Silk fibroin solution filtering device

Abstract

The utility model relates to the technical field of silk fibroin solutions, in particular to a silk fibroin solution filtering device which comprises a peripheral supporting body, a sealing cover used for heat preservation is arranged on the peripheral supporting body, a motor is arranged at the bottom of the peripheral supporting body, and a mold cavity used for storing a silk fibroin solution is arranged in the peripheral supporting body. A heat conduction material used for conducting heat is arranged at the bottom of the peripheral supporting body, a pressure reduction cover used for reducing internal pressure is arranged on the sealing cover, and a plurality of heat conduction rod bodies used for heating a silk fibroin solution are arranged in the mold cavity. According to the utility model, heat is uniformly conducted to the interior of the mold cavity through the heat conducting material and the heat conducting rod bodies, and the more the heat conducting rod bodies are arranged, the more uniform the heat transfer received by the silk fibroin solution is, so that the silk fibroin solution in the cavity forms more uniform ice crystals, and silk fibroin in the silk fibroin solution is self-assembled and folded into microspheres with uniform particle sizes.

Description

Technical Field

[0001] The utility model relates to the technical field of fibroin protein solution, in particular to a fibroin protein solution filtering device. Background Art

[0002] Fibroin protein microspheres are micron-sized spherical materials made of fibroin protein with good biocompatibility, having unique biodegradability and biological activity. The preparation technology usually involves forming microspheres by methods such as emulsification, freeze self-assembly, spray drying or electrospray of fibroin protein solution, and then solidifying and shaping by freeze drying or other cross-linking technologies.

[0003] Fibroin protein microspheres have a wide range of uses, including as drug delivery systems, cell carriers in tissue engineering, and applications in the cosmetics and food industries. They can control the release of drugs, promote cell growth and differentiation, and have good mechanical properties and stability. However, the preparation and application of fibroin protein microspheres still face some challenges. The main problem to be solved in the prior art is the uneven control and distribution of the particle size of microspheres.

[0004] Therefore, we have designed a fibroin protein solution filtering device. Summary of the Utility Model

[0005] The purpose of the utility model is to provide a fibroin protein solution filtering device to solve the problem of uneven particle size distribution of fibroin protein microspheres.

[0006] To achieve the above purpose, the utility model adopts the following technical scheme:

[0007] A fibroin protein solution filtering device includes an outer support body, on which a sealing cover for heat preservation is provided, a motor is provided at the bottom of the outer support body, a mold cavity for storing fibroin protein solution is provided inside the outer support body, a heat-conducting material for conducting heat is provided at the bottom of the outer support body, a pressure-reducing cover for reducing the internal pressure is provided on the sealing cover, a plurality of heat-conducting rod bodies for heating fibroin protein solution are provided inside the mold cavity, a stretching rod with a micro-adjustable length is provided on the mold cavity, and a fitting block for correcting the rotation orientation is provided on the mold cavity.

[0008] Preferably, the heat-conducting material is fixedly connected to the outer support body through a fastener, and a cold source for absorbing heat is provided at the bottom of the heat-conducting material;

[0009] The motor is fixedly connected to the cold source through a rotating ring, the rotating ring penetrates through the heat-conducting material and is connected to the inner wall of the outer support body in communication, and the rotating ring is fixedly connected to the bottom of the mold cavity.

[0010] Preferably, the pressure-reducing cover is fixedly connected to the sealing cover through a fastener, and a plurality of pressure relief openings for leaking excess pressure are provided on the pressure-reducing cover.

[0011] Preferably, the heat-conducting rod bodies are linearly arranged in the mold cavity, and a plurality of heat-insulating rings for maintaining a constant temperature of the fibroin protein solution are provided in the mold cavity.

[0012] Preferably, the mold cavity is symmetrically provided with misalignment shafts for lateral adjustment, and the side wall of the mold cavity is adapted to the misalignment shafts. The mold cavity is symmetrically provided with fixing blocks for fixing the stretching rods, and the stretching rods are adapted to the misalignment shafts. The mold cavity is provided with overlapping seams for reducing adjustment friction.

[0013] Preferably, a guide rail is provided on the inner wall of the peripheral support body, and the fitting block is fixedly connected to the fixed block by welding.

