Device for promoting healing and protecting after tooth extraction wound of patient

Abstract

The utility model provides a patient tooth extraction post-wound healing promoting and protecting device, which belongs to the technical field of oral cavity medical treatment, and comprises a device main body, the device main body comprises two tooth socket parts, a solid part and a medicine placing cavity, the solid part is arranged in the center of the device main body, the two tooth socket parts are respectively arranged on two sides of the solid part, and the medicine placing cavity is arranged in the solid part. A medicine containing cavity is formed in the lower portion of the solid part, healing promoting materials are placed in the medicine containing cavity, the tooth socket part is of a hollow structure with an opening formed in the lower portion, the solid part is of a solid cubic structure, the solid part is higher than the tooth socket part and is parallel to the tooth socket part through pressing, and the device body is made of latex materials. The device can fill tooth missing gaps and prevent a patient from licking a wound and adjacent teeth and shifting jaw teeth; temporarily restoring partial chewing function of the patient; the in-position of the healing-promoting material is assisted, and a suturing process can be omitted.

Description

Technical Field

[0001] The utility model relates to the technical field of oral medical treatment, in particular to a device for promoting healing and protecting a wound after tooth extraction. Background Art

[0002] Tooth extraction is a common operation in dentistry. The healing of tooth extraction wounds in normal patients is divided into the following four processes, including bleeding and blood clot formation, inflammatory stage of granulation tissue formation, woven bone formation and functional bone remodeling stage. The routine operation after tooth extraction is to suture the wound or wait for it to heal naturally. However, due to the physiological activity of natural teeth, it is easy for adjacent teeth to shift and the opposing teeth to elongate during the period of missing teeth after tooth extraction.

[0003] In addition, delayed healing or even poor healing of extraction sockets is often found in patients with poorly controlled or untreated diabetes, which can easily induce dry sockets in the alveolar bone. This is mainly caused by two factors: first, the high blood sugar microenvironment will directly inhibit the formation of new blood vessels, thereby inhibiting bone formation, and ultimately affecting wound healing; in addition, persistent chronic inflammation in the wounds of diabetic patients is also one of the important reasons affecting their healing, mainly manifested in their high levels of reactive oxygen species, dysregulated macrophage polarization, and disordered release of pro-inflammatory factors. Poor healing of extraction wounds, such as alveolar bone absorption, thinning, or defects, will greatly affect the subsequent repair or implant treatment of the missing tooth area. Diabetes ranks third among the most common chronic diseases in the oral field, and more than 90% of diabetic patients have oral manifestations.

[0004] Currently, the most commonly used material for promoting the healing of tooth extraction wounds in clinical practice is gelatin sponge, but the effect of gelatin sponge on diabetic patients is limited, and the field of materials specifically for promoting the healing of tooth extraction wounds in diabetic patients is almost blank. Tooth extraction is generally not recommended for those with fasting blood sugar higher than ≥8.8mmol / L, but considering the possible sudden trauma or emergency medical needs, it is necessary to develop a device that can promote the healing of tooth extraction wounds in diabetic patients and preserve the missing tooth space. Summary of the invention

[0005] In view of the problems of the prior art, the purpose of the utility model is to provide a device for promoting healing and protecting patients' tooth extraction wounds, which can assist in the placement of healing-promoting materials (this healing-promoting material can solve the problems of existing healing-promoting materials used for diabetic patients' tooth extraction wounds, such as weak antibacterial efficacy, difficulty in preservation, low efficiency, and limited scope of application. It promotes the healing of diabetic patients' tooth extraction wounds through acute hemostasis, control of local blood sugar, and controlled release of anti-inflammatory and osteogenic drugs); at the same time, the device can fill the gaps between missing teeth, prevent patients from licking wounds and adjacent teeth, and prevent displacement of opposing teeth.

[0006] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0007] A device for promoting healing and protecting patients' post-tooth extraction wounds, characterized in that it includes a device body, the device body includes a braces part, a solid part, and a medicine cavity, the solid part is arranged at the center of the device body, there are two braces parts, which are respectively arranged on both sides of the solid part, a medicine cavity is arranged below the solid part, and a healing promoting material is placed inside the medicine cavity, the braces part is a hollow structure with an opening at the bottom, the solid part is a solid cube structure, the solid part is higher than the braces part, and the solid part is parallel to the braces part by pressing.

[0008] Furthermore, the top of the brace part is configured to be in a tooth surface shape, and the bottom edge is configured to be in an arc shape.

