Dissolving equipment for cytarabine and daunorubicin compound liposome

Abstract

The utility model relates to dissolving equipment for cytarabine and daunorubicin compound lipidosome, which belongs to the technical field of medicine processing equipment and comprises a base, a connecting frame is mounted at the top of the base, a dissolving bin is mounted on one side, close to the center of the base, of the connecting frame, and a leakage bin is fixedly connected to the bottom of the dissolving bin. A dissolving tank is mounted in the dissolving bin, and a heater is mounted on the inner wall of the dissolving bin; a stirring mechanism for increasing the dissolving speed is mounted in the dissolving tank. The lipid dissolving device has the beneficial effects that through the arrangement of the stirring mechanism, the arc-shaped stirring paddle can be driven to rotate through the rotating motor and the rotating shaft, and lipid in the dissolving tank is stirred through the arc-shaped stirring paddle, so that the dissolving speed is increased, and meanwhile, one side of the arc-shaped stirring paddle is attached to the inner wall of the dissolving tank, so that the lipid dissolving effect is improved. The leakage holes can be prevented from being blocked by lipid, and it is ensured that dissolved liquid is smoothly discharged out of the dissolving tank.

Description

Technical Field

[0001] The utility model relates to the technical field of medicine processing equipment, in particular to a dissolving device for cytarabine and daunorubicin compound liposome. Background Art

[0002] Fixed liposome compound preparations composed of cytarabine and daunorubicin can be used to treat two types of adult patients with acute myeloid leukemia. During the production process, the liposomes need to be dissolved first and the different raw materials need to be mixed. The fusion effect is poor in the solid state, which in turn affects the efficacy of the drug.

[0003] For example, the application number is: CN202320181997.X; a cytarabine and daunorubicin compound liposome reaction tank with a feeding function is disclosed, and the key points of its technical solution are: by setting a feeding chamber, two feeding barrels improve the feeding efficiency, and a spiral conveying shaft is set in the feeding barrel to achieve uniform feeding. The material is conveyed and stirred by a motor, which reduces the production cost. The reaction effect is improved by the cooperation of the stirring rod and the stirring paddle group, and the practicability is strong.

[0004] The dissolution equipment of cytarabine and daunorubicin compound liposomes in the above-mentioned comparative documents did not dissolve the solid lipids. When the raw materials in the solid state were mixed, the mixing effect was poor and there was insufficient mixing, which in turn affected the efficacy. To address the above problems, we have launched a spray cooling device for automated machine tools. Utility Model Content

[0005] The purpose of the utility model is to provide a dissolving device for cytarabine and daunorubicin compound liposomes to solve the problems raised in the above background technology.

[0006] The technical solution of the utility model is: comprising a base, a connecting frame is installed on the top of the base, a dissolving bin is installed on one side of the connecting frame close to the center of the base, a leakage bin is fixedly connected to the bottom of the dissolving bin, a dissolving tank is installed inside the dissolving bin, and a heater is installed on the inner wall of the dissolving bin;

[0007] A stirring mechanism for increasing the dissolution rate is installed inside the dissolution tank;

[0008] The interior of the dissolving bin is provided with a barrier mechanism for concentrating the dissolved liquid.

[0009] Furthermore, a mobile platform is installed at one end of the base, an insertion plate is installed at the center of one side of the mobile platform close to the base, an insertion slot is opened inside the base, and a heightening frame is fixedly installed at the top center of the mobile platform. The mobile platform and the base can be positioned and assembled through the insertion plate and the insertion slot.

[0010] A lifting cylinder is fixedly installed at the center of the top of the heightening frame. An installation plate is installed at the top of the lifting cylinder, and a rotating motor is installed at the top of the installation plate. The height of the installation plate can be adjusted through the lifting cylinder, so as to move the position of the arc-shaped stirring paddle.

[0011] Furthermore, the stirring mechanism includes a rotating shaft installed at the power output end of the rotating motor, and an arc-shaped stirring paddle is fixedly connected to one end of the rotating shaft. Through the action of the arc-shaped stirring paddle, while completing the stirring of the lipid, it can also avoid the situation of blocking the leakage holes.

[0012] Furthermore, leakage holes are equidistantly distributed inside the dissolution tank, and the dissolution tank is fixedly connected to the dissolution chamber through installation blocks. After dissolution, the dissolved liquid is timely discharged from the dissolution tank 5 through the leakage holes.

[0013] Furthermore, the blocking mechanism includes a blocking plate fixedly installed at the top of the leakage bin. A through hole is opened at the center of the blocking plate. Sliding rails are fixedly connected to both ends of the bottom of the blocking plate, and a partition plate is embedded on the opposite side of the sliding rails. The dissolved liquid can be centrally collected through the blocking plate, and when needed, the liquid can be centrally discharged for use.

