Drug target residence time detector

Abstract

The utility model discloses a drug target residence time detector, which relates to the field of drug detection, and comprises a detection box, the inner bottom wall of the detection box is fixedly connected with a support frame, the top of the support frame is provided with a drug placing box, and the middle of the top of the detection box is provided with a control mechanism. A testing assembly is fixedly connected to the side face of the top of the detection box, a cleaning assembly is rotationally connected to one side of the inner wall of the detection box by installing a first bearing, and through arrangement of the testing assembly and the cleaning assembly, a lead screw is rotated to drive two moving plates to move relatively under limiting of a limiting rod; the two moving plates drive the cleaning sponge to clamp and wrap the detection head, then the air cylinder drives the detection head to move up and down, the detection head is cleaned through the cleaning sponge, it is avoided that the accuracy of the next test result is affected when the detection head is not cleaned, meanwhile, the bolt is screwed out of the threaded hole, and then the mounting plate is conveniently disassembled. And therefore, the cleaning sponge can be detached and replaced conveniently.

Description

Technical Field

[0001] The utility model relates to the field of drug detection, in particular to a drug target residence time detector. Background Art

[0002] At present: The retention time of drug receptor binding is an emerging molecular binding kinetic concept in recent years. This concept is defined as the existence time of the complex formed by the drug and the receptor after the two bind. Determining the molecular kinetic characteristics of drug-target binding is of great significance in the early drug design and screening process. Studies have shown that optimizing the residence time of the drug on the target can improve the clinical efficacy or toxicity of the drug: for the target of drug action, drugs with long residence time can show higher and more lasting efficacy, while for other non-drug targets, drugs with short residence time can effectively avoid off-target effects and reduce drug toxicity.

[0003] For example, Chinese patent: Publication No. CN213302169U discloses a device for detecting the residence time of a drug target, which includes a drug slot with a plurality of drug detection probes disposed on the upper end; a plurality of equally spaced partitions are welded in the drug slot, and the partitions separate the drug slot into a plurality of cavities, the number of which is the same as that of the drug detection probes; a control box is fixed to the upper end of the detection box body by bolts.

[0004] Although the drug-receptor-bound composition can be placed in the drug placement slot, the composition can be directly detected through the detection probe at the top, and the drug target residence time can be directly detected through the target drug signal device and the control panel in the control box, it will not cause damage to the microenvironment where the drug receptor is located, thereby ensuring the accuracy of the detection result; and multiple groups of compositions can be detected simultaneously through the cooperation of multiple cavities and multiple detection probes in the drug placement slot, which is suitable for batch operation and can effectively improve the detection effect. However, the detection probe lacks a mechanism for cleaning it after detection, which can easily affect the accuracy of the test result next time.

[0005] To this end, we propose a drug target residence time detector. Utility Model Content

[0006] The utility model provides a drug target residence time detector.

[0007] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a drug target residence time detector, comprising a detection box, the inner bottom wall of the detection box is fixedly connected to a support frame, the top of the support frame is provided with a medicine box, the middle of the top of the detection box is provided with a control mechanism, the side of the top of the detection box is fixedly connected to a test assembly, one side of the inner wall of the detection box is rotatably connected to a cleaning assembly by installing a first bearing, and a transparent plate is embedded in the front of the detection box;

[0008] The cleaning assembly includes a screw rod, one end of which is connected to the inside of the first bearing, and one end of the screw rod is rotatably connected to the inside of one side of the back side of the detection box by installing the second bearing and is connected to a torque, both sides of the surface of the screw rod are threadedly connected to driving plates, one side of the two driving plates is fixedly connected to a movable plate, the other sides of the two movable plates are fixedly connected to a limiting plate, the surfaces of the two limiting plates pass through the limiting rod, and the two ends of the limiting rod are respectively fixedly connected to the two sides of the inner wall of the detection box, and threaded holes are opened in the middle of the top and bottom of the two movable plates, and a mounting plate is installed inside the threaded hole by bolts, and a cleaning sponge is fixedly connected to one side of the mounting plate.

[0009] Preferably, the test assembly includes a descending plate, both sides of the upper surface of the descending plate are fixedly connected to a cylinder, and the bottom of the descending plate is fixedly connected to a detection head; the control panel starts the cylinder to extend, driving the multiple detection heads at the bottom of the descending plate to detect the composition in the medicine box.

[0010] Preferably, the control mechanism includes a control box, a battery is provided on one side of the control box, a target drug signal device and a signal amplifier are provided on the other side of the control box, and a control panel is fixedly connected to the top of the control box; the target drug signal device and the detection head are connected via the signal amplifier, and the detection result is transmitted to the target drug signal device via the signal amplifier to complete the detection.

[0011] Preferably, an inlet and outlet are provided on one side of the detection box, and slide grooves are provided on both sides of the inlet and outlet, and a sealing plate is slidably connected inside the slide groove; the sealing plate slides with the slide groove, and then the inlet and outlet of the detection box can be closed and shielded by the sealing plate to avoid affecting the normal operation of the drug detection head.

