Gavage tube capsule protection device and gavage device

Abstract

The utility model discloses a gavage tube capsule protection device and a gavage apparatus, which belong to the technical field of medicine detection equipment, and the protection device comprises a gavage tube, a protection sleeve, an air supply mechanism and a traction mechanism. Wherein one end of the lavage tube is configured to be a placing end, and the opposite end of the lavage tube is configured to be an air inlet end. The placing end is matched with the capsule, and the air inlet end is connected with an air supply mechanism. The protective sleeve is movably arranged at the placing end and arranged on the capsule in a sleeving mode. The traction mechanism is connected with the protective sleeve; during intragastric administration, the traction mechanism is tightened towards the air inlet end, the protective sleeve can be fixed to the placing end, and the capsule is protected; when the traction mechanism extends towards the placing end, the protective sleeve can be opened, and the air supply mechanism can pump the capsule into the stomach through air pressure. According to the protection device, the influence of moisture and mucus in the esophagus on the capsule before the capsule reaches the stomach is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of drug detection equipment, in particular to a gastric gavage tube capsule protection device and a gastric gavage device. Background Art

[0002] During animal experiments on capsule preparations, the capsules need to be administered to the stomach of animals (usually beagles). The capsules dissolve and rupture under the action of gastric juice in the stomach, releasing the active ingredients of the drug. Experimenters draw blood at different time points after administration to determine the concentration of the active substances in the capsule preparations in the animal's blood. This test is generally conducted on multiple animals to evaluate the overall blood drug concentration trend and its variability (CV%) among multiple animals, etc. This is used as one of the key indicators in the drug development process to guide subsequent clinical research on the drug.

[0003] Capsule administration is generally carried out by water washing or gavage tube administration. The operating steps for direct water washing are as follows: the experimenter opens and fixes the beagle's mouth by hand, inserts the capsule into the beagle's throat by hand, draws clean water with a syringe, and washes the capsule down the beagle's throat. The disadvantages are: this method is not suitable for capsules with a certain viscosity, and water washing cannot guarantee that the capsule will be washed into the stomach and may stick to the esophagus; it is not suitable for capsules encapsulated in capsule shells with strong water solubility, and water washing may cause the capsule to begin to dissolve and rupture the moment it comes into contact with water, and begin to release before reaching the stomach, resulting in erroneous experimental results.

[0004] The operation steps of the traditional gavage tube are as follows: the experimenter clamps the capsule at one end of the gavage tube, opens and fixes the beagle's mouth by hand, inserts the end of the gavage tube with the capsule clamped into the dog's throat, continues to extend downward, and finally reaches the stomach, and uses a syringe to quickly inject air at the other end of the gavage tube to push out the capsule at the other end through air pressure; the disadvantages are: the capsule clamped at one end of the gavage tube contacts a large amount of water, mucus, etc. during the process of passing through the esophagus into the stomach, and may soften. The softened capsule cannot ensure that a section of the gavage tube is filled (sealed), so that air pressure cannot be formed when air is injected with a syringe, and then the capsule cannot be pressed out, resulting in drug administration failure; in addition, even if the capsule is successfully pressed out by air, it also contacts water during the drug administration process, resulting in premature softening or rupture, and the degree of softening or rupture cannot be controlled, resulting in the initial state of the capsule after entering the stomach being difficult to control, introducing uncontrollable fluctuations in experiments on multiple dogs, distorting the results.

[0005] Both of the above methods have the problem that the capsules come into contact with water or mucus in the mouth and esophagus before reaching the stomach, causing some capsules to stick to the esophagus, soften or rupture prematurely, resulting in uncontrollable experimental process and large fluctuations in experimental data. Utility Model Content

[0006] Based on this, the utility model provides a gavage tube capsule protection device and a gavage apparatus. The protection device adds a capsule protection cover on the basis of a traditional gavage tube to ensure that the capsule does not contact any liquid in the esophagus before reaching the target site, thereby ensuring the parallelism of data between multiple animals during animal experiments to the greatest extent.

[0007] The technical solution adopted by the utility model is:

[0008] A gastric gavage tube capsule protection device, comprising:

[0009] A gavage tube, one end of which is configured as a placement end, and the other end opposite thereto is configured as an air intake end; the placement end is adapted to fit the capsule, and the air intake end is connected to an air supply mechanism;

[0010] A protective cover, movably disposed on the placement end and sleeved on the capsule;

[0011] A traction mechanism connected to the protective cover;

[0012] During intragastric administration, the traction mechanism is tightened toward the air inlet end, and the protective cover can be fixed to the placement end to protect the capsule; when the traction mechanism is extended toward the placement end, the protective cover can be opened, and the air supply mechanism can pump the capsule into the stomach through air pressure.

