Device capable of flexibly distributing continuous arterial perfusion medicine dosage
Through the nested design of the main catheter and microcatheter, combined with guidewire guidance and sealing parts, flexible distribution of drug dosage in the liver is achieved, solving the problem of insufficient or excessive drug distribution in the existing technology, improving the treatment effect and reducing damage to normal cells.
Patent Information
- Application Number
- CN202422448200.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-10
- Publication Date
- 2025-10-14
- Estimated Expiration
- 2034-10-10
AI Technical Summary
The existing hepatic artery perfusion treatment method cannot flexibly allocate chemotherapy drug doses according to the treatment needs of different parts of the liver, resulting in insufficient drug allocation to target tumors or excessive killing rate of normal liver cells.
The system adopts a nested design of main catheter and microcatheter, and realizes flexible distribution of drugs in different parts of the liver through the side opening of the main catheter and the independent channel of the microcatheter. It uses a guidewire to guide precise positioning, and combines sealing parts and indicator marks to ensure accurate control of drug dosage.
It achieves precise attack on tumors in the liver, flexibly allocates drug dosage according to the severity of the disease in different parts of the body, improves the treatment effect and reduces the killing rate of normal cells.
Smart Images
Figure CN223429814U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of medical auxiliary equipment, in particular to a device capable of flexibly distributing continuous arterial perfusion drug dosages. Background Art
[0002] For patients with liver cancer, whether undergoing continuous hepatic arterial infusion chemotherapy (HAIC) or transarterial chemoembolization (TACE), interventional treatment involves selectively or superselectively inserting a catheter into the target blood vessels supplying the tumor. Chemotherapy drugs are then injected directly into the target vessels within the liver at an appropriate rate. The drugs flow through the bloodstream into the liver's various tissues, achieving targeted treatment for the tumor and achieving better therapeutic effects while avoiding the side effects of systemic chemotherapy. Direct injection of chemotherapy drugs results in higher concentrations compared to systemic intravenous administration, with localized administration exceeding systemic concentrations by approximately 200 times. Consequently, they can significantly damage normal liver cells. Because the human liver consists of a left and right hemisphere, further divided into five lobes, the two halves differ significantly in size, necessitating different drug dosages. Furthermore, the severity of cancer in the two halves or lobes can also vary. For example, if the left hemisphere is severely cancerous while the right hemisphere is mildly cancerous, the required drug dosage for the left and right hemispheres will also differ. However, the existing injection method of first injecting drugs into the hepatic aorta and then allowing the drugs to flow into the various tissue cells of the liver through the blood circulation is obviously unable to inject different doses of chemotherapy drugs according to the treatment needs of different parts of the liver. It is easy to cause insufficient distribution of drugs required by the target tumor, affecting the efficacy, and normal liver cells may be allocated excessive drugs, resulting in a significant increase in the killing rate. Utility Model Content
[0003] In order to solve the above problems, the purpose of the present invention is to provide a device that can flexibly distribute the dosage of continuous arterial perfusion drugs, which can not only achieve precise attack on tumors in organs, but also flexibly distribute the drug dosage according to the severity of the disease in different parts of the organs, thereby reducing the killing rate of normal cells.
[0004] In order to achieve the above purpose, the utility model adopts the following technical solutions:
[0005] The utility model provides a device that can flexibly distribute the dosage of continuously perfused drugs, comprising a main catheter and a microcatheter, a first through hole is arranged axially in the main catheter, a first drug injection port is arranged on the rear end wall of the main catheter, the front end head of the main catheter is a first drug outlet, a side opening is arranged on the front end wall of the main catheter, the first drug injection port, the first drug outlet and the side opening are all in communication with the first through hole, a second through hole is arranged axially in the microcatheter, the microcatheter is arranged in the first through hole of the main catheter, the front end head of the microcatheter is arranged to pass through the side opening, a first fluid channel is formed between the inner wall of the main catheter and the outer wall of the microcatheter, and the second through hole serves as a second fluid channel.
[0006] More preferably, a plurality of side openings are arranged on the front end wall of the main catheter, the side openings are arranged axially at intervals, and a sealing member is arranged on each side opening.
[0007] More preferably, the sealing member is a film provided with a cross-shaped or Y-shaped slit.
[0008] More preferably, an indication mark is arranged at the side opening.
[0009] The utility model has the following beneficial effects:
[0010] The device that can flexibly distribute the dosage of continuously perfused drugs of the utility model is characterized in that the main catheter and the microcatheter are nested and matched, and the microcatheter can pass through the side opening of the main catheter, so that a drug injection channel is formed between the inner wall of the main catheter and the outer wall of the microcatheter, the second through hole in the microcatheter serves as an independent drug injection channel, thereby forming two drug injection channels, medical staff can flexibly distribute the dosage of drugs in different parts according to the severity of the disease in different parts of the organ and other treatment requirements after calculating the total dosage, improve the treatment effect, and reduce the killing rate of normal cells. BRIEF DESCRIPTION OF DRAWINGS
[0011] Figure 1 It is a structural schematic view of the main catheter of the utility model;
[0012] Figure 2 It is a structural schematic view of the microcatheter of the utility model;
[0013] Figure 3 It is a use diagram of the main catheter and the microcatheter of the utility model;
[0014] Figure 4 It is a use state diagram of the guide wire of the utility model.