[0014] Furthermore, an adjusting piece is fixedly connected to one side of the bottom of the partition plate close to the center of the blocking plate. A bidirectional adjusting screw rod is threadedly connected inside the adjusting piece, and a rotating motor is installed at one end of the bidirectional adjusting screw rod. By rotating the bidirectional adjusting screw rod, the partition plate can be driven to move relatively, ensuring that the liquid smoothly enters the inside of the leakage bin and is discharged from the bottom of the leakage bin.

[0015] First: In the present utility model, through the setting of the stirring mechanism, the rotating motor and the rotating shaft can drive the arc-shaped stirring paddle to rotate, and the lipid inside the dissolution tank can be stirred by the arc-shaped stirring paddle, increasing the dissolution rate. At the same time, the setting that one side of the arc-shaped stirring paddle is in contact with the inner wall of the dissolution tank can avoid the lipid from blocking the leakage holes and ensure that the dissolved liquid smoothly drains out of the inside of the dissolution tank.

[0016] Second: In the present utility model, through the combined use of the blocking mechanism and its internal parts, when it is necessary to centrally discharge the dissolved liquid, by rotating the bidirectional adjusting screw rod, the positions of the adjusting piece and the blocking plate can be driven to move relatively along the sliding rails as the trajectory, and the through hole can be made unobstructed, enabling the dissolved liquid to enter the inside of the leakage bin and ensuring the centralized discharge of the liquid through the leakage bin. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The present utility model will be further explained below with reference to the drawings and embodiments:

[0018] Figure 1 is the front elevation three-dimensional structure schematic diagram of the present utility model;

[0019] Figure 2 is the three-dimensional structure schematic diagram of the dissolution bin of the present utility model;

[0020] Figure 3 is the three-dimensional sectional structure schematic diagram of the dissolution bin of the present utility model;

[0021] Figure 4 is the sectional structure schematic diagram of the base of the present utility model.

[0022] Description of reference numerals: 1, base; 2, connecting frame; 3, dissolution bin; 4, leakage bin; 5, dissolution tank; 6, heater; 7, moving platform; 8, insertion plate; 9, heightening frame; 10, lifting cylinder; 11, mounting plate; 12, rotating motor; 13, rotating shaft; 14, arc-shaped stirring paddle; 15, partition board; 16, sliding rail; 17, isolation board; 18, adjusting piece; 19, bidirectional adjusting lead screw; 20, rotating motor. Specific embodiments

[0023] The following will be combined with the attached Figures 1 to 4 The present utility model will be described in detail. The technical solutions in the embodiments of the present utility model are clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative work shall fall within the protection scope of the present utility model.

[0024] The present utility model provides a dissolution device for a compound liposome of cytarabine and daunorubicin through improvement. As Figures 1-4 shown, it includes a base 1. A connecting frame 2 is installed on the top of the base 1. A dissolution bin 3 is installed on one side of the connecting frame 2 close to the center of the base 1. A leakage bin 4 is fixedly connected to the bottom of the dissolution bin 3. A dissolution tank 5 is installed inside the dissolution bin 3. A heater 6 is installed on the inner wall of the dissolution bin 3; A stirring mechanism for improving the dissolution speed is installed inside the dissolution tank 5; A blocking mechanism for concentrating the dissolved liquid is arranged inside the dissolution bin 3. A moving platform 7 is installed at one end of the base 1. An insertion plate 8 is installed at the center of the side of the moving platform 7 close to the base 1. An insertion groove is opened inside the base 1. A heightening frame 9 is fixedly installed at the center of the top of the moving platform 7. A lifting cylinder 10 is fixedly installed at the center of the top of the heightening frame 9. A mounting plate 11 is installed on the top of the lifting cylinder 10. A rotating motor 12 is installed on the top of the mounting plate 11.

[0025] In this embodiment: First, when the dissolution operation is required, the position of the mobile station 7 is moved by the balls at the bottom of the mobile station 7, and the insertion plate 8 is inserted into the insertion groove opened inside the base 1. Since the outer surface of the dissolution tank 5 is fitted with the inner surface of the heater 6, the high temperature generated when the heater 6 is started is used to dissolve the lipid. The dissolved liquid is discharged from the dissolution tank 5 through the leakage holes. The position of the mounting plate 11 is lifted and lowered by the lifting cylinder 10, so that the position of the arc-shaped stirring paddle 14 is lowered.

