Automatic cup splicing device of enzyme immunoassay detector and enzyme immunoassay detector

Abstract

The utility model is applicable to the field of medical equipment, and provides an automatic cup splicing device of an enzyme immunoassay detector, which comprises a plate moving mechanism for conveying an elisa plate to a cup removing position, and a plurality of independent reaction cups are placed on the elisa plate; the bare board table is used for placing a bare board, and a plurality of cup positions for placing independent reaction cups are arranged on the bare board; the cup moving mechanism is used for transferring the independent reaction cups on the elisa plate at the cup removing position to the cup position; the automatic cup splicing device comprises a plate moving mechanism, a cup moving mechanism and a controller, the controller is in communication connection with the plate moving mechanism and the cup moving mechanism and controls the plate moving mechanism and the cup moving mechanism to automatically operate, independent reaction cups on an elisa plate can be transferred to cup positions of an empty plate through the automatic cup splicing device, the whole process is controlled by the controller to be automatically completed, manual participation is not needed, the cup splicing efficiency is greatly improved, and the production cost is reduced. And automation is realized.

Description

Technical Field

[0001] The utility model belongs to the field of medical devices, and particularly relates to an automatic cuvette splicing device for an enzyme immunoassay analyzer and an enzyme immunoassay analyzer. Background Art

[0002] At present, as an important carrier for enzyme-linked immunosorbent assay, the enzyme-labeled plate not only serves as a reaction container, but also coats antigens / antibodies in its reaction micro-wells and participates in the test as part of the reagent.

[0003] Existing enzyme-labeled plates are usually in the form of a whole plate, and the whole plate of enzyme-labeled plates needs to be put into the analyzer for detection each time an analysis and detection is carried out. Hospitals usually conduct centralized detection after collecting a large number of samples. However, in the case of a limited number of samples submitted for inspection, it takes a long time to collect samples. But if directly detecting a small number of samples, a whole plate of enzyme-labeled plates needs to be used for detection, resulting in a large waste of the coated reagent in the enzyme-labeled plates. Summary of the Utility Model

[0004] An embodiment of the utility model provides an automatic cuvette splicing device for an enzyme immunoassay analyzer, aiming to solve the problems of low reaction cup splicing efficiency and inability to achieve automation when using the existing enzyme immunoassay analyzer for tests.

[0005] The embodiment of the utility model is implemented as follows. An automatic cuvette splicing device for an enzyme immunoassay analyzer includes:

[0006] A plate moving mechanism for transferring an enzyme-labeled plate to a cup removing position, where a plurality of independent reaction cups are placed on the enzyme-labeled plate;

[0007] An empty plate table for placing an empty plate, and a plurality of cup positions for placing the reaction cups are arranged on the empty plate;

[0008] A cup moving mechanism for transferring the independent reaction cups on the enzyme-labeled plate at the cup removing position to the cup positions according to the detection requirements; and

[0009] A controller respectively connected to the plate moving mechanism and the cup moving mechanism for controlling the actions of the plate moving mechanism and the cup moving mechanism.

[0010] Optionally, the plate moving mechanism includes:

[0011] A placing rack divided into a plurality of intervals corresponding to the detection items of the enzyme-labeled plate;

[0012] A cup removing rack arranged at the cup removing position;

[0013] A transfer assembly for transferring the enzyme-labeled plate from the placing rack to the cup removing rack.

[0014] Optionally, a plurality of the intervals are stacked;

[0015] The cup removal rack is disposed adjacent to the placement rack. The cup removal rack includes a bracket and a support plate that can move up and down along the bracket. The height of the bracket is greater than or equal to the height of the topmost interval in the placement rack;

[0016] The transfer assembly includes a telescopic member and a clamping member disposed at the extended end of the telescopic member. The transfer assembly is disposed on the cup removal rack and moves up and down synchronously with the support plate.

[0017] Optionally, the cup moving mechanism includes:

[0018] A moving rack, which is connected and communicates with the controller;

[0019] A moving member, which is disposed on the moving rack. One end of the moving member is connected to the moving rack, and the moving member is driven by the moving rack to move between the plate moving mechanism and the empty plate table;

[0020] A cup picking member, which is disposed at the other end of the moving member and is used for grasping the reaction cup.

[0021] Optionally, the cup picking member includes a spreading and retracting portion that can be spread or retracted. The circumferential diameter of the spreading and retracting portion when retracted is smaller than the inner cavity diameter of the reaction cup, and the circumferential diameter of the spreading and retracting portion when spread is equal to the inner cavity diameter of the reaction cup.

[0022] Optionally, a detection device connected and communicating with the controller is disposed on the cup picking member and is used for detecting the positions of the reaction cups on the enzyme-labeled plate and the cup positions on the empty plate.

[0023] Optionally, the controller controls the moving rack to pass through each reaction cup on the enzyme-labeled plate and each cup position on the empty plate along an "S"-shaped path, and determines whether there is a reaction cup on the enzyme-labeled plate and whether the cup position on the empty plate is an empty cup position according to the degree of spreading of the spreading and retracting portion.

[0024] Optionally, the automatic cup assembling device further includes a cup ejecting mechanism for ejecting all the reaction cups on the enzyme-labeled plate and a cup pressing mechanism for pressing all the remaining reaction cups on the enzyme-labeled plate tightly;

[0025] The cup ejecting mechanism is disposed at the cup removal position;

[0026] The cup pressing mechanism is provided with a receiving structure to move the cup pressing mechanism to the receiving position;

[0027] The working position of the cup pressing mechanism is disposed opposite to the cup ejecting mechanism.