[0009] Furthermore, the healing promoting material comprises gelatin nanoparticles loaded with naringin, loaded glucose oxidase-catalase (GOX-CAT) complex enzyme, and quaternized chitosan.

[0010] Furthermore, the healing-promoting material is cut according to the size of the wound and placed inside the medicine placement cavity.

[0011] Furthermore, the heights of the braces portion, the solid portion, and the medicine cavity are 0.5 cm-1 cm.

[0012] Furthermore, the device body is made of latex material, the solid part and the braces part are made of relatively tough latex, and the medicine cavity is made of relatively soft latex.

[0013] Furthermore, the healing-promoting material is a composite sponge.

[0014] Advantages of the utility model:

[0015] The device proposed by the utility model can fill the gap of missing teeth, prevent the patient from licking the wound and adjacent teeth, and the displacement of the opposing teeth; temporarily restore the patient's partial chewing function; assist in the placement of the healing-promoting material, and can omit the suturing process; at the same time, the healing-promoting material in the device can solve the problems of weak antibacterial efficacy, difficulty in preservation, low efficiency, and limited scope of application of the existing healing-promoting materials used for tooth extraction wounds of diabetic patients. This healing-promoting material is universal for patients with type 1 and type 2 diabetes, and has good hemostatic, antibacterial, anti-inflammatory and bone regeneration capabilities. It promotes the healing of tooth extraction wounds of diabetic patients through acute hemostasis, control of local blood sugar and anti-inflammatory, and controlled release of osteogenic drugs; the utility model first reduces inflammation and intelligently releases osteogenic drugs, which is more efficient. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the main body of the device of the utility model;

[0017] Figure 2It is a schematic diagram of the composite sponge of the utility model;

[0018] Figure 3 This is a schematic diagram of the utility model after the composite sponge is placed in the main body of the device;

[0019] Figure 4 for Figure 3 Schematic diagram after pressing the solid part;

[0020] In the figure: 1. Braces part, 2. Solid part, 3. Drug placement cavity, 4. Composite sponge, 5. Gelatin nanoparticles loaded with naringin, 6. Loaded glucose oxidase-catalase (GOX-CAT) complex enzyme. DETAILED DESCRIPTION

[0021] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model. Therefore, the following detailed description of the embodiments of the utility model provided in the drawings is not intended to limit the scope of the utility model for which protection is claimed, but merely represents selected embodiments of the utility model.

[0022] like Figure 1 As shown, a device for promoting healing and protecting patients' post-tooth extraction wounds includes a device body, wherein the device body includes a braces part 1, a solid part 2, and a medicine cavity 3. The solid part 2 is arranged at the center of the device body. There are two braces parts 1, which are respectively arranged on both sides of the solid part 2. A medicine cavity 3 is arranged below the solid part 2, and a healing-promoting material is placed inside the medicine cavity 3. The braces part 1 is hollow, and has an open structure at the bottom and away from the solid part end. The solid part 2 is a solid cube structure, and the solid part 2 is higher than the braces part 1. The device body is made of latex material.

[0023] The healing promoting material is a composite sponge 4, which can be cut according to the size of the wound and placed inside the medicine placement cavity. Figure 2 As shown, the composite sponge has a length of 20 mm, a width of 20 mm, and a thickness of 5 mm.

[0024] As a preferred embodiment of the utility model, the composite sponge 4 contains gelatin nanoparticles 5 loaded with naringin, glucose oxidase-catalase (GOX-CAT) complex enzyme 6, and quaternized chitosan base, so as to achieve the sequential progress of hypoglycemic, anti-inflammatory and bone-promoting processes.

[0025] There are two significant characteristics of wounds in diabetic patients. One is the direct influence of the hyperglycemic microenvironment, and the other is the indirect influence of the persistent inflammatory state and high levels of advanced glycation end products and reactive oxygen species. These factors inhibit the formation of blood vessels in diabetic wounds, thereby affecting bone formation. The GOX-CAT complex enzyme can cleverly solve the adverse effects of the hyperglycemic microenvironment on wounds. Li et al. successfully prepared GOX-CAT nanozymes and loaded them into chitosan hydrogels. The spatial distance between GOX and CAT is very close. GOX consumes glucose to produce H2O2, and then CAT further catalyzes the decomposition of H2O2 to provide sufficient oxygen. Endogenous H2O2 can also be catalyzed and decomposed by CAT to provide oxygen. At the same time, the generated oxygen can in turn improve the catalytic activity of GOX, enabling it to regulate blood sugar more effectively. In this way, effective regulation of blood sugar, control of reactive oxygen species, and continuous delivery of oxygen are achieved to promote cell proliferation, migration and angiogenesis, thereby accelerating the healing of diabetic wounds.