[0014] The beneficial effects of the present utility model are as follows:

[0015] 1. In the present utility model, heat is evenly conducted to the inside of the mold cavity through the heat-conducting material and the heat-conducting rod bodies. The more heat-conducting rod bodies are provided, the more uniform the heat transfer received by the fibroin protein solution is, so that relatively uniform ice crystals are formed in the fibroin protein solution in the cavity, and the fibroin protein in the fibroin protein solution self-assembles and folds into microspheres with a uniform particle size.

[0016] 2. In the present utility model, by setting different numbers of bottom heat-conducting rod bodies in the mold cavity or changing the material of the heat-conducting rod bodies, the regulation of fibroin protein microspheres with different particle sizes can be realized. By setting the misalignment shafts and overlapping seams, the specifications of the mold cavity for storing the fibroin protein solution can be changed. By setting the rotating ring, the mold cavity can be rotated according to the setting of the guide rail, thereby improving the filtration efficiency of the fibroin protein solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is a schematic structural diagram of a fibroin protein solution filtration device proposed by the present utility model;

[0018] Figure 2 is a three-dimensional schematic diagram of a fibroin protein solution filtration device proposed by the present utility model;

[0019] Figure 3 is an internal structure diagram of a fibroin protein solution filtration device proposed by the present utility model;

[0020] Figure 4 is Figure 3 an enlarged view of the structure marked with A in

[0021] In the figure: 1. Sealing cover; 2. Peripheral support; 3. Heat-conducting material; 4. Cold source; 5. Motor; 6. Pressure-reducing cover; 7. Rotating ring; 8. Mold cavity; 9. Heat-conducting rod; 10. Heat-insulating ring; 11. Misaligned shaft; 12. Overlapping seam; 13. Fixed block; 14. Tensile rod; 15. Fitting block; 16. Guide rail. Detailed implementation mode

[0022] Refer to Figures 1 - 4 , a silk fibroin solution filtering device, including a peripheral support 2 which is the outer surrounding structure of the whole device, wrapping the silk fibroin solution inside for filtering work. The sealing cover 1 is a component used to block the top of the peripheral support 2 in the prior art, and a rubber ring is provided around the sealing cover 1, which can effectively avoid leakage problems. The motor 5 is a power-driven component in the prior art, and the power drive is completed through a storage battery. The mold cavity 8 is rectangular and is used to store the silk fibroin solution to heat it to achieve the filtering process.

[0023] The bottom of the peripheral support 2 is provided with a heat-conducting material 3 for conducting heat. The heat-conducting material 3 is made of graphite in the prior art and can effectively guide out the heat. The heat-conducting material 3 is fixedly connected to the peripheral support 2 through a fastener. The fastener is an auxiliary connecting component. The bottom of the heat-conducting material 3 is provided with a cold source 4 for absorbing heat; the cold source 4 is composed of refrigeration equipment in the prior art, and the contact surface with low temperature is in contact with the heat-conducting material 3 to achieve the effect of absorbing heat.

[0024] The motor 5 is fixedly connected to the cold source 4 through the rotating ring 7. The rotating ring 7 is located at the bottom of the cold source 4, and the output end of the motor 5 is fixedly connected to the rotating ring 7. The rotating ring 7 penetrates through the heat-conducting material 3 and is connected to the inner wall of the peripheral support 2. The protruding end of the rotating ring 7 penetrates through the peripheral support 2, and the rotating ring 7 is fixedly connected to the bottom of the mold cavity 8. After the rotating ring 7 is fixedly connected to the mold cavity 8, the rotation of the mold cavity 8 can be realized.

[0025] The sealing cover 1 is provided with a pressure-reducing cover 6 for reducing the internal pressure. The pressure-reducing cover 6 is mainly used to release the excess pressure in the mold cavity 8 to avoid strong pressure on the mold cavity 8 and the peripheral support 2, and prevent bursting when reaching the critical point. The pressure-reducing cover 6 is fixedly connected to the sealing cover 1 through a fastener. The fastener is an auxiliary connecting component. The pressure-reducing cover 6 is provided with a plurality of pressure relief ports for leaking the excess pressure.

[0026] A plurality of heat-conducting rods 9 for heating the silk fibroin solution are arranged in the mold cavity 8. The heat-conducting rods 9 are made of graphite in the prior art and can effectively transfer heat to the silk fibroin solution. The heat-conducting rods 9 are linearly arranged in the mold cavity 8, and there are a total of nine heat-conducting rods 9. A plurality of heat-insulating rings 10 for keeping the temperature of the silk fibroin solution constant are arranged in the mold cavity 8. The heat-insulating rings 10 are made of heat-insulating materials and can effectively reduce the loss of temperature.

