Device for simulating process of infecting escherichia coli with bacteriophage

Abstract

The utility model discloses a device for simulating the process of infecting escherichia coli with bacteriophage, which comprises a bacteriophage model and an escherichia coli model, the bacteriophage model comprises an icosahedron head, the outer wall of the head is connected with a substrate through a tail sheath, the outer surface of the substrate is fixedly connected with a tail filament, the escherichia coli model comprises a shell, and the shell is fixedly connected with the escherichia coli model. An annular magnet is fixedly connected to the inner wall of the shell, a through hole is formed in the position, corresponding to the axis of the annular magnet, of the side wall of the shell in a penetrating mode, the phage model is composed of the head, the tail sheath, the base plate and the tail wire, and escherichia coli is supported by the shell. The annular magnet for adsorbing the tail filament is arranged in the shell, so that the bacteriophage can be adsorbed outside the shell to simulate that the bacteriophage is adsorbed on escherichia coli, and the structure of the bacteriophage and the escherichia coli and the process that the bacteriophage infects the escherichia coli can be vividly displayed.

Description

Technical Field

[0001] The utility model relates to the technical field of teaching aids, in particular to a device for simulating the process of bacteriophage infecting Escherichia coli. Background Art

[0002] Teaching aids are physical objects used to disseminate science and educate people. They are complete scientific and technological media and are indispensable equipment for youth science and technology activities. Teaching aids used in science and technology activities include both physical and replica teaching aids. Specifically, these include specimens or samples from nature, such as biological specimens, mineral specimens, fossils, rocks, and rare animal samples used in science and technology education activities. There are also replicas and models of specimens: some specimens are so precious (such as the Peking Man skull fossil) that they should not be disseminated widely, so people create various replicas and models to disseminate scientific and technological information. Examples include human anatomy models and models used in aviation, maritime, and automotive models. Teaching aids can also be divided into two types: those used for demonstration and those used for practical operation.

[0003] When students study the second compulsory high school biology textbook "Exploring whether genetic material is DNA or RNA", in order to make students more clear about the process of phage infecting the E. coli model and clearly understand the appearance and structure of the E. coli model and phage, a phage infection E. coli process demonstration teaching aid is urgently needed to help students understand and remember, so as to solve the above-mentioned problems. Utility Model Content

[0004] The purpose of the utility model is to provide a device for simulating the process of bacteriophage infecting Escherichia coli, so as to solve the problems raised in the above background technology.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions: a device for simulating the process of phage infecting Escherichia coli, comprising a phage model and an Escherichia coli model, wherein the phage model comprises an icosahedral head, the outer wall of the head is connected to a base plate through a tail sheath, the outer surface of the base plate is fixedly connected to a tail wire, the Escherichia coli model comprises an outer shell, the inner wall of the outer shell is fixedly connected to a ring magnet, and a through hole is penetrated through the side wall of the outer shell corresponding to the axis of the ring magnet.

[0006] According to the above technical solution, the head is hollow, and a nucleic acid model is provided inside the head. The nucleic acid model is composed of several spheres connected by a connecting rope. The tail sheath is connected to the head, and the bottom of the tail sheath passes through the end face of the substrate.

[0007] According to the above technical solution, the tail sheath includes a connecting tube fixedly connected to the head, the outer surface of the connecting tube is sleeved with a movable tube, the inner circumferential surface of the movable tube is provided with an annular groove, the annular groove is coaxially arranged with the movable tube, the outer wall of the connecting tube is fixedly connected to a limiting ring corresponding to the annular groove, and a first spring is provided between the limiting ring and the annular groove, the inner wall of the connecting tube is symmetrically provided with elastic parts, the side wall of the connecting tube is provided with a through groove corresponding to the upper end of the movable tube, the surface of the elastic part is fixedly connected with a top block corresponding to the through groove, one end of the nucleic acid model is connected to a counterweight block, and the counterweight block is located between the corresponding elastic parts inside the connecting tube.

[0008] According to the above technical solution, one end of the shell is open, and a sealing cover is provided at the opening. The inner surface of the sealing cover is fixedly connected to a movable column, the outer surface of the movable column is fixedly connected to a plurality of replicating phage models, and a second spring is provided between the movable column and the shell.

[0009] According to the above technical solution, a movable block is provided inside the movable column, and an annular limit block is fixedly connected to the end of the inner circumference of the movable column away from the sealing cover. The inner surface of the outer shell is connected to the connecting block through a connecting rod, and the surface of the connecting block is fixedly connected to a connecting column, and the end of the connecting column away from the connecting block is fixedly connected to the movable block.

