in perianal eczema, reduce the risk of recurrence, and is suitable for long-term and repeated use on the delicate perianal area.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: In a first aspect, the present invention provides a wet wipe solution for the care of perianal eczema, prepared from the following raw materials in 100% by mass fraction: 0.05~0.20% borneol, 0.05~0.20% Lithospermum erythrorhizon extract, 0.50~1.50% hydroxypropyl-β-cyclodextrin, 0.20~1.00% Lactobacillus fermentation lysate, 0.10~0.50% α-glucan oligosaccharide, 0.10~0.30% dipotassium glycyrrhizate, and 0.10~0.40%... The ingredients are: Sophora flavescens extract, 0.10-0.40% Phellodendron chinense extract, 0.10-0.40% Witch hazel extract, 0.03-0.08% Chlorhexidine gluconate, 1.50-3.00% Propylene glycol, 0.10-0.30% Caprylyl glycol, 0.05-0.15% Ethylhexylglycerin, 0.20-0.50% Phenoxyethanol, and the balance being purified water.

[0007] In the above technical solution, by optimizing the components of each substance, it is possible to achieve multi-target synergistic anti-inflammatory and healing effects, significantly accelerate the repair of eczema wounds, strengthen the antibacterial barrier, and at the same time provide long-lasting hydration and moisturization for dry and scaly skin lesions around the anus, avoiding epidermal cracking after wiping. It is suitable for the care and repair of perianal eczema.

[0008] As a preferred embodiment of the present invention, the wet wipe liquid, calculated by mass fraction (100%), is prepared from the following raw materials: 0.05-0.15% borneol, 0.05-0.15% Lithospermum erythrorhizon extract, 0.50-1.00% hydroxypropyl-β-cyclodextrin, 0.30-0.80% Lactobacillus fermentation lysate, 0.20-0.40% α-glucan oligosaccharide, 0.15-0.25% dipotassium glycyrrhizate, and 0.20-0.35%... The ingredients are: Sophora flavescens extract, 0.20-0.35% Phellodendron chinense extract, 0.20-0.35% Witch hazel extract, 0.04-0.07% Chlorhexidine gluconate, 1.80-2.50% Propylene glycol, 0.10-0.25% Caprylyl glycol, 0.05-0.12% Ethylhexylglycerin, 0.20-0.40% Phenoxyethanol, and the balance being purified water.

[0009] As a further preferred embodiment of the technical solution of the present invention, the wet wipe liquid, in terms of a total mass fraction of 100%, is prepared from the following raw materials: 0.10% borneol, 0.10% Lithospermum erythrorhizon extract, 0.80% hydroxypropyl-β-cyclodextrin, 0.50% Lactobacillus fermentation lysate, 0.30% α-glucan oligosaccharide, 0.15% dipotassium glycyrrhizate, 0.20% Sophora flavescens extract, 0.20% Phellodendron chinense extract, 0.20% witch hazel extract, 0.05% chlorhexidine gluconate, 2.00% propylene glycol, 0.20% caprylyl glycol, 0.10% ethylhexylglycerin, 0.30% phenoxyethanol, with the balance being purified water.

[0010] As a preferred embodiment of the present invention, the preparation of the Lithospermum erythrorhizon extract includes the following steps: S1. Take the rhizome of Lithospermum erythrorhizon, dry it, cut it into 0.5-1cm segments, spread it out and microwave irradiate it. After the treatment, place it in a low-temperature environment for freezing treatment for 1-2 hours, then crush and sieve it to obtain Lithospermum erythrorhizon ultrafine dry powder. S2. Add the ultrafine dry powder of Lithospermum erythrorhizon obtained in step S1 to ultrapure water, stir, add food-grade citric acid to adjust the pH value of the system, then add compound enzyme for enzymatic hydrolysis. After the enzymatic hydrolysis is completed, the enzymatic hydrolysate is obtained for later use. S3. Prepare a eutectic solvent and add it to the enzymatic hydrolysate obtained in step S2. Simultaneously, turn on ultrasonic-assisted stirring. After stirring, centrifuge to obtain the extract. Add purified water to dilute it. After adsorption and impurity removal by macroporous adsorption resin column, elute and collect the eluent. Concentrate the eluent under reduced pressure and freeze dry it under vacuum to obtain the Lithospermum erythrorhizon extract.

[0011] As a preferred embodiment of the technical solution of the present invention, in step S1, the microwave irradiation power density is 10~15W / g, the treatment time is 30~60s, the low temperature is -15~-10℃, and the sieve mesh is 150~200 mesh. In step S2, the solid-liquid mass ratio is 1:(4~8); the pH of the system is adjusted to 4.2~4.6; the compound enzyme is composed of pectinase, cellulase and neutral xylanase; the pectinase activity is ≥50000 U / g, and the dosage is 0.3~0.6% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the cellulase activity is ≥20000 U / g, and the dosage is 0.2~0.4% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the neutral xylanase activity is ≥30000 U / g, and the dosage is 0.1~0.2% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the enzymatic hydrolysis temperature is 35~40℃, and the enzymatic hydrolysis time is 60~120min; In step S3, the preparation of the eutectic solvent includes the following steps: weigh choline chloride, 1,3-butanediol and lactic acid in a molar ratio of 1:1:1, mix them and stir at 65~70℃ for 45~90 min; The ratio of ultrafine dry powder of Lithospermum erythrorhizon to eutectic solvent is 1g:(10~20)mL, the ultrasonic power is 200~300W, the stirring temperature is 25~35℃, and the stirring time is 30~90min; The conditions for vacuum concentration are: vacuum degree -0.09~-0.095 MPa, temperature 40~45℃.

[0012] Secondly, the present invention also provides a method for preparing the aforementioned wet wipe liquid, comprising the following steps: (1) Take purified water, heat it up and add hydroxypropyl-β-cyclodextrin, stir until completely dissolved, then add borneol and Lithospermum erythrorhizon extract, seal and sonicate, and heat and stir; after the treatment is completed, cool and filter to obtain mixed phase A; (2) Take purified water, and then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract, witch hazel extract, α-glucan oligosaccharide and Lactobacillus fermentation lysate according to the formula amount, and stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, slowly add chlorhexidine gluconate and mix evenly again to obtain mixed phase C; (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to 4.8~5.2 and filter it through a fine filter.

