Transvascular intervention ultrasonic stimulation device

Abstract

The utility model relates to a transvascular intervention ultrasonic stimulation device which comprises a blood vessel dilator and an ultrasonic stimulation device body, the blood vessel dilator comprises a dilation part and a conveying catheter, the dilation part is arranged outside the conveying catheter, and the dilation part is used for being conveyed to a target position in a brain blood vessel through a minimally invasive means and then dilating the blood vessel. The conveying catheter is used for accommodating the ultrasonic stimulation device body; the ultrasonic stimulation device body comprises a stimulation part, a connecting part and an ultrasonic generation device, the stimulation part is electrically connected with the ultrasonic generation device through the connecting part, an ultrasonic stimulation unit is arranged on the stimulation part, and the stimulation part is used for penetrating through a conveying catheter to be conveyed to a target position in a brain blood vessel; the ultrasonic generating device located in vitro controls the ultrasonic stimulation unit to conduct ultrasonic stimulation on the target position of the brain. Compared with the prior art, the utility model has the advantages of small trauma, low risk and low treatment side effect, can relieve the psychological pressure of patients and family members, and has positive influence on treatment.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a transvascular interventional ultrasonic stimulation device. Background Art

[0002] Stroke, also known as "cerebral infarction", is a disease caused by ruptured and hemorrhaged cerebral blood vessels or cerebral ischemia and hypoxia caused by blood vessel blockage. It is the leading cause of death in my country. According to statistics, 80% of patients suffer from ischemic stroke. The normal variation of the cerebral arterial circle (Willis arterial circle) and the collateral circulation of each blood vessel, arteriosclerosis and other arterial diseases can affect the compensation of the collateral circulation, increasing the chance of cerebral ischemia caused by the blockage of a single artery.

[0003] Conventional post-stroke treatments include medication, surgery, and non-invasive stimulation. Medication has certain side effects, and patients are prone to drug tolerance. The blood barrier makes it difficult to selectively treat brain tissue, resulting in ineffective long-term medication. Surgical treatment, an invasive treatment, may cause bleeding, accidents, and other risks. It is difficult to restore neural circuits after the brain tissue is cut, and there is a risk of affecting the functions of other brain areas. Conventional non-invasive stimulation methods include transcranial magnetic stimulation (TMS) and transcranial current stimulation (TCS). TMS is a painless, non-invasive, and safe brain nerve stimulation method based on electromagnetic induction technology. It generates a strong pulse magnetic field around the stimulation coil through a short and strong pulse current in the stimulation coil placed on the head. This pulse magnetic field can penetrate the scalp and skull and generate an induced current in the skull. When the intensity of the induced current exceeds the excitation threshold of the nerve tissue, it will cause the action potential of the nerve tissue, thereby stimulating the nerve tissue. For example, the transcranial magnetic stimulation system disclosed in Chinese patent CN112827065A rapidly releases the charge of the energy storage capacitor in the main motor box, passes a pulse current into the stimulation coil placed above the head, and then generates a pulse magnetic field around the stimulation coil. The magnetic lines of force penetrate the skin and skull to the brain nerves with less resistance and non-traumatically, generating a conductive induced current in the skull, thereby stimulating the corresponding cranial nerve units. The therapeutic effect of TMS is related to the intensity and depth of magnetic stimulation, and the intensity of magnetic stimulation decays with increasing distance, so the depth of magnetic stimulation of the cerebral cortex is generally only 1 to 2 centimeters. To improve the therapeutic effect, the intensity and depth of magnetic stimulation must be increased, and the voltage at both ends of the stimulation coil and the current in the stimulation coil must be increased. This not only increases the manufacturing difficulty and cost of the TMS device, but the excessive current in the stimulation coil will cause the stimulation coil to heat up, which may cause burns to the head; and high-intensity magnetic stimulation must first pass through the scalp and skull before reaching the deeper cerebral cortex. Therefore, when the nerves deep in the brain are properly stimulated, the scalp and skull close to the stimulation coil may be overly stimulated, which in turn causes side effects of local pain and limits its clinical application.

