Sample adding assembly, dyeing module and dyeing system

Abstract

The utility model provides a sample adding assembly, a dyeing module and a dyeing system, and belongs to the field of pathological tissue sample treatment equipment. The sample adding assembly comprises a main body part, a waste suction head for sucking waste liquid on the glass slide is arranged on the main body part, a flowing channel for the waste liquid to flow is arranged in the waste suction head, the flowing channel is provided with a liquid inlet for sucking the waste liquid and a liquid outlet for being connected with a negative pressure device, the liquid inlet is a slit, the slit has a set length, and the length of the slit is set to be smaller than that of the waste liquid. Therefore, waste suction operation can be carried out on a target range on the glass slide. The dyeing module comprises the sample adding assembly. The dyeing system comprises the dyeing module. The liquid inlet in the waste suction head is arranged to be the slit, so that the waste suction head has a better suction effect, the liquid inlet can sweep over a larger area during use, higher waste suction efficiency is ensured, an air blowing nozzle is not needed, the structures of a sample adding assembly and a dyeing system are simplified, and the cost is reduced. Meanwhile, the diffusion of the evaporated dyeing waste liquid is also inhibited.

Description

Technical Field

[0001] The utility model belongs to the field of pathological tissue sample processing equipment, and particularly relates to a sample adding component, a staining module and a staining system. Background Technique

[0002] With the development of pathological technology, the automation degree of staining systems for staining pathological tissue sections is getting higher and higher, and they can efficiently replace manual staining operations.

[0003] The existing Chinese invention patent application with the publication number of CN105980828A and the publication date of September 28, 2016 discloses an automatic tissue staining system. The system includes a stainer module. The stainer module has a housing and a sample adding component (i.e., a head component) disposed in the housing for adding reagents and cleaning agents to a glass slide and removing waste liquid on the glass slide. The sample adding component includes a main body part and a sample adding structure disposed at the bottom of the main body part. The sample adding structure is specifically two rows of nozzles, and the nozzles can spray staining reagents downward; a waste liquid suction head for sucking the waste liquid on the glass slide is also disposed at the bottom of the main body part. The waste liquid suction head is a circular tubular structure. A blowing nozzle with a V-shaped structure is also disposed at the bottom of the main body part. A plurality of spray holes arranged along the blowing nozzle are disposed on the blowing nozzle, and the gas sprayed out of the spray holes can form a V-shaped air knife.

[0004] During use, the above-mentioned air knife can gather the waste liquid on the glass slide at the waste liquid suction head for the waste liquid suction head to suck. Moreover, the length of the air knife is greater than the width of the glass slide. The sample adding component only needs to walk along the length direction of the glass slide once to suck all the waste liquid on the glass slide, and the efficiency is relatively high. If the waste liquid suction head in the above technical solution is used independently, the waste liquid suction operation cannot be efficiently completed. And setting up the blowing nozzle requires another device to provide high-pressure gas and corresponding pipelines, resulting in a complex structure of the sample adding component and the entire staining system. In addition, using the gas blown out by the blowing nozzle to blow the waste liquid easily causes the waste liquid to evaporate and diffuse into the environment, polluting the surrounding environment. Summary of the Utility Model

[0005] One object of the utility model is to provide a sample adding component to solve the technical problems in the prior art that setting up a blowing nozzle to gather the waste liquid on the glass slide for the waste liquid suction head to suck requires equipment for providing high-pressure gas and corresponding pipelines, resulting in a complex structure of the sample adding component and the staining system, and the gas blown out by the blowing nozzle easily causes the waste liquid to evaporate and spread, polluting the surrounding environment.

[0006] Another object of the utility model is to provide a staining module to solve the above technical problems.

[0007] Another object of the utility model is to provide a staining system to solve the above technical problems.

[0008] To achieve the above object, the technical solution of the sample adding assembly provided by the present utility model is as follows:

[0009] A sample adding assembly includes a main body part. A waste liquid suction head for sucking waste liquid on a glass slide is arranged on the main body part. A flow channel for the waste liquid to flow is arranged inside the waste liquid suction head. The flow channel has a liquid inlet for sucking the waste liquid and a liquid outlet for connecting to a negative pressure device. The liquid inlet is a slit, and the slit has a set length so as to be able to perform waste liquid suction operation on a target range on the glass slide.

