Single-gene genetic disease detecting and screening device
By setting breaking grooves and reinforcement strips on the side wall of the tube cover of the single-gene genetic disease detection device, the problem of controlling the breaking force of the swab when couples of childbearing age collect saliva samples themselves is solved, achieving the effect of reducing the risk of falling off and improving the convenience of detection.
Patent Information
- Application Number
- CN202422242522.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-12
- Publication Date
- 2025-09-12
- Estimated Expiration
- 2034-09-12
AI Technical Summary
When couples of childbearing age collect saliva samples themselves, it is difficult to control the force of the swab breaking, which leads to the risk of the tube body, tube cap and swab falling off, affecting the accuracy and convenience of single-gene genetic disease testing.
A single-gene genetic disease detection and screening device was designed, which adopts a tube body and tube cover connected by threads. The side wall of the tube cover is provided with a break groove to accommodate the swab, and the break groove is abutted against the swab to achieve clamping. Combined with a reinforcement strip, the rigidity of the tube cover is improved to reduce the risk of falling off.
It is convenient for couples of childbearing age to collect saliva samples by themselves, reduces the risk of detachment of the tube body, tube cover and swab, and improves the convenience and accuracy of testing.
Smart Images
Figure CN223323542U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the field of medical device technology, and in particular to a device for detecting and screening single-gene genetic diseases. Background Art
[0002] Monogenic diseases are genetic disorders controlled by a single pair of alleles. There are over 8,000 such diseases, with the number increasing by 10-50 each year. These diseases pose a significant threat to human health. Genetic screening for couples of childbearing age can effectively reduce the incidence of monogenic diseases.
[0003] In existing technologies, in addition to going to specialized medical institutions for genetic testing to screen for single-gene genetic diseases in advance, couples of childbearing age can also mail their biological samples (saliva, blood, hair, etc. containing epithelial cells) to specialized medical institutions and entrust them to conduct testing.
[0004] Since saliva can be stored at room temperature, couples of childbearing age can purchase sampling devices for genetic testing and screening to collect saliva samples, and then mail the sampling devices containing saliva samples to specialized medical institutions for genetic testing and screening.
[0005] In the prior art, the sampling device includes a sample tube and a swab. After a couple of childbearing age uses the swab to take a sample in the mouth, they need to insert the end of the swab with the sample into the body of the sample tube, and press the tube cover of the sample tube against the swab to break the swab and store the swab section with the sample in the sample tube.
[0006] Since the couple of childbearing age is not a professional medical staff, it is difficult for them to control the breaking force of the tube body, tube cover and swab when breaking the swab, which causes the risk of the tube body, tube cover and swab falling off. Utility Model Content
[0007] In order to facilitate saliva sampling for couples of childbearing age to detect and screen for single-gene genetic diseases, the present application provides a single-gene genetic disease detection and screening device.
[0008] This application provides a single gene genetic disease detection and screening device, which adopts the following technical solutions:
[0009] A single-gene genetic disease detection and screening device comprises a tube body and a tube cover that cover each other, wherein the tube body is threadedly connected to the tube cover; the tube body is used to contain a sample preservation liquid, and a side wall of the tube cover begins to have a break groove, which is used to accommodate a swab; when the bottom wall of the break groove is used to abut against the break point of the swab, the tube body is inserted into the tube cover.
[0010] By adopting the above technical solution, the groove is broken off at the side of the tube cap, so that the tube cap and the tube body clamp the swab. When the swab is broken, the tube body is partially inserted into the tube cap, making it easier for the user to grasp the tube body. When the user breaks the swab, the risk of the tube body, tube cap, and swab becoming detached is reduced, making it easier for couples of childbearing age to collect saliva samples for testing and screening for single-gene genetic diseases.
[0011] Optionally, the width of the breaking groove decreases along the direction away from the tube body.
[0012] By adopting the above technical solution, the width of the breaking groove decreases gradually as the user places the swab in the breaking groove.
[0013] Optionally, the broken groove is a step groove, and along the direction away from the tube body, the broken groove includes a first groove and a second groove that are connected, the width of the second groove is smaller than the width of the first groove, and the width of the second groove is greater than the width of the swab.