[0027] The mold cavity 8 is provided with a stretching rod 14 with micro-adjustable length. The stretching rod 14 is made of aluminum alloy and is mainly used for lateral adjustment of the mold cavity 8. The mold cavity 8 is symmetrically provided with an offset axis 11 for lateral adjustment. The offset axis 11 can help the side walls of the mold cavity 8 to stagger each other, so that the specifications of the mold cavity 8 change, and the side walls of the mold cavity 8 are adapted to the offset axis 11. The mold cavity 8 is symmetrically provided with a fixing block 13 for fixing the stretching rod 14. The fixing block 13 is used to fix the stretching rod 14, and the stretching rod 14 is adapted to the offset axis 11. The mold cavity 8 is provided with an overlapping seam 12 for reducing adjustment friction. The overlapping seam 12 can avoid friction on the inner wall of the mold cavity 8.

[0028] The mold cavity 8 is provided with a bonding block 15 for correcting the rotation orientation. The bonding block 15 is mainly used for the rotation stability of the mold cavity 8. The inner wall of the outer support body 2 is provided with a guide rail 16. The guide rail 16 is used to guide the bonding block 15. The bonding block 15 is fixedly connected to the fixing block 13 by welding. Welding can improve the connection strength between the two.

[0029] The working principle of the utility model is as follows: placing the silk fibroin solution in the mold cavity 8, then sealing the peripheral support body 2 with the sealing cover 1, and then starting the motor 5 to make the rotating ring 7 rotate the mold cavity 8, so that the filtration efficiency of the silk fibroin solution is improved.

[0030] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A silk fibroin solution filtering device, comprising an outer peripheral support (2), a sealing cover (1) for heat preservation is arranged on the outer peripheral support (2), a motor (5) is arranged at the bottom of the outer peripheral support (2), and a mold cavity (8) for storing silk fibroin solution is arranged inside the outer peripheral support (2), characterized in that, A heat-conducting material (3) for conducting heat is provided at the bottom of the peripheral support (2). A pressure-reducing cover (6) for reducing the internal pressure is provided on the sealing cover (1). A plurality of heat-conducting rod bodies (9) for heating the fibroin solution are provided in the mold cavity (8). A stretching rod (14) with a micro-adjustable length is provided on the mold cavity (8). A fitting block (15) for correcting the rotation orientation is provided on the mold cavity (8).

2. The silk fibroin solution filtering device according to claim 1, characterized in that, The heat-conducting material (3) is fixedly connected to the peripheral support (2) through a fastener. A cold source (4) for absorbing heat is provided at the bottom of the heat-conducting material (3); The motor (5) is fixedly connected to the cold source (4) through a rotating ring (7). The rotating ring (7) penetrates through the heat-conducting material (3) and is connected to the inner wall of the peripheral support (2) in communication, and the rotating ring (7) is fixedly connected to the bottom of the mold cavity (8).

3. The silk fibroin solution filtering device according to claim 1, characterized in that, The pressure-reducing cover (6) is fixedly connected to the sealing cover (1) through a fastener. A plurality of pressure relief ports for leaking excess pressure are provided on the pressure-reducing cover (6).

4. A silk fibroin solution filtration device according to claim 1, characterized in that, The heat-conducting rod bodies (9) are linearly arranged in the mold cavity (8). A plurality of heat-insulating rings (10) for keeping the fibroin solution at a constant temperature are provided in the mold cavity (8).

5. A silk fibroin solution filtration device according to claim 1, characterized in that Misalignment shafts (11) for lateral adjustment are symmetrically provided on the mold cavity (8), and the side wall of the mold cavity (8) is adapted to the misalignment shafts (11). Fixing blocks (13) for fixing the stretching rod (14) are symmetrically provided on the mold cavity (8), and the stretching rod (14) is adapted to the misalignment shafts (11). An overlapping seam (12) for reducing adjustment friction is provided on the mold cavity (8).

6. The silk fibroin solution filtering device according to claim 5, characterized in that, A guide rail (16) is provided on the inner wall of the peripheral support (2). The fitting block (15) is fixedly connected to the fixing block (13) by welding.

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