[0010] As a further improvement, the lower end of the waste liquid suction head shrinks to form a waste liquid suction ridge line, and the liquid inlet is arranged at the waste liquid suction ridge line and arranged along the waste liquid suction ridge line.

[0011] As a further improvement, the waste liquid suction head includes a triangular prism part, the edge of the triangular prism part extends horizontally, and the edge at the bottom end of the triangular prism part constitutes the waste liquid suction ridge line.

[0012] As a further improvement, the waste liquid suction head further includes a cuboid part integrally connected to the triangular prism part, and the cuboid part is located above the triangular prism part.

[0013] As a further improvement, the target range is 0.8 - 1.5 times the width of the waste liquid distribution.

[0014] As a further improvement, the liquid inlet has a structure that gradually shrinks from the outside to the inside.

[0015] As a further improvement, the waste liquid suction head is integrally connected to the main body part and the waste liquid suction head is located directly below the main body part, and the liquid outlet penetrates the main body part upward.

[0016] As a further improvement, the length direction of the slit is perpendicular to the moving direction of the main body part during use.

[0017] As a further improvement, the sample adding assembly further includes a connecting part integrally connected to the main body part. The connecting part is located on one side above the main body part, and the main body part and the connecting part together form an L shape.

[0018] The beneficial effects are as follows: The sample adding component provided by the present utility model belongs to an invention creation with element changes. The liquid inlet of the waste suction head in the sample adding component is a slit, so that the liquid inlet has a smaller flow area, ensures a better suction effect, and enables the liquid inlet to cover a larger range in its length direction. When in use, as the sample adding component moves, the area swept by the liquid inlet is larger, ensuring a higher waste liquid suction efficiency. Compared with the prior art, the sample adding component in the present utility model has a stronger waste suction ability, and there is no need to set up a blowing nozzle for gathering waste liquid, so there is no need to connect a device for providing high-pressure gas and arrange corresponding pipelines, effectively simplifying the structure of the sample adding component and the structure of the staining system applying the sample adding component. And because the blowing nozzle is no longer set, the polluted gas after the evaporation of the staining waste liquid is easily sucked away by the waste suction head together with the staining waste liquid and is not easily diffused into the surrounding environment to pollute the environment.

[0019] To achieve the above object, the technical solution of the staining module provided by the present utility model is:

[0020] A staining module includes a housing and a sample adding component disposed in the housing. A moving mechanism for driving the sample adding component to move is further disposed in the housing. The sample adding component includes a main body portion. A waste suction head for sucking the waste liquid on the glass slide is disposed on the main body portion. A flow channel for the waste liquid to flow is provided inside the waste suction head. The flow channel has a liquid inlet for sucking the waste liquid and a liquid outlet for connecting to a negative pressure device. The liquid inlet is a slit, and the slit has a set length to enable waste suction operation on the target range on the glass slide.

[0021] As a further improvement, the lower end of the waste suction head shrinks to form a waste suction ridge line, and the liquid inlet is disposed at the waste suction ridge line and arranged along the waste suction ridge line.

[0022] As a further improvement, the waste suction head includes a triangular prism portion, and the edges of the triangular prism portion extend horizontally. The edges at the bottom end of the triangular prism portion form the waste suction ridge line.

[0023] As a further improvement, the waste suction head further includes a rectangular parallelepiped portion integrally connected to the triangular prism portion, and the rectangular parallelepiped portion is located above the triangular prism portion.

[0024] As a further improvement, the target range is 0.8 - 1.5 times the width of the waste liquid distribution.

[0025] As a further improvement, the liquid inlet has a structure that gradually contracts from the outside to the inside.

[0026] As a further improvement, the waste suction head is integrally connected to the main body portion and the waste suction head is located directly below the main body portion, and the liquid outlet penetrates the main body portion upward.

[0027] As a further improvement, the length direction of the slit is perpendicular to the moving direction of the main body portion during use.