[0013] As a preferred embodiment of the technical solution of the present invention, in step (1), the ultrasonic power is 300~500W, the ultrasonic frequency is 30~50kHz, the heating and stirring treatment temperature is 45~50℃, and the treatment time is 60~90min.

[0014] Thirdly, the present invention also aims to protect the use of the above-mentioned wet wipe liquid in the preparation of sanitary wet wipes.

[0015] Fourthly, the present invention also claims protection for a sanitary wipe, comprising a substrate and a medicinal liquid impregnated on said substrate, the medicinal liquid being the aforementioned wipe liquid.

[0016] Fifthly, the present invention also provides a method for preparing the above-mentioned sanitary wipes, comprising the following steps: Cut and fold the virgin wood pulp spunlace nonwoven fabric for later use; Spray or soak the aforementioned wet wipe liquid onto the folded non-woven fabric, controlling the mass ratio of wet wipe liquid to non-woven fabric to be 2~2.5:1; Finally, bag and seal it.

[0017] Compared with the prior art, the present invention has the following beneficial effects: The wet wipe liquid provided by this invention, through the screening of active ingredients, has multiple functions such as antibacterial, repair and moisturizing, and is suitable for the care of perianal eczema.

[0018] The wet wipe liquid provided by this invention uses chlorhexidine gluconate as a bactericide, which is also a common ingredient in conventional wet wipes. However, although it has a strong antibacterial effect, its high concentration can also kill the resident symbiotic probiotics in the perianal area, destroy the local acidic microenvironment and biological barrier, leading to recurrent eczema or inducing secondary drug-resistant infections. Therefore, this invention, on the one hand, uses plant polyphenols such as Sophora flavescens, Phellodendron chinense, and witch hazel to exert a highly efficient and synergistic inhibitory effect on target pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Candida albicans. On the other hand, it creatively combines α-glucan oligosaccharide and Lactobacillus fermentation lysate: α-glucan oligosaccharide can be specifically metabolized and utilized by the dominant probiotics in the perianal area, preferentially supporting the colonization and proliferation of resident symbiotic bacteria; Lactobacillus fermentation lysate provides natural antimicrobial peptides, organic acids, and cell wall antigen fragments, which can rapidly lower the pH of the affected area, form competitive sites to block the adhesion of pathogenic bacteria, and upregulate the expression of tight junction proteins in epidermal keratinocytes. By using the above components in combination, the concentration of chlorhexidine gluconate is reduced to 0.03~0.08%, which reduces the risk of mistakenly killing the perianal probiotics.

[0019] The wet wipe liquid provided by this invention uses comfrey extract prepared using a specific process. Specifically, it first undergoes microwave irradiation treatment, overcoming the shortcomings of traditional pulverization or extraction methods that lead to oxidation, discoloration, and hydrolysis of comfrey. Instead, it utilizes the thermal effect and electromagnetic non-thermal effect generated by the microwave high-frequency alternating electric field to cause irreversible denaturation and inactivation of polyphenol oxidases deep within plant tissues, thus cutting off the self-oxidation pathway of the active ingredient at its source. Next, a slightly acidic system is precisely constructed using food-grade citric acid. This pH range is not only the optimal activity range for the synergistic catalysis of pectinase, cellulase, and neutral xylanase, but also constructs a naturally stable acidic protective barrier for comfrey. The three enzymes synergistically cleave the polyphenol oxidase at multiple sites. The cell wall skeleton is completely broken down, facilitating the efficient release of bound shikonin precursors. Extraction is then performed using a eutectic solvent of choline chloride-1,3-butanediol-lactic acid, and the precursor is added in situ to the enzymatic hydrolysate. The inherent water content of the enzymatic hydrolysis reaction is cleverly utilized to dilute and regulate the viscosity and polarity of the system, eliminating the need for cumbersome solid-liquid separation and concentration processes. Under ultrasonic assistance, the eutectic solvent exerts a strong penetrating and destructive force on cell debris, exhibiting extremely high selective solubility for highly hydrophobic shikonin compounds. Ultrasonic mass transfer extraction of shikonin can be achieved at near-room temperature, significantly shortening the extraction time and preventing high-temperature degradation. Finally, purification of the extract is achieved through elution with macroporous resin.

[0020] The wet wipe liquid provided by this invention utilizes a synergistic effect of multiple substances to target inflammation and promote healing, significantly accelerating the repair of eczema lesions. Sophora flavescens extract and Phellodendron amurense extract exert heat-clearing, dampness-drying, broad-spectrum antifungal, and astringent effects. Witch hazel extract, rich in condensed tannins and flavonoids, can constrict microvessels in the affected area and significantly reduce inflammatory tissue fluid exudation during the acute phase of eczema. Dipotassium glycyrrhizate blocks the cascade release of prostaglandin E2 and interleukin-like pro-inflammatory factors, which aligns with the effect of shikonin in promoting angiogenesis and collagen deposition in granulation tissue. Propylene glycol, caprylyl glycol, ethylhexylglycerin, and a low dose of phenoxyethanol form a mild self-preservative and synergistic system, which not only significantly reduces the irritation of traditional chemical preservatives to damaged mucosa sites but also further strengthens the antibacterial barrier by synergistically destroying the cell membranes of pathogenic bacteria through polyols. Simultaneously, it provides long-lasting hydration and moisturization for dry, scaly skin lesions around the anus, preventing epidermal cracking after wiping.