[0028] Optionally, a plurality of the intervals are stacked;

[0029] The decuping rack is arranged adjacent to the placement rack. The decuping rack includes a bracket and a support plate that can move up and down along the bracket. The height of the bracket is equal to the height of the topmost interval in the placement rack;

[0030] The transfer assembly includes a telescopic member, and a set of the transfer assemblies is arranged in each interval;

[0031] The controller is used to control the telescopic member to push the microplate placed in the specified interval onto the support plate when the support plate moves to the specified interval.

[0032] The present utility model further provides an enzyme immunoassay detector, which includes the automatic cup-assembling device of the enzyme immunoassay detector described above.

[0033] By providing a plate moving mechanism, an empty plate table and a cup moving mechanism, the plate moving mechanism conveys the microplate to the decuping position, the empty plate table is provided with empty plates, and the cup moving mechanism transfers the independent reaction cups on the microplate located at the decuping position to the cup positions of the empty plates according to the detection requirements, which can meet the detection requirements of different sample volumes, realize customized cup-assembling of the microplate, and reduce the waste of reaction cups. Description of the Drawings

[0034] Figure 1 is a schematic structural diagram of the automatic cup-assembling device of the enzyme immunoassay detector provided by an embodiment of the present utility model;

[0035] Figure 2 is a schematic structural diagram of the plate moving mechanism provided by an embodiment of the present utility model;

[0036] Figure 3 is a schematic structural diagram of the cup moving mechanism provided by an embodiment of the present utility model;

[0037] Figure 4 is a schematic structural diagram of the cup taking member provided by an embodiment of the present utility model;

[0038] Figure 5 is a schematic structural diagram of the cup pressing mechanism provided by an embodiment of the present utility model;

[0039] Figure 6 is a control block diagram of the controller of the present utility model.

[0040] Reference Numerals in the Drawings:

[0041] 100. Plate moving mechanism;

[0042] 110. Microplate; 111. Reaction cup; 120. Placement rack; 130. Decuping rack; 131. Bracket; 132. Support plate; 140. Transfer assembly; 141. Telescopic member; 142. Clamping member

[0043] 200. Empty plate table; 210. Empty plate; 211. Cup position;

[0044] 300, Cup transfer mechanism; 310, Moving frame; 320, Moving part; 321, Cup picking part; 322, Supporting and picking part; 323, Detection device; 330, Cup lifting mechanism; 340, Cup pressing mechanism; 350, Storage structure;

[0045] 400, Controller;

[0046] 500, Cup removal position. Detailed implementation mode

[0047] In order to make the purpose, technical solution and advantages of the present utility model clearer, the present utility model will be further described in detail below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0048] The present utility model is provided with a plate transfer mechanism for transferring an enzyme-labeled plate to the cup removal position, an empty plate table for placing empty plates, a cup transfer mechanism, and a controller that is communicatively connected to the plate transfer mechanism and the cup transfer mechanism respectively, and can realize the automatic transfer of designated reaction cups to specific cup positions. The present utility model can be transferred to the cup position according to the detection requirements, realizes cup combination, and reduces waste.

[0049] Embodiment

[0050] Reference Figure 1 , this embodiment provides an automatic cup combination device for an enzyme immunoassay detector, including:

[0051] A plate transfer mechanism 100 for transferring the enzyme-labeled plate 110 to the cup removal position 500, and a plurality of independent reaction cups 111 are placed on the enzyme-labeled plate 110;

[0052] An empty plate table 200 for placing an empty plate 210, and a plurality of cup positions 211 for placing independent reaction cups 111 are provided on the empty plate 210;

[0053] A cup transfer mechanism 300 for transferring the independent reaction cups 111 on the enzyme-labeled plate 110 at the cup removal position 500 to the cup positions 211 according to the detection requirements; and

[0054] A controller 400 that is communicatively connected to the plate transfer mechanism 100 and the cup transfer mechanism 300 respectively, and controls the actions of the plate transfer mechanism 100 and the cup transfer mechanism 300.

[0055] In this embodiment, the ELISA plate 110 includes a plate rack and reaction cups 110. Cup positions 211 are provided on the plate rack, and the cup positions 211 are used to place the reaction cups 110. One reaction cup 110 is placed in each cup position 211. Different substrates are placed in the reaction cups 110. According to different detection requirements, the reaction cups 110 containing different substrates are selected. The reaction cups 110 with the same substrate are preset on the same ELISA plate 110. The empty plate 210 is an empty plate rack, which is used to wait for the reaction cups 110 on the ELISA plate 110 to be transferred to the empty cup positions 211 according to the detection requirements.

[0056] Specifically, the transfer of the reaction cups 110 can be carried out one by one, or multiple reaction cups can be grouped together and transferred group by group.

[0057] The detection requirements include the number of samples to be detected and the detection items. The same sample needs to be detected for one or more different detection items. For different detection items, the reaction cups 110 with different substrates should be selected. The detection items required for different samples may vary. The automatic cup assembly device provided in the embodiment of the present application can determine the number of reaction cups required for each detection item according to the number of samples to be detected actually and the detection items corresponding to each sample, and automatically assemble the number of reaction cups required for each detection item onto the same empty plate, so as to be provided to the ELISA analyzer for detection, which can meet the detection requirements of different sample volumes, realize the customized cup assembly of the ELISA plate, reduce the waste of reaction cups, especially in the detection scenario of small sample volumes, and can greatly reduce the detection cost of ELISA detection.