[0028] As a further improvement, the sample adding component further includes a connecting portion integrally connected to the main body portion. The connecting portion is located on one side above the main body portion, and the main body portion and the connecting portion together form an L shape.

[0029] The beneficial effects are as follows: The staining module provided by the present utility model is an improvement over the prior art. In this staining module, the liquid inlet of the waste suction head of the sample adding component is a slit, so that the liquid inlet has a smaller flow area, ensuring a better suction effect, while enabling the liquid inlet to cover a larger range in its length direction. During use, as the sample adding component moves, the area swept by the liquid inlet is larger, ensuring a higher waste liquid suction efficiency. Compared with the prior art, the sample adding component in the present utility model has a stronger waste suction ability, eliminating the need to set up a blowing nozzle for gathering waste liquid. Therefore, there is no need to connect equipment for providing high-pressure gas or arrange corresponding pipelines, effectively simplifying the structure of the sample adding component, the structure of the staining module, and the structure of the staining system applying this sample adding component. And because the blowing nozzle is no longer set up, the polluted gas after the evaporation of the staining waste liquid is easily sucked away by the waste suction head along with the staining waste liquid, and is not easily diffused into the surrounding environment to pollute the environment.

[0030] To achieve the above object, the technical solution of the staining system provided by the present utility model is as follows:

[0031] A staining system includes a frame and a staining module installed on the frame. The staining module includes a housing and a sample adding component disposed inside the housing. A moving mechanism for driving the sample adding component to move is further disposed inside the housing. The sample adding component includes a main body portion, and a waste suction head for sucking the waste liquid on the glass slide is disposed on the main body portion. A flow channel for the waste liquid to flow is provided inside the waste suction head. The flow channel has a liquid inlet for sucking the waste liquid and a liquid outlet for connecting to a negative pressure device. The liquid inlet is a slit, and the slit has a set length to enable waste suction operation on the target range on the glass slide.

[0032] As a further improvement, the lower end of the waste suction head shrinks to form a waste suction edge line, and the liquid inlet is disposed at the waste suction edge line and arranged along the waste suction edge line.

[0033] As a further improvement, the waste suction head includes a triangular prism portion, and the edges of the triangular prism portion extend horizontally. The edge at the bottom end of the triangular prism portion constitutes the waste suction edge line.

[0034] As a further improvement, the waste suction head further includes a rectangular parallelepiped portion integrally connected to the triangular prism portion, and the rectangular parallelepiped portion is located above the triangular prism portion.

[0035] As a further improvement, the target range is 0.8 - 1.5 times the width of the waste liquid distribution.

[0036] As a further improvement, the liquid inlet has a structure that gradually contracts from the outside to the inside.

[0037] As a further improvement, the waste suction head is integrally connected to the main body part and the waste suction head is located directly below the main body part, and the liquid outlet penetrates upward through the main body part.

[0038] As a further improvement, the length direction of the slit is perpendicular to the moving direction of the main body part during use.

[0039] As a further improvement, the sampling component further includes a connecting part integrally connected to the main body part, the connecting part is located on one side above the main body part, and the main body part and the connecting part together form an L shape.

[0040] The beneficial effects are as follows: The staining system provided by the present utility model is an improvement on the prior art. In this staining system, the liquid inlet on the waste suction head of the sampling component is a slit, so that the liquid inlet has a smaller flow area, while ensuring a better pumping effect, enabling the liquid inlet to cover a larger range in its length direction. During use, as the sampling component moves, the area swept by the liquid inlet is larger, ensuring a higher waste liquid suction efficiency. Compared with the prior art, the sampling component in the present utility model has a stronger waste suction ability, and there is no need to set up a blowing nozzle for gathering waste liquid. Therefore, there is no need to connect equipment for providing high-pressure gas and arrange corresponding pipelines, effectively simplifying the structure of the sampling component, the structure of the staining module, and the structure of the staining system. And because the blowing nozzle is no longer set, the polluted gas after the evaporation of the staining waste liquid is easily sucked away by the waste suction head together with the staining waste liquid, and is not easily diffused into the surrounding environment to pollute the environment. Description of the Drawings

[0041] Figure 1 It is a schematic structural diagram of a staining module in an embodiment of the staining system in the present utility model;

[0042] Figure 2 It is a schematic structural diagram of a sampling component and a moving mechanism in an embodiment of the staining system in the present utility model;

[0043] Figure 3 It is a schematic structural diagram of a sampling component in an embodiment of the staining system in the present utility model;

[0044] Figure 4 It is a sectional view of a sampling component in an embodiment of the staining system in the present utility model.

