Fixing device for proton and photon irradiation animal experiment

Abstract

The utility model relates to a fixing device for a proton photon irradiation animal experiment, which comprises a plurality of tubular fixators, the tubular fixators are arranged on a base through a horizontal moving mechanism, and each tubular fixer comprises a fixing tube body, a height adjusting piece, a head limiting clamping plate and a tail limiting baffle, the fixed pipe body is vertically arranged, and the upper end and the lower end of the side wall of the fixed pipe body are each provided with a limiting guide groove. According to the utility model, the radiation depth of the tubular fixer on which the experimental animal is fixed is adjusted in the horizontally arranged proton photon irradiation animal experiment through the horizontal moving mechanism; the abdomen of the mouse can be directly exposed in front of a radiation source through the tubular fixator which is vertically arranged and provided with a head limiting clamping plate and a tail limiting baffle, and meanwhile the mouse is prevented from moving randomly in the tubular fixator; and the height adjusting piece is used for meeting the positioning requirements of different animals under irradiation.

Description

Technical Field

[0001] The utility model belongs to the technical field of proton-photon irradiation experimental equipment, in particular to a fixing device used for proton-photon irradiation animal experiments. Background Art

[0002] Radiotherapy mainly uses the physical effects of various radiation rays to kill or inhibit the growth of residual tumor cells. It is an important treatment for patients with many types of tumors. Although previous high-dose radiotherapy damaged normal tissues, with the advancement of radiation technology, including the use of treatment planning systems and new rays, the protection of normal tissues has been improved, making re-radiotherapy possible. In 2022, the European Society for Radiation Oncology and the European Organization for Research and Treatment of Cancer published an article in "The Lancet Oncology" stating that for locally recurrent tumors, re-radiotherapy can be considered to achieve lasting local control of tumor patients. However, at present, whether it is new radiotherapy rays such as protons, or traditional photon radiotherapy, the biological effects after radiation irradiation are still unclear, and effective experimental methods and models are urgently needed to explore and study them.

[0003] In clinical research, experimental animals such as laboratory mice are usually used to establish animal experimental models to study the effects of radiation on animal physiology and pathology. Currently, the experimental animal fixation devices on the market, especially those for rats and mice, usually use tubular fixators to fix the experimental animals. However, this tubular fixator simply limits the position of the experimental animal in the length direction through the front and rear baffles. In proton horizontal beam irradiation experiments, it is sometimes necessary to perform radiotherapy experiments on vertically arranged mice. Conventional tubular fixators cannot fix the mouse's head when arranged vertically, resulting in the mouse's movement affecting the experimental results. Therefore, there is an urgent need for a fixation device that can fix mice and adjust according to the irradiation site, the different depths of irradiation placement, etc. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a fixing device for proton-photon irradiation animal experiments, which can fix mice in a vertical direction to prevent the mice's heads from moving around, and can adjust the irradiation position and irradiation depth as needed.

[0005] The technical solution adopted by the utility model to solve its technical problems is as follows: providing a fixing device for proton-photon irradiation animal experiments, comprising a plurality of tubular fixtures, the tubular fixtures being arranged on a base through a horizontal moving mechanism, the tubular fixtures comprising a fixed tube body, a height adjusting member, a head limiting splint and a tail limiting baffle, the fixed tube body being arranged vertically, and limiting guide grooves being provided at the upper and lower ends of its side walls; the height adjusting member being provided on the surface of the fixed tube body and connected to the end of the horizontal moving mechanism for adjusting the height of the tubular fixture; the head limiting splint having an outer diameter matching the inner diameter of the tubular fixture, a slot having a size matching the neck size of the experimental animal being provided on its surface, and a limiting adjusting member matching the limiting guide groove being provided on its side wall; the tail limiting baffle having an outer diameter matching the inner diameter of the tubular fixture, a through groove having a size matching the tail size of the experimental animal being provided on its surface, and a limiting adjusting member matching the limiting guide groove being provided on its side wall.

[0006] Preferably, the base comprises a horizontally arranged bottom plate and two side baffles parallel to the moving direction of the horizontal moving mechanism.

[0007] Preferably, the horizontal movement mechanism includes a slide rail provided on the base and a slider matched with the slide rail, a vertical plate is provided on the top of the slider, and the tubular fixer is provided on the surface of the vertical plate.

[0008] Preferably, the limit adjustment member includes a threaded hole provided in the side wall of the head limit clamping plate and the tail limit baffle, and a limit bolt is screwed into the threaded hole, and the screw head diameter of the limit bolt is larger than the slot width of the limit guide slot.

[0009] Preferably, the tubular holder, the horizontal moving mechanism and the base are all made of transparent acrylic.

[0010] Preferably, a handle is provided on the upper portion of the side baffle and an armrest is provided on the side.

[0011] Preferably, the surface of the slide rail is marked with scale lines.

