Micro-needle drug delivery device integrated with heating module

Abstract

The utility model relates to the technical field of microneedle administration, and provides a microneedle administration device integrated with a heating module, which comprises a fixed seat, a mounting groove is arranged on the fixed seat, and an opening is arranged on at least one side of the mounting groove; the microneedle assembly can be inserted into the mounting groove from the opening or pulled out of the mounting groove; a microneedle array is arranged on one surface, deviating from the fixed seat, of the microneedle assembly; the heating module is connected with the fixed seat, and the heating module is located on the side, away from the microneedle array, of the microneedle assembly. The micro-needle drug delivery device can overcome the defects that an existing micro-needle drug delivery device only has a basic drug delivery function, and the micro-needle and drugs in the micro-needle are difficult to replace, so that the drug absorption rate is low, the treatment time is long, the treatment cost is high, and the universality is poor.

Description

Technical Field

[0001] The utility model relates to the technical field of microneedle drug delivery, in particular to a microneedle drug delivery device with an integrated heating module. Background Art

[0002] Microneedle drug delivery is a new type of drug delivery method that uses a microneedle array composed of several microneedles to penetrate the surface of the skin to achieve effective drug delivery. Compared with traditional injection methods, microneedle drug delivery has the advantages of no need for frequent injections, less drug waste, less pain, and good patient compliance. However, most existing microneedle drug delivery devices only have basic drug delivery functions, and lack auxiliary functions to promote patient absorption of drugs. Patients have low drug absorption rates and long absorption times, which will slow down treatment progress and increase treatment costs. At the same time, most existing microneedle drug delivery devices are of an integrated design, and the types of microneedles and drugs stored in the microneedles are difficult to replace. When a variety of microneedles and drugs of different specifications need to be prepared due to different treatment purposes, multiple microneedle drug delivery devices can only be prepared at the same time, which has poor versatility, is inconvenient to use, and will further increase treatment costs. Utility Model Content

[0003] The purpose of the present utility model is to overcome the shortcomings of existing microneedle drug delivery devices, which only include basic drug delivery functions and are difficult to replace the microneedles and the drugs inside them, resulting in low drug absorption rate, long treatment time, high treatment cost and poor versatility, and to provide a microneedle drug delivery device with an integrated heating module.

[0004] In a first aspect, the present invention provides a microneedle drug delivery device with an integrated heating module, comprising:

[0005] A fixing seat, wherein the fixing seat is provided with a mounting groove, and at least one side of the mounting groove is provided with an opening;

[0006] A microneedle assembly, which can be inserted into or removed from the mounting groove through the opening; a microneedle array is provided on a side of the microneedle assembly facing away from the fixing seat;

[0007] The heating module is connected to the fixing seat and is located on a side of the microneedle assembly away from the microneedle array.

[0008] The heating module includes but is not limited to a resistance wire heating module, a hot air heating module, and an electromagnetic induction heating module.

[0009] The microneedle drug delivery device with an integrated heating module of this solution can heat the microneedle assembly and the skin underneath it through the heating module during microneedle drug delivery, thereby promoting local blood circulation, accelerating the diffusion and absorption of drugs, shortening treatment time, and enhancing the patient's treatment effect and compliance; at the same time, this solution also opens one side of the installation groove so that the microneedle assembly can be installed or replaced in a plug-in manner, making it convenient for operators to replace microneedle assemblies with different drugs or microneedle arrays according to different treatment needs, thereby improving the versatility of this solution.

[0010] Preferably, the heating module comprises a far-infrared heating device.

[0011] The far-infrared heating device is, for example, a device that performs heating using light waves in the 2 μm to 1000 μm region of the spectrum.

[0012] Compared with traditional resistance wire heating, the heating module of this solution preferably uses a far-infrared heating device, which has a relatively gentle, uniform and comfortable heating effect, is not likely to cause skin burns or discomfort, and has higher heating safety; at the same time, far-infrared light waves are directly absorbed by the human body, have little heat loss during heat transfer, have stronger absorption of carbohydrates, and have a good carbon atom resonance effect, so that this solution can better heat the skin and internal tissues at lower power, thereby improving the patient's drug absorption rate and having good product efficacy.

