Composite chitosan hemostatic dressing

Abstract

The utility model provides a composite chitosan hemostatic dressing. The hemostatic dressing comprises a back lining layer, a hemostatic layer is arranged on the back lining layer, a gel layer is arranged on the hemostatic layer, an easy-to-tear layer is arranged on the gel layer, the back lining layer is a polyurethane film coated with a pressure-sensitive adhesive, the hemostatic layer is a non-woven fabric with chitosan particles loaded on the surface, and the gel layer is a composite woven fabric. The gel layer is arranged on the hemostasis layer, when the gel layer makes contact with a wound, the gel layer can rapidly absorb surface blood to form gel, the gel layer is made to present a uniform porous structure, the pain feeling of nerve endings can be relieved, and the porous structure further ensures that the hemostasis layer makes direct contact with the wound to achieve the hemostasis effect; meanwhile, chitosan particles on the surface of the hemostasis layer are prevented from falling off, and the risk of thrombus is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of hemostatic materials, in particular to a composite chitosan hemostatic dressing. Background Art

[0002] Blood is an important substance for maintaining life. The blood volume of an adult accounts for about 8% of body weight. If the amount of bleeding reaches 40% (1600mL) of the total blood volume or more, severe shock symptoms may occur, which may endanger life at any time. Therefore, shortening the time of hemostasis and reducing the amount of bleeding are effective ways to improve the survival rate of patients with massive bleeding. To this end, under the guidance of the hemostasis mechanism, people have developed and clinically used a variety of advanced hemostatic materials and hemostatic technologies.

[0003] Chitosan has excellent hemostatic effects and is widely used in various hemostatic materials because it has a positive charge and can absorb and aggregate red blood cells and platelets to form primary thrombi, and can form a gel-like substance to adhere to wounds, and is independent of its own coagulation mechanism. In order to prevent chitosan particles from falling during transportation and handling, existing hemostatic materials cover chitosan gauze with water-soluble polyvinyl alcohol fibers through intermittent sutures, but there is still a risk of particle falling and thrombosis in actual application. In addition, chitosan gauze will form a solid clot-gauze complex after absorbing blood, causing the gauze to stick to the wound, and the wound is often torn when the dressing is removed, causing secondary bleeding and pain. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a composite chitosan hemostatic dressing to solve the problems that chitosan particles are easy to fall off and gauze adheres to the wound.

[0005] To solve the above technical problems, the technical solution of this novel invention is as follows:

[0006] A composite chitosan hemostatic dressing comprises a backing layer, a hemostatic layer is arranged on the backing layer, a gel layer is arranged on the hemostatic layer, an easy-tear layer is arranged on the gel layer, the backing layer is a polyurethane film coated with a pressure-sensitive adhesive, the hemostatic layer is a non-woven fabric with chitosan particles loaded on the surface, and the gel layer is a composite woven fabric.

[0007] Optionally, the chitosan particles are bonded to the surface of the non-woven fabric.

[0008] Optionally, the chitosan particles are bonded to the surface of the non-woven fabric via a polyacrylate pressure-sensitive adhesive or a polyurethane pressure-sensitive adhesive.

[0009] Optionally, the loading amount of chitosan particles on the hemostatic layer is 40-100 g / m 2 .

[0010] Optionally, the length of the hemostatic layer is smaller than the length of the backing layer, and the width of the hemostatic layer is smaller than the width of the backing layer.

[0011] Optionally, the length of the gel layer is equal to the length of the hemostatic layer, and the width of the gel layer is equal to the width of the hemostatic layer.

[0012] Optionally, the non-woven fabric is made of absorbent cotton or viscose non-woven fabric.

[0013] Optionally, the gel layer is a twill weave formed by alternating water-soluble polyvinyl alcohol yarns and water-soluble chitosan yarns as warp and weft yarns.

[0014] Optionally, the diameters of the water-soluble polyvinyl alcohol yarn and the water-soluble chitosan yarn are both 1-3 mm.

[0015] Optionally, the easy-tear layer is composed of release paper.

[0016] The above solution of the utility model includes at least the following beneficial effects:

[0017] In the above scheme of the utility model, a gel layer is provided on the hemostatic layer. When the gel layer contacts the wound, it will quickly absorb the surface blood to form a gel, so that the gel layer presents a uniform porous structure, which can not only reduce the pain of nerve endings, but also ensure that the hemostatic layer is in direct contact with the wound to exert a hemostatic effect, while avoiding the falling of chitosan particles on the surface of the hemostatic layer and the risk of causing thrombosis. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic structural diagram of the composite chitosan hemostatic dressing of the utility model.

