Pulse electric field ablation catheter

Abstract

The utility model is suitable for the technical field of pulsed electric field ablation catheters, and provides a pulsed electric field ablation catheter which comprises a catheter body part and an expansion part, the catheter body part comprises a main body tube and a push-pull tube, the push-pull tube is movably arranged in the main body tube in a penetrating mode, and at least part of the push-pull tube extends out of the far end of the main body tube; the expansion part comprises an expansion pipe, and a plurality of branch pipes are formed between the near end and the far end of the expansion pipe; the branch tube is provided with at least one treatment electrode, a cooling gap communicated with the external environment is arranged between the branch tube and the treatment electrode, the main tube is provided with a first perfusion channel, the branch tube is provided with a second perfusion channel, the first perfusion channel is communicated with the second perfusion channel, and the second perfusion channel is communicated with the cooling gap. According to the pulsed electric field ablation catheter provided by the invention, a perfusion hole does not need to be formed in the surface of the treatment electrode, the spark discharge phenomenon on the treatment electrode can be effectively avoided, and the reliability is relatively high.

Description

Technical Field

[0001] The present application belongs to the technical field of medical devices, and more specifically, relates to a pulse electric field ablation catheter. Background Art

[0002] The pulsed electric field ablation catheter is a medical device used for cardiac electrophysiological ablation surgery. Its working principle is to transmit a high-intensity pulsed electric field to the heart tissue through the catheter to destroy the conduction path of abnormal cardiac electrical signals, thereby treating diseases such as arrhythmias. The pulsed electric field ablation catheter is usually composed of a catheter body, an electrode head, and a pulse generator. During the operation, the doctor inserts the catheter into the heart through the blood vessels, so that the electrode head contacts the part that needs to be ablated, and then starts the pulse generator to generate a pulsed electric field, causing irreversible electroporation and apoptosis of the cells, thereby achieving the effect of ablation. During the use of the pulsed electric field ablation catheter, it is necessary to control the temperature of the electrode head in real time. The temperature rise control of the electrode by the existing pulsed electric field ablation catheter is generally achieved by perfusion of cold saline. For the cold saline perfusion of the electrode, it is necessary to set a perfusion channel on the body of the pulsed electric field ablation catheter, open a perfusion hole on the surface of the electrode, and perfuse the electrode through the perfusion hole to achieve the purpose of controlling the temperature of the electrode head.

[0003] However, opening perfusion holes on the electrode surface may lead to the formation of tips. When there are tips on the surface of the electrode, spark discharge may occur between the working electrode and the tips, forming local high temperature and causing the formation of thrombosis or scab, affecting the effectiveness and safety of the operation. Utility Model Content

[0004] The purpose of the embodiments of the present application is to provide a pulsed electric field ablation catheter, aiming to solve the technical problem in the prior art that the pulsed electric field ablation catheter has perfusion holes on the electrode surface, which causes spark discharge to easily occur during the operation of the electrode.

[0005] To achieve the above-mentioned purpose, according to one aspect of the present application, a pulsed electric field ablation catheter is provided, the pulsed electric field ablation catheter comprising: a tube body and an expansion portion, wherein the tube body comprises a main tube and a push-pull tube, the push-pull tube is movably arranged in the main tube and at least partially extends from the distal end of the main tube; the expansion portion comprises an expansion tube, a plurality of branch tubes are formed between the proximal end and the distal end of the expansion tube, the plurality of branch tubes are arranged at intervals along the circumference of the expansion tube, the proximal end of the expansion tube is connected to the distal end of the main tube, and the distal end of the expansion tube is connected to the distal end of the push-pull tube; at least one treatment electrode is arranged on the branch tube, a cooling gap connected to the external environment is provided between the branch tube and the treatment electrode, a first perfusion channel is provided on the main tube, a second perfusion channel is provided on the branch tube, the first perfusion channel is connected to the second perfusion channel, and the second perfusion channel is connected to the cooling gap.

[0006] Optionally, the expansion tube is sleeved on the push-pull tube, and the expansion portion further includes a first seal, which is arranged on the proximal end of the expansion tube and located between the expansion tube and the push-pull tube for sealing the gap between the expansion tube and the push-pull tube.