[0014] By adopting the above technical solution, the width of the first groove is larger, so that the staff can place the swab in the breaking groove more easily; the width of the second groove is smaller, so as to improve the fixing effect of the second groove on the swab.
[0015] Optionally, a side wall of the breaking groove is provided with an arc-shaped guide surface, and the arc-shaped guide surface is arranged between the first groove and the second groove; the arc-shaped guide surface is used to guide the swab to move from the first groove to the second groove.
[0016] By adopting the above technical solution, the arc-shaped guide surface between the first groove and the second groove is conducive to the user moving the swab from the first groove to the second groove.
[0017] Optionally, a reinforcement strip is further included, which is arranged on the outside of the tube cover and along the outer edge of the broken groove. The reinforcement strip is integrally formed with the tube cover.
[0018] By adopting the above technical solution, the reinforcing strip can compensate for the reduction in rigidity of the pipe cover caused by the provision of the breaking groove, thereby improving the overall rigidity of the pipe cover.
[0019] Optionally, a protrusion is provided on the bottom wall of the breaking groove, and the protrusion is used to abut against the breaking point of the swab; and the area of the horizontal cross section of the protrusion decreases along the direction away from the bottom wall of the breaking groove.
[0020] By adopting the above technical solution, a protrusion is provided on the bottom wall of the breaking groove, thereby reducing the contact area between the tube cover and the swab, thereby facilitating the breaking of the swab.
[0021] Optionally, the vertical cross-section of the protrusion is triangular.
[0022] By adopting the above technical solution, the vertical cross-section of the raised portion is triangular, so that the user can break the swab better.
[0023] Optionally, a sealing ring is further included, which is bonded and fixed to the tube cover and is used to abut against the tube body.
[0024] By adopting the above technical solution, a sealing ring is provided between the tube cover and the tube body, thereby improving the sealing performance of the connection between the tube body and the tube cover, which is beneficial to the transportation of saliva samples.
[0025] In summary, this application includes at least one of the following beneficial technical effects:
[0026] 1. By breaking the groove on the side wall of the tube cap, the tube cap and the tube body clamp the swab, so that when the swab is broken, the tube body is partially inserted into the tube cap, making it easier for the user to hold the tube body. When the user breaks the swab, the risk of the tube body, tube cap and swab separating can be reduced, making it easier for couples of childbearing age to collect saliva samples for testing and screening for single-gene genetic diseases.
[0027] 2. The first groove is wider to facilitate the staff to place the swab in the breaking groove; the second groove is narrower to improve the fixing effect of the second groove on the swab. When the user breaks the swab, the risk of the swab and the tube cover sliding relative to each other can be reduced, making it easier for the wearer to break the swab;
[0028] 3. The rigidity of the pipe cover will be reduced at the place where the break groove is opened. By setting a reinforcement strip on the outer edge of the break groove, the rigidity reduction caused by the opening of the break groove can be compensated, so as to improve the overall rigidity of the pipe cover and reduce the structural deformation of the pipe cover, so as to facilitate the threaded connection of the pipe cover to the pipe body. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] Figure 1 Schematic diagram of the structure of the single gene genetic disease detection and screening device in Example 1.
[0030] Figure 2 This is a cross-sectional view of the structure of the single gene genetic disease detection and screening device in Example 1.
[0031] Figure 3 yes Figure 1 Enlarged view of point A in the middle.
[0032] Figure 4 yes Figure 2 Enlarged view of point B in the middle.
[0033] Figure 5Schematic diagram of the tube cover structure in Example 2.
[0034] Explanation of the accompanying drawings: 1. Tube body; 11. External thread; 2. Tube cover; 21. Internal thread; 3. Sealing ring; 4. Breaking groove; 41. First groove; 42. Second groove; 43. Arc-shaped guide surface; 5. Raised portion; 6. Reinforcement strip; 7. Swab; 71. Swab head; 72. Swab rod; 721. Breaking ring groove; 8. Anti-slip convex strip. DETAILED DESCRIPTION
[0035] The following is combined with Figure 1-5 This application is described in further detail.