[0019] Description of reference numerals: 1 - backing layer, 2 - hemostatic layer, 3 - gel layer, 4 - tearable layer. DETAILED DESCRIPTION

[0020] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0021] like Figure 1As shown, an embodiment of the utility model proposes a composite chitosan hemostatic dressing, comprising a backing layer 1, a hemostatic layer 2 is provided on the backing layer 1, a gel layer 3 is provided on the hemostatic layer 2, and an easy-tear layer 4 is provided on the gel layer 3. The backing layer 1 is a polyurethane film coated with a pressure-sensitive adhesive, the hemostatic layer 2 is a non-woven fabric with chitosan particles loaded on the surface, and the gel layer 3 is a composite woven fabric.

[0022] The composite chitosan hemostatic dressing proposed in the embodiment of the utility model has a gel layer on the hemostatic layer. When the gel layer contacts the wound, it will quickly absorb the surface blood to form a gel, so that the gel layer presents a uniform porous structure, which can not only reduce the pain of nerve endings, but also ensure that the hemostatic layer is in direct contact with the wound to exert a hemostatic effect, while avoiding the falling of chitosan particles on the surface of the hemostatic layer and the risk of causing thrombosis.

[0023] In an optional embodiment of the present invention, the chitosan particles are bonded to the surface of the non-woven fabric.

[0024] Specifically, chitosan particles are fixed to the surface of non-woven fabrics by medical pressure-sensitive adhesives. Medical pressure-sensitive adhesives are mainly made by reacting polyether polyols, polyester polyols or a mixture of the two with toluene, etc. This product is a solvent-based pressure-sensitive adhesive. Medical pressure-sensitive adhesives are odorless, have little skin irritation, have low adhesion and are easy to peel off, and are biodegradable. Medical pressure-sensitive adhesives are a lightweight, easy-to-use fixing material with a pore structure that allows the skin to breathe and helps heal skin wounds. The hemostatic layer formed by fixing chitosan particles on the surface of non-woven fabrics with medical pressure-sensitive adhesives can prevent chitosan particles from falling off, and the chitosan particles play a major hemostatic role when in use.

[0025] In an optional embodiment of the present invention, the backing layer 1 is a polyurethane film coated with a medical pressure-sensitive adhesive.

[0026] In an optional embodiment of the present invention, the chitosan particles are bonded to the surface of the non-woven fabric by polyacrylate pressure-sensitive adhesive or polyurethane pressure-sensitive adhesive.

[0027] Here, polyacrylate pressure-sensitive adhesive is resistant to low and high temperatures, has low condensable volatiles and mass loss rate, and no harmful gas escapes; polyurethane pressure-sensitive adhesive has excellent bonding properties and good durability. Polyacrylate pressure-sensitive adhesive or polyurethane pressure-sensitive adhesive can be selected as the medical pressure-sensitive adhesive for the hemostatic layer according to actual needs to improve the life and performance of the composite chitosan hemostatic dressing.

[0028] In an optional embodiment of the present invention, the loading amount of chitosan particles on the hemostatic layer 2 is 40-100 g / m 2 .

[0029] Specifically, since the composite chitosan hemostatic dressing needs to play a major hemostatic role through chitosan particles when in use, it is necessary to select a suitable loading amount to fix the chitosan particles on the gauze of the hemostatic layer to improve the hemostatic performance.

[0030] like Figure 1 As shown, in an optional embodiment of the present invention, the length of the hemostatic layer 2 is smaller than the length of the backing layer 1 , and the width of the hemostatic layer 2 is smaller than the width of the backing layer 1 .

[0031] It should be noted that when the hemostatic layer and the backing layer are both rectangular, the length, width and area of ​​the hemostatic layer are all smaller than the length, width and area of ​​the backing layer; when the hemostatic layer and the backing layer are both circular, the diameter of the hemostatic layer is smaller than the diameter of the backing layer. The above shapes are only for illustration. The hemostatic layer and the backing layer can be of the same shape or of different shapes. However, in the optimal embodiment, the hemostatic layer is arranged in the middle of the backing layer, and the overall size of the hemostatic layer is smaller than the overall size of the backing layer to ensure that the backing layer has space to be attached to the skin. It is convenient to attach the dressing to the wound to avoid sticking to the wound. Since the size of the hemostatic layer is smaller than the size of the backing, the medical pressure-sensitive adhesive around the backing layer can be used to fix the dressing to the wound during use.

[0032] like Figure 1 As shown, in an optional embodiment of the present invention, the length of the gel layer 3 is equal to the length of the hemostatic layer 2 , and the width of the gel layer 3 is equal to the width of the hemostatic layer 2 .

