Full-automatic antibody incubation device

Abstract

The utility model provides a full-automatic antibody incubation device, which relates to the field of antibody incubation devices, and comprises a full-automatic antibody incubation instrument, the full-automatic antibody incubation instrument comprises a shell, an antibody incubation tank is arranged in the shell, a reagent tube rack is arranged on the lower side of the antibody incubation tank, a cleaning tube is arranged on the upper side of the antibody incubation tank, and the reagent tube rack is connected with the cleaning tube. The upper end of the cleaning pipe is connected with a water supply pipe, the other end of the water supply pipe is connected with a water pump and a water tank, the upper end face of the reagent pipe frame is provided with a transverse flow groove and a longitudinal flow groove, one side of the reagent pipe frame is connected with a driving shaft, the outer end of the driving shaft is connected with a motor, and the bottom of the full-automatic antibody incubation instrument is connected with suction cup supporting legs. The upper ends of the sucker supporting legs are connected with connecting air pipes, and the outer ends of the connecting air pipes are connected with vacuum pumps. The full-automatic antibody incubation instrument solves the problems that an existing full-automatic antibody incubation instrument lacks a stable fixing structure, and an antibody incubation groove is inconvenient to clean.

Description

Technical Field

[0001] The utility model relates to the technical field of antibody incubation devices, in particular to a full-automatic antibody incubation device. Background Art

[0002] In protein-related laboratories, there are many experiments involving immune responses of various antibodies. In these experiments, specific antibodies need to react in contact with supports such as membranes that carry the experimenter's specific proteins. In addition, this type of reaction process involves the sequential reactions of various antibodies and multiple washing steps. The entire experiment has many repetitive operations and takes a long time. After searching, the prior art (publication number: CN215866709U) records "a fully automatic antibody incubator, including a mainframe housing, a pipetting assembly, a reagent tube rack, a gun head rack, a shaker, a control circuit and a liquid pipeline. The pipetting assembly includes a pipetting arm and a three-axis motion module. The three-axis motion module drives the pipetting arm to move in three directions: up and down, left and right, and front and back. The pipetting arm is equipped with a sample gun and a liquid discharge port. The liquid discharge port is connected to multiple groups of injection components through pipelines. Multiple antibody incubation tanks are arranged on the shaker, and a waste liquid collection tank is arranged outside the shaker. The waste liquid collection tank is connected to the interface position of the waste liquid discharge port through a pipeline. A power switch and a display screen controller are arranged on the mainframe housing. The incubator can automatically complete the steps of sealing, membrane washing, primary antibody incubation, secondary antibody incubation, etc. in one device, saving a lot of manpower and time, and improving the efficiency and progress of the entire experiment."

[0003] Although the fully automatic antibody incubator in the prior art has achieved improved test efficiency and progress, there are still some shortcomings: the antibody incubation tank involved in the existing fully automatic antibody incubator needs to maintain the overall stability of the device when in use, and the bottom of the existing instrument lacks a stable fixed structure, which causes accidental contact and slight movement, which can easily affect the disorder of the automated operation process, especially during the injection of reagents; secondly, the antibody incubation tank is not easy to clean after use, and the cleaned sewage is not easy to discharge. Utility Model Content

[0004] In order to overcome the defects of the prior art, a fully automatic antibody incubation device is now provided to solve the problem that the existing fully automatic antibody incubator lacks a stable fixed structure and is inconvenient to clean the antibody incubation tank.

[0005] To achieve the above-mentioned purpose, a fully automatic antibody incubation device is provided, comprising: a fully automatic antibody incubator, the fully automatic antibody incubator comprising a shell, and an antibody incubation tank is arranged inside the shell, and a reagent tube rack is arranged on the lower side of the antibody incubation tank, a cleaning pipe is arranged on the upper side of the antibody incubation tank, and the upper end of the cleaning pipe is connected to a water supply pipe, and the other end of the water supply pipe is connected to a water pump and a water tank, a transverse flow groove and a longitudinal flow groove are arranged on the upper end surface of the reagent tube rack, and a driving shaft is connected to one side of the reagent tube rack, and a motor is connected to the outer end of the driving shaft, a suction cup support foot is connected to the bottom of the fully automatic antibody incubator, and a connecting air pipe is connected to the upper end of the suction cup support foot, and a vacuum pump is connected to the outer end of the connecting air pipe.

