Subpackaging device for magnetic particle reagent production

Abstract

The utility model discloses a split charging device for producing a magnetic particle reagent. The split charging device comprises a speed-adjustable shaking table and a peristaltic pump, the shaking table comprises a base, a supporting plate is installed on the upper side of the base, a plurality of triangular flasks capable of containing magnetic particle reagents are installed on the upper side of the supporting plate, the supporting plate is provided with supporting tables corresponding to the triangular flasks, the supporting tables are provided with clamping arms for clamping the triangular flasks, and arc-shaped clamping pieces are installed at the ends of the clamping arms and abut against the side walls of the triangular flasks for clamping. A prepared magnetic particle reagent to be subpackaged is placed on a supporting table and fixed through a clamping arm, a disposable clean hose is used for communicating a reagent bottle with a peristaltic pump, parameters such as the flow speed, the volume and the interval time of the peristaltic pump are adjusted, after debugging is completed, a horizontal shaking table is started for gentle and uniform mixing, and the peristaltic pump is started after complete uniform mixing. And constant subpackaging can be carried out downstream according to set subpackaging parameters, and human intervention on the device is not needed in the midway.

Description

Technical Field

[0001] The utility model belongs to the technical field of reagent dispensing equipment, and particularly relates to a dispensing device for the production of magnetic particle reagents. Background Art

[0002] In the in vitro diagnosis industry, magnetic particles are a widely used solid-phase carrier, with characteristics such as rapid magnetic response, strong inertness, and high-efficiency cleaning, such as in application fields like magnetic particle nucleic acid extraction and magnetic particle chemiluminescence immunoassay.

[0003] The main component of magnetic particle particles is an iron compound, which is prone to sedimentation and adsorption on magnetic substances, and cannot be evenly mixed using a magnetic stirring instrument. This brings great trouble to the production of IVD enterprises. Conventional magnetic particle dispensing often uses mechanical oscillation on a vortex mixing device or a blood mixing device, and after mixing evenly, it is then dispensed. After a certain period of time, due to the sedimentation of magnetic particles, it is necessary to oscillate and mix again, and so on. This method has disadvantages such as time-consuming, laborious, difficult to standardize, and large-scale production. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a dispensing device for the production of magnetic particle reagents, which solves the problems of time-consuming, laborious, difficult to standardize, and large-scale production existing in the current magnetic particle reagent dispensing.

[0005] To solve the above technical problems, the utility model is realized through the following technical solutions:

[0006] A dispensing device for the production of magnetic particle reagents includes an adjustable-speed shaker and a peristaltic pump;

[0007] The shaker includes a base, a support plate is installed on the upper side of the base, and a plurality of Erlenmeyer flasks capable of containing magnetic particle reagents are installed on the upper side of the support plate. The support plate has a support platform corresponding to each single Erlenmeyer flask. The support platform is provided with a clamping arm for clamping the Erlenmeyer flask. An arc-shaped clamping piece is installed at the end of the clamping arm, and the clamping piece is used to abut against and clamp the side wall of the Erlenmeyer flask.

[0008] Further, a first spring is installed at the bottom of the support platform. The clamping arm is an L-shaped structure. The clamping arm is hinged to the support plate at the corresponding corner position. One end of the clamping arm fixes the clamping piece, and the other end extends to the bottom of the support platform and contacts the bottom of the support platform through a roller.

[0009] A limiting groove is provided at the bottom of the support platform corresponding to the roller to enable the roller to move inside the limiting groove. A positioning rod is provided at the center of the bottom of the support platform. The support plate has a positioning sleeve for the telescopic movement of the positioning rod. The first spring is sleeved on the positioning rod.

[0010] Further, a groove body is provided on the inner arc side corresponding to the clamping piece, and a rubber strip is installed in the groove body.

[0011] Further, the corresponding corner positions of the support plate and the base are supported by the second spring.

[0012] The utility model has the following beneficial effects: The device consists of two instruments, an upper adjustable-speed shaker and a lower peristaltic pump with adjustable volumetric flow rate. The prepared magnetic particle reagent to be subpackaged is placed on the support table and fixed by the clamping arm. A disposable clean hose is used to connect the reagent bottle and the peristaltic pump. Parameters such as the flow rate, volume, and interval time of the peristaltic pump are adjusted. After debugging, the horizontal shaker is started for gentle mixing. After complete mixing, the peristaltic pump is turned on, and constant subpackaging can be carried out downstream according to the set subpackaging parameters, without the need for manual intervention in the device during the process.

[0013] The subpackaging device can be integrated into a single device according to the volume of the selected instrument, different reagent items can be placed in different support tables of the adjustable-speed shaker, and it can be connected to the downstream production line to achieve stable and efficient subpackaging purposes. Description of the Drawings

[0014] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings required for describing the embodiments will be briefly introduced below.

[0015] Figure 1 : Schematic diagram of the shaker structure of the present utility model.

[0016] Figure 2 : Schematic diagram of the disassembled structure of the local support table of the present utility model.

[0017] Figure 3 : Schematic diagram of the overall processing flow structure of the present utility model.

[0018] In the drawings, the list of components represented by each reference numeral is as follows: base 1, support plate 2, Erlenmeyer flask 3, support table 5, clamping arm 4, clamping piece 41, first spring 21, roller 42, limit groove 51, positioning rod 52, rubber strip 43, second spring 11. Detailed Embodiments

[0019] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments.