[0033] It should be noted that when the gel layer and the hemostatic layer are both rectangular, the length, width and area of ​​the gel layer and the hemostatic layer are the same; when the gel layer and the hemostatic layer are both circular, the diameter of the gel layer is smaller than the diameter of the hemostatic layer. The above shapes are only for illustration, and the gel layer and the hemostatic layer can be the same shape or different shapes, as long as the size of the gel layer and the hemostatic layer is the same, so as to give full play to the role of the chitosan particles.

[0034] In an optional embodiment of the present invention, the non-woven fabric is made of absorbent cotton or viscose non-woven fabric.

[0035] Specifically, absorbent cotton has the advantages of good water absorption, good sterility, softness and comfort. The non-woven fabric of the hemostatic layer made of absorbent cotton can improve the usage experience and safety. Viscose non-woven fabric has the advantages of good air permeability, softness and comfort, good moisture absorption and strong waterproof ability. The use of viscose non-woven fabric in the hemostatic layer is beneficial to improving the air permeability and waterproof function.

[0036] The hemostatic layer uses acrylic medical pressure-sensitive adhesive or polyurethane medical pressure-sensitive adhesive to load chitosan particles onto the surface of absorbent cotton or viscose non-woven fabric. When used, the chitosan particles play a major role in hemostasis. The loading amount is 40-100g / m 2 , can be used to stop bleeding at puncture sites, lacerations, cuts and other wounds of varying degrees.

[0037] In an optional embodiment of the present invention, the gel layer 3 is a twill weave formed by alternating water-soluble polyvinyl alcohol yarns and water-soluble chitosan yarns as warp and weft yarns.

[0038] Here, the gel layer is made of water-soluble polyvinyl alcohol yarn and water-soluble chitosan yarn. When in use, the water-soluble polyvinyl alcohol yarn dissolves, and the water-soluble chitosan yarn contacts the blood on the wound surface to form a gel, so that the gel layer 3 as a whole presents a uniform porous structure. The gel layer can not only serve as a barrier to reduce the pain of nerve endings, but also avoid the falling of chitosan particles on the surface of the hemostatic layer and the risk of causing thrombosis. The porous structure it presents can also make the hemostatic layer directly contact the wound to exert a hemostatic effect. When changing the dressing, it can also effectively prevent the traditional gauze solid clot-gauze complex from adhering to the wound.

[0039] In an optional embodiment of the present invention, the weight of the non-woven fabric of the hemostatic layer 2 is 90-200 g / m 2 .

[0040] Set the weight of the hemostatic layer nonwoven fabric to 90-200g / m 2 It can provide certain support and auxiliary hemostasis for the dressing, ensuring that the dressing can maintain its shape after absorbing blood. At the same time, it can reduce the overall weight of the dressing and improve the comfort of use.

[0041] In an optional embodiment of the present invention, the loading area of ​​the chitosan particles on the hemostatic layer 2 is smaller than the size of the non-woven fabric of the hemostatic layer 2 .

[0042] It should be noted that the load area of ​​the hemostatic layer chitosan particles is less than the overall area of ​​the hemostatic layer non-woven fabric. Specifically, the load position of the chitosan particles is located in the central area of ​​the non-woven fabric, and there is a distance of 4-8mm around the non-woven fabric, so that the gel layer can be bonded to the surroundings of the non-woven fabric that is not loaded with chitosan particles by hot pressing. When in use, the falling of chitosan particles can be avoided to form thrombi and the clot-gauze composite of the hemostatic layer can be prevented from adhering to the wound, and there is no need to introduce complex production equipment and other raw materials by hot pressing bonding, so as to reduce costs. Avoid excessive load area, chitosan particles fall off from the non-woven fabric. At the same time, it is convenient to fix the non-woven fabric of the gel layer and the hemostatic layer that is not loaded with chitosan particles.

[0043] In an optional embodiment of the present invention, the diameters of the water-soluble polyvinyl alcohol yarn and the water-soluble chitosan yarn are both 1-3 mm.

[0044] Specifically, the gel layer made of 1-3 mm water-soluble polyvinyl alcohol yarn and water-soluble chitosan yarn can give full play to the advantages of the porous structure and improve the performance of the dressing.

[0045] In an optional embodiment of the present invention, the easy-tear layer 4 is composed of release paper.

[0046] Specifically, the release paper mainly serves to isolate the gel layer from the outside world, prevent the gel layer and the hemostatic layer from being contaminated, and improve the safety of use. When in use, the easy-tear layer can be directly removed.

[0047] In an optional embodiment of the utility model, the thickness of the polyurethane film coated with medical pressure-sensitive adhesive on the backing layer 1 is 0.04-0.08mm, which can fix the dressing on the wound site and has the function of waterproofing and antibacterial. There is no requirement for its specific size, and it can be adapted to wounds of various shapes according to actual needs, and the application scenarios are more extensive.