[0045] Description of the Reference Numerals:

[0046] 1. Outer shell; 2. Sampling assembly; 201. Main body part; 202. Connecting part; 203. Weight reduction hole; 204. Sampling needle; 205. Communication cavity; 206. First connector; 207. Waste suction head; 208. Flow channel; 209. Liquid inlet; 210. Second connection hole; 211. Second connector; 3. Moving mechanism. Detailed implementation mode

[0047] The following further describes the present utility model in detail with reference to embodiments.

[0048] To solve the problems in the prior art structure, the basic concept of the present utility model is to set the liquid inlet on the waste suction head as a slit, so as to ensure good suction effect of the waste suction head. At the same time, when in use, the liquid inlet can sweep a large area, ensuring high waste suction efficiency. There is no need to set a blowing nozzle, which simplifies the structures of the sampling assembly, dyeing module, and dyeing system. At the same time, it also inhibits the diffusion after the evaporation of the dyeing waste liquid.

[0049] Specific embodiments of the dyeing system provided by the present utility model:

[0050] A dyeing system includes a frame. A port for feeding a tray is provided on the frame. A drying module, a dyeing module, a cover glass module, and a curing unit are provided inside the frame. A transport module for transferring the tray between various parts is also provided on the frame.

[0051] Among them, the frame, drying module, cover glass module, curing unit, and transport module are all prior art. Refer to the appendix Figure 1 , the dyeing module includes an outer shell 1 and a sampling assembly 2 provided inside the outer shell 1 for adding reagents, cleaning agents to the glass slide and removing the waste liquid on the glass slide. A moving mechanism 3 for driving the sampling assembly 2 to move in three mutually perpendicular directions of X, Y, and Z is also provided inside the outer shell 1. The moving mechanism 3 is prior art and will not be elaborated here.

[0052] Refer to the appendix Figure 2 and the appendix Figure 3 , the sampling assembly 2 includes a main body part 201. A vertical connecting part 202 is provided on one side of the main body part 201. The connecting part 202 is located above the main body part 201. The connecting part 202 and the main body part 201 are integrally L-shaped. The main body part 201 and the connecting part 202 are integrally formed. The top wall of the connecting part 202 is fixedly connected to the moving mechanism 3 by bolts. A weight reduction hole 203 for weight reduction is provided on the connecting part 202. In other implementation modes, the connecting part 202 can be separately manufactured from the main body part 201. In order to reduce the weight of the connecting part 202, the connecting part 202 can be a frame structure; or the connecting part 202 can also be not provided, and the main body part 201 can be directly connected to the moving mechanism 3.

[0053] A sampling structure for dripping reagents onto a glass slide is provided directly below the main body 201. The sampling structure specifically includes three sampling needles 204, which are arranged in a straight line, and the arrangement direction of the sampling needles 204 is the same as the width direction of the glass slide during use. The sampling needles 204 are hollow needle tubes. A communication cavity 205 for communicating each sampling needle 204 is processed inside the main body 201. A first connection hole communicating with the communication cavity 205 is opened on the top wall of the main body 201, and a first connector 206 is installed in the first connection hole. The first connector 206 is used to connect a hose, and then connect to a reagent supply device through the hose. The reagent supply device fills the staining reagent into the communication cavity 205 through the hose. After the staining reagent is evenly distributed to each sampling needle 204 in the communication cavity 205, it is dripped onto the glass slide. The reagent supply device is prior art and will not be elaborated here. To reduce the processing difficulty of the communication cavity 205, in this embodiment, a hole is drilled on the lateral side wall of the main body 201 to form the communication cavity 205, and the orifice of the drilled hole needs to be blocked before use.