[0026] In the first embodiment, during the dissolution process, the lipid is likely to block the leakage holes, affecting the feeding speed. The specific operation is as follows:

[0027] As Figure 1 and Figure 2 and Figure 4 As shown, the stirring mechanism includes a rotating shaft 13, which is installed at the power output end of the rotating motor 12. One end of the rotating shaft 13 is fixedly connected with an arc-shaped stirring paddle 14. The leakage holes are equally distributed inside the dissolution tank 5, and the dissolution tank 5 is fixedly connected to the dissolution chamber 3 through a mounting block;

[0028] In this embodiment: The rotating motor 12 is started, the rotating shaft 13 is driven to rotate by the rotating motor 12, and the arc-shaped stirring paddle 14 is driven to rotate by the rotating shaft 13. Since one side surface of the arc-shaped stirring paddle 14 is fitted with the inner surface of the dissolution tank 5, the lipid inside the dissolution tank 5 is pushed by the rotation of the arc-shaped stirring paddle 14, thus preventing the lipid from blocking the leakage holes.

[0029] In the first embodiment, after the lipid is dissolved, the liquid needs to be discharged centrally. The specific operation is as follows:

[0030] As Figure 3 shown, the blocking mechanism includes a blocking plate 15, which is fixedly installed at the top of the leakage bin 4. A through hole is opened at the center of the blocking plate 15. Sliding rails 16 are fixedly connected to both ends of the bottom of the blocking plate 15, and a partition plate 17 is embedded on the opposite side of the sliding rails 16. A regulating piece 18 is fixedly connected to one side of the bottom of the partition plate 17 close to the center of the blocking plate 15. A bidirectional regulating screw rod 19 is threadedly connected inside the regulating piece 18, and a rotating motor 20 is installed at one end of the bidirectional regulating screw rod 19.

[0031] In this embodiment: Start the rotation motor 20, and drive the bidirectional adjustment screw rod 19 to rotate through the rotation motor 20. Since the bidirectional adjustment screw rod 19 penetrates the inside of the adjustment piece 18, and the adjustment piece 18 and the isolation plate 17 form an integrated structure, the rotation of the bidirectional adjustment screw rod 19 drives the isolation plate 17 to move along the sliding rail 16, so that the through port is opened, and the dissolved liquid can be smoothly discharged from the leakage bin 4.

[0032] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A dissolving device for a compound liposome of cytarabine and daunorubicin, characterized in that: It includes a base (1), a connecting frame (2) is installed on the top of the base (1), a dissolving bin (3) is installed on one side of the connecting frame (2) close to the center of the base (1), a leakage bin (4) is fixedly connected to the bottom of the dissolving bin (3), a dissolving tank (5) is installed inside the dissolving bin (3), and a heater (6) is installed on the inner wall of the dissolving bin (3); A stirring mechanism for improving the dissolving speed is installed inside the dissolving tank (5); A blocking mechanism for concentrating the dissolved liquid is arranged inside the dissolving bin (3).

2. The dissolving device for a compound liposome of cytarabine and daunorubicin according to claim 1, characterized in that: A moving platform (7) is installed at one end of the base (1), an insertion plate (8) is installed at the center of the side of the moving platform (7) close to the base (1), an insertion groove is formed inside the base (1), and a heightening frame (9) is fixedly installed at the center of the top of the moving platform (7).

3. The dissolving device for a compound liposome of cytarabine and daunorubicin according to claim 2, characterized in that: A lifting cylinder (10) is fixedly installed at the center of the top of the heightening frame (9), a mounting plate (11) is installed at the top of the lifting cylinder (10), and a rotating motor (12) is installed on the top of the mounting plate (11).

4. The dissolving device for a compound liposome of cytarabine and daunorubicin according to claim 1, characterized in that: The stirring mechanism includes a rotating shaft (13), the rotating shaft (13) is installed at the power output end of the rotating motor (12), and an arc-shaped stirring paddle (14) is fixedly connected to one end of the rotating shaft (13).

5. The dissolving device for a compound liposome of cytarabine and daunorubicin according to claim 1, wherein: Leakage holes are equidistantly distributed inside the dissolving tank (5), and the dissolving tank (5) is fixedly connected to the dissolving bin (3) through a mounting block.

6. The dissolving device for a compound liposome of cytarabine and daunorubicin according to claim 5, characterized in that: The blocking mechanism includes a blocking plate (15), the blocking plate (15) is fixedly installed on the top of the leakage bin (4), a through port is formed at the center of the inside of the blocking plate (15), sliding rails (16) are fixedly connected to both ends of the bottom of the blocking plate (15), and an isolation plate (17) is embedded on the opposite sides of the sliding rails (16).

7. A dissolving device for a compound liposome of cytarabine and daunorubicin according to claim 6, characterized in that: One side of the bottom of the isolation plate (17) close to the center of the blocking plate (15) is fixedly connected to an adjusting piece (18), a bidirectional adjusting screw rod (19) is threadedly connected inside the adjusting piece (18), and a rotating motor (20) is installed at one end of the bidirectional adjusting screw rod (19).

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