Cell freezing storage device

By setting up multiple sets of cooling chambers and refrigeration components in the cell freezing reservoir, the problem that the prior art cannot meet the different storage temperature requirements of different cells is solved, and simultaneous storage and flexibility of different cells are improved.

CN222583465UActive Publication Date: 2025-03-11WUHAN SHANEN BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202421334007.2
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-06-12
Publication Date
2025-03-11
Estimated Expiration
2034-06-12

AI Technical Summary

Technical Problem

The existing cell cryopreservation chamber cannot cryopreserve different cells because all test tubes are in the same space and maintain the same temperature, which cannot meet the different storage temperature requirements of different cells.

Method used

A cell freezing reservoir is designed, and the cooling chamber cavity is divided into multiple sets of cooling chambers by setting up multiple sets of partitions in the storage box, and each set of cooling chambers is independently refrigerated through the refrigeration component to achieve freezing storage of different cells.

Benefits of technology

The simultaneous storage of different cells is achieved, and the flexibility of the storage box is improved, so that different cells can be stored at the appropriate temperature.

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Abstract

The utility model relates to the technical field of cell storage, in particular to a cell freezing storage device which comprises a storage box, a storage assembly used for freezing and storing cell test tubes is installed in the storage box, and a refrigeration assembly used for cooling the storage assembly is installed in the storage box. According to the utility model, through the arrangement of the storage assembly and the refrigeration assembly, when different cells are stored, different cell test tubes are respectively placed in different cooling cavities, the different cells are isolated, then the cooling cavities are refrigerated through the cooling mechanism, and the different cells are frozen and stored; meanwhile, a temperature sensor in the cooling cavity detects the temperature in the cooling cavity in real time, and when the temperature of the cooling cavity reaches a set value, a transmission pipe corresponding to the cooling cavity is closed under the action of an electromagnetic valve, so that the storage effect of different cells is achieved, the storage box can store different cells at the same time, and the flexibility of the storage box is improved.
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Description

Technical Field

[0001] The utility model belongs to the technical field of cell storage, and particularly relates to a cell freezing storage device. Background Art

[0002] Stem cells are a type of multipotent cells that have the ability to self-renew and self-replicate. Stem cells can be divided into embryonic stem cells and adult stem cells. According to different differentiation potentials, they can be divided into totipotent stem cells, pluripotent stem cells, and unipotent stem cells. They have the characteristics of multidirectional differentiation potential, unlimited division, and proliferation. With the development of society, the storage boxes used for stem cell transportation are constantly updated. In order to ensure the activity of existing stem cells during transportation, most of them are stored in frozen storage boxes with freezing function.

[0003] After searching, in the prior art, Chinese patent application number: CN202321314538.0 discloses a cell freezing storage box. It includes a top-opening box, a cooling assembly is provided in the box, a support assembly is also provided in the box, which is used to support and fix the cold storage tube, and a sealing assembly is provided at the opening of the box, and the sealing assembly can be opened or closed corresponding to the position of the support assembly supporting the cold storage tube. This application has the effect of reducing the temperature impact on the stored cold storage tube when the storage box is frequently opened to store the cold storage tube, and avoiding poor cell storage.

[0004] However, the device still has the following defects:

[0005] When the device preserves cells, the box is cooled by the refrigeration component, and the test tubes on the support component are frozen and preserved. The test tubes in the box are located in the same space when they are preserved, and the test tubes in the box are kept at the same temperature. When the box needs to freeze different cells, different cells require different preservation temperatures, so the box cannot store different cells, which affects the storage of cells. Utility Model Content

[0006] The purpose of the utility model is to provide a cell freezing storage device, which enables different cells to be stored simultaneously in a storage box by providing a storage component and a refrigeration component, thereby improving the flexibility of the storage box and solving the problems raised in the above-mentioned background technology.

[0007] To achieve the above-mentioned object, the utility model provides the following technical solutions: a cell freezing storage device, comprising a storage box, in which a storage component for freezing and storing cell test tubes is installed, and in which a refrigeration component for cooling the storage component is installed;

[0008] The storage component includes a cooling box, which is installed in a storage box. A cavity is provided in the cooling box. A plurality of groups of partitions are installed inside the cooling box. The plurality of groups of partitions are equidistantly arranged, and the plurality of groups of partitions divide the inner cavity of the cooling box into a plurality of groups of cooling cavities. A plurality of groups of limiting grooves are provided on the bottom inner walls of the plurality of groups of cooling cavities. The plurality of groups of limiting grooves are in an arc-shaped structure. A plurality of groups of first through holes are provided on the tops of the plurality of groups of cooling cavities. The plurality of groups of first through holes and limiting grooves are equidistantly arranged.