[0026] Naringin is a dihydroflavonoid compound with strong anti-inflammatory and osteogenic effects. In recent years, it has gradually been used in the field of bone repair. Dong et al. found that naringin is also effective in the field of bone repair in osteomyelitis. Poor healing of tooth extraction wounds in diabetic patients may lead to dry socket, which is pathologically manifested as localized alveolar osteomyelitis. Naringin can prevent the occurrence of dry socket by anti-inflammatory and osteogenic effects, and its effectiveness against osteomyelitis also makes it useful in patients with dry socket. In wounds involving bone healing, the order of tissue regeneration is first the initial inflammatory stage, and osteoblasts are recruited in the later stage of tissue regeneration. The drug delivery system based on nanospheres has the advantage of sustained-release formulations. The nanosphere system loaded with naringin is designed and constructed to achieve a logical treatment sequence and improve the efficiency of promoting wound healing. The colloidal network assembled by gelatin nanoparticles can be degraded under the induction of matrix metalloproteinases (MMPs) (in the proliferative phase after the inflammatory phase, various MMPs are upregulated to stimulate the proliferation and migration of epithelial cells), so it can be determined when to start the release of naringin.

[0027] Quaternized chitosan is a derivative of chitosan. The introduction of a large number of positive charges by quaternization increases the hydrophilicity of the derivative, greatly improving the solubility of quaternized chitosan in neutral and alkaline solutions. Therefore, it has a wider range of applications and more effective antibacterial properties than unmodified chitosan. In addition, the byproduct gluconic acid produced by the cascade reaction of the GOX-CAT complex enzyme consuming glucose can activate the amino group of chitosan to enhance the antibacterial properties and prevent microbial infection.

[0028] The preparation process of the composite sponge is as follows: first, glucose oxidase and catalase are acrylated, and then the two are polymerized under a nitrogen environment to produce a GOX-CAT composite enzyme; the cohesive interaction between the amphiphilic gelatin macromolecules is used to form a gelatin nanoparticle colloidal network. The network is freeze-dried, and the obtained nanoparticles are stored at 4oC. The naringin solution and gelatin nanoparticles are directly mixed, and naringin is loaded onto the gelatin nanoparticles by diffusion loading; the GOX-CAT composite enzyme, the gelatin nanoparticle suspension loaded with naringin, and the quaternized chitosan-based solution are mixed, and the composite sponge is prepared by freeze-drying or other suitable methods.

[0029] like Figure 3 As shown, the composite sponge 4 is cut according to the size of the wound and placed inside the drug placement cavity. After the composite sponge is finally placed in the tooth extraction wound, it first achieves acute hemostasis of the tooth extraction wound with its unique porous structure and high liquid absorption rate. As the sponge matrix degrades, the GOX-CAT complex enzyme is released, catalyzing the decomposition of local glucose and H2O2 to produce oxygen, relieving the direct effects of high blood sugar and high active oxygen microenvironment on wound healing. The generated oxygen can also improve the catalytic activity of GOX, so that the regulation of blood sugar is self-reinforced. As the inflammatory state subsides, matrix metalloenzymes (MMPs) are upregulated, inducing the decomposition of gelatin nanoparticles to release naringin, and bone regeneration begins to be promoted.

[0030] like Figure 4 As shown, the entity part 2 is parallel to the brace part 1 by pressing. After the affected tooth is extracted, a composite sponge of suitable size is placed in the medicine cavity, and then the brace parts on both sides are fixed on the adjacent teeth on both sides of the affected tooth, and the entity part is pressed to almost the same height as the brace part until it cannot be pressed down, thereby completing the drug administration process. The descent of the entity part can maintain the space for the missing teeth and restore some chewing functions. The top of the medicine cavity is in pressure-free contact with the wound surface to prevent the healing material from falling off. In addition, the protective device can prevent the patient from licking the wound and avoid artificial infection.

[0031] As a preferred embodiment of the utility model, the top of the brace part 1 is set to be tooth surface-shaped, and the bottom edge is set to be arc-shaped. When in use, the bottom is in contact with the gingival margin to enhance retention.