[0048] In an optional embodiment of the present invention, the gel layer 3 and the non-woven fabric of the hemostatic layer 2 not loaded with chitosan are bonded by heat pressing.

[0049] The hot pressing bonding method does not require the introduction of complex production equipment and other raw materials, which helps to reduce costs.

[0050] When using the composite chitosan hemostatic dressing of the embodiment of the utility model, the outer packaging is opened and the dressing is taken out, the easy-tear layer 4 is directly peeled off, and then the gel layer 3 in the central area of ​​the dressing is covered on the wound surface and the edge of the backing layer 1 is pressed and smoothed, and the dressing is fixed to the skin around the wound by the pressure-sensitive adhesion effect of the pressure-sensitive adhesive, and the dressing can be peeled off after the wound is completely hemostatic.

[0051] The composite chitosan hemostatic dressing of the utility model embodiment has the following advantages:

[0052] (1) The polyurethane film coated with medical pressure-sensitive adhesive on the backing layer can be used to adhere and fix the dressing to the skin surface through the pressure-sensitive adhesion of the pressure-sensitive adhesive, thereby achieving waterproof and antibacterial effects and being easy to remove.

[0053] (2) The non-woven fabric loaded with chitosan particles in the hemostatic layer plays a major role in rapid hemostasis. The main mechanism is that chitosan particles quickly absorb water from the blood, increase the concentration of red blood cells, platelets and other blood cells in a short period of time, and quickly aggregate and coagulate. They also use their positive charge to produce electrostatic adsorption with red blood cells in the blood to aggregate red blood cells and exert excellent hemostatic effects. Because it does not rely on the coagulation mechanism and is not affected by the function and number of platelets, it is also suitable for people with coagulation disorders. In addition, no heat is released during the hemostasis process, avoiding secondary damage to the wound.

[0054] (3) When the gel layer comes into contact with the wound, the water-soluble polyvinyl alcohol yarn therein dissolves directly, and the water-soluble chitosan yarn quickly absorbs the surface blood to form a thin layer of gel, so that the gel layer presents a uniform porous structure. This not only reduces the pain of nerve endings, but also ensures that the hemostatic layer is in direct contact with the wound to exert a hemostatic effect. At the same time, it avoids the falling of chitosan particles on the surface of the hemostatic layer and the risk of causing thrombosis. It can also effectively prevent the adhesion of the traditional gauze solid clot-gauze complex to the wound when changing the dressing.

[0055] (4) The tear-away layer isolates the hemostatic layer, gel layer, and the side of the backing layer that contacts the hemostatic layer from the outside world, thereby protecting the dressing, preventing contamination of the dressing, and improving the safety of the dressing.

[0056] The composite chitosan hemostatic dressing of the utility model embodiment has a simple structure and is easy to use, and solves the problem that particles falling off during the use of traditional chitosan gauze easily cause thrombosis and the solid clot-gauze composite easily adheres to the wound.

[0057] The above is a preferred embodiment of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A composite chitosan hemostatic dressing, characterized in that: The invention comprises a backing layer (1), a hemostatic layer (2) is provided on the backing layer (1), a gel layer (3) is provided on the hemostatic layer (2), an easy-tear layer (4) is provided on the gel layer (3), the backing layer (1) is a polyurethane film coated with a pressure-sensitive adhesive, the hemostatic layer (2) is a non-woven fabric with chitosan particles loaded on the surface, and the gel layer (3) is a composite woven fabric.

2. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The chitosan particles are bonded to the surface of the non-woven fabric.

3. The composite chitosan hemostatic dressing according to claim 2, characterized in that: The chitosan particles are bonded to the surface of the non-woven fabric through polyacrylate pressure-sensitive adhesive or polyurethane pressure-sensitive adhesive.

4. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The loading amount of chitosan particles on the hemostatic layer (2) is 40-100 g / m 2 .

5. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The length of the hemostatic layer (2) is smaller than the length of the backing layer (1), and the width of the hemostatic layer (2) is smaller than the width of the backing layer (1).

6. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The length of the gel layer (3) is equal to the length of the hemostatic layer (2), and the width of the gel layer (3) is equal to the width of the hemostatic layer (2).

7. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The non-woven fabric is made of absorbent cotton or viscose non-woven fabric.

8. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The gel layer (3) is a twill weave formed by alternating water-soluble polyvinyl alcohol yarns and water-soluble chitosan yarns as warp and weft yarns.

9. The composite chitosan hemostatic dressing according to claim 8, characterized in that: The diameters of the water-soluble polyvinyl alcohol yarn and the water-soluble chitosan yarn are both 1-3 mm.

10. The composite chitosan hemostatic dressing according to claim 1, characterized in that: The easy-tear layer (4) is composed of release paper.

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