[0036] The present application embodiment discloses a single gene genetic disease detection and screening device. Figure 1 and Figure 2 The single gene genetic disease detection and screening device includes a tube body 1 and a tube cover 2, which are covered with each other, and a sealing ring 3.
[0037] The tube body 1 is used to hold a sample preservative solution. After the user uses a swab 7 to collect saliva, the swab 7 containing the saliva sample is placed in the sample preservative solution in the tube body 1. The outer side of the tube body 1 is provided with an external thread 11, and the inner sidewall of the tube cover 2 is provided with an internal thread 21. Through the threaded fit of the external thread 11 and the internal thread 21, the tube body 1 and the tube cover 2 are threadedly and sealed. In this embodiment, a clearance is provided between the external thread 11 of the tube body 1 and the opening of the tube body 1. A clearance is also provided between the internal thread 21 of the tube cover 2 and the opening of the tube cover 2, thereby achieving partial plug-in fixation of the tube body 1 and the tube cover 2.
[0038] Reference Figure 2 The sealing ring 3 is bonded and fixed to the tube cover 2, and the sealing ring 3 is used to abut against the tube body 1. This improves the sealing performance of the connection between the tube body 1 and the tube cover 2, which is beneficial to the transportation of the saliva sample.
[0039] Reference Figure 3 and Figure 4 The side wall of the tube cover 2 begins to have a break groove 4, which is used to accommodate the swab 7. When the bottom wall of the break groove 4 is used to abut the break point of the swab 7, the tube body 1 is inserted into the tube cover 2. As a result, the tube cover 2 and the tube body 1 clamp the swab 7, breaking the swab 7; at the same time, the tube body 1 is partially inserted into the tube cover 2, making it easier for the user to grasp the tube body 1. When the user breaks the swab 7, the risk of the tube body 1, the tube cover 2, and the swab 7 separating can be reduced, thereby facilitating saliva sampling for couples of childbearing age to detect and screen for single-gene genetic diseases.
[0040] Reference Figure 2 and Figure 4The swab 7 includes a swab stick 72 and a swab head 71. The swab head 71 is disposed at the sampling end of the swab stick 72. A breaking groove 721 is provided at the breaking point of the swab stick 72 near the swab head 71, facilitating the user's ability to break the swab 7 and place the swab head 71 within the tube 1. The swab stick 72 can be made of polystyrene (or ABS) plastic, while the swab head 71 can be made of chemical synthetic fibers such as polyester (terylene) and polyamide (nylon). These materials are fixed to the sampling end of the swab stick 72 through a flocking process to increase its adsorption capacity.
[0041] Reference Figure 3 and Figure 4 In this embodiment, the break groove 4 is a stepped groove. Along the direction away from the tube body 1, the break groove 4 includes a first groove 41 and a second groove 42 that are interconnected. The width of the second groove 42 is smaller than that of the first groove 41, and the width of the second groove 42 is larger than that of the swab 7. The sidewalls of the break groove 4 are provided with an arcuate guide surface 43, disposed between the first and second grooves 41, 42. The arcuate guide surface 43 is used to guide the swab 7 from the first groove 41 to the second groove 42. The first groove 41 is relatively wide, making it easier for the user to place the swab 7 in the break groove 4. The arcuate guide surface 43 between the first and second grooves 41, 42 facilitates the user's movement from the first groove 41 to the second groove 42. The second groove 42 is relatively narrow, which improves the second groove 42's ability to secure the swab 7. This reduces the risk of the swab 7 sliding relative to the tube cover 2 when the user breaks the swab 7, making it easier for the wearer to break the swab 7.
[0042] Reference Figure 3 and Figure 4 To facilitate the user's breaking of the swab 7, a raised portion 5 is provided on the bottom wall of the break groove 4. The raised portion 5 is designed to abut the breaking point of the swab 7. The horizontal cross-sectional area of the raised portion 5 decreases as it moves away from the bottom wall of the break groove 4. In this embodiment, the vertical cross-sectional area of the raised portion 5 is triangular. Providing the raised portion 5 on the bottom wall of the break groove 4 reduces the contact area between the tube cover 2 and the swab 7, increasing the pressure exerted by the tube cover 2 on the breaking point of the swab 7, thereby facilitating the breaking of the swab 7. In other embodiments, the vertical cross-sectional area of the raised portion 5 may also be an isosceles trapezoid.