[0010] Compared with the prior art, the beneficial effects achieved by the present invention are as follows: the present invention provides a bacteriophage model and an E. coli model, wherein the bacteriophage model is composed of a head, a tail sheath, a base plate and tail filaments, and the E. coli is supported by an outer shell, and an annular magnet for adsorbing the tail filaments is provided inside the outer shell, so that the bacteriophage can be adsorbed on the outside of the outer shell to simulate the adsorption of the bacteriophage on the E. coli, thereby more vividly displaying the structure of the bacteriophage and E. coli and the process of the bacteriophage infecting the E. coli. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0012] Figure 1 This is a schematic diagram of the main cross-sectional structure of the bacteriophage of the present invention;

[0013] Figure 2 This is a schematic diagram of the main cross-sectional structure of the utility model during bacteriophage infection;

[0014] Figure 3 This is a schematic diagram of the main cross-sectional structure of the utility model;

[0015] Figure 4 yes Figure 1 A in the middle is an enlarged structural diagram;

[0016] In the figure: 1-head, 2-base plate, 3-tail wire, 4-housing, 5-annular magnet, 6-through hole, 7-connecting tube, 8-movable tube, 9-annular groove, 10-limiting ring, 11-elastic member, 12-through groove, 13-top block, 14-counterweight block, 15-cover, 16-movable column, 17-replica phage model, 18-second spring, 19-movable block, 20-annular limiting block, 21-connecting block, 22-connecting column. DETAILED DESCRIPTION

[0017] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0018] See also Figure 1-4 The utility model provides a technical solution: a device for simulating the process of bacteriophage infecting Escherichia coli, including a bacteriophage model and an Escherichia coli model, such as Figure 1 As shown, the phage model includes an icosahedral head 1, the outer wall of the head 1 is connected to a base plate 2 via a tail sheath, and the outer surface of the base plate 2 is fixedly connected to a tail wire 3. The head 1, base plate 2, tail sheath and tail wire 3 constitute a phage model, which can vividly display the appearance of the phage. The E. coli model includes a shell 4, the inner wall of the shell 4 is fixedly connected to a ring magnet 5, and the side wall of the shell 4 is penetrated by a through hole 6 corresponding to the axis of the ring magnet 5. For ease of display, the shell 4 is made of a transparent material;

[0019] Specifically, the head 1 is hollow, and a nucleic acid model is provided inside the head 1. The nucleic acid model is composed of several spheres connected by a connecting rope to ensure that the nucleic acid model is flexible as a whole and can flow into the shell 4 through the tail sheath to simulate the process of phage infecting E. coli. The tail sheath is connected to the head 1, and the bottom of the tail sheath penetrates the end surface of the substrate 2 to facilitate the nucleic acid model inside the head 1 to enter the shell 4.

[0020] Specifically, the tail sheath includes a connecting tube 7 fixedly connected to the head 1, the outer surface of the connecting tube 7 is sleeved with a movable tube 8, the connecting tube 7 and the movable tube 8 are coaxially arranged, the inner circumferential surface of the movable tube 8 is provided with an annular groove 9, the annular groove 9 and the movable tube 8 are coaxially arranged, the outer wall of the connecting tube 7 is fixedly connected to the annular groove 9 corresponding to the limit ring 10, under the action of the limit ring 10, the movable tube 8 will not be separated from the connecting tube 7, and a first spring is provided between the limit ring 10 and the annular groove 9, under the action of the first spring, the limit ring 10 is located at one end close to the head 1, as shown in FIG. Figure 4 As shown, the inner wall of the connecting tube 7 is symmetrically provided with elastic members 11, and the side wall of the connecting tube 7 is provided with a through groove 12 corresponding to the upper end of the movable tube 8, and the surface of the elastic member 11 is fixedly connected with a top block 13 corresponding to the through groove 12. Figure 1 As shown, under the action of the top block 13, the top block 13 drives the elastic member 11, so that the two elastic members 11 are close to each other, and one end of the nucleic acid model is connected to a counterweight block 14, and the counterweight block 14 is located between the corresponding elastic members 11 inside the connecting tube 7. Under the action of the elastic member 11, the counterweight block 14 will not flow out of the tail sheath. During the simulated infection process, the head 1 is pushed to make the connecting tube 7 slide relative to the movable tube 8 to overcome the first spring, and the top block 13 enters the interior of the annular groove 9. The elastic member 11 is reset under the elastic action, and the nucleic acid model is injected into the interior of the housing 4 through the connecting tube 7;

[0021] Specifically, one end of the housing 4 is open, and a cover 15 is provided at the opening. A movable column 16 is fixedly connected to the inner surface of the cover 15, and a plurality of replica phage models 17 are fixedly connected to the outer surface of the movable column 16. A second spring 18 is provided between the movable column 16 and the housing 4. Under the action of the second spring 18, the cover 15 is tightly fitted with the opening. When the cover 15 is pulled out, the movable column 16 is driven to move, and the movable column 16 brings out the replica phage models 17, simulating the release process of the phage.

