Implantable drug delivery device

Abstract

The utility model relates to an implantable dosing device. The implantable dosing device comprises an injection seat, a puncture pad and a liquid medicine cavity, the puncture pad seals an upper opening of the liquid medicine cavity and is used for inserting a puncture needle so as to introduce liquid medicine into the liquid medicine cavity; the puncture pad is made of a puncture-resistant material, and the injection seat extends downwards from the peripheral surface of the side part of the puncture pad to wrap the whole bottom surface of the liquid medicine cavity; the liquid medicine cavity is provided with a connecting pipe used for guiding liquid medicine into a catheter, and the connecting pipe penetrates out of the side portion of the injection base. The puncture pad is in interference fit with the opening of the liquid medicine cavity to seal the opening of the liquid medicine cavity. The connection between the puncture pad and the inner wall of the liquid medicine cavity is tighter and firmer through interference fit, the sealing performance and the pressure resistance of the puncture pad are enhanced, and the situations of loosening and medicine leakage are avoided.

Description

Technical Field

[0001] The present disclosure relates to the technical field of medical devices, and in particular to an implantable drug delivery device. Background Art

[0002] An implantable drug delivery device (infusion port) is an infusion device that is completely placed in the body to reduce drug stimulation to the patient's blood vessels. It is suitable for patients who need long-term infusion and injection of contrast agents, and patients who use chemotherapy drugs for a long time. The implantable drug delivery device is mainly composed of an injection seat and a venous catheter system. It establishes a long-term vascular channel in the body, which can avoid repeated injections for patients, reduce the risk of infection and thrombosis in patients, and has a long service life and simple maintenance, which greatly improves the quality of life of patients. There are various optimized and improved implantable drug delivery devices on the market.

[0003] For example, CN202020988408.5 discloses an implantable drug delivery device, in which a soft rubber pad is provided on the top of the injection seat, and the bottom and the surrounding surface are wrapped with an outer soft rubber layer, and the soft rubber pad and the outer soft rubber layer constitute a fully wrapped elastic shell of the injection seat. Its catheter passes through the outer soft rubber layer and is connected to the interface on the surrounding surface of the injection seat. In this scheme, due to the wrapping of the soft rubber layer and the provision of the soft rubber pad, the overall appearance of the injection seat is soft and has a certain degree of elasticity, which can reduce the patient's foreign body sensation after implantation, and reduce the types of materials in contact with human tissues, and has better compatibility with the human body.

[0004] CN202211280530.7 provides an implantable intravenous drug delivery device provided with a circuit board, an electromagnetic induction coil and a near-infrared LED lamp. The near-infrared LED lamp in the device facilitates imaging through existing infrared imaging technology to achieve positioning of multiple light sources, thereby providing intuitive puncture guidance for medical staff. For another example, in the implantable drug delivery device of CN202020979790.3, the catheter is clamped by the combination of the outer undercut on the outer circumference of the injection seat handle and the inner undercut on the inner circumference of the catheter lock, which can effectively prevent the catheter from falling off and improve clinical safety.

[0005] The above and similar schemes improve the adaptability and convenience between the implantable drug delivery device and the human body from different angles. However, in most existing implantable drug delivery devices, the soft rubber pad used to insert the puncture needle is directly fixed on the top of the drug liquid chamber, and the pressure resistance is not strong enough. Long-term use may affect the sealing and cause loosening and drug leakage, which brings limitations to clinical use. Utility Model Content

[0006] The purpose of the present invention is to improve the sealing and pressure resistance of a soft rubber pad in an implantable drug delivery device.

[0007] To achieve the above objectives, the present disclosure provides the following technical solutions:

[0008] An implantable drug delivery device comprises an injection seat, a puncture pad and a drug solution chamber;

[0009] The puncture pad seals the upper opening of the drug liquid chamber and is used to insert a puncture needle to introduce the drug liquid into the drug liquid chamber;

[0010] The puncture pad is made of puncture-resistant material, and the injection seat extends downward from the side circumference of the puncture pad to wrap around the entire bottom surface of the drug liquid chamber;

[0011] The liquid medicine chamber is provided with a connecting tube for introducing the liquid medicine into the catheter, and the connecting tube passes through the side of the injection seat;

[0012] Wherein, the puncture pad seals the opening of the drug liquid chamber by interference fit with the opening of the drug liquid chamber.

[0013] Preferably, the inner hole of the connecting tube is level with the lowest point of the inner wall of the liquid medicine chamber.

[0014] More preferably, the bottom surface of the drug liquid chamber is provided with a drug liquid guide portion inclined toward the inner hole.