[0012] Preferably, a T-shaped slide groove is provided in the middle of the top of the support frame, and a T-shaped slide bar is slidably connected inside the T-shaped slide groove, and the top of the T-shaped slide bar is fixedly connected to the bottom of the medicine box; the T-shaped slide bar is slidably connected to the T-shaped slide groove, so that the opposite medicine box can be slid, making it convenient to move the medicine box to the outside of the detection box and pour the drug composition into the opposite medicine box.

[0013] Preferably, the control panel is connected to the target drug signal device and the battery respectively through a first wire, and the target drug signal device is connected to the detection head through a second wire; the signal of the drug detection head is amplified by a signal amplifier, thereby improving the detection accuracy of the target drug signal device.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] The utility model is provided with a test component and a cleaning component. When in use, the screw rod is rotated. Under the limit of the limit rod, the screw rod rotates to drive the two movable plates to move relative to each other. The two movable plates drive the cleaning sponge to clamp and wrap the detection head. Then the cylinder drives the detection head to move up and down, and then the detection head is cleaned by the cleaning sponge, so as to avoid that the detection head is not cleaned and affects the accuracy of the next test result. At the same time, the bolt is screwed out of the threaded hole, so that it is convenient to disassemble the mounting plate, thereby facilitating the disassembly and replacement of the cleaning sponge. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0017] Figure 2 This is a schematic diagram of the control mechanism structure of the utility model;

[0018] Figure 3 This is a schematic diagram of the structure of the test assembly of the utility model;

[0019] Figure 4 This is a schematic diagram of the structure of the cleaning component of the utility model.

[0020] In the figure: 1. test box; 2. support frame; 3. medicine box; 4. control mechanism; 41. control box; 42. battery; 43. target drug signal; 44. signal amplifier; 45. control panel; 5. test assembly; 51. descending plate; 52. cylinder; 53. test head; 6. cleaning assembly; 61. screw rod; 62. moving plate; 63. limit rod; 64. mounting plate; 65. cleaning sponge; 7. sealing plate; 8. T-shaped slide bar. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Example 1

[0023] See also Figure 1-4, a drug target residence time detector shown in the figure comprises a detection box 1, a support frame 2 is fixedly connected to the inner bottom wall of the detection box 1, a medicine box 3 is arranged on the top of the support frame 2, a control mechanism 4 is arranged in the middle of the top of the detection box 1, a test component 5 is fixedly connected to the side of the top of the detection box 1, a cleaning component 6 is rotatably connected to one side of the inner wall of the detection box 1 by installing a first bearing, and a transparent plate is embedded in the front of the detection box 1;

[0024] The cleaning assembly 6 includes a screw rod 61, one end of which is connected to the inside of the first bearing, and one end of the screw rod 61 is rotatably connected to the inside of one side of the back side of the detection box 1 by installing the second bearing and is connected to a torque, both sides of the surface of the screw rod 61 are threadedly connected with driving plates, one side of the two driving plates is fixedly connected with a movable plate 62, and the other sides of the two movable plates 62 are fixedly connected with limiting plates, the surfaces of the two limiting plates pass through the limiting rod 63, and the two ends of the limiting rod 63 are respectively fixedly connected to the two sides of the inner wall of the detection box 1, and the middle parts of the top and bottom of the two movable plates 62 are provided with threaded holes, and the inside of the threaded holes is installed with a mounting plate 64 by bolts, and one side of the mounting plate 64 is fixedly connected with a cleaning sponge 65.

[0025] In this embodiment: a display screen is provided on the control panel 45. First, multiple groups of drug-receptor binding compositions are poured into the drug box 3. The drug box 3 is provided with a partition to divide the inside of the drug box 3 into a plurality of placement cavities. Then, the drug box 2 is pushed and slid into the detection box 1. Then, the cylinder 52 is started to extend through the control panel 45, driving the multiple detection heads 53 at the bottom of the descending plate 51 to detect the composition in the drug box 3. The detection results are transmitted to the target drug signal device 43 through the signal amplifier 44 to complete the detection. Finally, the processing results are displayed on the display screen. The results are displayed in real time for observation and recording. After the detection is completed, the screw rod 61 is rotated. Under the limit of the limit rod 63, the screw rod 61 rotates to drive the two movable plates 62 to move relative to each other. The two movable plates 62 drive the cleaning sponge 65 to clamp and wrap the detection head 53. Then the cylinder 52 drives the detection head 53 to move up and down, and then the detection head 53 is cleaned by the cleaning sponge 65, so as to avoid the detection head 53 being uncleaned and affecting the accuracy of the next test result. At the same time, the bolt is screwed out of the threaded hole, so as to facilitate the disassembly of the mounting plate 64, thereby facilitating the disassembly and replacement of the cleaning sponge 65.

[0026] See also Figure 1 and Figure 2 In the figure, the control mechanism 4 includes a control box 41, a battery 42 is arranged on one side of the control box 41, a target drug signal device 43 and a signal amplifier 44 are arranged on the other side of the control box 41, and a control panel 45 is fixedly connected to the top of the control box 41.