[0058] Optionally, the automatic cup assembly device provided in the embodiment of the present application can also directly receive the number of reaction cups required for each detection item through the controller, and automatically assemble the number of reaction cups required for each detection item onto the same empty plate.

[0059] In this embodiment, the ELISA analyzer is applied in the enzyme-linked immunosorbent assay. In order to avoid the waste of the ELISA plate 110 during reagent detection, during the preparation stage before the enzyme-linked immunosorbent assay, the reaction cups 111 participating in the detection need to be removed from the participating ELISA plate 110 by the automatic cup assembly device and spliced onto the empty plate 210, and then the spliced ELISA plate 110 is used to participate in the test.

[0060] In this embodiment, the automatic cup assembly device places the empty plate 210 through the empty plate table 200. When performing cup assembly, the ELISA plate 110 with multiple independent reaction cups 111 is conveyed to the cup removal position 500 through the plate transfer mechanism 100, and then the reaction cups 111 on the ELISA plate 110 are transferred to the empty plate 210 according to the detection requirements through the cup transfer mechanism 300, thereby completing the cup assembly.

[0061] In this embodiment, the automatic cup assembling device transfers the microplate 110 through the plate moving mechanism 100. A cup removing position 500 is provided within the range that the plate moving mechanism 100 can cover. Multiple microplates 110 can be stacked on one side of the cup removing position 500. The plate moving mechanism 100 can transfer the microplate 110 with reaction cups 111 placed thereon to the cup removing position 500. Specifically, the plate moving mechanism 100 can be a lifting frame for transferring the flat plate device, or a manipulator, etc. The plate moving mechanism 100 can transfer the microplate 110 to the cup removing position 500 for the cup moving mechanism 300 to pick up the reaction cups 111. During the transfer process, the side of the microplate 110 with the reaction cups 111 placed thereon can always remain upward, thus preventing the reaction cups 111 from falling off during the transfer. After the microplate 110 reaches the cup removing position 500, the reaction cups 111 placed thereon are removed and transferred.

[0062] In one embodiment, an empty plate table 200 is provided on the other side of the cup removing position 500. An empty plate 210 is placed on the empty plate table 200. Multiple empty cup positions 211 are provided on the empty plate 210 for receiving and placing the reaction cups 111 removed from the cup removing position 500. When the required number of reaction cups 111 are transferred onto the empty plate 210, one cup assembling operation is completed. At this time, a new empty plate 210 can be replaced and placed on the empty plate table 200 for the next cup assembling.

[0063] In another embodiment, the automatic cup assembling device further includes a cup moving mechanism 300. The cup moving mechanism 300 is arranged between the empty plate table 200 and the plate moving mechanism 100. The cup moving mechanism 300 can first remove and pick up a single reaction cup 111 from the microplate 110 that reaches the cup removing position 500 from one side thereof, transfer it to the other side and place it in the empty plate 210 on the empty plate table 200, and repeat the transfer according to the required number of reaction cups 111 until one cup assembling operation is completed. Specifically, the cup moving mechanism 300 can be a gripper with picking ability, or a robotic arm, etc.

[0064] The plate moving mechanism 100 and the cup moving mechanism 300 are respectively connected and communicate with the controller 400. Under the control of the controller 400, the plate moving mechanism 100 can automatically transfer the microplate 110 to the cup removing position 500, and then the cup moving mechanism 300 can transfer the reaction cups 111 on the microplate 110 to the empty plate 210 on the empty plate table 200 through the linkage of the plate moving mechanism 100 and the cup moving mechanism 300.

[0065] Specifically, the controller 400 can establish a communication connection with the plate moving mechanism 100 and the cup moving mechanism 300 through a data line. The plate moving mechanism 100 can transmit the position data of the microplate 110 to the controller 400, and at the same time, the cup moving mechanism 300 can transmit the position information of the reaction cups 111 to the controller 400.

[0066] Thus, when cup combination is required, first, an ELISA plate 110 with multiple reaction cups 111 placed thereon is arranged on one side of the cup removal position 500, and an empty plate 210 with multiple cup positions 211 is arranged on the empty plate table 200 on the other side of the cup removal position 500. When starting cup combination, the controller 400 controls the operation of the plate transfer mechanism 100 to transfer an ELISA plate 110 to the cup removal position 500. Then, it controls the operation of the cup transfer mechanism 300 to move above the ELISA plate 110, pick up a reaction cup 111, remove it from the ELISA plate 110, and transfer it to a cup position 211 of the empty plate 210. According to the required quantity, the reaction cups 111 are transferred until one-time cup combination is completed. At this time, a new empty plate 210 can be replaced on the empty plate table 200 to perform the next cup combination.

[0067] The automatic cup combination device of the ELISA detector provided in this embodiment can transfer the reaction cups 111 from the ELISA plate 110 to the empty plate 210 through the plate transfer mechanism 100 with a transfer function, the cup transfer mechanism 300 with the function of transferring the reaction cups 111, and the controller 400. Different reaction cups are selected according to the detection needs and transferred to the cup positions, realizing cup combination and reducing waste.