[0007] Optionally, the tube body also includes a connecting tube, two ends of which are respectively sleeved on the proximal end of the expansion tube and the distal end of the main tube, for connecting the expansion tube and the main tube.

[0008] Optionally, a shunt cavity is formed between the proximal end of the expansion tube, the distal end of the main tube and the inner side wall of the connecting tube, and the first perfusion channel and the second perfusion channel can be communicated through the shunt cavity.

[0009] Optionally, a perfusion hole is provided on the branch tube, and the position of the perfusion hole corresponds to the position of the treatment electrode, and is used to connect the second perfusion channel and the cooling gap.

[0010] Optionally, a cooling recess is provided on the outer wall of the branch tube, the position of the cooling recess corresponds to the position of the treatment electrode, a cooling gap is formed between the cooling recess and the treatment electrode, and both ends of the perfusion hole are respectively connected to the cooling recess and the second perfusion channel.

[0011] Optionally, the treatment electrode is an annular electrode, which is sleeved on the branch tube. There are multiple cooling recesses and perfusion holes, and the multiple cooling recesses are spaced apart along the circumference of the branch tube. The multiple perfusion holes correspond one-to-one to the multiple cooling recesses.

[0012] Optionally, the first sealing member includes a sealing tube, which is passed through the expansion tube and sleeved on the push-pull tube, the outer wall of the sealing tube is fixedly connected to the inner wall of the expansion tube, and the inner wall of the sealing tube abuts against the outer wall of the push-pull tube.

[0013] Optionally, a plurality of treatment electrodes are arranged on the branch tube, and the plurality of treatment electrodes are arranged at intervals along the extension direction of the branch tube.

[0014] Optionally, the expansion part further includes a second sealing member, which is disposed on the distal end of the expansion tube and is used to seal the distal end of the second perfusion channel.

[0015] The beneficial effect of the pulsed electric field ablation catheter provided by the present application is that, compared with the prior art, the pulsed electric field ablation catheter provided by the present application is achieved by movably inserting the push-pull tube into the main body, and making the push-pull tube at least partially extend from the distal end of the main body tube, and at the same time making the two ends of the expansion tube respectively connected to the distal end of the main body tube and the distal end of the push-pull tube, so that the multiple branch tubes located between the proximal end and the distal end of the expansion tube provided by the present application can be deformed in the radial direction of the expansion tube as the push-pull tube moves, and by arranging at least one treatment electrode on the branch tube, the treatment electrode provided by the present application can be adjusted in the radial direction of the expansion tube as the branch tube is deformed, and at the same time, by A cooling gap connected to the external environment is set between the tube and the treatment electrode, a first perfusion channel is set on the main tube, and a second perfusion channel is set on the branch tube, and the first perfusion channel is connected to the second perfusion channel, and the second perfusion channel is connected to the cooling gap, so that the cold saline in the first perfusion channel can be perfused into the cooling gap between the branch tube and the treatment electrode through the second perfusion channel, and flow to the external environment, thereby realizing cooling of the treatment electrode. Compared with the pulsed electric field ablation catheter in the prior art, the pulsed electric field ablation catheter provided in the present application does not need to open a perfusion hole on the surface of the treatment electrode, so it can effectively avoid the phenomenon of spark discharge on the treatment electrode, and has higher reliability. During the process of ablating the target tissue by the pulsed electric field ablation catheter provided in the present application, cold saline can be discharged to the vicinity of the treatment electrode through the cooling gap and mixed with the blood near the treatment electrode, thereby reducing the treatment impedance of the treatment electrode, allowing the pulsed electric field generated on the treatment electrode to act on the target tissue more easily, and in the case where the treatment electrode has a tip, the cold saline discharged from the cooling gap to the vicinity of the treatment electrode can also coat the tip in the form of water droplets, thereby improving the uniformity of the electric field distribution on the end surface and tip of the treatment electrode, and preventing spark discharge caused by uneven electric field distribution of the treatment electrode. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0017] Figure 1 A schematic diagram of the structure of a pulsed electric field ablation catheter provided in an embodiment of the present application;

[0018] Figure 2 A partial cross-sectional schematic diagram of a pulsed electric field ablation catheter provided in an embodiment of the present application;

[0019] Figure 3 A partial cross-sectional schematic diagram of a pulsed electric field ablation catheter at another position provided by an embodiment of the present application;

