Emulsifying and mixing device for cytarabine and daunorubicin compound liposome

Abstract

The utility model relates to an emulsifying and mixing device for cytarabine and daunorubicin compound lipidosome, which belongs to the technical field of mixing devices and comprises a support frame, a support plate is fixedly connected to the inner wall of the support frame, a mixing tank is fixedly connected to the inside of the support plate, a sealing cover is connected to the upper end face of the mixing tank in an attached manner, and the sealing cover is fixedly connected to the upper end face of the mixing tank. A driving shaft is rotationally connected to the center of the interior of the sealing cover, and a stirring rod is fixedly connected to the outer wall of the driving shaft. The cytarabine and daunorubicin mixing tank has the beneficial effects that the turning plate rotates in the vertical direction at the bottom of the mixing tank, so that the material accumulation at the bottom of the mixing tank can be broken, the deposition and layering of the material at the bottom are effectively prevented, the uniform distribution of cytarabine and daunorubicin in the mixing process is ensured, and the mixing effect and the product quality are improved; and the material at the bottom can be turned upwards to be fully mixed with the material at the upper layer, so that the mixing process is accelerated, the mixing is more uniform, and the mixing efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of mixing devices, in particular to an emulsifying and mixing device for cytarabine and daunorubicin compound liposomes. Background Art

[0002] A fixed liposome compound preparation composed of cytarabine and daunorubicin can be used to treat two types of adult patients with acute myeloid leukemia. During the production process of the drug liposome, the mixed raw materials need to be stirred with the dispersion, so a reaction tank is required to complete the production process.

[0003] During the stirring process in traditional mixing equipment, materials tend to accumulate at the bottom of the mixing tank, resulting in uneven material distribution, which in turn affects the quality and stability of the product. In addition, dead corners are prone to appear during the stirring process, making it difficult for some materials to be fully mixed, reducing mixing efficiency. At the same time, since materials on the inner wall of the mixing tank are difficult to remove, they often lead to material waste and residue, increasing production costs and product quality risks. To address the above situation, we have launched an emulsification and mixing device for cytarabine and daunorubicin compound liposomes. Utility Model Content

[0004] The purpose of the utility model is to provide an emulsifying and mixing device for cytarabine and daunorubicin compound liposomes, so as to solve the problem of low mixing efficiency proposed in the above background technology.

[0005] The technical solution of the utility model is:

[0006] A support frame, wherein the inner wall of the support frame is fixedly connected to a support plate, the interior of the support plate is fixedly connected to a mixing tank, the upper end surface of the mixing tank is fittedly connected to a sealing cover, the inner center of the sealing cover is rotatably connected to a drive shaft, the outer wall of the drive shaft is fixedly connected to a stirring rod, and the end of the stirring rod is fixedly connected to a scraper;

[0007] The outer wall of the lower end of the driving shaft is rotatably connected to the gear housing, and a driving gear is provided inside the gear housing, and the driving gear is fixedly connected to the lower end of the driving shaft. A positioning groove is provided on the inner wall of the mixing tank, and a positioning block is slidably connected to the inside of the positioning groove, and a connecting shaft is rotatably connected to the inside of the positioning block. The outer wall of the connecting shaft is fixedly connected to a flap, and the end of the connecting shaft close to the gear housing is fixedly connected to a transmission gear, and the transmission gear is meshed with the driving gear.

[0008] Furthermore, a sliding groove is provided on the inner wall of the support frame, a threaded rod is rotatably connected to the lower end wall of the sliding groove, and the threaded rod is threadedly connected to the sealing cover.

[0009] The threaded rod is driven by a motor to drive the sealing cover upward along the slide groove, thereby moving the drive shaft out of the interior of the mixing tank, making it easier to clean the stirring equipment. When the drive shaft is assembled downward, the positioning block is rotated to correspond to the positioning groove, and then the drive shaft is downwardly installed into the interior of the mixing tank.

[0010] Furthermore, two groups of metering barrels are provided on the upper end of the sealing cover, and valves are provided at the flow points between the lower ends of the metering barrels and the mixing tank.

[0011] First, close the valve, put the raw materials into the metering barrel and observe the amount, then open the valve to send the controlled raw materials into the mixing tank. By observing the amount of raw materials in the metering barrel, the amount of raw materials sent into the mixing tank each time can be accurately controlled, which is crucial to ensuring product quality and stability.