[0068] In some embodiments, referring to Figure 2 , the plate transfer mechanism 100 specifically includes:

[0069] A placement rack 120, which is divided into multiple intervals corresponding to the detection items of the ELISA plate 110 respectively;

[0070] A cup removal rack 130 arranged at the cup removal position 500;

[0071] A transfer component 140 for transferring the ELISA plate 110 from the placement rack 120 to the cup removal rack 130.

[0072] In this embodiment, the plate transfer mechanism 100 includes a placement rack 120, a cup removal rack 130, and a transfer component 140, where the placement rack 120 is divided into multiple different intervals. The ELISA plates 110 have different functions and are used for different detections. The ELISA plates 110 for different detection items are stored separately in different intervals. Specifically, the placement rack 120 can be provided with several levels in the vertical direction, and each level can be an interval corresponding to a function. Different types of ELISA plates 110 can be placed on the corresponding levels. The placement rack 120 and the cup removal rack 130 can be placed side by side. The transfer component 140 can be installed on the cup removal rack 130 and can move freely in the vertical direction along the cup removal rack 130. Specifically, the transfer component 140 can be a robotic arm with a transfer function, which can transfer the ELISA plate 110 from the placement rack 120 to the cup removal rack 130.

[0073] Specifically, the placement rack 120 can be formed by welding multiple steel pipes. A plurality of partitions can be provided in the middle of the placement rack 120. Through different types of enzyme-labeled plates 110, the placement rack 120 can be sequentially divided into multiple different functional areas, and the enzyme-labeled plates 110 of the same type can be stored in the corresponding areas.

[0074] The cup-removing rack 130 can specifically be formed by welding I-beams. Both sides are fixed to the plane and part of it can be provided with slide rails. The transfer assembly 140 can be installed on the cup-removing rack 130 in a sliding connection manner, and the transfer assembly 140 can slide along the cup-removing rack 130. Furthermore, it drives the enzyme-labeled plate 110 to move up and down.

[0075] When it is necessary to transfer the enzyme-labeled plate 110 on the placement rack 120 to the cup-removing position 500, the transfer assembly 140 moves along the cup-removing rack 130 to the lower end of the enzyme-labeled plate 110 to be transferred, and horizontally takes out the enzyme-labeled plate 110 from the placement rack 120. Then the transfer assembly 140 moves upward along the cup-removing rack 130 and transports the enzyme-labeled plate 110 to the cup-removing position 500.

[0076] Dividing the placement rack 120 into multiple different areas facilitates the separate storage of the enzyme-labeled plates 110 according to their types when storing, facilitates the transfer assembly 140 to accurately find the position of the enzyme-labeled plates 110 participating in the reaction, shortens the running time of the transfer assembly 140. At the same time, the transfer assembly 140 is provided on the cup-removing rack 130, and the enzyme-labeled plates 110 on the placement rack 120 can be transferred to the cup-removing position 500 to realize the automatic transfer of the enzyme-labeled plates 110.

[0077] In some embodiments, referring to Figure 2 , multiple areas are arranged in a stacked manner;

[0078] The cup-removing rack 130 is arranged adjacent to the placement rack 120. The cup-removing rack 130 includes a bracket 131 and a support plate 132 that can move up and down along the bracket 131. The height of the bracket 131 is greater than or equal to the height of the topmost area in the placement rack 120;

[0079] The transfer assembly 140 includes a telescopic member 141 and a clamping member 142 provided at the extended end of the telescopic member 141. The transfer assembly 140 is provided on the cup-removing rack 130 and moves up and down synchronously with the support plate 132.

[0080] In this embodiment, different interval brackets 131 are arranged in a stacked manner, so that more types of enzyme-labeled plates 110 can be stored in the placement rack 120. Among them, the cup-removing rack 130 is arranged adjacent to the placement rack 120, facilitating the transfer component 140 on the cup-removing rack 130 to take out the enzyme-labeled plate 110 from the placement rack 120. The cup-removing rack 130 further includes a bracket 131 and a support plate 132 that can move up and down along the bracket 131. Both ends of the support plate 132 can be respectively arranged on the brackets 131 on both sides in a sliding connection manner. The transfer component 140 can be fixed on the support plate 132 and move together with the support plate 132. In order to be able to transfer the enzyme-labeled plate 110 to the cup-removing position 500, the height of the bracket 131 is greater than or equal to the height of the placement rack 120.

[0081] The transfer component 140 includes a telescopic member 141 and a clamping member 142 arranged at the extended end of the telescopic member 141. The clamping member 142 can be fixed at one end where the telescopic member 141 extends. The telescopic member 141 can be a telescopic rod, a telescopic track, or other telescopic devices, which are not limited herein.

[0082] When the telescopic member 141 extends, it drives the clamping member 142 to penetrate into the placement rack 120. The clamping member 142 can specifically be a clamping jaw, and the enzyme-labeled plate 110 can be clamped by the clamping jaw. Subsequently, the telescopic member 141 retracts, driving the clamping member 142 to transfer the enzyme-labeled plate 110 out of the placement rack 120. After the enzyme-labeled plate 110 is moved onto the support plate 132, the clamping member 142 remains in the clamping state, playing a role in fixing the enzyme-labeled plate 110.