[0004] TCS is a non-invasive brain nerve stimulation technology that uses electric current to regulate the excitability of cerebral cortical neurons. It passes a tiny subthreshold stimulation current through the brain by attaching a large area of ​​electrode sheets to the scalp. Although this stimulation current cannot generate action potentials of nerve cells, it can affect the local potential and cell membrane potential of nerve cells, change the excitation threshold of nerve tissue, and thus indirectly affect the excitability of nerve tissue. TCS is dependent on stimulation polarity. The excitability of the cerebral cortex under the positive electrode increases, which reduces the stimulation threshold, and the excitability of the cerebral cortex under the negative electrode decreases. At present, TCS has many shortcomings. Its current stimulation intensity is small and its modulation effect on nerve tissue is relatively weak. TCS devices on the market are scarce and expensive. Moreover, TCS devices are now classified as Class III medical devices, which poses a greater risk in terms of safe use. During use, it must be connected to the mains power supply. The output electrode of this active device is directly connected to the human scalp. If the humidity in the environment changes, the insulation of the device decreases and the leakage current increases, which will increase the nerve stimulation of the brain and create the risk of iatrogenic injury.

[0005] In view of this, the utility model provides a transvascular interventional ultrasound stimulation device, which can deliver the ultrasound device to the vicinity of the target stimulation position through a balloon device after intracranial vascular intervention, and perform ultrasonic stimulation on the target stimulation position through the ultrasound device to achieve the purpose of treatment. Compared with the prior art, the utility model can penetrate deep into the brain through the blood vessels, and only requires low-intensity ultrasonic energy to perform targeted stimulation treatment on the nerves inside the brain. The stimulation is more precise, will not cause burns to the brain, and has a small range of influence, reduces damage to peripheral nerve tissue, and minimizes side effects. Moreover, compared with electrode implantation and surgical operations, the transvascular intervention method has less trauma, lower risk, and lower treatment side effects, and can also reduce the psychological pressure of patients and their families, which has a positive impact on treatment. Utility Model Content

[0006] The utility model is intended to provide a transvascular interventional ultrasound stimulation device to solve the deficiencies in the prior art. The technical problem to be solved by the utility model is achieved through the following technical solutions.

[0007] A transvascular interventional ultrasound stimulation device comprises a blood vessel dilator and an ultrasound stimulation device body, wherein the blood vessel dilator comprises an expansion part and a delivery catheter, wherein the expansion part is arranged outside the delivery catheter, and is used to be delivered to a target position in a brain blood vessel by minimally invasive means and then expand the blood vessel, and the delivery catheter is used to accommodate the ultrasound stimulation device body; the ultrasound stimulation device body comprises a stimulation part, a connection part and an ultrasound generating device, wherein the stimulation part is electrically connected to the ultrasound generating device through the connection part, and an ultrasound stimulation unit is arranged on the stimulation part, and the stimulation part is used to be delivered to a target position in a brain blood vessel through the delivery catheter, so that the ultrasound generating device located outside the body controls the ultrasound stimulation unit to perform ultrasound stimulation on the target position in the brain.

[0008] Preferably, the ultrasonic stimulation unit is a ring-shaped structure that is spaced around the periphery of the stimulation part.

[0009] Alternatively, the ultrasonic stimulation unit is arranged in a sheet shape on one side or multiple sides of the stimulation part.

[0010] Preferably, a position mark is provided at a portion of the connecting portion close to the ultrasonic generating device.

[0011] Preferably, an end of the stimulation portion away from the connecting portion is provided with a terminal, and the terminal is visible under X-rays.

[0012] Preferably, the average acoustic power of the ultrasonic stimulation unit does not exceed 50 W / cm 2 .

[0013] Preferably, the expansion portion is a vascular stent.