[0015] Preferably, the vertical section of the top of the injection seat is in the shape of a parabola with the opening facing downward.

[0016] More preferably, the injection seat has a streamlined curvature smoothly connected to the top end at least on the side opposite to the connecting tube.

[0017] Preferably, the injection seat is formed by curing epoxy resin.

[0018] Preferably, a first connecting portion extending horizontally outward is provided on the top circumference of the drug liquid chamber, and the puncture pad is provided with a wing portion covering the first connecting portion.

[0019] More preferably, the first connecting portion and the wing portion are respectively provided with a plurality of communicating through holes, and the epoxy resin flows through the through holes.

[0020] Preferably, the inner surface of the drug liquid chamber is provided with a second connecting portion in a continuous concave-convex shape, and the outer peripheral surface of the puncture pad is provided with an engaging portion engaged with the second connecting portion; or

[0021] The inner surface of the medicine liquid chamber is provided with continuous concave and convex shapes.

[0022] More preferably, the bottom center of the puncture pad is convex downward.

[0023] The technical solution claimed in the present disclosure has achieved the following beneficial effects:

[0024] 1) The connection between the puncture pad and the inner wall of the drug liquid chamber is made tighter and firmer through interference fit, thereby enhancing the pressure resistance and sealing of the puncture pad and avoiding loosening and drug leakage.

[0025] 2) The top of the injection seat with a downwardly opening parabolic shape forms an arc surface inclined toward the top of the puncture pad, which is conducive to applying force to the puncture pad;

[0026] The convex design at the bottom center of the puncture pad ensures that when the injection seat is under pressure, the liquid flow will press the puncture pad tightly against the inner wall of the medicine chamber, thereby increasing the sealing between the puncture pad and the medicine chamber and the pressure resistance of the puncture pad, while avoiding leakage.

[0027] 3) The inner hole of the connecting tube is set to be level with the lowest point of the inner wall of the medicine liquid chamber. Except for the inevitable wall adhesion, the medicine in the medicine liquid chamber will almost completely flow out along the pipeline of the connecting tube, thereby minimizing the dead space volume in the medicine liquid chamber and improving the utilization rate of expensive drugs (for example, chemotherapy drugs).

[0028] 4) The injection seat body is solidified and molded by epoxy resin, which makes the entire device more tightly and firmly combined to avoid leakage of drug solution; and various shapes can be naturally formed by epoxy resin, making the injection seat body molding method simpler and the molding cycle shorter; in addition, the streamlined design of the front end of the injection seat body reduces the volume of the device, making it easier to place the injection seat into the human body clinically.

[0029] 5) The perforated design of the puncture pad and the liquid medicine chamber allows the epoxy resin to flow through the perforations, and after curing and molding, the sealing between the puncture pad and the liquid medicine chamber is strengthened to prevent the puncture pad from loosening; the covering of the top of the liquid medicine chamber by the puncture pad also further strengthens the stability, pressure resistance and sealing of the connection between the puncture pad and the liquid medicine chamber. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the technical solutions in the embodiments of the present disclosure, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings in the following description are merely embodiments of the present disclosure, and a person of ordinary skill in the art can obtain other drawings based on the provided drawings without paying any creative work.

[0031] Figure 1 It is a cross-sectional schematic diagram of one embodiment of an implantable drug delivery device.

[0032] Figure 2 It is a cross-sectional schematic diagram of another embodiment of an implantable drug delivery device.

[0033] Figure 3 Schematic diagram of the explosion structure of the implantable drug delivery device.

[0034] Figure 4 Schematic diagram of the structure of the puncture pad.

[0035] Figure 5 It is a schematic diagram of the structure of the medicine liquid chamber.

[0036] Reference numerals:

[0037] 1-injection seat; 2-puncture pad; 3-drug solution cavity; 4-connecting tube; 5-top end; 6-first connecting part; 7-wing part; 8-perforation; 9-second connecting part; 10-clamp part. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and beneficial effects of the embodiments of the present disclosure clearer, the technical solution in the embodiments of the present disclosure will be clearly and completely described below in conjunction with the drawings in the embodiments of the present disclosure. Obviously, the described embodiments are part of the embodiments of the present disclosure, not all of the embodiments. Based on the embodiments of the present disclosure, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present disclosure.

[0039] Example 1

[0040] This embodiment provides an implantable drug delivery device.

[0041] Reference Figure 1 and attached Figures 3 to 5 The implantable drug delivery device in this embodiment includes an injection seat 1, a puncture pad 2 and a drug solution chamber 3.