[0083] Thus, the specific process of transferring the enzyme-labeled plate 110 from the placement rack 120 to the cup-removing position 500 is as follows: The support plate 132 on the cup-removing rack 130 moves downward along the bracket 131, and the transfer component 140 including the telescopic member 141 and the clamping member 142 can synchronously descend with the support plate 132. After moving to one side of the enzyme-labeled plate 110 that needs to participate in the reaction, the telescopic member 141 extends, driving the clamping member 142 to extend towards the enzyme-labeled plate 110. The clamping member 142 clamps the enzyme-labeled plate 110, and the telescopic member 141 retracts, simultaneously driving the clamping member 142 and the enzyme-labeled plate 110 to move away from the placement rack 120. After the telescopic member 141 completes contraction, the support plate 132 drives the telescopic member 141, the clamping member 142, and the enzyme-labeled plate 110 to rise along the bracket 131, reaching the cup-removing position 500, and completing the transfer of the enzyme-labeled plate 110 from the placement rack 120 to the cup-removing position 500.

[0084] In another embodiment, the support plate 132 can also be provided with a fixed chute (not shown in the figure), and the fixed chute is adapted to the outer edge of the enzyme-labeled plate. When the clamping member 142 moves the enzyme-labeled plate 110 onto the support plate 132, the enzyme-labeled plate 110 slides into the fixed chute, and the fixed chute provides guidance and positioning.

[0085] By arranging the cup removal rack 130 adjacent to the placement rack 120, the time duration for the transfer assembly 140 to move from the placement rack 120 to the cup removal position 500 can be shortened, and through the movement of the telescopic member 141, the clamping member 142 and the support plate 132, the ELISA plate 110 can be transferred from the placement rack 120 to the cup removal position 500, improving the efficiency of the test.

[0086] In some embodiments, referring to Figure 3 , the cup transfer mechanism 300 specifically includes:

[0087] A moving rack 310 connected and communicating with the controller 400;

[0088] A moving member 320 provided on the moving rack 310, one end of the moving member 320 is slidably connected to the moving rack 310, and the moving member 320 can be driven by the moving rack 310 to move between the plate transfer mechanism 100 and the empty plate table 200;

[0089] The other end of the moving member 320 is provided with a cup picking member 321.

[0090] In this embodiment, the cup transfer mechanism 300 includes a moving rack 310, a moving member 320 and a cup picking member 321, wherein the moving rack 310 is connected to the controller 400, one end of the moving member 320 is connected to the moving rack 310, and moves between the plate transfer mechanism 100 and the empty plate table 200 through the moving rack 310. A cup picking member 321 is further provided at the other end of the moving member 320.

[0091] Specifically, the moving rack 310 can specifically be a rotatable telescopic rod, and under the control of the controller 400, the moving rack 310 can freely rotate between the plate transfer mechanism 100 and the empty plate table 200. One end of the moving member 320 can be slidably connected to the moving rack 310, and the moving member 320 can slide on the moving rack 310.

[0092] In one embodiment, the moving rack 310 can be arranged between the cup removal position 500 and the empty plate table 200 for transferring the reaction cup 111. The moving rack 310 can specifically be composed of a telescopic rod that moves up and down in the vertical direction and a rotating head that can rotate in the horizontal plane. At the front end of the moving rack 310, the moving member 320 can be connected by means of a slide rail, and the control rack can drive the moving member 320 to move between the plate transfer mechanism 100 and the empty plate table 200.

[0093] The moving member 320 can specifically be a telescopic rod, and the moving member 320 and the moving rack 310 can be connected by bolts or by a slide rail. The extending end of the moving member 320 can be provided with a cup picking member 321, and the cup picking member 321 and the moving member 320 can be connected by means of inlay. The cup picking member 321 can be a clamping jaw or a clamping plate, and the reaction cup 111 at the cup removal position 500 can be picked up by the cup picking member 321.

[0094] In summary, when transferring the reaction cup 111 at the cup removal position 500 to the placement rack 120, the controller 400 controls the rotating frame 310 to rotate, and the rotating frame 310 drives the moving member 320 to rotate above the ELISA plate 110. The moving member 320 picks up the reaction cup 111, and then the moving member 320 drives the reaction cup 111 to separate from the ELISA plate 110. The controller 400 controls the rotating frame 310 to drive the reaction cup 111 and the moving member 320 to rotate together to the empty plate table 200, and the moving member 320 places the reaction cup 111 on the empty plate table 200, and the cup picking member 321 separates from the reaction cup 111, completing the transfer of the reaction cup 111.

[0095] By providing the rotating frame 310 and the moving member 320, the reaction cup 111 can be transferred from the ELISA plate 110 to the empty plate table 200. The rotating frame 310 and the moving member 320 can achieve the spatial movement of the reaction cup 111 through simple rotation and telescoping. The rotating frame 310 and the moving member 320 have simple structures, high working efficiency, and are also convenient for the transfer of the reaction cup 111.

[0096] In some embodiments, referring to Figure 4 , the cup picking member 321 includes a picking portion 322 that can be expanded or retracted. The circumferential diameter of the picking portion 322 when retracted is smaller than the inner cavity diameter of the reaction cup 111, and the circumferential diameter of the picking portion 322 when expanded is equal to the inner cavity diameter of the reaction cup 111.