[0013] In the gavage tube capsule protection device disclosed in the present application, the air supply mechanism is a syringe.

[0014] In the gavage tube capsule protection device disclosed in the present application, the traction mechanism has a traction line, and one end of the traction line is connected to the protection sleeve.

[0015] In the capsule protection device for the gastric gavage tube disclosed in the present application, the traction mechanism further comprises a buckle, the buckle is arranged on the outer surface of the gastric gavage tube, and one end of the traction line passes through the buckle and is connected to the protective sleeve.

[0016] In the gavage tube capsule protection device disclosed in the present application, there are multiple ring buckles; the multiple ring buckles are evenly arranged along the length direction of the gavage tube; one end of the traction line passes through the ring buckles from the air inlet end in sequence to the placement end and is connected to the protective cover.

[0017] In the gavage tube capsule protection device disclosed in the present application, the protection sleeve is made of rubber.

[0018] In the gavage tube capsule protection device disclosed in the present application, the traction wire is made of plastic.

[0019] In the gavage tube capsule protection device disclosed in the present application, the buckle is made of soft material.

[0020] Based on the same inventive concept, the present application also discloses a gastric irrigator, which comprises the aforementioned protective device.

[0021] Compared with the prior art, the beneficial effects of the utility model are:

[0022] The protective device of the present application is provided with a capsule protective cover, which reduces the contact of the capsule with moisture and mucus during the process of the drug passing through the mouth and esophagus; and the protective cover can be removed after reaching the administration site, so that the capsule can be smoothly pushed out into the stomach. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0024] Figure 1 Schematic diagram of the structure of the capsule protection device for the gavage tube Figure 1 ;

[0025] Figure 2 Schematic diagram of the structure of the capsule protection device for the gavage tube Figure 2 .

[0026] Reference numerals:

[0027] 10. Gavage tube; 11. Placement end; 12. Air inlet end;

[0028] 20. Protective cover;

[0029] 30. traction mechanism; 31. traction line; 32. buckle;

[0030] 40. Capsules. DETAILED DESCRIPTION

[0031] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. It is to be understood that the specific embodiments described herein are only used to explain the present application, rather than to limit the present application. It should also be noted that, for ease of description, only some structures related to the present application are shown in the accompanying drawings, rather than all structures. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0032] The terms "including" and "having" and any variations thereof in this application are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products or devices.

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention are only for describing specific embodiments and are not intended to limit the present invention.

[0034] Reference to "embodiments" in this application means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0035] Please see attached Figure 1 , 2 As shown, an embodiment of the present application provides a gavage tube capsule protection device, including a gavage tube 10, a protection sleeve 20, an air supply mechanism (not shown in the figure) and a traction mechanism 30.

[0036] One end of the gavage tube 10 is configured as a placement end 11, and the other end is configured as an air inlet end 12. The placement end 11 is adapted to the capsule 40, and the air inlet end 12 is connected to the air supply mechanism. The capsule 40 can be stuck at the placement end 11 and go deep into the dog's stomach along with the gavage tube 10. When the air supply mechanism supplies air from the air inlet end 12, the capsule 40 can be pumped into the stomach.

[0037] The protective cover 20 is movably disposed at the placement end 11 and sleeved on the capsule 40. The protective cover 20 is used to protect the capsule 40 and reduce the contact of the capsule 40 with water and mucus during the process of passing through the oral cavity and the esophagus.

[0038] The traction mechanism 30 is connected to the protective sleeve 20. During intragastric administration, the traction mechanism 30 is tightened toward the air inlet end 12, and the protective sleeve 20 can be fixed to the placement end 11 to protect the capsule 40. When the traction mechanism 30 is extended toward the placement end 11, the protective sleeve 20 can be opened, and the air supply mechanism supplies air from the air inlet end 12 to pump the capsule 40 into the stomach through air pressure.

[0039] The protective device of the present application is provided with a protective cover 20 to reduce the contact of the capsule 40 with moisture and mucus during the process of passing through the oral cavity and esophagus; and the protective cover 20 can be removed after reaching the administration site, so that the capsule 40 can be smoothly pushed out into the stomach.

[0040] In one embodiment, the air supply mechanism is a syringe, which is connected to the air inlet end 12. When the syringe piston is pressed, air pressure is formed in the gavage tube 10 to pump the capsule 40 into the stomach.

[0041] In one embodiment, the traction mechanism 30 has a traction line 31, one end of which is connected to the protective cover 20. During intragastric administration, when the traction line 31 is tightened toward the air inlet end 12, the protective cover 20 can be fixed to the placement end 11 to protect the capsule 40; when the traction line 31 is extended toward the placement end 11, the protective cover 20 can be opened, and the syringe pumps air from the air inlet end 12 to push the capsule 40 into the stomach.