[0021] The wet wipe preparation method provided by this invention addresses the issue that the active ingredients in the comfrey extract, such as shikonin, are highly lipophilic and contain an active conjugated naphthoquinone structure, making them prone to aggregation and precipitation in conventional aqueous environments. Furthermore, they are easily oxidized and degraded into inactive quinone polymers under the influence of light, heat, and dissolved oxygen. Simultaneously, the high volatility of borneol results in a short duration of efficacy and causes a strong, immediate burning sensation on eczema exudates and cracked wounds, leading to poor patient compliance. This invention specifically addresses this by employing the following process improvement: using neutral nonionic hydroxypropyl-β-cyclodextrin as a nanocarrier to encapsulate the comfrey extract and borneol. -β-Cyclodextrin is a neutral nonionic compound, and the cationic bactericide chlorhexidine gluconate does not undergo electrostatic binding reactions, ensuring the clarity and stability of the aqueous system. This treatment improves the water solubility of the comfrey extract and physically isolates the active ingredients from external oxygen and light, greatly enhancing the photothermal oxidation stability of comfrey extract. At the same time, it effectively inhibits the rapid volatilization of borneol, allowing it to act on nerve endings and damaged wounds in a controlled release manner. This avoids the burning sensation caused by excessively high instantaneous concentrations of free borneol in the local area and prolongs the activation time of local cold receptors, achieving a stable, gentle, and long-lasting analgesic and antipruritic effect. Detailed Implementation

[0022] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0023] Unless otherwise specified, all raw and auxiliary materials used in this invention are readily available and their specifications comply with national pharmaceutical standards.

[0024] As partly exemplary, information on some of the substances used in the embodiments of the present invention is as follows: Lactobacillus fermentation lysate was purchased from Beijing Belles Biotechnology Co., Ltd.; α-glucan oligosaccharide was purchased from Taian Jiangzhou Biotechnology Co., Ltd.; North American witch hazel extract was purchased from Wuhan Lingben Technology Co., Ltd.; hydroxypropyl-β-cyclodextrin was purchased from Shandong Aicai Biotechnology Co., Ltd.

[0025] Example 1 A method for preparing a purple gromwell extract includes the following steps: S1. Take the rhizome of Lithospermum erythrorhizon, dry it, cut it into small sections of about 1cm, spread it out and microwave irradiate it (15W / g, 45s). After the treatment, place it in a -15℃ low temperature environment for 1.5h for freezing treatment, then crush it and sieve it through 200 mesh to obtain Lithospermum erythrorhizon ultrafine dry powder. S2. According to the solid-liquid mass ratio of 1:6, add the ultrafine dry powder of Lithospermum erythrorhizon obtained in step S1 to ultrapure water, stir, add food-grade citric acid to adjust the pH of the system to 4.4, and then add compound enzyme for enzymatic hydrolysis (35℃, 90min). After the enzymatic hydrolysis is completed, the enzymatic hydrolysate is obtained for later use. S3. Weigh choline chloride, 1,3-butanediol, and lactic acid in a molar ratio of 1:1:1. Mix them and stir at 65°C for 60 min to obtain a eutectic solvent. Then, add the eutectic solvent to the enzymatic hydrolysate obtained in step S2 according to a ratio of 1 g:15 mL for the ultrafine dry powder of Lithospermum erythrorhizon and the eutectic solvent. Simultaneously, turn on ultrasonic-assisted stirring (250 W, 30°C, 45 min). After stirring, centrifuge to obtain the extract. Dilute with 1.5 times the volume of purified water, and elute using a macroporous adsorption resin column (D101 type) to remove impurities. Collect the eluent and concentrate it under reduced pressure (vacuum degree -0.095 MPa, temperature 40°C) to a relative density of about 1.10 (20°C). Then, freeze-dry under vacuum to obtain the Lithospermum erythrorhizon extract.

[0026] The compound enzyme is composed of pectinase, cellulase and neutral xylanase; the pectinase has an enzyme activity of ≥50000 U / g and is used at 0.4% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the cellulase has an enzyme activity of ≥20000 U / g and is used at 0.3% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the neutral xylanase has an enzyme activity of ≥30000 U / g and is used at 0.15% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon.

[0027] The elution process after adsorption and impurity removal using the macroporous adsorption resin column is as follows: the sample loading flow rate is controlled at 1.5 BV / h, the resin column is first rinsed with 5 BV of purified water at a flow rate of 2.0 BV / h, then eluted with 3 BV of 20% ethanol aqueous solution, and finally desorbed at a constant flow rate of 6 BV of 85% ethanol aqueous solution at a flow rate of 1.0 BV / h.

[0028] Example 2 A wet wipe liquid, in 100% by mass fraction, is prepared from the following raw materials: 0.10% borneol, 0.10% Lithospermum erythrorhizon extract (prepared in Example 1), 0.80% hydroxypropyl-β-cyclodextrin, 0.50% Lactobacillus fermentation lysate, 0.30% α-glucan oligosaccharide, 0.15% dipotassium glycyrrhizate, 0.20% Sophora flavescens extract, 0.20% Phellodendron chinense extract, 0.20% witch hazel extract, 0.05% chlorhexidine gluconate, 2.00% propylene glycol, 0.20% caprylyl glycol, 0.10% ethylhexylglycerin, 0.30% phenoxyethanol, with the balance being purified water.

[0029] The preparation of the above-mentioned wet wipe liquid includes the following steps: (1) Take about 8wt% of purified water, heat it to 45℃ and add hydroxypropyl-β-cyclodextrin, stir until completely dissolved, then add borneol and Lithospermum erythrorhizon extract, seal and turn on sonication (400W, 40kHz), and heat and stir (45℃, 60min); after the treatment is completed, cool and filter to obtain mixed phase A; (2) Take 50wt% purified water, and then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract, witch hazel extract, α-glucan oligosaccharide and Lactobacillus fermentation lysate according to the formula amount, and stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, chlorhexidine gluconate is slowly added. After mixing evenly again at room temperature, mixed phase C is obtained. (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to about 4.8 and filter it through a fine filter.

[0030] Example 3 A wet wipe liquid, in 100% by mass fraction, is prepared from the following raw materials: 0.08% borneol, 0.12% Lithospermum erythrorhizon extract (prepared in Example 1), 0.90% hydroxypropyl-β-cyclodextrin, 0.45% Lactobacillus fermentation lysate, 0.25% α-glucan oligosaccharide, 0.10% dipotassium glycyrrhizate, 0.22% Sophora flavescens extract, 0.22% Phellodendron chinense extract, 0.22% witch hazel extract, 0.04% chlorhexidine gluconate, 2.20% propylene glycol, 0.18% caprylyl glycol, 0.12% ethylhexylglycerin, 0.25% phenoxyethanol, with the balance being purified water.