[0022] Specifically, a movable block 19 is provided inside the movable column 16. An annular limit block 20 is fixedly connected to the end of the inner circumference of the movable column 16 away from the cover 15. The inner surface of the housing 4 is connected to a connecting block 21 via a connecting rod. A connecting column 22 is fixedly connected to the surface of the connecting block 21, and the end of the connecting column 22 away from the connecting block 21 is fixedly connected to the movable block 19.

[0023] When the utility model is used, the phage model is brought close to the E. coli model, and the tail filament is adsorbed on the surface of the shell 4 under the action of the annular magnet 5, simulating the adsorption process. By pressing down the head 1, the connecting tube 7 overcomes the first spring and slides relative to the movable tube 8, and the top block 13 enters the inside of the annular groove 9. The elastic member 11 is reset under the elastic action, and the nucleic acid model is injected into the shell 4 through the connecting tube 7 under the action of gravity, simulating the nucleic acid injection process. Then, the sealing cap 15 is pulled out, driving the movable column 16 to move, and the movable column 16 brings out the replica phage model 17, simulating the release process of the phage.

[0024] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0025] Finally, it should be noted that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein with equivalents. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A device for simulating the process of bacteriophage infecting Escherichia coli, comprising a bacteriophage model and an Escherichia coli model, characterized in that: The bacteriophage model comprises an icosahedral head (1), the outer wall of the head (1) is connected to a base plate (2) via a tail sheath, the outer surface of the base plate (2) is fixedly connected to a tail filament (3), and the Escherichia coli model comprises an outer shell (4), the inner wall of the outer shell (4) is fixedly connected to an annular magnet (5), and a through hole (6) is provided through the side wall of the outer shell (4) corresponding to the axis of the annular magnet (5).

2. The device for simulating the process of bacteriophage infection of Escherichia coli according to claim 1, characterized in that: The head (1) is hollow, and a nucleic acid model is provided inside the head (1). The nucleic acid model is composed of a plurality of spheres connected by a connecting rope. The tail sheath is connected to the head (1), and the bottom of the tail sheath passes through the end surface of the substrate (2).

3. The device for simulating the process of bacteriophage infecting Escherichia coli according to claim 2, characterized in that: The tail sheath includes a connecting tube (7) fixedly connected to the head (1), the outer surface of the connecting tube (7) is provided with a movable tube (8), the inner circumference of the movable tube (8) is provided with an annular groove (9), and the annular groove (9) is coaxially arranged with the movable tube (8). The outer wall of the connecting tube (7) is fixedly connected to a limiting ring (10) corresponding to the annular groove (9), and a first spring is provided between the limiting ring (10) and the annular groove (9). The inner wall of the connecting tube (7) is symmetrically provided with an elastic member (11), and a through groove (12) is passed through the side wall of the connecting tube (7) corresponding to the upper end of the movable tube (8), and a top block (13) is fixedly connected to the surface of the elastic member (11) corresponding to the through groove (12). One end of the nucleic acid model is connected to a counterweight block (14), and the counterweight block (14) is located between the corresponding elastic members (11) inside the connecting tube (7).

4. The device for simulating the process of bacteriophage infecting Escherichia coli according to claim 3, characterized in that: One end of the shell (4) is open, and a cover (15) is provided at the opening. A movable column (16) is fixedly connected to the inner surface of the cover (15), and a plurality of replicating phage models (17) are fixedly connected to the outer surface of the movable column (16). A second spring (18) is provided between the movable column (16) and the shell (4).

5. The device for simulating the process of bacteriophage infecting Escherichia coli according to claim 4, characterized in that: The movable column (16) is provided with a movable block (19) for internal movement. The inner peripheral surface of the movable column (16) is fixedly connected to an annular limit block (20) at one end away from the sealing cover (15). The inner surface of the shell (4) is connected to a connecting block (21) via a connecting rod. The surface of the connecting block (21) is fixedly connected to a connecting column (22), and the end of the connecting column (22) away from the connecting block (21) is fixedly connected to the movable block (19).

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