[0013] Preferably, one side of the heat conducting plate abuts against the microneedle assembly, and the other side of the heat conducting plate abuts against the heating module.

[0014] The heat conducting plate includes but is not limited to a heat conducting silicone plate, a heat conducting gel plate, a heat conducting ceramic substrate, etc.; the heat conducting plate can be connected to the fixing seat or to the microneedle assembly.

[0015] This solution sets a heat conducting plate between the microneedle assembly and the heating module, which is conducive to more uniform heating of the microneedle assembly and prevents uneven temperature distribution of the microneedle assembly from causing local overheating or local insufficient temperature.

[0016] Preferably, a closing portion is provided at one end of the mounting groove close to the microneedle array, and the width of the closing portion is smaller than the width of the rest of the mounting groove; the cross-sectional shape of the microneedle assembly matches the cross-sectional shape of the mounting groove.

[0017] This solution closes one end of the mounting groove close to the microneedle array, for example, the mounting groove is T-shaped, inverted trapezoidal, or other shapes with a larger top and a smaller bottom, which can prevent the microneedle assembly from falling out of the mounting groove.

[0018] Preferably, the fixing seat is further connected to a control module, which is used to control the start and stop of the heating module and the heating power.

[0019] The control module includes but is not limited to PID control module, fuzzy control module, neural network controller, predictive control module, etc.

[0020] This solution can automatically control the start and stop and heating power of the heating module through the control module to optimize the drug absorption rate and avoid skin burns, thereby reducing the workload of operators.

[0021] Preferably, a temperature sensor is also connected to the fixing seat, and the temperature sensor is communicatively connected to the control module.

[0022] Communication connections include but are not limited to wireless connections and wired connections.

[0023] This solution can help the control module obtain the external temperature, such as the temperature of the heating module or the temperature of the skin, so as to more accurately and effectively adjust the start and stop and heating power of the heating module to optimize the drug absorption rate and avoid skin burns.

[0024] Preferably, a protective shell is connected to a side of the fixing seat facing away from the microneedle array, and the heating module is located in a cavity enclosed by the protective shell and the fixing seat.

[0025] This solution can protect the components inside the protective shell, such as the heating component, and prevent the operation of the internal components from being disturbed by the outside world.

[0026] Preferably, the protective shell includes a transparent structure, and the transparent structure is used to observe the interior of the protective shell.

[0027] The protective shell includes a transparent structure, and specific forms include but are not limited to providing one or more transparent windows on the protective shell, or making the protective shell as a whole a transparent material component; the transparent material includes but is not limited to acrylic, organic glass, and polycarbonate.

[0028] This solution can facilitate operators to observe the inside of the protective shell; when the internal components of the protective shell, such as the heating component, fail, the operator can discover it in time and take corresponding disposal measures.

[0029] Preferably, a flexible structure is provided at one end of the fixing seat close to the microneedle array, and the flexible structure is used to abut against the skin.

[0030] The flexible structure includes but is not limited to providing a plurality of flexible legs or pads at one end of the fixing base close to the microneedle array, or making the entire fixing base a flexible material component; the flexible material includes but is not limited to rubber, silicone, and nylon.

[0031] This solution enables the fixing seat and the microneedle array connected thereto to fit the skin surface more closely during use, thereby achieving a better drug delivery effect.

[0032] Preferably, a display device is provided on a side of the fixing base facing away from the microneedle array, and the display content of the display device includes the temperature of the heating module.

[0033] Display devices include but are not limited to thermometers, mechanical dials, and display screens.

[0034] This solution can facilitate operators to obtain the current working status of the heating module, so as to determine whether it is necessary to turn the heating module on or off or adjust the heating power of the heating module, thereby preventing insufficient heating power from causing a decrease in the patient's absorption efficiency, or excessive heating power from causing burns to the patient's skin.