[0043] Since the pipe cover 2 is provided with the breaking groove 4, the rigidity of the pipe cover 2 and the breaking groove 4 is reduced. Therefore, the present embodiment makes further configurations on the pipe cover 2.
[0044] Reference Figure 3 and Figure 4A reinforcing strip 6 is provided on the outside of the pipe cover 2, and is arranged along the outer edge of the break groove 4. The reinforcing strip 6 is integrally formed with the pipe cover 2. Specifically, the reinforcing strip 6 is provided on the outer edge of the break groove 4 to compensate for the reduced rigidity of the pipe cover 2 caused by the break groove 4, thereby improving the overall rigidity of the pipe cover 2 and reducing structural deformation of the pipe cover 2, thereby facilitating the threaded connection of the pipe cover 2 to the pipe body 1.
[0045] Reference Figure 3 and Figure 4 The outer side of the pipe cover 2 is also provided with anti-slip ridges 8. The anti-slip ridges 8 are arranged vertically and opposite to the reinforcing strips 6. The anti-slip ridges 8 are integrally formed with the pipe cover 2. The anti-slip ridges 8 not only provide a better foothold for the user to rotate the pipe cover 2, but also serve as a positioning guide, making it easier for the user to find the broken groove 4.
[0046] Example 2
[0047] The difference between this embodiment 2 and embodiment 1 is that:
[0048] Reference Figure 5 The width of the break groove 4 decreases gradually as it moves away from the tube body 1. The width of the break groove 4 decreases gradually because the user places the swab 7 in the break groove 4 and the swab 7 abuts against the bottom wall of the break groove 4. In this embodiment, the break groove 4 has a trapezoidal cross-section.
[0049] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.
Claims
1. A single gene genetic disease detection and screening device, characterized by: The invention comprises a tube body (1) and a tube cover (2) which cover each other, wherein the tube body (1) is threadedly connected to the tube cover (2); the tube body (1) is used to contain a sample preservation liquid, and a breaking groove (4) is formed at the beginning of the side wall of the tube cover (2), and the breaking groove (4) is used to contain a swab (7); when the bottom wall of the breaking groove (4) is used to abut against the breaking point of the swab (7), the tube body (1) is inserted into the tube cover (2).
2. The single gene genetic disease detection and screening device according to claim 1, characterized in that: The width of the breaking groove (4) decreases gradually in a direction away from the tube body (1).
3. The single gene genetic disease detection and screening device according to claim 1, characterized in that: The broken groove (4) is a stepped groove. Along the direction away from the tube body (1), the broken groove (4) comprises a first groove (41) and a second groove (42) that are connected. The width of the second groove (42) is smaller than the width of the first groove (41), and the width of the second groove (42) is larger than the width of the swab (7).
4. The single gene genetic disease detection and screening device according to claim 3, characterized in that: The side wall of the breaking groove (4) is provided with an arc-shaped guide surface (43), and the arc-shaped guide surface (43) is arranged between the first groove (41) and the second groove (42); the arc-shaped guide surface (43) is used to guide the swab (7) to move from the first groove (41) to the second groove (42).
5. The single gene genetic disease detection and screening device according to claim 1, characterized in that: It also includes a reinforcement strip (6), which is arranged on the outside of the tube cover (2) and along the outer edge of the breaking groove (4). The reinforcement strip (6) and the tube cover (2) are integrally formed.
6. The single gene genetic disease detection and screening device according to claim 1, characterized in that: The bottom wall of the break groove (4) is provided with a raised portion (5), and the raised portion (5) abuts against the break point of the swab (7); along the direction away from the bottom wall of the break groove (4), the area of the horizontal cross section of the raised portion (5) decreases.
7. The single gene genetic disease detection and screening device according to claim 6, characterized in that: The vertical cross section of the raised portion (5) is triangular.
8. The single gene genetic disease detection and screening device according to claim 1, characterized in that: It also includes a sealing ring (3), which is bonded and fixed to the tube cover (2), and the sealing ring (3) is used to abut against the tube body (1).