[0031] The preparation of the above-mentioned wet wipe liquid includes the following steps: (1) Take about 8wt% of purified water, heat it to 45℃ and add hydroxypropyl-β-cyclodextrin, stir until completely dissolved, then add borneol and Lithospermum erythrorhizon extract, seal and turn on sonication (400W, 40kHz), and heat and stir (45℃, 60min); after the treatment is completed, cool and filter to obtain mixed phase A; (2) Take 50wt% purified water, and then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract, witch hazel extract, α-glucan oligosaccharide and Lactobacillus fermentation lysate according to the formula amount, and stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, chlorhexidine gluconate is slowly added. After mixing evenly again at room temperature, mixed phase C is obtained. (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to about 4.8 and filter it through a fine filter.

[0032] Example 4 A wet wipe liquid, in 100% by mass fraction, is prepared from the following raw materials: 0.11% borneol, 0.09% Lithospermum erythrorhizon extract (prepared in Example 1), 0.85% hydroxypropyl-β-cyclodextrin, 0.55% Lactobacillus fermentation lysate, 0.32% α-glucan oligosaccharide, 0.18% dipotassium glycyrrhizate, 0.18% Sophora flavescens extract, 0.18% Phellodendron chinense extract, 0.18% witch hazel extract, 0.06% chlorhexidine gluconate, 2.40% propylene glycol, 0.22% caprylyl glycol, 0.08% ethylhexylglycerin, 0.25% phenoxyethanol, with the balance being purified water.

[0033] The preparation of the above-mentioned wet wipe liquid includes the following steps: (1) Take about 8wt% of purified water, heat it to 45℃ and add hydroxypropyl-β-cyclodextrin, stir until completely dissolved, then add borneol and Lithospermum erythrorhizon extract, seal and turn on sonication (400W, 40kHz), and heat and stir (45℃, 60min); after the treatment is completed, cool and filter to obtain mixed phase A; (2) Take 50wt% purified water, and then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract, witch hazel extract, α-glucan oligosaccharide and Lactobacillus fermentation lysate according to the formula amount, and stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, chlorhexidine gluconate is slowly added. After mixing evenly again at room temperature, mixed phase C is obtained. (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to about 4.8 and filter it through a fine filter.

[0034] Comparative Example 1 A method for preparing a purple gromwell extract includes the following steps: Take the rhizome of Lithospermum erythrorhizon, dry it, cut it into small sections of about 1 cm, add 10 times the amount of 95% ethanol, and reflux extract it twice at 75℃ for 2 hours each time. Combine the extracts, recover the ethanol under reduced pressure and concentrate it into a thick paste, and then vacuum dry it.

[0035] Comparative Example 2 Compared to Example 1, Comparative Example 2 omits the microwave irradiation and low-temperature freezing treatment in step S1. Specifically, a method for preparing a purple gromwell extract includes the following steps: S1. Take the rhizome of Lithospermum erythrorhizon, dry it, cut it into small sections of about 1cm, crush it, and sieve it through a 200-mesh sieve to obtain Lithospermum erythrorhizon ultrafine dry powder. S2. According to the solid-liquid mass ratio of 1:6, add the ultrafine dry powder of Lithospermum erythrorhizon obtained in step S1 to ultrapure water, stir, add food-grade citric acid to adjust the pH of the system to 4.4, and then add compound enzyme for enzymatic hydrolysis (35℃, 90min). After the enzymatic hydrolysis is completed, the enzymatic hydrolysate is obtained for later use. S3. Weigh choline chloride, 1,3-butanediol, and lactic acid in a molar ratio of 1:1:1. Mix them and stir at 65°C for 60 min to obtain a eutectic solvent. Then, add the eutectic solvent to the enzymatic hydrolysate obtained in step S2 according to a ratio of 1 g:15 mL for the ultrafine dry powder of Lithospermum erythrorhizon and the eutectic solvent. Simultaneously, turn on ultrasonic-assisted stirring (250 W, 30°C, 45 min). After stirring, centrifuge to obtain the extract. Dilute with 1.5 times the volume of purified water, and elute using a macroporous adsorption resin column (D101 type) to remove impurities. Collect the eluent and concentrate it under reduced pressure (vacuum degree -0.095 MPa, temperature 40°C) to a relative density of about 1.10 (20°C). Then, freeze-dry under vacuum to obtain the Lithospermum erythrorhizon extract.

[0036] The compound enzyme is composed of pectinase, cellulase and neutral xylanase; the pectinase has an enzyme activity of ≥50000 U / g and is used at 0.4% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the cellulase has an enzyme activity of ≥20000 U / g and is used at 0.3% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the neutral xylanase has an enzyme activity of ≥30000 U / g and is used at 0.15% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon.

[0037] The elution process after adsorption and impurity removal using the macroporous adsorption resin column is as follows: the sample loading flow rate is controlled at 1.5 BV / h, the resin column is first rinsed with 5 BV of purified water at a flow rate of 2.0 BV / h, then eluted with 3 BV of 20% ethanol aqueous solution, and finally desorbed at a constant flow rate of 6 BV of 85% ethanol aqueous solution at a flow rate of 1.0 BV / h.