[0020] Figure 4 A partial cross-sectional schematic diagram of a pulsed electric field ablation catheter at another position provided in an embodiment of the present application;

[0021] Figure 5 A partial working schematic diagram of a pulsed electric field ablation catheter provided in an embodiment of the present application without cold saline irrigation of the treatment electrode;

[0022] Figure 6 A partial working schematic diagram of a pulsed electric field ablation catheter for performing cold saline perfusion on a treatment electrode provided in an embodiment of the present application;

[0023] Figure 7 A partial cross-sectional schematic diagram of a pulsed electric field ablation catheter with its tip coated with cold saline provided in an embodiment of the present application;

[0024] The reference numerals in the above drawings are as follows:

[0025] 10. Tube body; 11. Main tube; 111. First perfusion channel; 112. Push-pull channel; 12. Push-pull tube; 13. Connecting tube;

[0026] 20, expansion part; 21, expansion tube; 211, branch tube; 2111, second perfusion channel; 2112, perfusion hole; 212, treatment electrode; 22, first sealing member; 23, second sealing member;

[0027] 30. Cooling gap;

[0028] 40. Shunt cavity;

[0029] 50. Power supply line;

[0030] 60. Blood;

[0031] 70. Mixed conductive solution;

[0032] 80. Cold salt water;

[0033] 90. Cutting edge. DETAILED DESCRIPTION

[0034] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0035] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or indirectly connected to the other element. In the absence of conflict, the embodiments in this application and the features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0036] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0037] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0038] As described in the background technology, the pulsed electric field ablation catheter is a medical device used for cardiac electrophysiological ablation surgery. Its working principle is to transmit a high-intensity pulsed electric field to the heart tissue through the catheter to destroy the conduction path of abnormal cardiac electrical signals, thereby treating diseases such as arrhythmias. The pulsed electric field ablation catheter is usually composed of a catheter body, an electrode head, and a pulse generator. During the operation, the doctor inserts the catheter into the heart through the blood vessels, so that the electrode head contacts the part that needs to be ablated, and then starts the pulse generator to generate a pulsed electric field, causing irreversible electroporation and apoptosis of the cells, thereby achieving the effect of ablation. During the use of the pulsed electric field ablation catheter, it is necessary to control the temperature of the electrode head in real time. The temperature rise control of the electrode by the existing pulsed electric field ablation catheter is generally achieved by perfusion of cold saline. For the cold saline perfusion of the electrode, it is necessary to set a perfusion channel on the body of the pulsed electric field ablation catheter, open a perfusion hole on the surface of the electrode, and perfuse the electrode through the perfusion hole to achieve the purpose of controlling the temperature of the electrode head. However, opening perfusion holes on the electrode surface may lead to the formation of tips. When there are tips on the surface of the electrode, spark discharge may occur between the working electrode and the tips, forming local high temperature and causing the formation of thrombosis or scab, affecting the effectiveness and safety of the operation.