[0054] A waste suction head 207 for sucking waste liquid on the glass slide is also provided directly below the main body 201. The waste suction head 207 is integrally connected to the main body 201. The waste suction head 207 is in an overall strip-shaped structure, and its length direction is parallel to the arrangement direction of the sampling needles 204. Refer to Figure 3 and Figure 4 , a flow channel 208 is provided inside the waste suction head 207. The flow channel 208 has a liquid inlet 209 and a liquid outlet. The lower end of the waste suction head 207 shrinks to form a waste suction edge line. The length direction of the waste suction edge line is the same as the length direction of the waste suction head. The liquid inlet 209 is located at the waste suction edge line. The liquid inlet 209 is a slit, and the length direction of the slit is the same as the length direction of the waste suction edge line, that is, the slit is arranged along the waste suction edge line.

[0055] The waste suction head 207 includes an integrally connected cuboid part and a triangular prism part. The cuboid part is located above the triangular prism part. The edge of the triangular prism part extends horizontally. The edge at the bottom end of the triangular prism part constitutes the above-mentioned waste suction edge line, which is convenient for the processing of the waste suction head 207. The lower end of the waste suction head 207 needs to be close enough to the glass slide. The waste suction edge line can make the thickness of the lower end of the waste suction head 207 smaller, preventing interference with other objects during use. The waste suction edge line can have a certain width to facilitate the processing of the liquid inlet 209.

[0056] The slit has a set length to enable waste suction operation on the target range on the glass slide, where the target range is 0.8 - 1.5 times the width of the waste liquid distribution, so that during the movement of the main body 201, the range swept by the slit can cover the target range. And during use, the main body 201 moves along the length direction of the glass slide. At this time, the length direction of the slit is perpendicular to the movement direction of the main body 201, that is, the length direction of the slit is the same as the width direction of the glass slide. In other embodiments, the length direction of the slit can have a certain angle with the width direction of the glass slide, and it can also make the set length of the slit cover the width of the above-mentioned target range.

[0057] A second connection hole 210 penetrating the main body 201 is provided at the top of the main body 201. The axial direction of the second connection hole 210 is vertical. The lower end of the second connection hole 210 is communicated with the flow channel 208, and the second connection hole 210 serves as a part of the flow channel 208 to form the liquid outlet in this embodiment. A second connector 211 is installed in the second connection hole 210. The second connector 211 is connected to a negative pressure device through a hose, so that the flow channel 208 and the liquid inlet 209 are in a negative pressure state by using the negative pressure device to suck the waste liquid on the glass slide. The waste liquid on the glass slide enters the flow channel 208 from the liquid inlet 209 and then is discharged through the second connection hole 210.

[0058] The second connection hole 210 is located directly above the liquid inlet 209. The liquid inlet has a structure that gradually contracts from the outside to the inside, so that the airflow in the flow channel 208 is gradually accelerated, and after the waste liquid enters the liquid inlet 209, it is guided by the liquid inlet 209 and gradually converges during the flow process. The shape of the liquid inlet 209 is specifically an isosceles trapezoid structure, which is convenient for processing and manufacturing.

[0059] During staining, multiple glass slides are placed on the tray and the tray is sent into the housing 1 of the staining module. Then, the sampling assembly 2 is driven by the moving mechanism 3 to move from one end of the length direction of the glass slide to be stained to the other end. During this process, the staining reagent is dropped onto the glass slide by using the sampling needle 204.

[0060] After the staining reagent reaction is completed, the sampling assembly 2 is moved from one end of the length direction of the glass slide to the other end again. During the movement of the waste suction head 207, all the waste liquid within the swept range is sucked up. Therefore, after the sampling assembly 2 travels once, all the waste liquid on the glass slide can be removed. Compared with the prior art, there is no need to set up a structure for blowing air to gather the waste liquid on the glass slide, so the structure of the sampling assembly 2 can be simplified. Since there is no longer a structure for blowing air, the air polluted by the evaporation of the staining waste liquid can be more easily sucked away by the waste suction head, preventing it from spreading to the surrounding environment and polluting the environment.