[0009] Furthermore, limiting plates are installed in the multiple groups of cooling cavities, multiple groups of limiting plates are provided with multiple groups of second through holes, multiple groups of second through holes are arranged at equal intervals, and the first through holes, second through holes and limiting grooves are located on the same vertical line.

[0010] Furthermore, a plurality of groups of card slots are provided on the top outer wall of the cooling box, and the plurality of groups of card slots are all annular structures, and the plurality of groups of card slots are respectively located outside the plurality of groups of first through holes, and sealing covers are clamped in the plurality of groups of card slots.

[0011] Furthermore, a box cover is installed on the top of the storage box, first lock buckles are installed on both side outer walls of the storage box, and second lock buckles used in conjunction with the first lock buckles are installed on both side outer walls of the box cover.

[0012] Furthermore, a mounting groove for storing the cooling box is provided at the top of the storage box, and a refrigeration cavity for storing the refrigeration assembly is provided at the bottom of the storage box.

[0013] Furthermore, the refrigeration assembly includes a refrigeration mechanism, which is installed on the bottom inner wall of the refrigeration cavity, and a connecting pipe is installed on the output end of the refrigeration mechanism.

[0014] Furthermore, a connecting pipe is installed at one end of the connecting pipe away from the cooling mechanism, and the connecting pipe is installed on the bottom inner wall of the refrigeration cavity.

[0015] Furthermore, a plurality of transmission tubes are installed on a side of the interconnecting tube away from the connecting tube, and ends of the plurality of transmission tubes away from the interconnecting tube respectively penetrate into the plurality of cooling chambers, and solenoid valves are installed on the plurality of transmission tubes.

[0016] The beneficial effects of the utility model are:

[0017] The utility model arranges a storage component and a refrigeration component. When storing different cells, different cell test tubes are placed in different cooling chambers to isolate different cells. Then, the cooling chamber is refrigerated by a refrigeration mechanism to freeze and store different cells. At the same time, a temperature sensor in the cooling chamber detects the temperature in the cooling chamber in real time. When the temperature of the cooling chamber reaches a set value, the transmission pipe corresponding to the cooling chamber is closed under the action of a solenoid valve, thereby achieving a storage effect for different cells, allowing the storage box to store different cells at the same time, thereby improving the flexibility of the storage box. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 A schematic diagram of the structure according to an embodiment of the utility model is shown;

[0020] Figure 2 A schematic diagram of the top structure of a storage box according to an embodiment of the utility model is shown;

[0021] Figure 3 A schematic diagram of the card slot structure according to an embodiment of the utility model is shown;

[0022] Figure 4 A schematic diagram of the internal structure of a storage box according to an embodiment of the utility model is shown;

[0023] Figure 5 A schematic structural diagram of a refrigeration assembly according to an embodiment of the utility model is shown.

[0024] In the figure: 110, storage box; 111, first lock; 120, box cover; 121, second lock; 130, installation slot; 140, refrigeration chamber; 210, cooling box; 211, first through hole; 212, slot; 220, sealing cover; 230, limit plate; 231, second through hole; 240, partition; 250, cooling chamber; 251, limit slot; 260, temperature sensor; 310, cooling mechanism; 320, connecting pipe; 330, connecting pipe; 340, transmission pipe; 350, solenoid valve. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1-5 The utility model provides a technical solution: a cell freezing storage device. It includes a storage box 110, in which a storage component for freezing and storing cell test tubes is installed, and a refrigeration component for cooling the storage component is installed in the storage box 110;

[0027] The storage assembly includes a cooling box 210, which is installed in the storage box 110. The cooling box 210 is provided with a cavity. A plurality of partitions 240 are installed inside the cooling box 210. The plurality of partitions 240 are arranged at equal distances. The plurality of partitions 240 divide the inner cavity of the cooling box 210 into a plurality of cooling chambers 250. The plurality of cooling chambers 250 have a plurality of limiting grooves 251 on the bottom inner wall. The plurality of limiting grooves 251 are in an arc-shaped structure. The plurality of cooling chambers 250 have a plurality of first through holes 211 on the top. The plurality of first through holes 211 and the limiting grooves 251 are arranged at equal distances. A temperature sensor 260 is installed on one inner wall of the plurality of cooling chambers 250. The temperature in the cooling chamber 250 is monitored in real time by the temperature sensor 260, so that different cells can be stored at a suitable temperature. The partition 240 is made of heat-insulating material to reduce the impact of temperature differences between different cooling chambers 250 .