[0012] Preferably, the height adjustment member includes adjustment wings provided on both sides of the tubular fixer and a position adjustment hole provided on the vertical plate, the adjustment wings are provided with a plurality of limiting holes, and the limiting holes are provided with adjustment bolts matching the position adjustment holes.

[0013] Preferably, the position adjustment hole is a waist-shaped hole or a plurality of positioning threaded holes.

[0014] The beneficial effects are as follows: the utility model uses a horizontal moving mechanism to enable a tubular holder that fixes experimental animals (such as mice) to adjust the radiation depth in a horizontally arranged proton-photon irradiation animal experiment; the tubular holder is arranged vertically and is provided with a head limiting splint and a tail limiting baffle, so that the abdomen of the mouse can be directly exposed to the radiation source while preventing the mouse from moving around in the tubular holder; and the height adjustment part is used to meet the requirements of different animal positions under irradiation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a three-dimensional diagram of a fixture used for proton-photon irradiation animal experiments.

[0016] Figure 2 This is a front view of a fixture used for proton-photon irradiation animal experiments.

[0017] Figure 3 This is a top view of a fixture used for proton-photon irradiation animal experiments.

[0018] Figure 4 for Figure 1 Enlarged stereoscopic view of the middle base.

[0019] Figure 5 for Figure 1 Enlarged stereoscopic view of the horizontal moving mechanism.

[0020] Figure 6 for Figure 1 Enlarged stereoscopic view of the middle tubular fixator.

[0021] Among them, 1-base; 101-handle; 102-armrest; 103-slide rail; 104-side baffle; 105-scale line; 2-horizontal movement mechanism; 201-slider; 202-vertical plate; 203-positioning threaded hole; 204-slide groove; 3-tubular fixer; 301-fixed tube body; 302-adjusting wing; 303-head limit splint; 304-tail limit baffle; 305-limit bolt; 306-limit guide groove; 307-adjusting bolt.

[0022] The same reference numerals in the various drawings represent the same components. DETAILED DESCRIPTION

[0023] The present invention will be further described below with reference to specific embodiments. It should be understood that these embodiments are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. Furthermore, it should be understood that after reading the contents of this invention, those skilled in the art may make various changes or modifications to the present invention, and that such equivalents also fall within the scope of the claims appended hereto.

[0024] like Figure 1 、 23, the present invention provides a fixing device for proton-photon irradiation animal experiments, comprising a plurality of tubular fixtures 3, the tubular fixtures 3 being arranged on a base 1 via a horizontal moving mechanism 2, the tubular fixtures 3 comprising a fixed tube body 301, a height adjusting member, a head limiting splint 303 and a tail limiting baffle 304, the fixed tube body 301 being arranged vertically, and limiting guide grooves 306 being provided at the upper and lower ends of its side walls; the height adjusting member being arranged on the surface of the fixed tube body 301 and being aligned with the horizontal moving mechanism 2; The end of the moving mechanism 2 is connected to adjust the height of the tubular holder 3; the outer diameter of the head limit splint 303 matches the inner diameter of the tubular holder 3, its surface is provided with a slot whose size matches the neck size of the experimental animal, and its side wall is provided with a limit adjustment piece that matches the limit guide groove 306; the outer diameter of the tail limit baffle 304 matches the inner diameter of the tubular holder 3, its surface is provided with a through groove whose size matches the tail of the experimental animal, and its side wall is provided with a limit adjustment piece that matches the limit guide groove 306.

[0025] like Figure 4 As shown, in a specific embodiment, the base 1 includes a horizontally arranged bottom plate and two side baffles 104 parallel to the moving direction of the horizontal moving mechanism 2. No baffle is set on the front side of the moving direction of the horizontal moving mechanism 2 to prevent the radiation source from being additionally blocked by the front baffle when the tubular holder 3 is set at too low a height.

[0026] A handle 101 is provided on the upper portion of the side baffle 104 and an armrest 102 is provided on the side, so as to facilitate the operator to operate and transfer the fixing device.

[0027] like Figure 5 As shown, in one specific embodiment, the horizontal movement mechanism 2 includes a slide rail 103 mounted on the base 1 and a slider 201 adapted to fit the slide rail 103. A vertical plate 202 is provided at the top of the slider 201, and the tubular holder 3 is mounted on the surface of the vertical plate 202. The slider 201 slides horizontally along the slide rail 103 via a groove 204 at its bottom to adjust the horizontal distance between the tubular holder 3 and the radiation source. The slider 201 has a groove at its top and open slots on its two side walls. The lower portion of the vertical plate 202 is inserted into the open slots, providing a stable position and allowing for quick replacement.

[0028] The surface of the slide rail 103 is marked with scale lines 105, which can be directly read visually to confirm the distance between the slide rail 103 and the radiation source after adjustment.