[0012] The present invention provides an improved emulsifying and mixing device for cytarabine and daunorubicin compound liposomes, which has the following improvements and advantages compared with the prior art:

[0013] First, the utility model can rotate the flap in the vertical direction at the bottom of the mixing tank to break up the accumulation of materials at the bottom of the mixing tank, effectively prevent the sedimentation and stratification of materials at the bottom, and help ensure the uniform distribution of cytarabine and daunorubicin during the mixing process, thereby improving the mixing effect and product quality. It can flip the materials at the bottom upward and fully mix them with the materials on the upper layer, which accelerates the mixing process, makes the mixing more uniform, and improves the mixing efficiency.

[0014] Second: In the present invention, the rotation of the stirring rod and the scraper fixedly connected to the end of the stirring rod rotate along the inner wall of the mixing tank, which can effectively mix cytarabine and daunorubicin. At the same time, the rotation of the scraper along the inner wall of the mixing tank ensures that there are no dead angles in the mixing process, so that the two drugs can be mixed evenly, thereby improving the mixing efficiency, and effectively scraping off the materials attached to the tank wall, preventing the waste of materials and avoiding the quality problems that may be caused by material residues. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The present invention will be further explained below in conjunction with the accompanying drawings and Examples:

[0016] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0017] Figure 2 This is a schematic diagram of the connection structure of the sealing cover of the utility model;

[0018] Figure 3 It is a schematic diagram of the internal connection structure of the mixing tank of the utility model.

[0019] Explanation of the accompanying drawings: 1. Support frame; 2. Support plate; 3. Mixing tank; 301. Sealing cover; 302. Drive shaft; 303. Stirring rod; 304. Scraper; 4. Gear housing; 401. Drive gear; 402. Transmission gear; 403. Connecting shaft; 404. Flap; 405. Positioning block; 406. Positioning groove; 5. Measuring barrel; 501. Valve; 6. Slide; 601. Threaded rod; 7. Positioning rod; 8. Positioning hole; 9. Discharge port. DETAILED DESCRIPTION

[0020] The following will be combined with the Figures 1 to 3 This utility model is described in detail, and the technical solutions in the embodiments of this utility model are clearly and completely described. Obviously, the embodiments described are only some of the embodiments of this utility model, not all of them. Based on the embodiments of this utility model, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this utility model.

[0021] The utility model provides an improved emulsifying and mixing device for cytarabine and daunorubicin compound liposomes, such as Figure 1-Figure 3 As shown, it includes a support frame 1, a support plate 2 is fixedly connected to the inner wall of the support frame 1, a mixing tank 3 is fixedly connected to the interior of the support plate 2, a sealing cover 301 is fitted and connected to the upper end surface of the mixing tank 3, a driving shaft 302 is rotatably connected to the inner center of the sealing cover 301, a stirring rod 303 is fixedly connected to the outer wall of the driving shaft 302, and a scraper 304 is fixedly connected to the end of the stirring rod 303;

[0022] The outer wall of the lower end of the driving shaft 302 is rotatably connected to the gear housing 4, and a driving gear 401 is provided inside the gear housing 4, and the driving gear 401 is located at the lower end of the driving shaft 302 and is fixedly connected. A positioning groove 406 is provided on the inner wall of the mixing tank 3, and a positioning block 405 is slidably connected inside the positioning groove 406. The positioning block 405 is rotatably connected inside the connecting shaft 403, and the outer wall of the connecting shaft 403 is fixedly connected to the flap 404. The end of the connecting shaft 403 close to the gear housing 4 is fixedly connected to the transmission gear 402, and the transmission gear 402 is meshed with the driving gear 401, and the scraper 304 is fit-connected to the inner wall of the mixing tank 3.

[0023] In this embodiment, the driving shaft 302 is rotated by the motor, driving the rotation of the stirring rod 303 and the scraper 304 fixed to the end of the stirring rod 303 to rotate along the inner wall of the mixing tank 3, which can effectively mix cytarabine and daunorubicin. At the same time, the scraper 304 rotates along the inner wall of the mixing tank 3 to ensure that there is no dead angle in the mixing process, so that the two drugs can be evenly mixed, thereby improving the mixing efficiency and effectively scraping off the material attached to the tank wall, preventing the waste of material and avoiding the quality problems that may be caused by material residue. Then the positioning block 405 is clamped by the positioning groove 406. After the mixing tank 3 is closed and positioned, the driving shaft 302 drives the driving gear 401 to rotate, and the meshing connection between the transmission gear 402 and the driving gear 401 is realized to realize the rotation of the connecting shaft 403, thereby realizing the vertical rotation of the flap 404 at the bottom of the mixing tank 3, which can break the accumulation of materials at the bottom of the mixing tank 3, effectively prevent the sedimentation and stratification of materials at the bottom, and help to ensure the uniform distribution of cytarabine and daunorubicin during the mixing process, thereby improving the mixing effect and product quality, and can flip the material at the bottom upwards and fully mix it with the material on the upper layer, thereby accelerating the mixing process, making the mixing more uniform, and improving the mixing efficiency.