[0035] Compared with the existing technology, the beneficial effects of the present invention are:

[0036] The present utility model provides a microneedle drug delivery device with an integrated heating module. When performing microneedle drug delivery, the heating module can heat the microneedle assembly and the skin underneath, thereby promoting local blood circulation, accelerating the diffusion and absorption of drugs, shortening the treatment time, and enhancing the patient's treatment effect and compliance. At the same time, this solution also opens one side of the installation groove so that the microneedle assembly can be installed or replaced in a plug-in manner, making it convenient for operators to replace microneedle assemblies with different drugs or microneedle arrays according to different treatment needs, thereby improving the versatility of this solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 This is a schematic diagram of the three-dimensional structure of a microneedle drug delivery device with an integrated heating module of the present invention;

[0038] Figure 2 This is a schematic diagram of the three-dimensional structure of a microneedle drug delivery device with an integrated heating module of the present invention, when the protective shell is hidden;

[0039] Figure 3 This is a half-section schematic diagram of the three-dimensional structure of a microneedle drug delivery device with an integrated heating module of the present invention;

[0040] Figure 4 This is a schematic side view of the cross-sectional structure of a microneedle drug delivery device with an integrated heating module of the present invention;

[0041] Figure 5 This is a schematic diagram of the main cross-sectional structure of a microneedle drug delivery device with an integrated heating module of the present invention;

[0042] Icons: 1-fixing seat; 11-installation slot; 2-microneedle assembly; 21-fixing part; 22-microneedle plate; 23-heat conduction plate; 3-heating module; 4-control module; 5-protective shell; 6-display device. DETAILED DESCRIPTION

[0043] The present invention will be further described in detail below in conjunction with test examples and specific embodiments. However, this should not be understood as limiting the scope of the present invention to the following embodiments, and all technologies implemented based on the present invention fall within the scope of the present invention.

[0044] Unless otherwise specified, in the description of the specific embodiments of the present invention, the terms indicating orientation or positional relationships such as "upper," "lower," "left," "right," "center," "inside," and "outside" are based on the orientation or positional relationships shown in the accompanying drawings, or are the orientation or positional relationships in which the inventive product / device / apparatus is typically placed when in use. These terms indicating orientation or positional relationships are merely for the purpose of facilitating the description of the present invention or simplifying the description of the specific embodiments to facilitate a quick understanding of the solutions by technicians. They do not indicate or imply that a particular device / component / element must have a specific orientation or be constructed and operated in a specific positional relationship, and therefore should not be construed as limiting the present invention.

[0045] In addition, if the terms "horizontal", "vertical", "overhanging", "parallel" and the like appear, it does not mean that the corresponding devices / components / elements are required to be absolutely horizontal or vertical or overhanging or parallel, but may be slightly tilted or have deviations. For example, "horizontal" only means that its direction is more horizontal than "vertical", and does not mean that the structure must be completely horizontal, but may be slightly tilted. Alternatively, it can be simply understood that the corresponding devices / components / elements are set in directions such as "horizontal", "vertical", "overhanging", and "parallel", and can have an error / deviation of ±10% relative to the corresponding direction setting, more preferably an error / deviation within ±8%, more preferably an error / deviation within ±6%, more preferably an error / deviation within ±5%, and more preferably an error / deviation within ±4%. As long as the corresponding device / component / element is within the error / deviation range, it can still achieve its role in the solution of the present invention.

[0046] In addition, the expressions "first", "second", "third", etc. that appear in the terms are merely descriptions used to distinguish the same or similar components and should not be understood as emphasizing or implying the relative importance of specific components.

[0047] In addition, in the description of the embodiments of the present invention, "several," "plurality," and "a number" represent at least 2. It can also be 2, 3, 4, 5, 6, 7, 8, 9, or any other number, and can even be more than 9.

[0048] Furthermore, in the description of the technical solution of the present invention, unless otherwise expressly specified, defined, or limited, the terms "disposed," "installed," "connected," "connected," "provided with," "laid," and "arranged" should be understood broadly. For example, they may refer to fixed connections, detachable connections, or integral connections. They may be welded, riveted, bolted, threaded, or other commonly used connection methods in the art. Such connections may be mechanical, electrical, or communicative; they may be direct, indirect via an intermediate medium, or internally connected between two components.