[0042] In a preferred embodiment, the injection seat 1 body is formed by curing epoxy resin (AB glue), and various shapes can be naturally formed by epoxy resin, making the injection seat body molding method simpler and the molding cycle shorter; the puncture pad 2 is made of puncture-resistant material (such as silicone, rubber or any other soft puncture-resistant material), and the drug liquid chamber 3 can be integrally formed by 3D printing, and the material is preferably pure titanium or titanium alloy.

[0043] The puncture pad 2 is used to seal the upper opening of the drug liquid chamber 3, and the puncture pad 2 is used to insert the puncture needle to introduce the drug liquid into the drug liquid chamber. In this embodiment, the puncture pad seals the opening of the drug liquid chamber through an interference fit with the opening of the drug liquid chamber, so that the connection between the puncture pad and the inner wall of the drug liquid chamber is tighter and firmer, the pressure resistance of the puncture pad is enhanced, and drug leakage is avoided.

[0044] Reference Figure 1 The injection seat 1 extends downward from the side circumference of the puncture pad 2 and wraps around the entire bottom surface of the drug liquid chamber 3 to form the overall structure of the implantable drug delivery device.

[0045] In the preferred structure, the bottom center of the puncture pad 2 is designed to be convex with an arc surface, so when the injection seat 1 is under pressure, the drug flow will press the puncture pad 2 tightly against the inner wall of the drug chamber 3, increasing the sealing between the puncture pad 2 and the drug chamber 3, avoiding leakage and increasing the pressure resistance of the puncture pad.

[0046] The liquid medicine cavity 3 is provided with a connecting tube 4 for introducing liquid medicine into the catheter. In order to minimize the dead space volume in the liquid medicine cavity and to make sure that there is no residual liquid medicine in the liquid medicine cavity as much as possible, thereby improving the utilization rate of expensive drugs (e.g., chemotherapy drugs), in this embodiment, the inner hole of the connecting tube 4 is level with the lowest point of the inner wall of the liquid medicine cavity 3 and passes through the side of the injection seat 1.

[0047] In the exemplary structure, the connecting tube 4 can be horizontally connected to the side of the drug liquid chamber 3. At this time, the bottom of the drug liquid chamber 3 can be set to be horizontal, and the bottom surface of the inner hole of the connecting tube 4 and the bottom inner wall of the drug liquid chamber 3 are on the same horizontal plane. Except for the inevitable wall attachment, the drug liquid in the drug liquid chamber 3 will almost completely flow out along the pipeline of the connecting tube 4 and then be input into the patient's body through the catheter.

[0048] In a preferred structure, in order to reduce the volume of the implantable drug delivery device and make it easier to place the injection seat 1 into the human body during clinical operation, the injection seat 1 has a streamlined curvature as a whole. Among them, the vertical section of the top 5 of the injection seat 1 is a parabola with the opening facing downward. This structure can make the puncture pad 2 more stressed and prevent it from loosening during use. More preferably, the injection seat 1 has a streamlined curvature (for example, a curvature with the bottom end convex outward) that is smoothly connected to its top 5 on at least one side opposite to the connecting tube 4 (the front end of the injection seat).

[0049] In a preferred structure, in order to make the sealing between the puncture pad 2 and the liquid medicine chamber 3 stronger, a first connecting portion 6 extending horizontally outward is provided on the top circumference of the liquid medicine chamber 3, and the puncture pad 2 is provided with a wing portion 7 covering the first connecting portion 6. In the exemplary structure, the wing portion 7 is arranged in a U-shaped structure, sequentially covering the upper surface, the outer side surface and the lower bottom surface of the first connecting portion 6, effectively avoiding leakage and increasing the anti-detachment and pressure resistance of the puncture pad.

[0050] In the preferred structure, the first connection part 6 and the wing part 7 are respectively provided with a plurality of interconnected through holes 8, and the epoxy resin can flow into the through holes 8, so that the connection strength between the puncture pad 2 and the liquid medicine chamber 3 is further increased after the coating is cured, so that the injection seat 1 as a whole can better meet the pressure resistance requirements. Of course, since the coating structure between the puncture pad 2 and the liquid medicine chamber 3 itself has provided sufficient connection strength and pressure resistance, in order to further simplify the manufacturing process, the first connection part 6 and the wing part 7 may not be provided with the through holes 8.