[0014] Preferably, the expansion portion is a balloon, which includes a balloon body and a charging channel, the balloon body and the charging channel are connected to each other, the balloon body and the charging channel are arranged around the outer ring of the delivery catheter, and one end of the charging channel placed outside the body is provided with a charging port connected thereto, and a blood flow channel is provided at a portion of the balloon body located on one side of the delivery catheter, and the blood flow channel is used to allow blood to flow through after the balloon body is pressurized and expanded.

[0015] In the present invention, as shown in the figures and the drawings, when treating a patient after a stroke, the expansion part is first placed into the target treatment position in the brain blood vessel through the blood vessel by minimally invasive means, and then the expansion part is expanded to temporarily expand the tiny blood vessels in the brain to facilitate the insertion of the ultrasonic stimulation device body. Then the stimulation part is delivered to the target treatment position of the brain through the delivery catheter, and the ultrasonic generating device is turned on so that the ultrasonic stimulation unit on the stimulation part emits ultrasonic waves, and the mechanical vibration caused by the ultrasound is artificially focused in a certain area to stimulate the opening of the ion channel, thereby achieving the purpose of treatment.

[0016] Compared with the prior art, the utility model provides a transvascular interventional ultrasound stimulation device that can penetrate deep into the brain through blood vessels and only requires low-intensity ultrasonic energy to perform targeted stimulation treatment on the nerves inside the brain. The stimulation is more precise, will not cause burns to the brain, and has a small impact range, thereby reducing damage to surrounding nerve tissue and minimizing side effects. Compared with electrode implantation and surgical operations, the transvascular intervention method has less trauma, lower risk, and fewer treatment side effects, and can also reduce the psychological pressure of patients and their families, exerting a positive impact on treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a structural schematic diagram of an embodiment of the utility model;

[0018] Figure 2 It is a structural schematic diagram of an embodiment of the vascular dilator in the utility model;

[0019] Figure 3 It is a structural schematic diagram of another embodiment of the vascular dilator in the utility model;

[0020] The reference numerals in the accompanying drawings are, in order: 11, expansion part, 111, charging channel, 112, blood flow channel, 12, delivery catheter, 13, handle, 14, charging port, 21, stimulation part, 211, ultrasonic stimulation unit, 212, end, 22, connecting part, 23, ultrasonic generating device. DETAILED DESCRIPTION

[0021] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present utility model will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0022] Embodiment 1:

[0023] A transvascular ultrasound stimulation device, the improvement of which is that it comprises a blood vessel dilator and an ultrasound stimulation device body, the blood vessel dilator comprises a dilator 11 and a delivery catheter 12, the dilator 11 is arranged outside the delivery catheter 12, the dilator 11 is used to be delivered to a target position in a brain blood vessel by minimally invasive means and then expand the blood vessel, the delivery catheter 12 is used to accommodate the ultrasound stimulation device body; the ultrasound stimulation device body comprises a stimulation part 21, a connecting part 22 and an ultrasound generating device 23, the stimulation part 21 is electrically connected to the ultrasound generating device 23 through the connecting part 22, an ultrasound stimulation unit 211 is arranged on the stimulation part 21, the stimulation part 21 is used to be delivered to the target position in the brain blood vessel through the delivery catheter 12, so that the ultrasound generating device 23 located outside the body controls the ultrasound stimulation unit 211 to perform ultrasound stimulation on the target position in the brain.

[0024] In this embodiment, refer to Figure 1 and Figure 2 As shown, when treating a patient after a stroke, the expansion part 11 is first placed into the target treatment position in the brain blood vessels through a minimally invasive method, and then the expansion part 11 is expanded to temporarily expand the tiny blood vessels in the brain to facilitate the insertion of the ultrasonic stimulation device body. Then the stimulation part 21 is delivered to the target treatment position of the brain through the delivery catheter 12, and the ultrasonic generating device 23 is turned on, so that the ultrasonic stimulation unit 211 on the stimulation part 21 emits ultrasonic waves, and the mechanical vibration caused by the ultrasound is artificially focused in a certain area to stimulate the opening of ion channels, thereby achieving the purpose of treatment.