[0027] In this embodiment: the target drug signal device 43 and the detection head 53 are connected via a signal amplifier 44, and the detection result is transmitted to the target drug signal device 43 via the signal amplifier 44 to complete the detection.

[0028] Example 2

[0029] See also Figure 1 and Figure 3 This embodiment further explains Example 1. In the figure, the test assembly 5 includes a descending plate 51. Both sides of the upper surface of the descending plate 51 are fixedly connected to a cylinder 52, and the bottom of the descending plate 51 is fixedly connected to a detection head 53.

[0030] In this embodiment: the control panel 45 starts the cylinder 52 to extend, driving the multiple detection heads 53 at the bottom of the descending plate 51 to detect the composition in the medicine box 3.

[0031] See also Figure 2 In the figure, a T-shaped slide groove is opened in the middle of the top of the support frame 2, and a T-shaped slide bar 8 is slidably connected inside the T-shaped slide groove, and the top of the T-shaped slide bar 8 is fixedly connected to the bottom of the medicine box 3.

[0032] In this embodiment, the T-shaped slide bar 8 is slidably connected to the T-shaped slide groove, so that the medicine box 3 can be slid, so that the medicine box 3 can be moved to the outside of the detection box 1 and the medicine composition can be poured into the inside of the medicine box 3.

[0033] See also Figure 1 and Figure 2 In the figure, an inlet and outlet are provided on one side of the detection box 1, and slide grooves are provided on both sides of the inlet and outlet, and a sealing plate 7 is slidably connected inside the slide groove.

[0034] In this embodiment, the sealing plate 7 slides with the slide groove, and then the sealing plate 7 can be used to seal and shield the inlet and outlet of the detection box 1 to avoid affecting the normal operation of the drug detection head 53.

[0035] Example 3

[0036] See also Figure 2 In the figure, the control panel 45 is connected to the target drug signal device 43 and the battery 42 through the first wire, and the target drug signal device 43 is connected to the detection head 53 through the second wire.

[0037] In this embodiment: the signal of the drug detection head 53 is amplified by the signal amplifier 44, thereby improving the detection accuracy of the target drug signal device 43.

[0038] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include"-"comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process-method-article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process-method-article or device.

[0039] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A drug target residence time detector, characterized in that: The invention comprises a detection box (1), wherein the inner bottom wall of the detection box (1) is fixedly connected to a support frame (2), a medicine box (3) is arranged on the top of the support frame (2), a control mechanism (4) is arranged in the middle of the top of the detection box (1), a test assembly (5) is fixedly connected to the side of the top of the detection box (1), a cleaning assembly (6) is rotatably connected to one side of the inner wall of the detection box (1) by installing a first bearing, and a transparent plate is embedded in the front of the detection box (1); The cleaning assembly (6) comprises a screw rod (61), one end of which is connected to the inside of a first bearing, and one end of which is rotatably connected to the inside of a back side of the detection box (1) by installing a second bearing and is connected to a torsion bar, both sides of the surface of the screw rod (61) are threadedly connected to driving plates, one side of the two driving plates is fixedly connected to a movable plate (62), the other sides of the two movable plates (62) are fixedly connected to a limiting plate, the surfaces of the two limiting plates are penetrated by a limiting rod (63), the two ends of the limiting rod (63) are respectively fixedly connected to the two sides of the inner wall of the detection box (1), and threaded holes are provided in the middle of the top and bottom of the two movable plates (62), and a mounting plate (64) is mounted inside the threaded hole by bolts, and a cleaning sponge (65) is fixedly connected to one side of the mounting plate (64).

2. A drug target residence time detector according to claim 1, characterized in that: The test assembly (5) comprises a descending plate (51), both sides of the upper surface of the descending plate (51) are fixedly connected to cylinders (52), and the bottom of the descending plate (51) is fixedly connected to a detection head (53).

3. A drug target residence time detector according to claim 1, characterized in that: The control mechanism (4) comprises a control box (41), a battery (42) is arranged on one side of the control box (41), a target drug signal device (43) and a signal amplifier (44) are arranged on the other side of the control box (41), and a control panel (45) is fixedly connected to the top of the control box (41).

4. A drug target residence time detector according to claim 1, characterized in that: An inlet and an outlet are provided on one side of the detection box (1), and sliding grooves are provided on both sides of the inlet and an inner portion of the sliding groove is slidably connected with a sealing plate (7).

5. A drug target residence time detector according to claim 1, characterized in that: A T-shaped slide groove is provided in the middle of the top of the support frame (2), a T-shaped slide bar (8) is slidably connected inside the T-shaped slide groove, and the top of the T-shaped slide bar (8) is fixedly connected to the bottom of the medicine box (3).

6. A drug target residence time detector according to claim 3, characterized in that: The control panel (45) is connected to the target drug signal device (43) and the storage battery (42) respectively through a first wire, and the target drug signal device (43) is connected to the detection head (53) through a second wire.

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