[0039] See also Figures 1 to 7As shown, in order to solve the above problems, according to one aspect of the present application, an embodiment of the present application provides a pulsed electric field ablation catheter, which includes: a tube body 10 and an expansion portion 20, wherein the tube body 10 includes a main tube 11 and a push-pull tube 12, the push-pull tube 12 is movably arranged in the main tube 11, and at least partially extends from the distal end of the main tube 11; the expansion portion 20 includes an expansion tube 21, and a plurality of branch tubes 211 are formed between the proximal end and the distal end of the expansion tube 21, and the plurality of branch tubes 211 are spaced circumferentially along the expansion tube 21. It is arranged that the proximal end of the expansion tube 21 is connected to the distal end of the main tube 11, and the distal end of the expansion tube 21 is connected to the distal end of the push-pull tube 12; at least one treatment electrode 212 is arranged on the branch tube 211, and a cooling gap 30 connected to the external environment is provided between the branch tube 211 and the treatment electrode 212; a first perfusion channel 111 is arranged on the main tube 11, and a second perfusion channel 2111 is arranged on the branch tube 211, the first perfusion channel 111 is connected to the second perfusion channel 2111, and the second perfusion channel 2111 is connected to the cooling gap 30. The pulsed electric field ablation catheter provided in the present embodiment is provided with a push-pull tube 12 movably inserted into the main body, and the push-pull tube 12 is at least partially extended from the distal end of the main body tube 11, and the two ends of the expansion tube 21 are respectively connected to the distal end of the main body tube 11 and the distal end of the push-pull tube 12, so that a plurality of branch tubes 211 located between the proximal end and the distal end of the expansion tube 21 provided in the present embodiment can be deformed in the radial direction of the expansion tube 21 as the push-pull tube 12 moves, and at least one treatment electrode 212 is provided on the branch tube 211, so that the treatment electrode 212 provided in the present embodiment can be adjusted in the radial direction of the expansion tube 21 as the branch tube 21 is deformed. At the same time, a cooling space connected to the external environment is provided between the branch tube 211 and the treatment electrode 212. Gap 30, a first perfusion channel 111 is set on the main tube 11, and a second perfusion channel 2111 is set on the branch tube 211, and the first perfusion channel 111 is connected to the second perfusion channel 2111, and the second perfusion channel 2111 is connected to the cooling gap 30, so that the cold saline in the first perfusion channel 111 can be perfused into the cooling gap 30 between the branch tube 211 and the treatment electrode 212 through the second perfusion channel 2111, and flow into the external environment, thereby realizing cooling of the treatment electrode 212. Compared with the pulse electric field ablation catheter in the prior art, the pulse electric field ablation catheter provided in this embodiment does not need to open a perfusion hole 2112 on the surface of the treatment electrode 212, so it can effectively avoid the phenomenon of spark discharge on the treatment electrode 212, and has higher reliability.During the process of ablating the target tissue by the pulsed electric field ablation catheter provided in this embodiment, the cold saline 80 can be discharged to the vicinity of the treatment electrode 212 through the cooling gap 30 and mixed with the blood near the treatment electrode 212, thereby reducing the treatment impedance of the treatment electrode 212, so that the pulsed electric field generated on the treatment electrode 212 can more easily act on the target tissue, and when the treatment electrode 212 has a tip 90, the cold saline 80 discharged from the cooling gap 30 to the vicinity of the treatment electrode 212 can also coat the tip 90 in the form of water droplets, thereby improving the uniformity of the electric field distribution on the end face of the treatment electrode 212 and the tip 90, and preventing the occurrence of spark discharge caused by the uneven electric field distribution of the treatment electrode 212.

[0040] See also Figure 1 As shown, in a specific embodiment, the number of branch pipes 211 provided in this embodiment is five. Of course, in other embodiments, the number of branch pipes 211 provided in this embodiment may also be other numbers.

[0041] See also Figure 3 As shown, in a specific embodiment, the expansion tube 21 in this embodiment is sleeved on the push-pull tube 12, and the expansion part 20 also includes a first seal 22, which is arranged on the proximal end of the expansion tube 21 and located between the expansion tube 21 and the push-pull tube 12, and is used to seal the gap between the expansion tube 21 and the push-pull tube 12. By sleeved the expansion tube 21 provided in this embodiment on the push-pull tube 12, the multiple branch tubes 211 provided in this embodiment can be located radially outside the push-pull tube 12, so that the multiple branch tubes 211 are deformed in the radial direction of expansion as the push-pull tube 12 moves. At the same time, by arranging the first seal 22 on the proximal end of the expansion tube 21 and arranging the first seal 22 between the expansion tube 21 and the push-pull tube 12, the pulsed electric field ablation catheter provided in this embodiment can seal the gap between the expansion tube 21 and the push-pull tube 12 through the first seal 22.

[0042] See also Figure 1 and Figure 4 As shown, in a specific embodiment, the pipe body 10 in this embodiment further includes a connecting pipe 13, and the two ends of the connecting pipe 13 are respectively sleeved on the proximal end of the expansion pipe 21 and the distal end of the main pipe 11, so as to connect the expansion pipe 21 and the main pipe 11. By sleeved on the proximal end of the expansion pipe 21 and the distal end of the main pipe 11, the expansion pipe 21 and the main pipe 11 provided in this embodiment can be connected through the connecting pipe 13.