[0049] Example 1

[0050] like Figures 1 to 5 As shown, a microneedle drug delivery device with an integrated heating module comprises a mounting base 1, a microneedle assembly 2, and a heating module 3. The mounting base 1 is provided with a mounting slot 11, with an opening on at least one side thereof; the microneedle assembly 2 can be inserted into or removed from the mounting slot 11 through the opening; a microneedle array is provided on the side of the microneedle assembly 2 facing away from the mounting base 1; and the heating module 3 is connected to the mounting base 1 and is located on the side of the microneedle assembly 2 facing away from the microneedle array.

[0051] In an optional embodiment, if Figures 3 to 5 As shown, the microneedle assembly 2 comprises a fixing portion 21 and a microneedle plate 22, wherein the microneedle array is arranged on the side of the microneedle plate 22 away from the fixing seat 1, that is, Figure 4 the fixing portion 21 is provided along the edge of the microneedle plate 22 and is connected to the side of the microneedle plate 22 close to the fixing seat 1, ie Figure 4 the side of the fixing portion 21 is used to connect to the mounting groove 11; this can prevent the fragile microneedle plate 22 from being directly connected to the fixing seat 1, and on the other hand, it can also make the connection between the microneedle assembly 2 and the fixing seat 1 more reliable.

[0052] In an optional embodiment, the heating module 3 includes a far infrared heating device. Figure 3 As shown, the heating module 3 can adopt a carbon fiber heating tube, which has the advantages of low energy consumption, high infrared radiation intensity, long service life, and highly controllable temperature and power; and the carbon fiber heating tube has no instantaneous current shock and does not require a ballast for ignition, and there is no pulse current shock at startup, which simplifies the lighting power supply and protection circuit, and extends the service life of the power supply and related electrical appliances.

[0053] In an optional embodiment, one side of the heat conducting plate 23 abuts against the microneedle assembly 2, and the other side of the heat conducting plate 23 abuts against the heating module 3. The specific material of the heat conducting plate 23 can be a thermally conductive silicone sheet, such as XK-P80, XK-P60, or XK-P50.

[0054] In an optional embodiment, the heat conducting plate 23 is connected to the microneedle assembly 2, that is, the heat conducting plate 23 can be removed from the fixing seat 1 together with the microneedle assembly 2; this ensures that there will be no excessive residual heat in the fixing seat 1 when the microneedle assembly 2 is replaced.

[0055] In an optional embodiment, the mounting groove 11 is provided with a closing portion at one end close to the microneedle array, and the width of the closing portion is smaller than the width of the rest of the mounting groove 11; the cross-sectional shape of the microneedle assembly 2 matches the cross-sectional shape of the mounting groove 11. Figure 4 As shown, the cross-section of the mounting groove 11 can be roughly T-shaped, so that it has two widths, wherein the larger width portion is located at the end away from the microneedle array, and the smaller width portion is located at the end close to the microneedle array, i.e., the closing portion; inserting the microneedle assembly 2 having the same roughly T-shaped cross-section into the mounting groove 11 can prevent the microneedle assembly 2 from sliding along the microneedle array. Figure 4 The vertical direction is separated from the mounting groove 11.

[0056] In an optional embodiment, the fixing base 1 is further connected to a control module 4 for controlling the start and stop of the heating module 3 and the heating power. The control module 4 can adopt a fuzzy PID controller to monitor the heating temperature of the heating module 3 to ensure that it is always within a specified range. When the temperature approaches the upper limit of the specified range, the heating power of the heating module 3 is reduced, and when the temperature approaches the lower limit of the specified range, the heating power of the heating module 3 is increased, thereby improving the drug absorption rate and preventing skin burns.

[0057] In an optional embodiment, a temperature sensor is further connected to the fixing base 1, and the temperature sensor is communicatively connected to the control module 4. For example, the temperature sensor is set on a side of the fixing base 1 close to the microneedle array to directly detect the temperature of the patient's skin surface.

[0058] In an optional embodiment, a protective shell 5 is connected to the side of the mounting base 1 facing away from the microneedle array, and the heating module 3 is located in the cavity enclosed by the protective shell 5 and the mounting base 1. Furthermore, the control module 4, the display device 6 described below, and their corresponding electrical circuits can also be disposed in the cavity enclosed by the protective shell 5 and the mounting base 1.