[0028] When storing different cells, different cells are isolated by placing different cell test tubes in different cooling chambers 250 respectively, and the test tubes are limited by the first through hole 211, the second through hole 231 and the limiting groove 251, and then the sealing cover 220 is clamped in the clamping groove 212, and then the cooling chamber 250 is refrigerated by the cooling mechanism 310 through the connecting pipe 320, the connecting pipe 330 and the transmission pipe 340, and different cells are frozen and stored. At the same time, the temperature sensor 260 in the cooling chamber 250 detects the temperature in the cooling chamber 250 in real time. When the temperature of the cooling chamber 250 reaches the set value, the transmission pipe 340 corresponding to the cooling chamber 250 is closed under the action of the solenoid valve 350, thereby achieving the storage effect of different cells, so that the storage box 110 can store different cells at the same time, thereby improving the flexibility of the storage box 110.

[0029] Limiting plates 230 are installed in the plurality of cooling chambers 250, and a plurality of second through holes 231 are provided on the plurality of limiting plates 230. The plurality of second through holes 231 are arranged at equal intervals, and the first through holes 211, the second through holes 231 and the limiting grooves 251 are located on the same vertical line. The limiting plates 230 are used to limit the cell test tubes so that the cell test tubes can remain stable during storage.

[0030] The top outer wall of the cooling box 210 is provided with a plurality of slots 212, all of which are annular structures, and are respectively located outside the plurality of first through holes 211, and a sealing cover 220 is clamped in each of the plurality of slots 212. The sealing cover 220 is made of transparent material, which is convenient for observing the cells. The cooling chamber 250 is sealed by the sealing cover 220, so that after the cells are taken out, the temperature in the cooling chamber 250 is not easy to change, and the leakage of cold air in the cooling chamber 250 is reduced.

[0031] A box cover 120 is installed on the top of the storage box 110, first lock buckles 111 are installed on both sides of the outer wall of the storage box 110, and second lock buckles 121 used in conjunction with the first lock buckle 111 are installed on both sides of the outer wall of the box cover 120. A mounting groove 130 for storing the cooling box 210 is provided on the top of the storage box 110, and a refrigeration cavity 140 for storing the refrigeration assembly is provided at the bottom of the storage box 110. The box cover 120 is installed on the storage box 110 by the first lock buckle 111 and the second lock buckle 121, and a sealing gasket is provided between the storage box 110 and the box cover 120, thereby reducing the leakage of cold air in the storage box 110.

[0032] The refrigeration assembly includes a cooling mechanism 310, which is mounted on the bottom inner wall of the refrigeration chamber 140. A connecting pipe 320 is mounted on the output end of the cooling mechanism 310. A connecting pipe 330 is mounted on the end of the connecting pipe 320 away from the cooling mechanism 310. The connecting pipe 330 is mounted on the bottom inner wall of the refrigeration chamber 140. Multiple groups of transmission pipes 340 are mounted on the side of the connecting pipe 330 away from the connecting pipe 320. The ends of the multiple groups of transmission pipes 340 away from the connecting pipe 330 respectively penetrate into the multiple groups of cooling chambers 250, and the multiple groups of transmission pipes 340 are all mounted with solenoid valves 350. The cooling chamber 250 is cooled by the cooling mechanism 310. The solenoid valve 350 is used to control the opening and closing of the transmission tube 340. When the temperature in the cooling chamber 250 reaches the set value, the solenoid valve 350 will be closed to keep the cooling chamber 250 at the set temperature. When the temperature of the cooling chamber 250 exceeds the set value, the solenoid valve 350 will be opened to cool the cooling chamber 250. By setting up multiple groups of transmission tubes 340 and solenoid valves 350, multiple groups of cooling chambers 250 can be maintained at different temperatures, so that the storage box 110 can store different cells.