[0051] In a more preferred interference fit structure, in order to further increase the connection stability and sealing between the puncture pad 2 and the liquid medicine chamber 3, this embodiment adopts a curved seal between the inner wall of the liquid medicine chamber 3 and the outer wall of the puncture pad 2. Exemplarily, the inner surface of the liquid medicine chamber 3 is provided with a second connecting portion 9 with a continuous concave-convex shape, and the outer peripheral surface of the puncture pad 2 is provided with a clamping portion 10 that is tightly matched with the second connecting portion 9, and the clamping portion 10 has a convex and concave structure that is clamped with the concave and convex structure of the second connecting portion 9. In another preferred solution, continuous concave-convex shapes can also be provided only on the inner wall of the liquid medicine chamber 3, and the outer wall of the puncture pad 2 remains flat.

[0052] Example 2

[0053] This embodiment provides an implantable drug delivery device.

[0054] Reference Figure 2 and attached Figures 3 to 5 The implantable drug delivery device in this embodiment includes an injection seat 1, a puncture pad 2 and a drug solution chamber 3.

[0055] In a preferred embodiment, the injection seat 1 body is formed by curing epoxy resin (AB glue), and various shapes can be naturally formed by epoxy resin. The injection seat body is simply molded and has a short molding cycle. The puncture pad 2 is made of a puncture-resistant material (such as silicone, rubber or any other soft puncture-resistant material), and the drug liquid chamber 3 can be integrally formed by 3D printing, and the material is preferably pure titanium or titanium alloy.

[0056] The puncture pad 2 is used to seal the upper opening of the drug liquid chamber 3, and the puncture pad 2 is used to insert the puncture needle to introduce the drug liquid into the drug liquid chamber. In this embodiment, the puncture pad seals the opening of the drug liquid chamber through an interference fit with the opening of the drug liquid chamber, so that the connection between the puncture pad and the inner wall of the drug liquid chamber is tighter and firmer, the pressure resistance of the puncture pad is enhanced, and drug leakage is avoided.

[0057] Reference Figure 1 The injection seat 1 extends downward from the side circumference of the puncture pad 2 and wraps around the entire bottom surface of the drug liquid chamber 3 to form the overall structure of the implantable drug delivery device.

[0058] In the preferred structure, the bottom center of the puncture pad 2 is designed to be convex with an arc surface, so when the injection seat 1 is under pressure, the drug flow will press the puncture pad 2 tightly against the inner wall of the drug chamber 3, increasing the sealing between the puncture pad 2 and the drug chamber 3, avoiding leakage and increasing the pressure resistance of the puncture pad.

[0059] The liquid medicine cavity 3 is provided with a connecting tube 4 for introducing liquid medicine into the catheter. In order to minimize the dead space volume in the liquid medicine cavity and to make sure that there is no residual liquid medicine in the liquid medicine cavity as much as possible, thereby improving the utilization rate of expensive drugs (e.g., chemotherapy drugs), in this embodiment, the inner hole of the connecting tube 4 is level with the lowest point of the inner wall of the liquid medicine cavity 3 and passes through the side of the injection seat 1.

[0060] In the exemplary structure, the connecting tube 4 can be connected to the bottom surface of the liquid medicine cavity 3. In this case, the bottom surface of the liquid medicine cavity 3 can be set as an inclined surface inclined toward the connection between the connecting tube 4 and the bottom surface. The inclined surface serves as a liquid medicine guide portion for guiding the liquid medicine into the connecting tube 4. The inner hole of the connecting tube 4 at the connection with the bottom surface is on the same horizontal plane as the lowest point of the inner wall of the bottom surface of the liquid medicine cavity 3. Except for the inevitable wall adhesion, the liquid medicine in the liquid medicine cavity 3 will almost completely flow out along the pipeline of the connecting tube 4 and then be input into the patient's body through the catheter. Since the bottom surface of the liquid medicine cavity 3 is similar to the inverted cone design, the liquid medicine will form a vortex at the bottom of the liquid medicine cavity, which can clean up the liquid medicine remaining on the side wall of the liquid medicine cavity, and at the same time, the infusion flow rate will be 1 / 3 higher than that of similar products.

[0061] In a preferred structure, in order to reduce the volume of the implantable drug delivery device and make it easier to place the injection seat 1 into the human body during clinical operation, the injection seat 1 has a streamlined curvature as a whole. Among them, the vertical section of the top 5 of the injection seat 1 is a parabola with the opening facing downward. This structure can make the puncture pad 2 bear more force and prevent it from loosening during use. More preferably, the injection seat 1 has a streamlined curvature (for example, a curvature with the bottom end convex outward) that is smoothly connected to its top 5 on at least one side opposite to the connecting tube 4 (the front end of the injection seat).