[0006] Furthermore, two installation grooves are provided on one side of the shell of the fully automatic antibody incubator, and the water tank and the vacuum pump are respectively installed in the two installation grooves.

[0007] Furthermore, an electric push rod is installed on the rear side wall of the fully automatic antibody incubator, and the front end of the electric push rod is connected to the cleaning tube, and a plurality of nozzles are connected to the lower end of the cleaning tube at equal intervals.

[0008] Furthermore, both ends of the cleaning tube are connected with guide sleeves, and the guide sleeves are slidably connected with guide rods, and the rear end of the guide rods is vertically fixed to the rear inner wall of the fully automatic antibody incubator.

[0009] Furthermore, a test tube placement groove is opened on the upper side of the inner part of the reagent tube rack, and the transverse flow groove and the longitudinal flow groove are arranged in the gap of the test tube placement groove, and the transverse flow groove is vertically connected to the longitudinal flow groove, and the front end of the longitudinal flow groove extends to the outer edge of the reagent tube rack.

[0010] Furthermore, support plates are provided on both sides of the reagent tube rack, and the drive shaft rotates through the support plate on one side to be connected to the motor, and a rotating shaft is connected to the side of the reagent tube rack away from the motor, and the outer end of the rotating shaft is rotatably connected to the support plate.

[0011] Furthermore, the suction cup legs are configured as rubber suction cup structures installed at the four corners of the lower side of the fully automatic antibody incubator, and the rubber suction cups are all connected to the vacuum pump via connecting air pipes.

[0012] The beneficial effects of the utility model are:

[0013] 1. The suction cup foot installed at the lower end of the fully automatic antibody incubator is connected to the air pipe and the vacuum pump, so that the suction air flow of the vacuum pump is controlled, so that the suction cup foot maintains continuous suction on the desktop, thereby preventing the automatic antibody incubator from moving when accidentally touched, causing the disorder of the automatic operation process, thereby enhancing the stability of the instrument;

[0014] 2. During cleaning, first start the electric push rod to move the cleaning tube forward to the top of the antibody incubation tank through the guide rod and the guide sleeve, then start the water pump to pump the clean water in the water tank to the cleaning tube, and then spray it into the antibody incubation tank through the nozzle, and then use the shaker mechanism connected to the lower end of the antibody incubation tank to make the clean water vibrate and clean in the antibody incubation tank, and then start the motor so that the drive shaft drives the reagent tube rack to flip a certain angle as a whole, so that the sewage in the antibody incubation tank can be dumped out and collected through the pre-placed container. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a front view structural schematic diagram of a fully automatic antibody incubator according to an embodiment of the present utility model.

[0016] Figure 2 This is a schematic diagram of the top view of the reagent tube rack according to an embodiment of the utility model.

[0017] Figure 3 It is a partial side sectional structural schematic diagram of the fully automatic antibody incubator according to an embodiment of the utility model.

[0018] Figure 4 It is a schematic top view of the cleaning pipe structure of an embodiment of the utility model.

[0019] In the figure: 1. Fully automatic antibody incubator; 11. Antibody incubation tank; 12. Reagent tube rack; 121. Horizontal flow tank; 122. Vertical flow tank; 123. Drive shaft; 124. Motor; 125. Support plate; 2. Cleaning pipe; 21. Water supply pipe; 22. Water tank; 23. Electric push rod; 24. Nozzle; 25. Guide sleeve; 26. Guide rod; 3. Suction cup support foot; 31. Connecting air pipe; 32. Vacuum pump. DETAILED DESCRIPTION