[0059] In an optional embodiment, the protective shell 5 includes a transparent structure, which is used to observe the interior of the protective shell 5. For example, the entire protective shell 5 is made directly of a transparent material so that all components inside the protective shell 5 can be observed from the outside.

[0060] In an optional embodiment, a flexible structure is provided at one end of the fixing base 1 close to the microneedle array, and the flexible structure is used to contact the skin. For example, the entire base can be made directly of medical silicone.

[0061] In an optional embodiment, a display device 6 is provided on the side of the holder 1 facing away from the microneedle array, and the display content of the display device 6 includes the temperature of the heating module 3. For example, a touch screen can be connected to the protective shell 5, and the touch screen is in communication with the control module 4. This can not only display the working status of the heating module 3, but also facilitate the operator to manually set the heating temperature and heating time of the heating module 3 directly through the touch screen.

[0062] When performing microneedle drug delivery treatment, the side of the fixing base 1 close to the microneedle array is placed against the patient's skin surface, allowing the microneedle array to penetrate the patient's skin and deliver the drug into the patient's body; the heating module 3 and the control module 4 are started to heat the skin surface through far-infrared radiation to promote blood circulation in the corresponding part of the patient, and the heating power of the heating module 3 is controlled in real time by the control module 4 to improve the patient's drug absorption rate and avoid skin burns; after the rated heating time is reached, the fixing base 1 is removed to complete the treatment.

[0063] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A microneedle drug delivery device with an integrated heating module, characterized in that: Include: A fixing seat (1), wherein the fixing seat (1) is provided with a mounting groove (11), and at least one side of the mounting groove (11) is provided with an opening; A microneedle assembly (2), wherein the microneedle assembly (2) can be inserted into the mounting groove (11) or pulled out from the mounting groove (11) from the opening; a microneedle array is provided on a side of the microneedle assembly (2) facing away from the fixing seat (1); A heating module (3) is connected to the fixing seat (1), and the heating module (3) is located on a side of the microneedle assembly (2) facing away from the microneedle array.

2. The microneedle drug delivery device with integrated heating module according to claim 1, characterized in that: The heating module (3) comprises a far-infrared heating device.

3. The microneedle drug delivery device with integrated heating module according to claim 1, characterized in that: It also includes a heat conducting plate (23), one side of the heat conducting plate (23) abuts against the microneedle assembly (2), and the other side of the heat conducting plate (23) abuts against the heating module (3).

4. The microneedle drug delivery device with integrated heating module according to claim 1, characterized in that: The mounting groove (11) is provided with a closing portion at one end close to the microneedle array, and the width of the closing portion is smaller than the width of the remaining portion of the mounting groove (11); the cross-sectional shape of the microneedle assembly (2) matches the cross-sectional shape of the mounting groove (11).

5. The microneedle drug delivery device with integrated heating module according to any one of claims 1 to 4, characterized in that: The fixing seat (1) is also connected to a control module (4), and the control module (4) is used to control the start and stop of the heating module (3) and the heating power.

6. The microneedle drug delivery device with integrated heating module according to claim 5, characterized in that: The fixing seat (1) is also connected to a temperature sensor, and the temperature sensor is in communication connection with the control module (4).

7. The microneedle drug delivery device with integrated heating module according to any one of claims 1 to 4, characterized in that: A protective shell (5) is connected to the side of the fixing seat (1) facing away from the microneedle array, and the heating module (3) is located in a cavity enclosed by the protective shell (5) and the fixing seat (1).

8. The microneedle drug delivery device with integrated heating module according to claim 7, characterized in that: The protective shell (5) comprises a transparent structure, and the transparent structure is used to observe the interior of the protective shell (5).

9. The microneedle drug delivery device with integrated heating module according to any one of claims 1 to 4, characterized in that: A flexible structure is provided at one end of the fixing seat (1) close to the microneedle array, and the flexible structure is used for contacting the skin.

10. The microneedle drug delivery device with integrated heating module according to any one of claims 1 to 4, characterized in that: A display device (6) is provided on the side of the fixing seat (1) facing away from the microneedle array, and the display content of the display device (6) includes the temperature of the heating module (3).

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