[0020] As Figures 1-3 shown: A subpackaging device for the production of magnetic particle reagents includes an adjustable-speed shaker and a peristaltic pump;

[0021] The shaker includes a base 1. A support plate 2 is installed on the upper side of the base 1. A driving device is installed in the base to drive the support plate to perform a reciprocating movement in the horizontal position, generating shaking. Multiple triangular flasks 3 capable of containing magnetic particle reagents are installed on the upper side of the support plate 2. Specifically, there are three in a horizontal row and two in a vertical row, a total of six. The support plate 2 has a support platform 5 corresponding to each single triangular flask 3. The support platform is a circular plate structure, supported on the lower side by the support plate. The support platform 5 is provided with a clamping arm 4 for clamping the triangular flask 3. An arc-shaped clamping piece 41 is installed at the end of the clamping arm 4. The clamping piece 41 is used to abut and clamp against the side wall of the triangular flask 3. Specifically, there are three clamping arms, evenly surrounding the triangular flask. Since the side wall of the triangular flask is arc-shaped and has an inclined surface, clamping pieces are provided to improve the clamping stability. After the triangular flask is placed on the support platform, the driving clamping arm makes the clamping piece contact the side wall of the triangular flask, achieving the purpose of quickly fixing the triangular flask.

[0022] As Figures 1-2 shown: A first spring 21 is installed at the bottom of the support platform 5. The clamping arm 4 is an L-shaped structure. The clamping arm 4 is hinged to the support plate 2 at the corresponding corner position. An opening is made at the corner position, and the support plate is provided with a hinge shaft corresponding to the opening point. One end of the clamping arm 4 is fixed with the clamping piece 41, and the corresponding fixed point is located at the center of the outer arc side of the clamping arm. The other end extends to the bottom of the support platform 5 and contacts the bottom of the support platform 5 through a roller 42. When placing the triangular flask, due to the weight of the triangular flask compressing the first spring, the support platform moves downward. During the movement, the roller end corresponding to the clamping arm is further pressed, and the clamping arm is flipped through the hinge point. The end of the clamping arm corresponding to the clamping piece moves towards the side wall of the triangular flask for clamping, completing the clamping operation. It improves the clamping convenience.

[0023] The support platform 5 has a limit groove 51 at the position corresponding to the roller 42, enabling the roller 42 to move inside the limit groove 51. The limit groove is used to limit the movement track of the roller. At the same time, when the triangular flask is removed, the first spring rebounds, and the support platform moves upward. Under the limiting action of the limit groove, the clamping arm is reset to the open state, preparing for the next clamping process. A positioning rod 52 is provided at the center of the bottom of the support platform 5. The support plate 2 has a positioning sleeve for the positioning rod 52 to telescopically move. The first spring 21 is sleeved on the positioning rod 52. It is used to limit the movement of the support platform in the vertical direction.

[0024] As Figure 1 shown: The clamping piece 41 has a groove on the corresponding inner arc side, and a rubber strip 43 is installed in the groove. It is used to increase the friction with the glass side wall of the triangular flask. The corresponding corner positions of the support plate 2 and the base 1 are supported by a second spring 11.

[0025] This specification selects and specifically describes these embodiments to better explain the principle and practical application of the present invention, so that those skilled in the art in the relevant technical field can well understand and utilize the present invention.

Claims

1. A packaging device for producing magnetic particle reagents, characterized in that: The invention comprises a shaking table with adjustable speed and a peristaltic pump; the shaking table comprises a base (1); a support plate (2) is mounted on the upper side of the base (1); a plurality of triangular flasks (3) capable of containing magnetic particle reagents are mounted on the upper side of the support plate (2); the support plate (2) has a support platform (5) corresponding to each triangular flask (3); the support platform (5) is provided with a clamping arm (4) for clamping the triangular flask (3); an arc-shaped clamping piece (41) is mounted on the end of the clamping arm (4); the clamping piece (41) is used for clamping against the side wall of the triangular flask (3).

2. A magnetic particle reagent production packaging device according to claim 1, characterized in that: A first spring (21) is installed at the bottom of the support platform (5); the clamping arm (4) is an L-shaped structure; the clamping arm (4) is hinged to the support plate (2) at a position corresponding to the corner; one end of the clamping arm (4) fixes the clamping sheet (41); the other end extends to the bottom of the support platform (5) and contacts the bottom of the support platform (5) via a roller (42).

3. A magnetic particle reagent production packaging device according to claim 2, characterized in that: The bottom of the support platform (5) is provided with a limiting groove (51) at a position corresponding to the roller (42), so that the roller (42) moves inside the limiting groove (51).

4. A magnetic particle reagent production packaging device according to claim 2, characterized in that: The support platform (5) has a positioning rod (52) at the center of the bottom, the support plate (2) has a positioning sleeve for the positioning rod (52) to move telescopically, and the first spring (21) is sleeved on the positioning rod (52).

5. A magnetic particle reagent production packaging device according to claim 1, characterized in that: The clamping piece (41) has a groove body on the inner arc side corresponding to the groove body, and a rubber strip (43) is installed in the groove body.

6. A magnetic particle reagent production packaging device according to claim 1, characterized in that: The corner positions corresponding to the support plate (2) and the base (1) are supported by the second spring (11).

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