[0025] Compared with the prior art, the transvascular interventional ultrasound stimulation device provided in this embodiment can penetrate deep into the brain through blood vessels, and only requires low-intensity ultrasonic energy to perform targeted stimulation treatment on the nerves inside the brain. The stimulation is more precise, will not cause burns to the brain, and has a small impact range, thereby reducing damage to surrounding nerve tissue and minimizing side effects. Compared with electrode implantation and surgical operations, the transvascular intervention method has less trauma, lower risk, and fewer treatment side effects. It can also reduce the psychological pressure of patients and their families, and have a positive impact on treatment.

[0026] Furthermore, a handle 13 is provided at one end of the delivery catheter 12 away from the expansion portion 11.

[0027] Furthermore, the ultrasonic stimulation unit 211 is a ring-shaped structure that is spaced around the periphery of the stimulation part 21 .

[0028] Alternatively, the ultrasonic stimulation unit 211 is arranged in a sheet shape on one side or multiple sides of the stimulation part 21. Furthermore, a position mark is arranged at a portion of the connection part 22 close to the ultrasonic generating device 23.

[0029] In this embodiment, the position mark is provided to facilitate the operator to identify the side where the ultrasonic stimulation unit 211 is located, so as to adjust the direction of the ultrasonic stimulation unit 211, thereby achieving a better treatment effect.

[0030] Furthermore, an end of the stimulation portion 21 away from the connection portion 22 is provided with a terminal 212 , and the terminal 212 is visible under X-rays.

[0031] In this embodiment, the configuration of the end 212 facilitates identification of the position of the stimulation part 21 within the blood vessel.

[0032] Furthermore, the average acoustic power of the ultrasonic stimulation unit 211 does not exceed 50 W / cm 2 .

[0033] In this embodiment, the ultrasonic waves emitted by the ultrasonic stimulation unit 211 can achieve the purpose of stimulation therapy without causing burns to blood vessels or brain tissues due to excessive energy.

[0034] Embodiment 2:

[0035] Based on Example 1, Figure 1 and Figure 2 As shown, the expansion portion 11 is a vascular stent.

[0036] In this embodiment, the expansion part is a mesh vascular stent. After the expansion part 11 is delivered to the target position in the blood vessel by minimally invasive means, the vascular stent is expanded, thereby expanding the blood vessel. The mesh vascular stent allows normal blood flow. Then, the stimulation part 21 is delivered to the position of the vascular stent, that is, the target treatment position, through the delivery catheter 12, so that the ultrasonic stimulation unit 211 performs ultrasonic stimulation on the target position of the brain.

[0037] Embodiment 3:

[0038] Based on Example 1, Figure 3 As shown, the expansion part 11 is a balloon, and the balloon includes a balloon body and a pressure-charging channel 111, and the balloon body and the pressure-charging channel 111 are connected to each other, and the balloon body and the pressure-charging channel 111 are arranged around the outer ring of the delivery catheter 12, and the end of the pressure-charging channel 111 placed outside the body is provided with a pressure-charging port 14 connected thereto, and the part of the balloon body located on one side of the delivery catheter 12 is provided with a blood flow channel 112, and the blood flow channel 112 is used to allow blood to flow through after the balloon body is pressurized and expanded.

[0039] In this embodiment, the balloon body is a liquid-filled or air-filled balloon. After the expansion part 11 is delivered to the target position in the blood vessel, the balloon body is filled with liquid or air through the charging port 14 through the charging channel 111 to expand the balloon body, thereby expanding the blood vessel. The blood flow channel 112 on the balloon body is set so that the normal blood flow in the blood vessel can be allowed to pass when the balloon body is expanded. Then the stimulation part 21 is delivered to the position of the vascular stent, that is, the target treatment position, through the delivery catheter 12, so that the ultrasonic stimulation unit 211 performs ultrasonic stimulation on the target position of the brain.