[0024] In a preferred embodiment, a slide groove 6 is provided on the inner wall of the support frame 1, and the lower end wall of the slide groove 6 is rotatably connected to a threaded rod 601, and the threaded rod 601 is threadedly connected to the sealing cover 301. The set threaded rod 601 is driven by a motor to drive the sealing cover 301 upward along the slide groove 6, thereby moving the drive shaft 302 out of the interior of the mixing tank 3, thereby facilitating better cleaning of the stirring equipment, and then when the drive shaft 302 is assembled downward, the positioning block 405 is rotated to correspond to the positioning groove 406, and then the drive shaft 302 is downwardly installed into the interior of the mixing tank 3.

[0025] In a preferred embodiment, two groups of metering barrels 5 are provided at the upper end of the sealing cover 301, and a valve 501 is provided at the flow connection between the lower end of the metering barrel 5 and the mixing tank 3. First, the valve 501 is closed, and the raw materials are loaded into the metering barrel 5 to observe the amount. Then, the valve 501 is opened to send the controlled raw materials into the interior of the mixing tank 3. By observing the amount of raw materials in the metering barrel 5, the amount of raw materials sent into the mixing tank 3 each time can be accurately controlled, which is crucial for ensuring product quality and stability.

[0026] In a preferred embodiment, a positioning rod 7 is fixedly connected to the edge of the lower end face of the sealing cover 301, a positioning hole 8 is opened at the opening of the upper end face of the mixing tank 3, and a discharge port 9 is connected to the lower end of the mixing tank 3. The provided discharge port 9 is used to discharge the mixed material, and then the sealing cover 301 is engaged with the positioning hole 8 through the positioning rod 7 to achieve stability of the sealing cover 301 during connection.

[0027] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An emulsifying and mixing device for cytarabine and daunorubicin compound liposomes, characterized by: The invention comprises a support frame (1), wherein the inner wall of the support frame (1) is fixedly connected to a support plate (2), the interior of the support plate (2) is fixedly connected to a mixing tank (3), the upper end surface of the mixing tank (3) is fittedly connected to a sealing cover (301), the inner center of the sealing cover (301) is rotatably connected to a driving shaft (302), the outer wall of the driving shaft (302) is fixedly connected to a stirring rod (303), and the end of the stirring rod (303) is fixedly connected to a scraper (304); The outer wall of the lower end of the driving shaft (302) is rotatably connected to a gear housing (4), a driving gear (401) is provided inside the gear housing (4), and the driving gear (401) is located at the lower end of the driving shaft (302) and is fixedly connected, the inner wall of the mixing tank (3) is provided with a positioning groove (406), the interior of the positioning groove (406) is slidably connected to a positioning block (405), the interior of the positioning block (405) is rotatably connected to a connecting shaft (403), the outer wall of the connecting shaft (403) is fixedly connected to a flap (404), and the end of the connecting shaft (403) close to the gear housing (4) is fixedly connected to a transmission gear (402), and the transmission gear (402) is meshedly connected to the driving gear (401).

2. The emulsifying and mixing device for the cytarabine and daunorubicin compound liposome according to claim 1, characterized in that: A sliding groove (6) is provided on the inner wall of the support frame (1), and a threaded rod (601) is rotatably connected to the lower end wall of the sliding groove (6), and the threaded rod (601) is threadedly connected to the sealing cover (301).

3. The emulsifying and mixing device for the cytarabine and daunorubicin compound liposome according to claim 1, characterized in that: Two groups of metering barrels (5) are provided at the upper end of the sealing cover (301), and a valve (501) is provided at the flow point between the lower end of the metering barrel (5) and the mixing tank (3).

4. The emulsifying and mixing device for the cytarabine and daunorubicin compound liposome according to claim 1, characterized in that: A positioning rod (7) is fixedly connected to the edge of the lower end surface of the sealing cover (301).

5. The emulsifying and mixing device for the cytarabine and daunorubicin compound liposome according to claim 1, characterized in that: A positioning hole (8) is provided at the opening of the upper end surface of the mixing tank (3).

6. The emulsifying and mixing device for the cytarabine and daunorubicin compound liposome according to claim 1, characterized in that: The lower end of the mixing tank (3) is connected to a discharge port (9).

7. The emulsifying and mixing device for the cytarabine and daunorubicin compound liposome according to claim 1, characterized in that: The scraper (304) is in close contact with the inner wall of the mixing tank (3).

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