[0061] After that, the sample adding component 2 can be moved again along the length direction of the slide to drop a cleaning solution for cleaning on the slide. Or, with the moving direction of the sample adding component 2 as the front, the waste suction head 207 can be arranged in front of the sample adding needle 204. While sucking the waste liquid with the waste suction head 207 in the previous step, the cleaning solution can be dropped onto the slide.

[0062] In the above embodiments, the liquid inlet has a structure that gradually contracts from the outside to the inside, which can accelerate the air entering the liquid inlet and improve the waste suction effect. In other embodiments, the liquid inlet can also have an equal-diameter structure.

[0063] In the above embodiments, the liquid outlet is connected to the upper end of the flow channel, which can facilitate the extraction of the corresponding hose from the top of the main body. In other embodiments, the liquid outlet can also be arranged on the lateral side wall of the waste suction head and connected to the lateral side of the flow channel. In this embodiment, the hose used to connect to the flow channel is extracted from the lateral side of the waste suction head.

[0064] In other embodiments, the waste suction head can only include a triangular prism part. Or in other embodiments, the waste suction head only includes a cuboid part.

[0065] In the above embodiments, the waste suction head is integrally connected to the main body, which can improve the integrity and has relatively good sealing performance. In other embodiments, the waste suction head can also be an independent structure, and the waste suction head is fixedly installed on the main body by means of threads or bolts, which will not be elaborated here.

[0066] Specific embodiments of the staining module provided by the present utility model:

[0067] The sample adding component is the staining module in the specific embodiment of the above staining system, which will not be elaborated here.

[0068] Specific embodiments of the sample adding component provided by the present utility model:

[0069] The sample adding component is the sample adding component in the specific embodiment of the above staining system, which will not be elaborated here.

[0070] Finally, it should be noted that the above are only the preferred embodiments of the present utility model and are not used to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still make modifications to the technical solutions recorded in the foregoing embodiments without creative efforts, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present utility model shall be included in the protection scope of the present utility model.

Claims

1. A sample addition component, characterized in that It includes a main body part, on which there is a waste liquid suction head for sucking the waste liquid on a glass slide. Inside the waste liquid suction head, there is a flow channel for the waste liquid to flow. The flow channel has a liquid inlet for sucking the waste liquid and a liquid outlet for connecting to a negative pressure device. The liquid inlet is a slit, and the slit has a set length so as to be able to perform waste liquid suction operation on the target range on the glass slide.

2. The sample addition assembly according to claim 1, characterized in that The lower end of the waste liquid suction head shrinks to form a waste liquid suction ridge line, and the liquid inlet is arranged at the waste liquid suction ridge line and arranged along the waste liquid suction ridge line.

3. The sampling component according to claim 2, characterized in that The waste liquid suction head includes a triangular prism part, the edge of the triangular prism part extends horizontally, and the edge at the bottom end of the triangular prism part constitutes the waste liquid suction ridge line.

4. The sample adding component according to claim 3, characterized in that The waste liquid suction head further includes a cuboid part integrally connected to the triangular prism part, and the cuboid part is located above the triangular prism part.

5. The sampling component according to any one of claims 1-4, characterized in that, The target range is 0.8 - 1.5 times the width of the waste liquid distribution.

6. The sample adding component according to any one of claims 1-4, characterized in that, The liquid inlet is a structure that gradually shrinks from the outside to the inside.

7. The sample adding component according to any one of claims 1-4, characterized in that, The waste liquid suction head is integrally connected to the main body part and the waste liquid suction head is located directly below the main body part, and the liquid outlet penetrates the main body part upward.

8. The sampling component according to claim 7, characterized in that, The length direction of the slit is perpendicular to the moving direction of the main body part during use.

9. The sample addition component according to any one of claims 1-4, characterized in that, The sample adding assembly further includes a connecting part integrally connected to the main body part, the connecting part is located on one side above the main body part, and the main body part and the connecting part together form an L shape.

10. A dyeing module, comprising a housing and a sample adding component arranged in the housing, and a moving mechanism for driving the sample adding component to move is further arranged in the housing, characterized in that, The sample adding assembly is the sample adding assembly according to any one of claims 1 - 9.

11. A dyeing system, comprising a frame and a dyeing module mounted on the frame, characterized in that, The staining module is the staining module according to claim 10.

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