[0020] Reference Figures 1 to 4As shown, the utility model provides a fully automatic antibody incubation device, including: a fully automatic antibody incubator 1, the fully automatic antibody incubator 1 includes a shell, and an antibody incubation tank 11 is arranged inside the shell, and a reagent tube rack 12 is arranged on the lower side of the antibody incubation tank 11, a cleaning pipe 2 is arranged on the upper side of the antibody incubation tank 11, and a water supply pipe 21 is connected to the upper end of the cleaning pipe 2, and a water pump and a water tank 22 are connected to the other end of the water supply pipe 21, a transverse flow slot 121 and a longitudinal flow slot 122 are opened on the upper end surface of the reagent tube rack 12, and a driving shaft 12 is connected to one side of the reagent tube rack 12. 23, and the outer end of the driving shaft 123 is connected to the motor 124, the bottom of the full-automatic antibody incubator 1 is connected to a suction cup support foot 3, and the upper end of the suction cup support foot 3 is connected to a connecting air pipe 31, and the outer end of the connecting air pipe 31 is connected to a vacuum pump 32, the suction cup support foot 3 is configured to be a rubber suction cup structure installed at the four corners of the lower side of the full-automatic antibody incubator 1, and the rubber suction cups are connected to the vacuum pump 32 through the connecting air pipe 31, and two installation grooves are opened on one side of the shell of the full-automatic antibody incubator 1, and the water tank 22 and the vacuum pump 32 are respectively installed in the two installation grooves.

[0021] In this embodiment, the fully automatic antibody incubator 1 and the internal antibody incubation tank 11 adopt the same structure involved in the comparative document under the prior art, and the fully automatic antibody incubator 1 also includes the same structure as in the prior art to realize a complete antibody incubation process.

[0022] Specifically, a transparent cover is provided on the front side of the fully automatic antibody incubator 1 to facilitate observation of the internal automated operation process.

[0023] Specifically, a shaker is connected to the lower end of the antibody incubation tank 11, which has the same structure and function as the shaker involved in the comparative document, so as to realize the front and rear end oscillation of the antibody incubation tank 11 and the tilting of one end of the antibody incubation tank 11. At the same time, when tilting, the inclined end is opposite to the upper and lower positions of the cross-flow tank 121.

[0024] As a preferred embodiment, by providing the suction cup support 3 and the connected vacuum pump 32, a sustainable negative pressure state is formed inside the rubber suction cup, thereby enhancing the stability of the instrument when the instrument is working.

[0025] like Figure 3 and Figure 4 As shown, an electric push rod 23 is installed on the rear side wall of the fully automatic antibody incubator 1, and the front end of the electric push rod 23 is connected to the cleaning tube 2, and a plurality of nozzles 24 are evenly spaced and connected to the lower end of the cleaning tube 2, guide sleeves 25 are connected to both ends of the cleaning tube 2, and a guide rod 26 is slidably connected inside the guide sleeve 25, and the rear end of the guide rod 26 is vertically fixed to the rear inner wall of the fully automatic antibody incubator 1.

[0026] As a preferred embodiment, by providing an electric push rod 23, a guide sleeve 25 and a guide rod 26, the cleaning tube 2 can be easily stored backwards when not in use, thereby avoiding affecting the automated operation of the fully automatic antibody incubator 1. When cleaning, the cleaning tube 2 can be pushed forwards.

[0027] like Figure 1 and Figure 2 As shown, a test tube placement groove is opened on the upper inner side of the reagent tube rack 12, and the transverse flow groove 121 and the longitudinal flow groove 122 are arranged in the gap of the test tube placement groove, and the transverse flow groove 121 is vertically connected to the longitudinal flow groove 122, and the front end of the longitudinal flow groove 122 extends to the outer edge of the reagent tube rack 12, and bracket plates 125 are arranged on both sides of the reagent tube rack 12, and the driving shaft 123 rotates through the bracket plate 125 on one side to be connected to the motor 124, and a rotating shaft is connected to the side of the reagent tube rack 12 away from the motor 124, and the outer end of the rotating shaft is rotatably connected to the bracket plate 125.

[0028] As a preferred embodiment, by setting up a motor 124 and a drive shaft 123, when the antibody incubation tank 11 is dumped with sewage after cleaning, the sewage can flow downward through the cross-flow groove 121 and the longitudinal flow groove 122 into a pre-placed container, thereby facilitating cleaning and making it easier to switch between different antibody incubation operations.