[0043] In an optional embodiment, the connecting tube 13 provided in this embodiment is a Pebax thin-walled tube, the distal inner wall of the Pebax thin-walled tube provided in this embodiment is welded to the proximal outer wall of the expansion tube 21, and the proximal inner wall of the Pebax thin-walled tube is welded to the distal outer wall of the main tube 11 to achieve connection and communication between the expansion tube 21 and the main tube 11.

[0044] See also Figure 4 As shown, in order to evenly infuse the cold saline in the first infusion channel 111 provided in the present embodiment into the plurality of second infusion channels 2111, a shunt cavity 40 is formed between the proximal end of the expansion tube 21, the distal end of the main body tube 11, and the inner side wall of the connecting tube 13 in the present embodiment, and the first infusion channel 111 and the second infusion channel 2111 can be communicated through the shunt cavity 40. By providing the shunt cavity 40 between the proximal end of the expansion tube 21, the distal end of the main body tube 11, and the inner side wall of the connecting tube 13 provided in the present embodiment, the first infusion channel 111 can be simultaneously communicated with the plurality of second infusion channels 2111 through the shunt cavity 40, so that the cold saline in the first infusion channel 111 provided in the present embodiment can be evenly infused into the plurality of second infusion channels 2111.

[0045] The pulsed electric field ablation catheter in the prior art generally has a large number of electrodes, and each electrode requires a corresponding perfusion channel for cooling. However, the diameter of the main tube 11 of the pulsed electric field ablation catheter is limited. Therefore, the more perfusion channels are set, the smaller the inner diameter of a single perfusion channel is, the lower the space utilization rate of the main tube 11 is, the flow rate of cold saline in the perfusion channel will also be limited, and the cooling effect on the electrode will be worse. The pulsed electric field ablation catheter provided in this embodiment is provided with a single first perfusion channel 111 on the main body, and the first perfusion channel 111 is connected with multiple second perfusion channels 2111 through the shunt cavity 40. There is no need to set a corresponding number of perfusion channels on the main tube 11, and the space utilization rate of the main tube 11 is high, so that the cold saline perfusion flow rate of the pulsed electric field ablation catheter provided in this embodiment can be effectively improved.

[0046] See also Figure 2 As shown, in a specific embodiment, a perfusion hole 2112 is provided on the branch tube 211 in this embodiment, and the position of the perfusion hole 2112 corresponds to the position of the treatment electrode 212, which is used to connect the second perfusion channel 2111 and the cooling gap 30. By providing the perfusion hole 2112 corresponding to the position of the treatment electrode 212 on the branch tube 211 provided in this embodiment, the pulse electrode ablation catheter provided in this embodiment can connect the second perfusion channel 2111 and the cooling gap 30 through the perfusion hole 2112.

[0047] See also Figure 2As shown, in a specific embodiment, a cooling recess is provided on the outer wall of the branch pipe 211 in this embodiment, and the position of the cooling recess corresponds to the position of the treatment electrode 212. A cooling gap 30 is formed between the cooling recess and the treatment electrode 212, and both ends of the perfusion hole 2112 are respectively connected to the cooling recess and the second perfusion channel 2111. By providing a cooling recess on the outer wall of the branch pipe 211 provided in this embodiment, and making the position of the cooling recess correspond to the position of the treatment electrode 212, a cooling gap 30 can be formed between the cooling recess provided in this embodiment and the treatment electrode 212.

[0048] See also Figure 1 and Figure 2 As shown, in a specific embodiment, the treatment electrode 212 in this embodiment is a ring electrode, and the ring electrode is sleeved on the branch tube 211. There are multiple cooling recesses and perfusion holes 2112. The multiple cooling recesses are arranged at intervals along the circumference of the branch tube 211, and the multiple perfusion holes 2112 correspond to the multiple cooling recesses one by one. By setting the treatment electrode 212 provided in this embodiment as a ring electrode, and setting the cooling recesses and perfusion holes 2112 to multiple, and at the same time making the multiple cooling recesses arranged at intervals along the circumference of the branch tube 211, and the multiple perfusion holes 2112 correspond to the multiple cooling recesses one by one, the ring electrode provided in this embodiment can be perfused with cold saline through multiple cooling gaps 30, which effectively improves the cooling effect of the ring electrode.

[0049] In an optional embodiment, the present embodiment provides two cooling recesses and two injection holes 2112, the two cooling recesses are respectively arranged on both sides of the branch pipe 211 in the circumferential direction of the expansion pipe 21, and the two injection holes 2112 correspond to the two cooling recesses respectively.