[0040] It should be noted that the above detailed descriptions are exemplary and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present application belongs.

[0041] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments described in the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should also be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0042] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the terms used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0043] In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units that are not explicitly listed or inherent to these processes, methods, products, or apparatuses.

[0044] For ease of description, spatially relative terms, such as "above", "above", "on the upper surface of", "above", etc., may be used herein to describe the spatial positional relationship between a device or feature and other devices or features as shown in the figure. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figure. For example, if the device in the accompanying drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" may include both "above" and "below". The device may also be positioned in other different ways, such as rotated 90 degrees or in other orientations, and the spatially relative descriptions used herein are interpreted accordingly.

[0045] In the above detailed description, reference is made to the accompanying drawings, which form a part of this document. In the accompanying drawings, similar symbols typically identify similar components unless the context indicates otherwise. The illustrated embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be used, and other changes may be made, without departing from the spirit or scope of the subject matter presented herein.

[0046] The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A transvascular ultrasound stimulation device, characterized in that: The invention comprises a blood vessel dilator and an ultrasonic stimulation device body. The blood vessel dilator comprises a dilating part (11) and a delivery catheter (12). The dilating part (11) is arranged outside the delivery catheter (12). The dilating part (11) is used to be delivered to a target position in a brain blood vessel by minimally invasive means and then expand the blood vessel. The delivery catheter (12) is used to accommodate the ultrasonic stimulation device body. After the dilating part (11) is expanded, blood can flow through. The ultrasonic stimulation device body comprises a stimulation part (21), a connecting part (22) and an ultrasonic generating device (23). The stimulation part (21) is electrically connected to the ultrasonic generating device (23) through the connecting part (22). An ultrasonic stimulation unit (211) is arranged on the stimulation part (21). The stimulation part (21) is used to be delivered to a target position in a brain blood vessel through the delivery catheter (12), so that the ultrasonic generating device (23) located outside the body controls the ultrasonic stimulation unit (211) to perform ultrasonic stimulation on the target position in the brain.

2. The transvascular interventional ultrasound stimulation device according to claim 1, characterized in that: The ultrasonic stimulation unit (211) is a ring-shaped structure that is spaced around the periphery of the stimulation part (21).

3. The transvascular interventional ultrasound stimulation device according to claim 1, characterized in that: The ultrasonic stimulation unit (211) is arranged in a sheet shape on one side or multiple sides of the stimulation part (21).

4. The transvascular interventional ultrasound stimulation device according to claim 3, characterized in that: A position mark is provided at a portion of the connecting portion (22) close to the ultrasonic generating device (23).

5. The transvascular interventional ultrasound stimulation device according to claim 1, characterized in that: An end of the stimulation portion (21) away from the connection portion (22) is provided with a terminal (212), and the terminal (212) is visible under X-rays.

6. The transvascular interventional ultrasound stimulation device according to claim 1, characterized in that: The average acoustic power of the ultrasonic stimulation unit (211) does not exceed 50 W / cm 2 .

7. The transvascular interventional ultrasound stimulation device according to claim 1, characterized in that: The expansion part (11) is a blood vessel stent.

8. The transvascular interventional ultrasound stimulation device according to claim 1, characterized in that: The expansion portion (11) is a balloon, and the balloon comprises a balloon body and a charging channel (111). The balloon body and the charging channel (111) are connected to each other, and the balloon body and the charging channel (111) are arranged around the outer ring of the delivery catheter (12). One end of the charging channel (111) outside the body is provided with a charging port (14) connected thereto, and a blood flow channel (112) is provided at a portion of the balloon body located on one side of the delivery catheter (12). The blood flow channel (112) is used to allow blood to flow through after the balloon body is pressurized and expanded.

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