[0097] In this embodiment, the cup picking member 321 specifically includes a picking portion 322, and the picking portion 322 is fixedly connected to the reaction cup 111 by expanding and retracting. The cup picking member 321 can specifically be a retractable airbag or a retractable inner support type jaw. When the cup picking member 321 is in the retracted state, the maximum circumferential inner diameter of the picking portion 322 is smaller than the inner cavity diameter of the reaction cup 111. When the cup picking member 321 is in the expanded state, the maximum circumferential inner diameter of the picking portion 322 is equal to the inner cavity diameter of the reaction cup 111.

[0098] Based on the above structure, when it is necessary to pick up the reaction cup 111, at this time the picking portion 322 retracts, the circumferential inner diameter of the picking portion 322 is smaller than the inner cavity diameter of the reaction cup 111, the cup picking member 321 extends into the inner cavity of the reaction cup 111, and then the picking portion 322 expands, the circumferential inner diameter of the picking portion 322 becomes larger until it is equal to the inner cavity diameter of the reaction cup 111. At this time, the picking portion 322 has an interference fit with the inner wall of the reaction cup 111, so that the reaction cup 111 can move together with the cup picking member 321; when it is necessary to put down the reaction cup 111, the picking portion 322 retracts, the circumferential inner diameter of the picking portion 322 is smaller than the inner cavity diameter of the reaction cup 111, and the cup picking member 321 withdraws from the inner cavity of the reaction cup 111.

[0099] Due to the compact arrangement of the cup positions on the microplate 110, the grasping space outside the reaction cup 111 is small. The internal grasping method increases the contact area for grasping. By providing a cup picking member 321 with an adjustable circumferential diameter, the reaction cup 111 is transferred by expanding and retracting, which can increase the stability during the transfer of the reaction cup 111 and facilitate the transfer of the reaction cup 111.

[0100] In some embodiments, referring to Figure 4 , a detection device 323 connected and communicating with the controller 400 is provided on the cup picking member 321 for detecting the position of the reaction cup 111 on the microplate 110 and the position of the cup position 211 on the empty plate 210.

[0101] In this embodiment, a detection device 323 is further provided on the cup picking member 321. The detection device 323 can be an infrared sensor, or a radar detector, an ultrasonic detector, etc. Among them, the detector can be fixed in the cup picking member 321 by inlaying and is connected and communicating with the controller 400. The detection device 323 can transmit the position data of the reaction cup 111 on the microplate 110 and the position of the cup position 211 on the empty plate 210 to the controller 400, and the controller 400 can obtain the reaction cup 111 information of the microplate 110 and the empty plate 210 in real time.

[0102] When the cup picking member 321 picks up the reaction cup 111 from the microplate 110, the detection device 323 scans the entire microplate 110, transmits the scanned reaction cup 111 data to the controller 400, and the controller 400 controls the cup picking member 321 to accurately reach above the reaction cup 111 and pick up the reaction cup 111. Then, when the cup picking member 321 drives the reaction cup 111 to reach the empty plate 210, the detection device 323 will scan the position of the cup position 211 on the empty plate 210 and transmit the data information of the cup position 211 to the controller 400. The controller 400 controls the cup picking member 321 to accurately place the reaction cup 111 on the cup position 211.

[0103] Optionally, in one embodiment, the automatic cup combining device can, before cup picking, determine whether there is a reaction cup at the cup picking position of the microplate through the detection signal received by the detection device 323 at a cup picking position, and control the cup picking member to pick up the corresponding reaction cup from the cup picking position when it is determined that there is a reaction cup at the cup picking position; the automatic cup combining device can also judge whether the cup position on the empty plate is an empty cup position through the detection signal received by the detection device 323 at a cup position on the empty plate, and control the cup picking member to move down to the cup position and retract the grasping part of the cup picking member to place the reaction cup in the cup position when it is determined that the cup position is an empty cup position.

[0104] In another embodiment, the detection device 323 can also be arranged at a separate detection position. After the cup picking member makes a cup picking action, it moves to the detection position to detect whether there is a cup.

[0105] The detection device 323 can monitor the positions of the reaction cups 111 on the ELISA plate 110 and the positions of the reaction cups 111 on the empty plate 210, facilitating the cup picking member 321 to pick up the reaction cups 111 on the ELISA plate 110. At the same time, it also facilitates the cup picking member 321 to place the reaction cups 111 on the cup positions 211 of the empty plate 210, making the transfer of the reaction cups 111 more accurate and ensuring the safety during the transfer of the reaction cups 111.

[0106] In some embodiments, the controller 400 controls the moving frame 310 to pass through each reaction cup 111 on the ELISA plate 110 and each cup position 211 on the empty plate 210 along an "S"-shaped path, and determines whether there is a reaction cup 111 on the ELISA plate 110 and whether the cup position on the empty plate is an empty cup position according to the degree of opening of the picking part 322.

[0107] When transferring the reaction cups 111 on the ELISA plate 110 or placing the reaction cups 111 onto the cup positions 211, the controller 400 controls the moving frame 310 to move along an "S" on the ELISA plate 110 or the empty plate 210. By adopting the "S"-shaped moving mode, it can pass above each reaction cup 111 on the ELISA plate 110 and can also pass above all the empty positions on the empty plate 210.