[0050] See also Figure 3 As shown, in a specific embodiment, the first sealing member 22 in this embodiment includes a sealing tube, which is inserted into the expansion tube 21 and sleeved on the push-pull tube 12, and the outer wall of the sealing tube is fixedly connected to the inner wall of the expansion tube 21, and the inner wall of the sealing tube abuts against the outer wall of the push-pull tube 12. By inserting the sealing tube provided in this embodiment into the expansion tube 21 and sleeved on the push-pull tube 12, and at the same time making the outer wall of the sealing tube fixedly connected to the inner wall of the expansion tube 21, and the inner wall of the sealing tube abuts against the outer wall of the push-pull tube 12, the gap between the inner wall of the expansion tube 21 provided in this embodiment and the outer wall of the push-pull tube 12 can be effectively sealed by the sealing tube.

[0051] In an optional embodiment, the sealing tube provided in this embodiment is a TPU thin-walled tube, and the TPU thin-walled tube provided in this embodiment is fixedly connected to the inner wall of the expansion tube 21 by bonding.

[0052] In an optional embodiment, the TPU thin-walled tube provided in this embodiment has an interference fit with the push-pull tube 12. Since the TPU thin-walled tube has a certain elasticity, the TPU thin-walled tube can form a piston during the pushing and pulling process of the push-pull tube 12, thereby sealing the gap between the inner wall of the expansion tube 21 and the outer wall of the push-pull tube 12 in real time without affecting the pushing and pulling of the push-pull tube 12.

[0053] See also Figure 1 As shown, in a specific embodiment, a plurality of treatment electrodes 212 are arranged on the branch tube 211 in this embodiment, and the plurality of treatment electrodes 212 are arranged at intervals along the extension direction of the branch tube 211. By arranging a plurality of treatment electrodes 212 on the branch tube 211 provided in this embodiment, and arranging the plurality of treatment electrodes 212 at intervals along the extension direction of the branch tube 211, the pulsed electric field ablation catheter provided in this embodiment can have a better treatment effect.

[0054] In an optional embodiment, the multiple treatment electrodes 212 provided in this embodiment are arranged at intervals in the middle of the branch tube 211 .

[0055] In an optional embodiment, the distance between two adjacent treatment electrodes 212 provided in this embodiment is 2 mm.

[0056] In an optional embodiment, the number of treatment electrodes 212 on the single branch tube 211 provided in this embodiment is two. Of course, in other embodiments, the number of treatment electrodes 212 on the single branch tube 211 provided in this embodiment may also be other numbers.

[0057] See also Figure 1 As shown, in order to prevent the cold saline in the second perfusion channel 2111 from flowing into the external environment from the distal end of the second perfusion channel 2111, the expansion portion 20 in this embodiment further includes a second seal 23, which is arranged on the distal end of the expansion tube 21, and is used to seal the distal end of the second perfusion channel 2111. By arranging the second seal 23 on the distal end of the expansion tube 21 provided in this embodiment, the pulsed electric field ablation catheter provided in this embodiment can seal the distal end of the second perfusion channel 2111 through the second seal 23, and prevent the cold saline in the second perfusion channel 2111 from flowing into the external environment from the distal end of the second perfusion channel 2111, so that the cold saline in the second perfusion channel 2111 can only flow out from the cooling gap 30 through the perfusion hole 2112, so that the treatment electrode 212 provided in this embodiment can be fully cooled.

[0058] See also Figure 2As shown, in an optional embodiment, the pulsed electric field ablation catheter provided in this embodiment also includes a power supply line 50. The power supply line 50 provided in this embodiment is at least partially disposed in the second perfusion channel 2111 and is electrically connected to the treatment electrode 212. An external pulse power supply device can power the treatment electrode 212 through the power supply line 50.

[0059] In an optional embodiment, the power supply wire 50 provided in this embodiment is an enameled wire.

[0060] In an optional embodiment, a push-pull channel 112 is provided on the main tube 11 provided in this embodiment. The push-pull tube 12 provided in this embodiment can be movably inserted into the push-pull channel 112. The push-pull channel 112 provided in this embodiment is connected to the shunt cavity 40. The pulsed electric field ablation catheter provided in this embodiment can perform cold saline perfusion on the shunt cavity 40 through the gap between the push-pull tube 12 and the push-pull channel 112.