[0038] Comparative Example 3 Compared to Example 1, in Comparative Example 3, the eutectic solvent was replaced with an equal volume of 80% aqueous ethanol solution, while all other steps remained the same. Specifically, a method for preparing a purple gromwell extract includes the following steps: S1. Take the rhizome of Lithospermum erythrorhizon, dry it, cut it into small sections of about 1cm, spread it out and microwave irradiate it (15W / g, 45s). After the treatment, place it in a -15℃ low temperature environment for 1.5h for freezing treatment, then crush it and sieve it through 200 mesh to obtain Lithospermum erythrorhizon ultrafine dry powder. S2. According to the solid-liquid mass ratio of 1:6, add the ultrafine dry powder of Lithospermum erythrorhizon obtained in step S1 to ultrapure water, stir, add food-grade citric acid to adjust the pH of the system to 4.4, and then add compound enzyme for enzymatic hydrolysis (35℃, 90min). After the enzymatic hydrolysis is completed, the enzymatic hydrolysate is obtained for later use. S3. Following the ratio of 1g of ultrafine dry powder of Lithospermum erythrorhizon to 15mL of 80% ethanol aqueous solution, add the 80% ethanol aqueous solution to the enzymatic hydrolysate obtained in step S2, and simultaneously turn on ultrasonic-assisted stirring (250W, 30℃, 45min). After stirring, centrifuge to obtain the extract, dilute with 1.5 times the volume of purified water, remove impurities by adsorption using a macroporous adsorption resin column (D101 type), and elute. Collect the eluent, concentrate the eluent under reduced pressure (vacuum degree -0.095 MPa, temperature 40℃) to a relative density of about 1.10 (20℃), and then freeze-dry under vacuum to obtain the Lithospermum erythrorhizon extract.

[0039] The compound enzyme is composed of pectinase, cellulase and neutral xylanase; the pectinase has an enzyme activity of ≥50000 U / g and is used at 0.4% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the cellulase has an enzyme activity of ≥20000 U / g and is used at 0.3% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the neutral xylanase has an enzyme activity of ≥30000 U / g and is used at 0.15% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon.

[0040] The elution process after adsorption and impurity removal using the macroporous adsorption resin column is as follows: the sample loading flow rate is controlled at 1.5 BV / h, the resin column is first rinsed with 5 BV of purified water at a flow rate of 2.0 BV / h, then eluted with 3 BV of 20% ethanol aqueous solution, and finally desorbed at a constant flow rate of 6 BV of 85% ethanol aqueous solution at a flow rate of 1.0 BV / h.

[0041] Comparative Example 4 Compared to Example 2, the difference in the wet wipe solution provided in Comparative Example 4 is that 0.20% chlorhexidine gluconate was used in Comparative Example 4, and the use of α-glucan oligosaccharides and lactobacillus fermentation lysate was omitted. Specifically, a wet wipe solution, based on a total mass fraction of 100%, was prepared from the following raw materials: 0.10% borneol, 0.10% Lithospermum erythrorhizon extract (prepared in Example 1), 0.80% hydroxypropyl-β-cyclodextrin, 0.15% dipotassium glycyrrhizate, 0.20% Sophora flavescens extract, 0.20% Phellodendron chinense extract, 0.20% witch hazel extract, 0.20% chlorhexidine gluconate, 2.00% propylene glycol, 0.20% caprylyl glycol, 0.10% ethylhexylglycerin, 0.30% phenoxyethanol, with the balance being purified water.

[0042] The preparation of the above-mentioned wet wipe liquid includes the following steps: (1) Take about 8wt% of purified water, heat it to 45℃ and add hydroxypropyl-β-cyclodextrin, stir until completely dissolved, then add borneol and Lithospermum erythrorhizon extract, seal and turn on sonication (400W, 40kHz), and heat and stir (45℃, 60min); after the treatment is completed, cool and filter to obtain mixed phase A; (2) Take 50wt% purified water, then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract and witch hazel extract according to the formula amount, stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, chlorhexidine gluconate is slowly added. After mixing evenly again at room temperature, mixed phase C is obtained. (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to about 4.8 and filter it through a fine filter.

[0043] Comparative Example 5 Compared to Example 2, hydroxypropyl-β-cyclodextrin was omitted in Comparative Example 5, while all other components remained the same. Specifically, a wet wipe solution, based on a 100% mass fraction, was prepared from the following raw materials: 0.10% borneol, 0.10% Lithospermum erythrorhizon extract (prepared in Example 1), 0.50% Lactobacillus fermentation lysate, 0.30% α-glucan oligosaccharide, 0.15% dipotassium glycyrrhizate, 0.20% Sophora flavescens extract, 0.20% Phellodendron chinense extract, 0.20% witch hazel extract, 0.05% chlorhexidine gluconate, 2.00% propylene glycol, 0.20% caprylyl glycol, 0.10% ethylhexylglycerin, 0.30% phenoxyethanol, with the balance being purified water.

[0044] The preparation of the above-mentioned wet wipe liquid includes the following steps: (1) Take about 8wt% purified water, heat it to 45℃ and add borneol and Lithospermum erythrorhizon extract. After sealing, turn on the sonication (400W, 40kHz) and heat and stir (45℃, 60min). After the treatment is completed, cool and filter to obtain mixed phase A. (2) Take 50wt% purified water, and then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract, witch hazel extract, α-glucan oligosaccharide and Lactobacillus fermentation lysate according to the formula amount, and stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, chlorhexidine gluconate is slowly added. After mixing evenly again at room temperature, mixed phase C is obtained. (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to about 4.8 and filter it through a fine filter.

[0045] Comparative Example 6 Compared with Example 2, the extract of Lithospermum prepared in Comparative Example 1 was used, and all other aspects were the same.

[0046] Application examples A type of sanitary wipe, the preparation method of which is as follows: Cut and fold the virgin wood pulp spunlace nonwoven fabric for later use; The wet wipe liquid prepared in Example 2 and Comparative Examples 4-6 was sprayed onto the folded non-woven fabric, and the mass ratio of wet wipe liquid to non-woven fabric was controlled to be 2.2:1. Finally, bag and seal it.

[0047] Experimental Example 1 For the extracts of Lithospermum obtained in Example 1 and Comparative Examples 1-3, the total Shikonin compounds (calculated as L-Shikonin) in each group of extracts were quantitatively analyzed by high performance liquid chromatography. For specific detection, please refer to the "Determination Procedure of Naphthoquinone Components" in the Chinese Pharmacopoeia.

[0048] Meanwhile, the photothermal accelerated stability evaluation of the comfrey extracts obtained in Example 1 and Comparative Examples 1-3 was conducted. Specifically, the comfrey extract samples from each group were evenly spread in transparent, sealed glass dishes and placed in a comprehensive drug stability test chamber. They were continuously placed for 30 days under accelerated degradation conditions of 40℃±2℃ and strong light illuminance of (4500±500) lx. Samples were taken on day 0 and day 30, and the total comfrey content in the samples was determined again using the aforementioned method, and the retention rate was calculated. The test results are shown in Table 1.