[0033] It should be noted that the cooling mechanism 310 uses a cooling component disclosed in the prior art (application number CN202321314538.0, which discloses a cell freezing storage box), which will not be described in detail here.

[0034] Specifically, the internal electrical connection structure of the cooling mechanism 310 and the electromagnetic valve 350 is well known to those skilled in the art and will not be described in detail herein. The electrical components in this application are all connected to an external power source when in use.

[0035] The circuits, electrical components and modules involved are all prior art and can be fully implemented by those skilled in the art. Needless to say, the content protected by this utility model does not involve improvements to the software.

[0036] The control method of the present application document is automatic control through a controller. The control circuit of the controller can be realized by simple programming by technicians in this field, which is common knowledge in this field. In addition, the present application document is mainly used to protect mechanical devices, so the present application document will no longer explain the control method and circuit connection in detail.

[0037] Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A cell freezing storage device, characterized in that: include: A storage box (110), wherein a storage component for freezing and storing cell test tubes is installed in the storage box (110), and a refrigeration component for cooling the storage component is installed in the storage box (110); The storage component comprises a cooling box (210), wherein the cooling box (210) is installed in a storage box (110), wherein a cavity is arranged in the cooling box (210), wherein a plurality of groups of partitions (240) are installed inside the cooling box (210), wherein the plurality of groups of partitions (240) are arranged at equal distances, and the plurality of groups of partitions (240) divide the inner cavity of the cooling box (210) into a plurality of groups of cooling cavities (250), wherein a plurality of groups of limiting grooves (251) are arranged on the inner walls of the bottoms of the plurality of groups of cooling cavities (250), wherein the plurality of groups of limiting grooves (251) are in an arc-shaped structure, and wherein a plurality of groups of first through holes (211) are arranged on the tops of the plurality of groups of cooling cavities (250), wherein the plurality of groups of the first through holes (211) and the limiting grooves (251) are arranged at equal distances.

2. A cell freezing storage device according to claim 1, characterized in that: Limiting plates (230) are installed in the plurality of cooling cavities (250), and a plurality of second through holes (231) are provided on the plurality of limiting plates (230). The plurality of second through holes (231) are arranged at equal intervals, and the first through holes (211), the second through holes (231) and the limiting grooves (251) are located on the same vertical line.

3. A cell freezing storage device according to claim 2, characterized in that: A plurality of groups of slots (212) are provided on the top outer wall of the cooling box (210), the plurality of groups of slots (212) are all annular structures, the plurality of groups of slots (212) are respectively located outside the plurality of groups of first through holes (211), and a sealing cover (220) is clamped in the plurality of groups of slots (212).

4. A cell freezing storage device according to claim 3, characterized in that: A box cover (120) is installed on the top of the storage box (110), first lock buckles (111) are installed on both side outer walls of the storage box (110), and second lock buckles (121) used in conjunction with the first lock buckle (111) are installed on both side outer walls of the box cover (120).

5. A cell freezing storage device according to claim 4, characterized in that: The top of the storage box (110) is provided with a mounting groove (130) for storing the cooling box (210), and the bottom of the storage box (110) is provided with a refrigeration cavity (140) for storing the refrigeration assembly.

6. A cell freezing storage device according to claim 5, characterized in that: The refrigeration assembly comprises a refrigeration mechanism (310), the refrigeration mechanism (310) is installed on the bottom inner wall of the refrigeration cavity (140), and a connecting pipe (320) is installed on the output end of the refrigeration mechanism (310).

7. A cell freezing storage device according to claim 6, characterized in that: A connecting pipe (330) is installed at one end of the connecting pipe (320) away from the cooling mechanism (310), and the connecting pipe (330) is installed on the bottom inner wall of the refrigeration chamber (140).

8. A cell freezing storage device according to claim 7, characterized in that: A plurality of transmission tubes (340) are installed on a side of the connecting tube (330) away from the connecting tube (320), and one end of the plurality of transmission tubes (340) away from the connecting tube (330) respectively penetrates into a plurality of cooling chambers (250), and a solenoid valve (350) is installed on each of the plurality of transmission tubes (340).

Citation Information

Patent Citations

  • Cell cryopreservation box

    CN220441723U