[0032] Furthermore, the solid part 2 and the brace part 1 are made of relatively tough latex to improve the retention strength of the device, and the drug placement cavity 3 is made of relatively soft latex to facilitate drug administration.

[0033] Furthermore, the heights of the braces portion 1, the solid portion 2, and the medicine cavity 3 are 0.5 cm-1 cm.

[0034] As a preferred embodiment of the utility model, in addition to selecting quaternized chitosan, the sponge matrix can also select chitosan, various chitosan derivatives, alginate and its salts which also have antibacterial effects, and can also be mixed with one or more of collagen, gelatin, glycerol, polyvinyl alcohol, acetic acid, citric acid, starch, calcium chloride, lactic acid, and polyvinyl pyrrolidone to make the sponge.

[0035] As a preferred embodiment of the present invention, the osteogenic drug loaded on gelatin nanoparticles may be replaced by other osteogenic drugs such as bone morphogenetic protein, diatomaceous earth, teriparatide, etc. in addition to naringin.

[0036] As a preferred embodiment of the utility model, the utility model can also be applied to tooth extraction wounds of other types of patients by replacing the built-in sponge with other materials.

[0037] The method and principle of use of the device are as follows: after the patient has extracted a tooth, the protective device is fixed to the adjacent tooth and the solid part is pressed. While maintaining the missing tooth gap to prevent the adjacent tooth from shifting, the solid part presses the multifunctional healing sponge into the tooth extraction wound to exert its healing promoting effect. The top of the medicine cavity is covered on the tooth extraction wound without pressure, which can prevent the multifunctional sponge from falling off and food residues from entering, and can also prevent the patient from licking the wound to cause delayed healing of the wound. The solid part can also rely on the support provided by the braces part to exert part of the chewing function. The multifunctional sponge used in the utility model can achieve rapid hemostasis based on its porous structure and high liquid absorption rate. The GOX-CAT complex enzyme can directly reduce the ability of local blood sugar and reactive oxygen, so that the sponge can be used as a universal healing promoting material for diabetic patients, regardless of the type. In addition, chitosan has excellent antibacterial properties and can prevent secondary infection of the wound. Finally, the controlled release of naringin makes the healing promoting effect of the composite sponge more efficient. In addition to the release of naringin during bone regeneration, its ability to promote bone formation in the microenvironment after blood sugar adjustment is also stronger than that in the microenvironment of high blood sugar.

[0038] The above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Those skilled in the art can still adjust the technical solutions recorded in the above embodiments, or replace some of the technical features by equivalents. Therefore, if these modifications and variations of the utility model fall within the scope of the claims of the utility model and their equivalent technologies, the utility model is also intended to include these modifications and variations.

Claims

1. A device for promoting healing and protecting patients' tooth extraction wounds, characterized in that: The device comprises a device body, wherein the device body comprises a braces portion (1), a solid portion (2), and a medicine placement cavity (3); the solid portion (2) is arranged at the center of the device body; the braces portion (1) has two, which are arranged on both sides of the solid portion (2); a medicine placement cavity (3) is arranged below the solid portion (2); a healing promoting material is placed inside the medicine placement cavity (3); the braces portion (1) is a hollow structure with an opening at the bottom; the solid portion (2) is a solid structure; the solid portion (2) is higher than the braces portion (1); and the solid portion (2) is parallel to the braces portion (1) by pressing.

2. A device for promoting healing and protecting a patient's tooth extraction wound according to claim 1, characterized in that: The top of the tooth sleeve part (1) is arranged in a tooth surface shape, and the bottom edge is arranged in an arc shape.

3. A device for promoting healing and protecting wounds after tooth extraction according to claim 2, characterized in that: The healing-promoting material is cut according to the size of the wound and placed inside the medicine placement cavity.

4. A device for promoting healing and protecting wounds after tooth extraction according to claim 3, characterized in that: The heights of the dental brace part (1), the solid part (2), and the medicine cavity (3) are 0.5 cm to 1 cm.

5. The device for promoting healing and protecting a patient's tooth extraction wound according to claim 4, characterized in that: The device body is made of latex material, the solid part (2) and the brace part (1) are made of relatively tough latex, and the medicine cavity (3) is made of relatively soft latex.

6. A device for promoting healing and protecting wounds after tooth extraction according to claim 5, characterized in that: The healing-promoting material is a composite sponge (4).

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