[0049] Table 1. Detection results of the comfrey extract obtained in Example 1 and Comparative Examples 1-3 As shown in Table 1, the total shikonin extraction transfer rate of the lithospermum extract prepared in Example 1 reached 28.52 mg / g, and the effective total shikonin content (purity) in the extract was as high as 58.60%, with all indicators significantly exceeding those of the comparative proportions.

[0050] Experimental Example 2 The sanitary wipes prepared in the application example were cut into 2cm×3cm pieces as test samples. Antibacterial performance tests were conducted according to Appendix C4 of GB 15979-2024, the "Hygienic Standard for Disposable Sanitary Products". The strains used in the test were Staphylococcus aureus (ATCC 6538), Escherichia coli (8099), and Candida albicans (ATCC 10231), provided by the Guangdong Provincial Engineering Technology Research and Development Center for Food Microbiology Safety. Fresh slant cultures of the 5th generation were used for the test. The contact time was 5 minutes, the test environment temperature was 19-21℃, and the relative humidity was 45-60%. The test was repeated 3 times, with an incubation temperature of 37℃. The average kill rate of the wipes prepared from the solution provided in Example 2 after 5 minutes of contact was measured.

[0051] The test results show that the sanitary wipes prepared in this embodiment of the invention have an average kill rate of more than 99.9% against Staphylococcus aureus, Escherichia coli and Candida albicans after 5 minutes of contact, which meets the medical-grade high efficiency and comprehensive sterilization standard.

[0052] Experimental Example 3 Following the method of inducing a mouse perianal eczema model using DNCB, the nursing effect of the sanitary wipes of the present invention (prepared in the application example) on perianal eczema was investigated.

[0053] 3.1 Grouping and Dosing Seventy male ICR mice, weighing 18-22g, were randomly divided into four groups according to body weight: blank control group, model control group, positive control group (sanitary wipes soaked in 0.03% tacrolimus solution), example group, comparative example group 4, comparative example group 5, and comparative example group 6, with 10 mice in each group. Except for the normal control group, mice in all other groups were sensitized on day 1 by applying 25μL of 7% DNCB acetone solution to the perianal hair removal area. Sensitization was reinforced once on day 2 with 25μL of 7% DNCB acetone solution. Challenge was performed on days 5, 9, 13, and 17 by applying 25μL of 0.5% DNCB acetone solution to the perianal hair removal area. The normal control group received the same dose of acetone solution applied to the skin. Four hours after the first stimulation, except for the model control group which received the same dose of 0.9% sodium chloride injection, each group was given corresponding sanitary wipes to wipe the perianal skin twice a day for 7 consecutive days. After the last use, the mice in each group were sacrificed for sampling.

[0054] 3.2 Detection Indicators (1) Perianal skin lesion score The severity of perianal skin lesions in mice was assessed using four indicators: erythema, edema, erosion and exudation, and dry crusting. The scoring criteria were: 0 for no lesions, 1 for mild, 2 for moderate, and 3 for severe. The total score was the sum of the scores for all four indicators, ranging from 0 to 12. Scores were given independently by two researchers unaware of the group assignments, and the average score was used.

[0055] (2) Frequency of itching Thirty minutes after the last administration, four ICR mice without obvious irritation were randomly selected from each group and placed individually in a transparent observation cage for 10 minutes to acclimatize. The mice were then continuously video-recorded for 30 minutes, and the number of times they scratched the perianal skin lesions with their hind paws within those 30 minutes was counted. Each scratching action was counted as one instance of the mouse raising its hind paw to scratch the perianal skin lesions.

[0056] (3) Content of inflammatory factors The levels of TNF-α, IL-6, IL-4, and IFN-γ in the perianal skin lesions of ICR mice in each group were detected by ELISA. The procedure was performed according to the kit instructions: perianal skin lesion tissue homogenate was prepared, and the supernatant was collected by centrifugation; after the kit was equilibrated at room temperature, standard wells and sample wells were set up, and the steps of adding samples, incubation, washing, color development, and termination were completed in sequence; the OD value was measured at 450 nm using an ELISA reader, and a standard curve was plotted to calculate the cytokine concentration.

[0057] 3.3 Test Results (1) Perianal skin lesion scoring results Table 2. Perianal skin lesion scores of mice in each group (n=10, x±s) (Compared with the model control group, P* < 0.05, P** < 0.01) As shown in Table 2, after DNCB induction, the perianal skin of mice in the model control group showed diffuse deep erythema, severe edema and congestion, large-area epidermal peeling and exudation, and thick dry and cracked scabs. The comprehensive skin lesion score was as high as 9.74±0.85 points, indicating that the eczema model was successfully established and was in a severe acute skin lesion phase. After continuous wiping and care with wet wipes in the embodiment of this invention for 7 days, the perianal erythema of mice basically subsided, the edema was significantly absorbed, the exudation of the eroded wound completely stopped and epithelialized and healed, and the skin lesion score was greatly reduced to 3.86±0.71 points, which was significantly different from that of the model control group (P<0.01). Its healing and repair effect was comparable to that of the positive control group of the first-line clinical drug tacrolimus (3.21±0.64 points).

[0058] (2) Results of the number of times itching occurred Table 3 Results of the number of times mice itch in each group (n=10, x±s) (Compared with the model control group, P* < 0.05, P** < 0.01) As shown in Table 3, the mice in the model control group exhibited severe paroxysmal itching behavior due to the accumulation of inflammatory mediators in the perianal skin lesions and extreme sensitization of sensory nerve endings. The number of scratches reached 36.2±4.1 times within 30 minutes. This scratching led to further epidermal damage and bleeding, forming a vicious cycle of "itching-scratching-worsened lesions-increased itching." After wiping with the wet wipes from the embodiment of this invention, the number of scratches in the mice decreased sharply to 12.8±2.7 times, with an inhibition rate of 64.64% (P<0.01), demonstrating excellent and rapid analgesic and antipruritic efficacy.