[0029] Since the horizontal moving mechanism 2 has no baffle on the front, it is easy to directly remove and replace the slider 201 of the horizontal moving mechanism 2 during use. The vertical plate 202 is detachably connected to the slider 201, so two vertical plates 202 and corresponding test objects can be prepared, improving the efficiency of replacing test objects.

[0030] In a specific embodiment, the position-limiting adjustment member includes a position-limiting hole provided in the sidewalls of the head position-limiting clamping plate 303 and the tail position-limiting baffle 304. A position-limiting bolt 305 is provided in the position-limiting hole. The diameter of the screw head of the position-limiting bolt 305 is larger than the width of the position-limiting guide groove 306. During use, the position of the head position-limiting clamping plate 303 and the tail position-limiting baffle 304 within the position-limiting guide groove 306 can be controlled by untightening the position-limiting bolt 305. After the head of an experimental animal, such as a mouse, is inserted into the slot and the tail into the through slot, and the position is ensured to be fully extended, the position-limiting bolt 305 is tightened onto the outer surface of the tubular holder 3 to achieve position-limiting fixation.

[0031] like Figure 6 As shown, in one specific embodiment, the height adjustment member includes adjustment wings 302 disposed on both sides of the tubular holder 3 and position adjustment holes disposed on the vertical plate 202. The adjustment wings 302 are provided with a plurality of threaded holes, four of which are arranged in groups and located at the four corners of the adjustment wings 302. Adjustment bolts 307 that match the position adjustment holes are screwed into the threaded holes. Accordingly, the position adjustment holes are a plurality of positioning threaded holes 203, four of which are arranged in groups and have a one-to-one correspondence in position and spacing with the threaded holes on the adjustment wings. In other embodiments, the position adjustment holes are waist-shaped holes arranged along the height direction. During use, the adjustment wings 302 are fixed to the position adjustment holes at different heights using the adjustment bolts 307 to achieve height adjustment.

[0032] The tubular holder 3, the horizontal moving mechanism 2 and the base 1 are all made of transparent acrylic, which is convenient for the experimenter to observe the status of the mouse and the operation position in real time.

Claims

1. A fixation device for proton-photon irradiation animal experiments, comprising a plurality of tubular fixators, characterized in that: The tubular holder is arranged on the base through a horizontal moving mechanism. The tubular holder includes a fixed tube body, a height adjustment member, a head limiting splint and a tail limiting baffle. The fixed tube body is arranged vertically, and the upper and lower ends of its side walls are provided with limiting guide grooves. The height adjustment member is provided on the surface of the fixed tube body and is connected to the end of the horizontal movement mechanism, and is used to adjust the height of the tubular holder; The outer diameter of the head limiting splint matches the inner diameter of the tubular holder, a slot is opened on its surface with a size matching the size of the experimental animal's neck, and a limiting adjustment piece is provided on its side wall to match the limiting guide groove; The outer diameter of the tail limit baffle matches the inner diameter of the tubular holder, a through groove with a size matching the tail of the experimental animal is opened on its surface, and a limit adjustment piece matching the limit guide groove is provided on its side wall.

2. A fixing device for proton-photon irradiation animal experiments according to claim 1, characterized in that: The base comprises a horizontally arranged bottom plate and two side baffles parallel to the moving direction of the horizontal moving mechanism.

3. The fixing device for proton-photon irradiation animal experiments according to claim 1, characterized in that: The horizontal moving mechanism includes a slide rail arranged on the base and a slider matched with the slide rail. The top of the slider is provided with a vertical plate, and the tubular fixer is arranged on the surface of the vertical plate.

4. The fixing device for proton-photon irradiation animal experiments according to claim 1, characterized in that: The limit adjustment member includes threaded holes provided in the side walls of the head limit clamping plate and the tail limit baffle, and a limit bolt is screwed into the threaded hole, and the screw head diameter of the limit bolt is larger than the slot width of the limit guide slot.

5. The fixing device for proton-photon irradiation animal experiments according to claim 1, characterized in that: The tubular holder, the horizontal moving mechanism and the base are all made of transparent acrylic.

6. The fixing device for proton-photon irradiation animal experiments according to claim 2, characterized in that: A handle is provided on the upper portion of the side baffle, and an armrest is provided on the side portion.

7. The fixing device for proton-photon irradiation animal experiments according to claim 3, characterized in that: The surface of the slide rail is marked with scale lines.

8. The fixing device for proton-photon irradiation animal experiments according to claim 3, characterized in that: The height adjustment member includes adjustment wings arranged on both sides of the tubular fixer and a position adjustment hole arranged on the vertical plate. The adjustment wings are provided with a plurality of limiting holes, and the limiting holes are provided with adjustment bolts matching the position adjustment holes.

9. The fixing device for proton-photon irradiation animal experiments according to claim 8, characterized in that: The position adjustment hole is a waist-shaped hole or a plurality of positioning threaded holes.

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