[0062] In a preferred structure, in order to make the sealing between the puncture pad 2 and the liquid medicine chamber 3 stronger, a first connecting portion 6 extending horizontally outward is provided on the top circumference of the liquid medicine chamber 3, and the puncture pad 2 is provided with a wing portion 7 covering the first connecting portion 6. In the exemplary structure, the wing portion 7 is arranged in a U-shaped structure, sequentially covering the upper surface, the outer side surface and the lower bottom surface of the first connecting portion 6, effectively avoiding leakage and increasing the anti-detachment and pressure resistance of the puncture pad.

[0063] In the preferred structure, the first connection part 6 and the wing part 7 are respectively provided with a plurality of interconnected through holes 8, and the epoxy resin can flow into the through holes 8, so that the connection strength between the puncture pad 2 and the liquid medicine chamber 3 is further increased after the coating is cured, so that the injection seat 1 as a whole can better meet the pressure resistance requirements. Of course, since the coating structure between the puncture pad 2 and the liquid medicine chamber 3 itself has provided sufficient connection strength and pressure resistance, in order to further simplify the manufacturing process, the first connection part 6 and the wing part 7 may not be provided with the through holes 8.

[0064] In a more preferred interference fit structure, in order to further increase the connection stability and sealing between the puncture pad 2 and the liquid medicine chamber 3, this embodiment adopts a curved seal between the inner wall of the liquid medicine chamber 3 and the outer wall of the puncture pad 2. Exemplarily, the inner surface of the liquid medicine chamber 3 is provided with a second connecting portion 9 with a continuous concave-convex shape, and the outer peripheral surface of the puncture pad 2 is provided with a clamping portion 10 that is tightly matched with the second connecting portion 9, and the clamping portion 10 has a convex and concave structure that is clamped with the concave and convex structure of the second connecting portion 9. In another preferred solution, continuous concave-convex shapes can also be provided only on the inner wall of the liquid medicine chamber 3, and the outer wall of the puncture pad 2 remains flat.

[0065] The embodiments and application examples described above are merely illustrative descriptions of the present disclosure and are not intended to limit the scope of the present disclosure. Without departing from the design spirit of the present disclosure, various modifications and improvements made to the technical solutions of the present disclosure by ordinary technicians in this field should all fall within the protection scope determined by the present disclosure.

Claims

1. An implantable drug delivery device, characterized in that: It includes an injection seat, a puncture pad and a liquid medicine chamber; The puncture pad seals the upper opening of the drug liquid chamber and is used to insert a puncture needle to introduce the drug liquid into the drug liquid chamber; The puncture pad is made of puncture-resistant material, and the injection seat extends downward from the side circumference of the puncture pad to wrap around the entire bottom surface of the drug liquid chamber; The liquid medicine chamber is provided with a connecting tube for introducing the liquid medicine into the catheter, and the connecting tube passes through the side of the injection seat; Wherein, the puncture pad seals the opening of the drug liquid chamber by interference fit with the opening of the drug liquid chamber.

2. The implantable drug delivery device according to claim 1, characterized in that: The inner hole of the connecting tube is level with the lowest point of the inner wall of the liquid medicine chamber.

3. The implantable drug delivery device according to claim 2, characterized in that: The bottom surface of the drug liquid chamber is provided with a drug liquid guide portion inclined toward the inner hole.

4. The implantable drug delivery device according to claim 1, characterized in that: The vertical section of the top of the injection seat is in the shape of a parabola with the opening facing downward.

5. The implantable drug delivery device according to claim 4, characterized in that: The injection seat has a streamlined curvature smoothly connected to the top end at least on one side opposite to the connecting tube.

6. The implantable drug delivery device according to any one of claims 1 to 5, characterized in that: The injection seat is formed by curing epoxy resin.

7. The implantable drug delivery device according to claim 6, characterized in that: A first connecting portion extending horizontally outward is provided on the top circumference of the drug liquid chamber, and a wing portion covering the first connecting portion is provided on the puncture pad.

8. The implantable drug delivery device according to claim 7, characterized in that: The first connecting portion and the wing portion are respectively provided with a plurality of communicating through holes, and the epoxy resin flows through the through holes.

9. The implantable drug delivery device according to claim 1, characterized in that: The inner surface of the drug liquid chamber is provided with a second connecting portion in a continuous concave-convex shape, and the outer peripheral surface of the puncture pad is provided with an engaging portion engaged with the second connecting portion; or The inner surface of the medicine liquid chamber is provided with continuous concave and convex shapes.

10. The implantable drug delivery device according to claim 1, characterized in that: The bottom center of the puncture pad is convex downward.

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