[0059] (3) Results of inflammatory factor levels Table 4 Results of inflammatory factor levels (Compared with the model control group, P* < 0.05, P** < 0.01) As shown in Table 4, during the pathological process of DNCB-induced contact allergic perianal eczema, pro-inflammatory cytokines TNF-α and IL-6 (mainly mediating increased vascular permeability and inflammatory edema exudation in the acute phase) and Th1 / Th2 immune characteristic factors IL-4 and IFN-γ (mediating atopic immune infiltration and epidermal barrier degradation) were all rapidly overexpressed. After treatment with wet wipes in the embodiment of this invention, the levels of TNF-α, IL-6, IL-4, and IFN-γ in the perianal skin lesions of mice were downregulated to 108.6±10.2, 72.5±8.1, 58.7±6.6, and 47.6±5.8 pg / mL, respectively. The pro-inflammatory mediators were significantly cleared, with a downregulation of more than 60%~75% (P<0.01), effectively blocking the pro-inflammatory immune storm at the eczema site.

[0060] Test Example 4 To verify the actual efficacy and skin safety of the sanitary wipes of the present invention, a human efficacy evaluation test was conducted in accordance with the safety evaluation method for human trial testing in the "Cosmetic Safety Technical Specifications (2015 Edition)". The test sample was the sanitary wipes prepared using the wipe liquid of Example 2 in the application examples.

[0061] 4.1 Test Subjects Forty participants with mild to moderate perianal eczema, both male and female, aged 22–55 years, were selected. All participants experienced varying degrees of discomfort such as perianal itching, redness, dryness, and burning. All participants signed informed consent forms before the trial and voluntarily participated in this test. Those with severe perianal ulceration, purulent infection, concurrent skin diseases or systemic diseases, those who had used topical steroid medications within the past month, those with allergies, or those unable to cooperate with the trial were excluded.

[0062] 4.2 Test Methods After daily cleaning of the perianal area, all subjects used the sanitary wipes prepared according to the application example of this invention to wipe and gently apply to the affected area twice daily for 28 consecutive days. During the trial, subjects were prohibited from using other perianal care products, anti-inflammatory and antipruritic ointments, and irritating cleaning products, and maintained regular daily routines and diets.

[0063] Subjective rating methods were used to quantify the degree of itching, burning, tightness, stinging, dryness, and redness of the perianal skin in participants before use, 5 minutes after use, 14 days after use, and 28 days after use (0-9 points, with higher scores indicating more severe symptoms). Adverse reactions such as skin redness, swelling, allergies, irritation, and increased stinging were observed and recorded at each time point to evaluate product safety. A user satisfaction survey was conducted after the trial.

[0064] 4.3 Test Results 4.3.1 Product Efficacy Evaluation Using the pre-use symptom scores as a baseline, the subjects' perianal subjective symptom scores consistently decreased at 5 min, 14 d, and 28 d after sample use. Detailed quantitative scores for each symptom are shown in the table. After 14 days of use, the symptom scores showed statistically significant differences compared to baseline (P < 0.01). This invention's wipes can immediately and quickly relieve acute discomfort such as perianal burning, itching, and redness. With prolonged use, it can continuously improve chronic skin lesions such as dryness, tightness, and recurring itching, providing both immediate relief and long-term repair, and showing significant improvement in various symptoms of perianal eczema.

[0065] Table 5 Product Efficacy Evaluation Results 4.3.2 Product Safety Evaluation Throughout the 28-day trial period, no adverse reactions such as increased redness and swelling of the perianal skin, increased stinging, allergies, rashes, or ulceration occurred in any of the subjects at any of the testing time points, and there was no increase in skin safety-related scores. The results indicate that the sanitary wipes of this invention have a mild formula, are non-irritating to the skin, are suitable for the thin and sensitive skin around the anus, and are safe and reliable for long-term use.

[0066] 4.3.3 Product User Satisfaction Evaluation After 28 days of continuous use, the results of a questionnaire survey showed that: 100% of the participants reported a significant reduction in various discomfort symptoms around the anus after continuous use, and the problem of recurring itching around the anus was effectively relieved; 100% of the participants recognized the product's excellent cleaning effect and the refreshing and comfortable user experience; 100% of the participants rated the product as gentle and non-irritating, and said that sensitive perianal skin can use it safely for a long time, with an overall extremely high level of user satisfaction.

[0067] 4.4 Experimental Conclusions The sanitary wipes prepared according to the embodiments of the present invention are safe and gentle to use, non-irritating to the skin, and suitable for sensitive skin around the anus; they can quickly relieve discomfort such as itching, redness, burning, stinging, dryness and tightness caused by perianal eczema, and have a long-lasting repair effect. They take into account both perianal cleaning care and anti-inflammatory and soothing effects, providing an excellent user experience and are suitable for daily care by people with perianal eczema.

[0068] The applicant declares that the present invention is illustrated by the above embodiments, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions of individual raw materials in the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. A wet wipe solution for the care of perianal eczema, characterized in that, The product, in whole or in part (100% by mass), is prepared from the following raw materials: 0.05–0.20% borneol, 0.05–0.20% Lithospermum erythrorhizon extract, 0.50–1.50% hydroxypropyl-β-cyclodextrin, 0.20–1.00% Lactobacillus fermentation lysate, 0.10–0.50% α-glucan oligosaccharide, 0.10–0.30% dipotassium glycyrrhizate, 0.10–0.40% Sophora flavescens extract, 0.10–0.40% Phellodendron chinense extract, 0.10–0.40% witch hazel extract, 0.03–0.08% chlorhexidine gluconate, 1.50–3.00% propylene glycol, 0.10–0.30% caprylyl glycol, 0.05–0.15% ethylhexylglycerin, 0.20–0.50% phenoxyethanol, with the balance being purified water.