[0029] When in use, for cleaning, first start the electric push rod, so that the cleaning tube is moved forward to the top of the antibody incubation tank through the guide rod and the guide sleeve, and then start the water pump to pump the clean water in the water tank to the cleaning tube, and then spray it into the antibody incubation tank through the nozzle, and then through the shaking table mechanism connected to the lower end of the antibody incubation tank, the clean water is shaken and cleaned in the antibody incubation tank, and then start the motor so that the drive shaft drives the reagent tube rack to flip as a whole at a certain angle, so that the sewage in the antibody incubation tank can be poured out and collected through the pre-placed container.

[0030] The fully automatic antibody incubation device of the utility model can effectively solve the problems that the existing fully automatic antibody incubator lacks a stable fixed structure and is inconvenient to clean the antibody incubation tank. It achieves the improvement of the operational stability of the fully automatic antibody incubator and facilitates the cleaning of the antibody incubation tank on the basis of the existing fully automatic antibody incubator technology.

Claims

1. A fully automatic antibody incubation device, comprising: A fully automatic antibody incubator (1), the fully automatic antibody incubator (1) comprising a shell, an antibody incubation tank (11) being arranged inside the shell, and a reagent tube rack (12) being arranged at the lower side of the antibody incubation tank (11), characterized in that: a cleaning pipe (2) is arranged at the upper side of the antibody incubation tank (11), and the upper end of the cleaning pipe (2) is connected to a water supply pipe (21), and the other end of the water supply pipe (21) is connected to a water pump and a water tank (22), a transverse flow groove (121) and a longitudinal flow groove (122) are arranged at the upper end surface of the reagent tube rack (12), a driving shaft (123) is connected to one side of the reagent tube rack (12), and a motor (124) is connected to the outer end of the driving shaft (123), and a suction cup support foot (3) is connected to the bottom of the fully automatic antibody incubator (1), and the upper end of the suction cup support foot (3) is connected to a connecting air pipe (31), and the outer end of the connecting air pipe (31) is connected to a vacuum pump (32).

2. A fully automatic antibody incubation device according to claim 1, characterized in that: Two installation grooves are provided on one side of the housing of the fully automatic antibody incubator (1), and the water tank (22) and the vacuum pump (32) are respectively installed in the two installation grooves.

3. A fully automatic antibody incubation device according to claim 1, characterized in that: An electric push rod (23) is installed on the rear side wall of the fully automatic antibody incubator (1), and the front end of the electric push rod (23) is connected to the cleaning tube (2), and a plurality of nozzles (24) are connected to the lower end of the cleaning tube (2) at equal intervals.

4. A fully automatic antibody incubation device according to claim 1, characterized in that: Both ends of the cleaning tube (2) are connected to guide sleeves (25), and the guide sleeves (25) are slidably connected to guide rods (26) inside, and the rear end of the guide rods (26) is vertically fixed to the rear inner wall of the fully automatic antibody incubator (1).

5. A fully automatic antibody incubation device according to claim 1, characterized in that: A test tube placement groove is provided on the upper inner side of the reagent tube rack (12), and the transverse flow groove (121) and the longitudinal flow groove (122) are provided in the gap between the test tube placement grooves, and the transverse flow groove (121) is vertically connected to the longitudinal flow groove (122), while the front end of the longitudinal flow groove (122) extends to the outer edge of the reagent tube rack (12).

6. A fully automatic antibody incubation device according to claim 1, characterized in that: Support plates (125) are provided on both sides of the reagent tube rack (12), and the driving shaft (123) rotates through the support plate (125) on one side to be connected to the motor (124), and a rotating shaft is connected to the side of the reagent tube rack (12) away from the motor (124), and the outer end of the rotating shaft is rotatably connected to the support plate (125).

7. A fully automatic antibody incubation device according to claim 1, characterized in that: The suction cup legs (3) are configured as rubber suction cup structures installed at the four corners of the lower side of the fully automatic antibody incubator (1), and the rubber suction cups are connected to the vacuum pump (32) via connecting air pipes (31).

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