[0061] See also Figure 5 As shown, when the pulsed electric field ablation catheter provided in this embodiment is not cooled by perfusing the treatment electrode 212 with cold saline 80, the pulsed electric field generated on the treatment electrode 212 needs to pass through the blood 60 to act on the target tissue, resulting in high impedance and poor treatment effect. Figure 6 As shown, when the pulsed electric field ablation catheter provided in this embodiment uses cold saline 80 to infuse and cool the treatment electrode 212, the cold saline 80 will be discharged to the vicinity of the treatment electrode 212 through the cooling gap 30, thereby increasing the contact area between the treatment electrode 212 and the blood 60. In addition, the cold saline 80 has a certain conductivity, and its impedance is generally lower than that of the blood 60. Therefore, the cold saline 80 can mix with the blood 60 near the treatment electrode 212 to form a mixed conductive solution 70, thereby reducing the treatment impedance of the treatment electrode 212, allowing the pulsed electric field generated on the treatment electrode 212 to act on the target tissue more easily, thereby improving the treatment effect of the treatment electrode 212.

[0062] In a specific embodiment, see Figure 7 As shown, in the case where the treatment electrode 212 provided in the present embodiment has a tip 90, the pulsed electric field ablation catheter provided in the present embodiment can coat the tip 90 in the form of water droplets by discharging cold saline 80 from the cooling gap 30 to the vicinity of the treatment electrode 212, thereby improving the uniformity of the electric field distribution on the end face of the treatment electrode 212 and the tip 90, and preventing spark discharge caused by uneven electric field distribution of the treatment electrode 212.

[0063] In summary, the pulsed electric field ablation catheter provided in this embodiment has at least the following beneficial technical effects: the pulsed electric field ablation catheter provided in this embodiment is configured such that the push-pull tube 12 is movably inserted into the main body, and the push-pull tube 12 is at least partially extended from the distal end of the main body tube 11, and the two ends of the expansion tube 21 are respectively connected to the distal end of the main body tube 11 and the distal end of the push-pull tube 12, so that the multiple branch tubes 211 located between the proximal end and the distal end of the expansion tube 21 provided in this embodiment can be deformed in the radial direction of the expansion tube 21 as the push-pull tube 12 moves, and by setting a plurality of branch tubes 211 to The treatment electrode 212 provided in this embodiment can be adjusted in the radial direction of the expansion tube 21 as the branch tube 211 is deformed. At the same time, a cooling gap 30 connected to the external environment is provided between the branch tube 211 and the treatment electrode 212, a first perfusion channel 111 is provided on the main tube 11, a second perfusion channel 2111 is provided on the branch tube 211, and the first perfusion channel 111 is connected to the second perfusion channel 2111, and the second perfusion channel 2111 is connected to the cooling gap 30, so that the cold saline in the first perfusion channel 111 can be poured into the main tube 111 through the cooling gap 30. The second perfusion channel 2111 is perfused into the cooling gap 30 between the branch tube 211 and the treatment electrode 212, and flows into the external environment, thereby cooling the treatment electrode 212. Compared with the pulsed electric field ablation catheter in the prior art, the pulsed electric field ablation catheter provided in this embodiment does not need to open a perfusion hole 2112 on the surface of the treatment electrode 212, so it can effectively avoid the phenomenon of spark discharge on the treatment electrode 212, and has high reliability. During the process of the pulsed electric field ablation catheter provided in this embodiment performing ablation operation on the target tissue, the cold saline 80 can pass through the cooling gap 3 0 is discharged to the vicinity of the treatment electrode 212 and mixed with the blood near the treatment electrode 212, thereby reducing the treatment impedance of the treatment electrode 212, so that the pulsed electric field generated on the treatment electrode 212 can act on the target tissue more easily, and when the treatment electrode 212 has a tip 90, the cold saline 80 discharged from the cooling gap 30 to the vicinity of the treatment electrode 212 can also coat the tip 90 in the form of water droplets, thereby improving the uniformity of the electric field distribution on the end face of the treatment electrode 212 and the tip 90, and preventing the spark discharge phenomenon caused by the uneven electric field distribution of the treatment electrode 212.