2. The wet wipe solution for perianal eczema care according to claim 1, characterized in that, The product, in whole or in part (by mass fraction), is prepared from the following raw materials: 0.05–0.15% borneol, 0.05–0.15% Lithospermum erythrorhizon extract, 0.50–1.00% hydroxypropyl-β-cyclodextrin, 0.30–0.80% Lactobacillus fermentation lysate, 0.20–0.40% α-glucan oligosaccharide, 0.15–0.25% dipotassium glycyrrhizate, 0.20–0.35% Sophora flavescens extract, 0.20–0.35% Phellodendron chinense extract, 0.20–0.35% witch hazel extract, 0.04–0.07% chlorhexidine gluconate, 1.80–2.50% propylene glycol, 0.10–0.25% caprylyl glycol, 0.05–0.12% ethylhexylglycerin, 0.20–0.40% phenoxyethanol, with the balance being purified water.

3. The wet wipe solution for perianal eczema care according to claim 1 or 2, characterized in that, The product, in whole or in part (100% by mass), is prepared from the following raw materials: 0.10% borneol, 0.10% Lithospermum erythrorhizon extract, 0.80% hydroxypropyl-β-cyclodextrin, 0.50% Lactobacillus fermentation lysate, 0.30% α-glucan oligosaccharide, 0.15% dipotassium glycyrrhizate, 0.20% Sophora flavescens extract, 0.20% Phellodendron chinense extract, 0.20% witch hazel extract, 0.05% chlorhexidine gluconate, 2.00% propylene glycol, 0.20% caprylyl glycol, 0.10% ethylhexylglycerin, 0.30% phenoxyethanol, with the balance being purified water.

4. The wet wipe solution for perianal eczema care according to claim 3, characterized in that, The preparation of the comfrey extract includes the following steps: S1. Take the rhizome of Lithospermum erythrorhizon, dry it, cut it into 0.5-1cm segments, spread it out and microwave irradiate it. After the treatment, place it in a low-temperature environment for freezing treatment for 1-2 hours, then crush and sieve it to obtain Lithospermum erythrorhizon ultrafine dry powder. S2. Add the ultrafine dry powder of Lithospermum erythrorhizon obtained in step S1 to ultrapure water, stir, add food-grade citric acid to adjust the pH value of the system, then add compound enzyme for enzymatic hydrolysis. After the enzymatic hydrolysis is completed, the enzymatic hydrolysate is obtained for later use. S3. Prepare a eutectic solvent and add it to the enzymatic hydrolysate obtained in step S2. Simultaneously, turn on ultrasonic-assisted stirring. After stirring, centrifuge to obtain the extract. Add purified water to dilute it. After adsorption and impurity removal by macroporous adsorption resin column, elute and collect the eluent. Concentrate the eluent under reduced pressure and freeze dry it under vacuum to obtain the Lithospermum erythrorhizon extract.

5. The wet wipe solution for perianal eczema care according to claim 3, characterized in that, In step S1, the microwave irradiation power density is 10~15W / g, the treatment time is 30~60s, the low temperature is -15~-10℃, and the sieve mesh size is 150~200 mesh. In step S2, the solid-liquid mass ratio is 1:(4~8); the pH of the system is adjusted to 4.2~4.6; the compound enzyme is composed of pectinase, cellulase and neutral xylanase; the pectinase activity is ≥50000 U / g, and the dosage is 0.3~0.6% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the cellulase activity is ≥20000 U / g, and the dosage is 0.2~0.4% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the neutral xylanase activity is ≥30000 U / g, and the dosage is 0.1~0.2% of the mass of the ultrafine dry powder of Lithospermum erythrorhizon; the enzymatic hydrolysis temperature is 35~40℃, and the enzymatic hydrolysis time is 60~120min; In step S3, the preparation of the eutectic solvent includes the following steps: weigh choline chloride, 1,3-butanediol and lactic acid in a molar ratio of 1:1:1, mix them and stir at 65~70℃ for 45~90 min; The ratio of ultrafine dry powder of Lithospermum erythrorhizon to eutectic solvent is 1g:(10~20)mL, the ultrasonic power is 200~300W, the stirring temperature is 25~35℃, and the stirring time is 30~90min; The conditions for vacuum concentration are: vacuum degree -0.09~-0.095 MPa, temperature 40~45℃.

6. A method for preparing the wet wipe liquid according to any one of claims 1 to 5, characterized in that, Includes the following steps: (1) Take purified water, heat it up and add hydroxypropyl-β-cyclodextrin, stir until completely dissolved, then add borneol and Lithospermum erythrorhizon extract, seal it and turn on the sonication, and heat and stir it; after the treatment is completed, cool and filter to obtain mixed phase A; (2) Take purified water, and then add dipotassium glycyrrhizate, Sophora flavescens extract, Phellodendron chinense extract, witch hazel extract, α-glucan oligosaccharide and Lactobacillus fermentation lysate according to the formula amount, and stir until completely dissolved to obtain mixed phase B; (3) After mixing propylene glycol, phenoxyethanol, octyl glycol and ethylhexylglycerin evenly, slowly add chlorhexidine gluconate and mix evenly again to obtain mixed phase C; (4) Slowly add mixed phase A to mixed phase B and stir evenly. Then add mixed phase C and stir evenly. Then add the remaining purified water to 100% of the total formula and stir evenly again. Finally, adjust the pH of the system to 4.8~5.2 and filter it through a fine filter.

7. The method for preparing the wet wipe liquid according to claim 6, characterized in that, In step (1), the ultrasonic power is 300~500W, the ultrasonic frequency is 30~50kHz, the heating and stirring treatment temperature is 45~50℃, and the treatment time is 60~90min.

8. The use of the wet wipe liquid according to any one of claims 1 to 5 in the preparation of sanitary wet wipes.

9. A type of sanitary wipe, characterized in that, It includes a substrate and a medicinal liquid impregnated on the substrate, wherein the medicinal liquid is the wet wipe liquid according to any one of claims 1 to 5.

10. A method for preparing the sanitary wipes according to claim 9, characterized in that, Includes the following steps: Cut and fold the virgin wood pulp spunlace nonwoven fabric for later use; The wet wipe liquid according to any one of claims 1 to 5 is sprayed or soaked onto the folded non-woven fabric, and the mass ratio of wet wipe liquid to non-woven fabric is controlled to be 2 to 2.5:1; Finally, bag and seal it.

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