[0108] If there is a reaction cup 111 on the cup position 211, the cup wall of the reaction cup 111 will limit the degree of opening that the picking part 322 can achieve. When the degree of opening of the picking part 322 is equal to the inner diameter of the reaction cup 111, it is determined that there is a reaction cup on the cup position 211. When the degree of opening of the picking part 322 is greater than the inner diameter of the reaction cup 111, it is determined that there is no reaction cup on the cup position 211 and it is an empty cup position.

[0109] In some embodiments, refer to Figure 5 , the automatic cup combining device further includes a cup ejecting mechanism 330 for ejecting all the reaction cups 111 on the ELISA plate 110 and a cup pressing mechanism 340 for pressing all the remaining reaction cups 111 on the ELISA plate 110;

[0110] The cup ejecting mechanism 330 is arranged at the cup removing position 500;

[0111] The cup pressing mechanism 340 is provided with a receiving structure 350 to move the cup pressing mechanism 340 to the receiving position;

[0112] The working position of the cup pressing mechanism 340 is arranged opposite to the cup ejecting mechanism 330.

[0113] In this embodiment, the automatic cup assembling device further specifically includes a cup lifting mechanism 330 and a cup pressing mechanism 340. The cup lifting mechanism 330 and the cup pressing mechanism 340 can be connected through a storage structure 350. The storage structure 350 can be a stepping motor. The cup pressing mechanism 340 can be connected to the storage structure 350 by means of bolt connection. And the cup lifting mechanism 330 is specifically divided into a storage position and a working position according to its location. The working position is arranged opposite to the cup lifting mechanism 330.

[0114] According to the position where the cup pressing mechanism 340 is located, it can be specifically divided into a storage position and a working position. When the cup pressing mechanism 340 moves to the storage position through the storage structure 350, the reaction cup 111 on the ELISA plate 110 can be lifted out by the cup lifting mechanism 330. When the cup pressing mechanism 340 moves to the working position through the storage structure 350, the cup pressing mechanism 340 can press the remaining reaction cups 111 on the ELISA plate 110.

[0115] Specifically, the cup lifting mechanism 330 is used to lift out the reaction cup 111 on the ELISA plate 110. It can specifically have a telescopic structure, such as a flat plate with a telescopic rod at the bottom. When the telescopic rod extends, the cup can be lifted out. It can also be a slope structure, and the cup can be lifted out by using the slope during the process of moving the plate.

[0116] The pressing plate mechanism is used to press the reaction cup 111. It can be a flat plate that can rotate around a rotating shaft. When the flat plate rotates to the working position of the cup pressing mechanism 340, the cup pressing mechanism 340 presses the reaction cup 111 to fix the remaining reaction cups 111 on the ELISA plate 110. When the pressing plate mechanism is in the storage position, the pressing plate mechanism is located on one side of the ELISA plate 110.

[0117] Based on the above structure, when the reaction cup 111 needs to be separated from the ELISA plate 110, the cup lifting mechanism 330 moves upward, and the reaction cup 111 is lifted out by the cup lifting mechanism 330, so that the reaction cup 111 can smoothly separate from the ELISA plate 110. The controller 400 controls the cup picking member 321 of the cup transferring mechanism 300 to transfer the reaction cup 111. After the required number of reaction cups 111 are transferred, the cup pressing mechanism 340 rotates from the storage position to the working position and presses the remaining reaction cups 111. After being pressed by the cup pressing mechanism 340, the reaction cup 111 is fixed on the ELISA plate 110.

[0118] In this way, since there is a cup lifting mechanism 330 at the cup separating position 500, only a very small force is required when the cup picking member 321 picks up and transfers the reaction cup 111, which is convenient for the cup picking member 321 to pick up the reaction cup 111 from the ELISA plate 110. Correspondingly, there is also a cup pressing mechanism 340. After the reaction cup 111 is transferred, the remaining reaction cups 111 are pressed back on the ELISA plate 110 again. When the reaction cup 111 is transferred, it is not easy to fall off from the ELISA plate 110, which is convenient for the transfer of the remaining reaction cups 111.

[0119] In some embodiments, the automatic cup combining device includes a plurality of intervals arranged in a stacked manner;

[0120] The cup removing rack 130 is arranged adjacent to the placing rack 120. The cup removing rack 130 includes a bracket 131 and a support plate 132 that can move up and down along the bracket 131. The height of the bracket 131 is greater than or equal to the height of the topmost interval in the placing rack 120;

[0121] The transfer assembly 140 includes a telescopic member 141, and a set of transfer assemblies is arranged in each interval;

[0122] The controller is used to control the telescopic member to push out the ELISA plate placed in the specified interval to the support plate when the support plate moves to the specified interval.

[0123] Specifically, when the telescopic member 141 is in the retracted state, the ELISA plate 110 is placed in the specified interval. When it is necessary to take the reaction cups on the ELISA plate 110 in the specified interval, the controller controls the support plate 132 to move to the specified interval, and then controls the telescopic member 141 to extend, and pushes out the ELISA plate placed in the specified interval to the support plate 132.

[0124] Specifically, a clamping member 142 can be arranged at the extending end of the telescopic member 141. When the telescopic member 141 is in the retracted state, the clamping member 142 clamps the ELISA plate 110, so that the ELISA plate 110 is fixedly placed in each layer of the placing rack 120. When it is necessary to move the ELISA plate 110 in a certain layer, the support plate 132 moves to the corresponding position of the ELISA plate 110, the telescopic member 141 extends, drives the clamping member 142 to move the ELISA plate 110 onto the support plate 132, the clamping member 142 disengages from the ELISA plate 110, and the telescopic member 141 retracts.