[0064] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A pulsed electric field ablation catheter, characterized in that: The pulsed electric field ablation catheter comprises: A tube body (10), the tube body (10) comprising a main body tube (11) and a push-pull tube (12), the push-pull tube (12) being movably arranged inside the main body tube (11) and at least partially extending from the distal end of the main body tube (11); An expansion part (20), the expansion part (20) comprising an expansion tube (21), a plurality of branch tubes (211) being formed between the proximal end and the distal end of the expansion tube (21), the plurality of branch tubes (211) being arranged at intervals along the circumference of the expansion tube (21), the proximal end of the expansion tube (21) being connected to the distal end of the main tube (11), and the distal end of the expansion tube being connected to the distal end of the push-pull tube (12); At least one treatment electrode (212) is arranged on the branch tube (211), and a cooling gap (30) connected to the external environment is provided between the branch tube (211) and the treatment electrode (212); a first perfusion channel (111) is provided on the main tube (11), and a second perfusion channel (2111) is provided on the branch tube (211); the first perfusion channel (111) is connected to the second perfusion channel (2111), and the second perfusion channel (2111) is connected to the cooling gap (30).

2. The pulsed electric field ablation catheter according to claim 1, characterized in that: The expansion tube (21) is sleeved on the push-pull tube (12), and the expansion part (20) also includes a first sealing member (22). The first sealing member (22) is arranged on the proximal end of the expansion tube (21) and is located between the expansion tube (21) and the push-pull tube (12), and is used to seal the gap between the expansion tube (21) and the push-pull tube (12).

3. The pulsed electric field ablation catheter according to claim 2, characterized in that: The tube body (10) further comprises a connecting tube (13), the two ends of which are respectively sleeved on the proximal end of the expansion tube (21) and the distal end of the main tube (11), and are used to connect the expansion tube (21) and the main tube (11).

4. The pulsed electric field ablation catheter according to claim 3, characterized in that: A diversion cavity (40) is formed between the proximal end of the expansion tube (21), the distal end of the main tube (11) and the inner wall of the connecting tube (13), and the first perfusion channel (111) and the second perfusion channel (2111) can be connected through the diversion cavity (40).

5. The pulsed electric field ablation catheter according to claim 1, characterized in that: The branch pipe (211) is provided with a perfusion hole (2112), the position of the perfusion hole (2112) corresponds to the position of the treatment electrode (212), and is used to connect the second perfusion channel (2111) and the cooling gap (30).

6. The pulsed electric field ablation catheter according to claim 5, characterized in that: A cooling recess is provided on the outer wall of the branch tube (211), and the position of the cooling recess corresponds to the position of the treatment electrode (212). The cooling gap (30) is formed between the cooling recess and the treatment electrode (212), and the two ends of the perfusion hole (2112) are respectively connected to the cooling recess and the second perfusion channel (2111).

7. The pulsed electric field ablation catheter according to claim 6, characterized in that: The treatment electrode (212) is an annular electrode, which is sleeved on the branch tube (211). There are multiple cooling recesses and multiple perfusion holes (2112). The multiple cooling recesses are arranged at intervals along the circumference of the branch tube (211), and the multiple perfusion holes (2112) correspond one-to-one to the multiple cooling recesses.

8. The pulsed electric field ablation catheter according to claim 2, characterized in that: The first sealing member (22) comprises a sealing tube, the sealing tube is passed through the expansion tube (21) and sleeved on the push-pull tube (12), the outer wall of the sealing tube is fixedly connected to the inner wall of the expansion tube (21), and the inner wall of the sealing tube abuts against the outer wall of the push-pull tube (12).

9. The pulsed electric field ablation catheter according to any one of claims 1 to 8, characterized in that: A plurality of treatment electrodes (212) are arranged on the branch tube (211), and the plurality of treatment electrodes (212) are arranged at intervals along the extension direction of the branch tube (211).

10. The pulsed electric field ablation catheter according to any one of claims 1 to 8, characterized in that: The expansion portion (20) further comprises a second sealing member (23), wherein the second sealing member (23) is arranged on the distal end of the expansion tube (21) and is used to seal the distal end of the second perfusion channel (2111).

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