[0042] In one embodiment, the traction mechanism 30 further has a buckle 32, which is disposed on the outer surface of the gavage tube 10, and one end of the traction line 31 passes through the buckle 32 and is connected to the protective sleeve 20. The buckle 32 is used to limit the position of the traction line 31 for easy operation.

[0043] In one embodiment, there are multiple ring buckles 32, which are evenly arranged along the length direction of the gavage tube 10. One end of the traction line 31 passes through the ring buckles 32 from the air inlet end 12 to the placement end 11 and is connected to the protective cover 20.

[0044] In one embodiment, the protective sleeve 20 is made of rubber, and the traction line 31 is made of plastic. When the traction line 31 made of plastic is pushed toward the placement end 11, the protective sleeve 20 can be separated from the capsule 40, so that the capsule 40 can be pushed into the stomach.

[0045] In one embodiment, the buckle 32 is made of soft material to avoid causing damage to the animal's mouth and esophagus.

[0046] The present application also provides a gastric irrigator, which comprises the aforementioned protection device.

[0047] In a specific embodiment, during gavage, after the capsule 40 is stuck in the placement end 11 of the gavage tube 10, it is loaded with the protective cover 20, and the traction line 31 is pulled from the air inlet end 12 to make the protective cover 20 completely fit the capsule 40; after completing the loading step, the end with the capsule 40 is deeply inserted into the dog's stomach, and the traction line 31 is pushed forward from the air inlet end 12 exposed outside the dog's mouth to make the protective cover 20 detach from the capsule 40, and a syringe is used to push air from the air inlet end 12 outside the animal's mouth to pump the capsule 40 out and into the stomach.

[0048] The protective device of the present application reduces the contact of the capsule 40 with moisture and mucus during the passage of the drug through the oral cavity and esophagus by providing a protective cover 20; and the protective cover 20 can be removed after reaching the administration site, so that the capsule 40 can be smoothly pushed out into the stomach.

[0049] In a specific embodiment, a capsule is used as a sample (the capsule shell and active substance of this product are both soluble in water) to compare three administration methods:

[0050] 1. Take directly with water: The capsule softens and breaks immediately when it comes into contact with water, resulting in failure of administration.

[0051] 2. Traditional gavage tube: During the drug administration process, the capsule softens when it comes into contact with water and cannot be tightly plugged into and seal a section of the gavage tube, resulting in drug administration failure.

[0052] 3. This application: The drug administration process was smooth, and the drug blood concentration detection value was logical, reflecting the actual blood concentration change of the drug after administration to beagle dogs. The results are as follows:

[0053]

[0054]

[0055] Note: BQL in the table means below the lower limit of quantitation.

[0056] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may be subject to various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A capsule protection device for a gastric tube, characterized in that: include: A gavage tube, one end of which is configured as a placement end and the other end opposite thereto is configured as an air intake end; The placement end is adapted to the capsule, and the air inlet end is connected to the air supply mechanism; A protective cover, movably disposed on the placement end and sleeved on the capsule; A traction mechanism connected to the protective cover; During intragastric administration, the traction mechanism is tightened toward the air inlet end, and the protective cover can be fixed to the placement end to protect the capsule; When the traction mechanism is extended toward the placement end, the protective sleeve can be opened, and the air supply mechanism can pump the capsule into the stomach through air pressure.

2. The gavage tube capsule protection device according to claim 1, characterized in that: The gas supply mechanism is a syringe.

3. The capsule protection device for the gastric tube according to claim 1, characterized in that: The traction mechanism has a traction line, one end of which is connected to the protective cover.

4. The capsule protection device for the gastric tube according to claim 3, characterized in that: The traction mechanism also has a buckle, which is arranged on the outer surface of the gavage tube, and one end of the traction line passes through the buckle and is connected with the protective sleeve.

5. The capsule protection device for the gastric tube according to claim 4, characterized in that: There are multiple ring buckles; the multiple ring buckles are evenly arranged along the length direction of the gavage tube; one end of the traction line passes through the ring buckles in sequence from the air inlet end to the placement end and is connected to the protective cover.

6. The gavage tube capsule protection device according to any one of claims 1 to 5, characterized in that: The protective cover is made of rubber.

7. The capsule protection device for the gastric tube according to claim 3, characterized in that: The traction wire is made of plastic.

8. The capsule protection device for the gastric lavage tube according to claim 4 or 5, characterized in that: The ring buckle is made of soft material.

9. A gastric gavage device, characterized in that: A protective device comprising any one of claims 1 to 8.

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