[0125] The support plate 132 can also be provided with a fixed chute (not shown in the figure). The fixed chute is adapted to the outer edge of the ELISA plate. When the clamping member 142 moves the ELISA plate 110 onto the support plate 132, the ELISA plate 110 slides into the fixed chute, and the fixed chute provides guidance and positioning.

[0126] An ELISA detector provided in this embodiment includes the above-mentioned automatic cup combining device of the ELISA detector.

[0127] In this embodiment, by providing a plate moving mechanism 100, an empty plate table 200 and a cup moving mechanism 300 in the automatic cup combining device, the ELISA plate 110 is transferred to the cup removing position 500 through the plate moving mechanism 100, and the independent reaction cups 111 on the ELISA plate 110 located at the cup removing position 500 are transferred to the cup positions 211 of the empty plate 210 by using the cup moving mechanism 300. It can be transferred to the cup positions according to the detection requirements, realizing cup combining and reducing waste.

[0128] It is understandable that those skilled in the art can, under the teaching of the above embodiments, combine various implementation manners in the above respective embodiments to obtain technical solutions of various implementation manners.

[0129] The above are only preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model shall be included within the protection scope of the present utility model.

Claims

1. An automatic cup-mixing device, characterized in that: include: The plate transfer mechanism is used to transfer the ELISA plate to the cup removal position, where a plurality of independent reaction cups are placed on the ELISA plate; An empty plate platform, used for placing an empty plate, wherein the empty plate is provided with a plurality of cup positions for placing the reaction cups; A cup transfer mechanism, used to transfer the independent reaction cup on the ELISA plate located at the cup removal position to the cup position according to the detection requirements; as well as The controller is connected to the plate moving mechanism and the cup moving mechanism respectively, and is used to control the execution of the actions of the plate moving mechanism and the cup moving mechanism.

2. The automatic cup-mixing device according to claim 1, characterized in that: The plate shifting mechanism comprises: A placement rack, wherein the placement rack is divided into a plurality of sections corresponding to the detection items of the ELISA plate; A cup removing rack, arranged at the cup removing position; The transfer component is used to transfer the ELISA plate from the placement rack to the cup removal rack.

3. The automatic cup-mixing device according to claim 2, characterized in that: A plurality of the intervals are arranged in a stacked manner; The cup-removing rack is arranged adjacent to the placing rack, and the cup-removing rack comprises a bracket and a support plate that can be raised and lowered along the bracket, and the height of the bracket is greater than or equal to the height of the topmost interval in the placing rack; The transfer assembly comprises a telescopic member and a clamping member arranged at the extended end of the telescopic member. The transfer assembly is arranged on the cup removing rack and rises and falls synchronously with the supporting plate.

4. The automatic cup-mixing device according to claim 1, characterized in that: The cup moving mechanism comprises: A mobile frame connected to communicate with the controller; A moving member is arranged on the moving frame, one end of the moving member is connected to the moving frame, and the moving member is driven by the moving frame to move between the plate moving mechanism and the empty pallet; The cup-taking component is arranged at the other end of the moving component and is used for grabbing the reaction cup.

5. The automatic cup-mixing device according to claim 4, characterized in that: The cup taking member comprises a holding portion which can be opened or retracted. The circumferential diameter of the holding portion when retracted is smaller than the inner cavity diameter of the reaction cup, and the circumferential diameter of the holding portion when opened is equal to the inner cavity diameter of the reaction cup.

6. The automatic cup-mixing device according to claim 4, characterized in that: The cup taking member is provided with a detection device connected and communicating with the controller, and is used for detecting the position of the reaction cup on the ELISA plate and the position of the cup position on the empty plate.

7. The automatic cup-mixing device according to claim 5, characterized in that: The controller controls the movable frame to pass through each reaction cup on the ELISA plate and each cup position on the empty plate in an "S"-shaped path, and determines whether there is a reaction cup on the ELISA plate and whether a cup position on the empty plate is an empty cup position according to the degree of support of the support portion.

8. The automatic cup-mixing device according to claim 2, characterized in that: The automatic cup assembly device also includes a cup-pushing mechanism for ejecting all reaction cups on the ELISA plate and a cup-pressing mechanism for pressing all remaining reaction cups on the ELISA plate; The cup lifting mechanism is arranged at the cup removing position; The cup pressing mechanism is provided with a storage structure, and the cup pressing mechanism is moved to a storage position; The working position of the cup pressing mechanism is arranged opposite to the cup lifting mechanism.

9. The automatic cup-mixing device according to claim 2, characterized in that: A plurality of the intervals are arranged in a stacked manner; The cup-removing rack is arranged adjacent to the placing rack, and the cup-removing rack comprises a bracket and a support plate that can be raised and lowered along the bracket, and the height of the bracket is equal to the height of the topmost interval in the placing rack; The transfer assembly includes a telescopic member, and a group of the transfer assembly is arranged in each interval of each layer; The controller is used for controlling the telescopic member to push the ELISA plate placed in the designated interval to the support plate when the support plate moves to the designated interval.

10. An enzyme immunoassay tester, characterized in that: The invention comprises the automatic cup-mixing device according to any one of claims 1 to 9.

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