[0015] MARKS:
[0016] 10. Main conduit; 11. First through hole; 12. First injection port; 13. Side opening; 14. Sealing member; 15. Indicator mark; 16. First drug outlet; 17. First fluid channel;
[0017] 20. Microcatheter; 21. Second through hole; 22. Second drug injection port; 23. Second drug outlet;
[0018] 30. Guide wire; 40. Left hepatic artery; 50. Common hepatic artery; 60. Proper hepatic artery; 70. Right hepatic artery. DETAILED DESCRIPTION
[0019] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments:
[0020] See also Figures 1 to 3A device for flexible distribution of continuous arterial perfusion drug dosage, comprising a main catheter 10 and a micro catheter 20. The main catheter 10 is provided with a first through hole 11 along the axial direction, the rear end wall of the main catheter 10 is provided with a first drug injection port 12, the front end head of the main catheter 10 is a first drug outlet 16, and the rear end opening of the main catheter 10 can be used to pass through a guide wire 30 and set the micro catheter 20 after the guide wire 30 is pulled out. The front end wall of the main catheter 10 is provided with a side opening 13, and the first drug injection port 12, the side opening 13 and the first drug outlet 16 are in communication with the first through hole 11. The micro catheter 20 is provided with a second through hole 21 along the axial direction, the micro catheter 20 is arranged in the first through hole 11 of the main catheter 10, and the front end head of the micro catheter 20 passes out of the side opening 13. The inner wall of the main catheter 10 and the outer wall of the micro catheter 20 form a first fluid channel 17, for example, the inner diameter of the main catheter 10 ranges from 1.32mm to 1.99mm, i.e. 4.0-6.0Fr, and the outer diameter of the micro catheter 20 ranges from 0.74mm to 0.9mm, i.e. 2.2-2.7Fr. After the micro catheter 20 is passed into the main catheter 10, the gap formed by the difference between the inner diameter and the outer diameter of the two forms the first fluid channel 17. The second through hole 21 serves as a second fluid channel, the rear end opening of the second through hole 21 is a second drug injection port 22, and the front end opening is a second drug outlet 23. Since the main catheter 10 enters the first artery tube that needs to inject drugs, the micro catheter 20 enters the second artery tube that needs to inject drugs, and the relative position between the second artery tube and the first artery tube is determined according to the actual treatment requirement, in order to improve the adaptability of the micro catheter 20 to the position of the second artery tube, the front end wall of the main catheter 10 is provided with a plurality of side openings 13, and each side opening 13 is arranged along the axial direction. For example, the frontmost side opening 13 is 3-5cm away from the front end head of the main catheter 10, then a side opening 13 is opened every 1cm, and 5 side openings 13 are distributed at equal intervals. The micro catheter 20 can be selected to pass out of one of the side openings 13 according to the position of the second artery tube. Preferably, in order to accurately control the drug injection dosage and prevent the drug needed to be injected into the first artery tube from leaking out of the remaining side openings 13, each side opening 13 is provided with a sealing member 14, and the sealing member 14 is a thin film or sheet provided with a cross-shaped or Y-shaped slit, such as a thin silica gel film or a thin silica gel sheet.
[0021] Preferably, in order to enable the operator to more easily position the position of the side opening 13 under fluoroscopy or X-ray, an indicating mark 15 is arranged at the side opening 13. The indicating mark 15 can be "T" shaped, and can be a indicating ring arranged along the edge of the side opening 13.
[0022] When the main catheter 10 needs to turn a certain angle to enter the first arterial duct, or when the microcatheter 20 needs to turn a certain angle to pass through the side opening 13, the head section of the guide wire 30 can be shaped and slightly bent at a certain angle before entry. For example, the range of the angle α at the bend of the guide wire 30 is: 90°≤α≤170°.
[0023] Since the guide wire 30 is a commonly used auxiliary accessory during arterial cannulation and is a well-known technology in the artery, the present device also requires the guide wire 30 to guide it during actual use. Taking the main catheter 10 entering the right hepatic artery 70 and the microcatheter 20 entering the left hepatic artery 40 as an example, the use process of the present device is as follows: Figure 4 First, a guidewire 30 is used in conjunction with the main catheter 10 to enter the femoral artery, passing through the hepatic aorta 50 and the proper hepatic artery 60, and then into the right hepatic artery 70. Because the right hepatic artery 70 is located at a certain angle to the proper hepatic artery 60, the tip of the guidewire 30 is slightly bent before entering the main catheter 10. This allows the guidewire 30 to smoothly guide the main catheter 10 into the right hepatic artery 70. The main catheter 10 is rotated to ensure that the side opening 13 on the main catheter 10 faces the left hepatic artery 40, and then the guidewire 30 is withdrawn. The guidewire 30 is then inserted into the microcatheter 20, which is then inserted into the first through-hole 11 of the main catheter 10. When the microcatheter 20 reaches the vicinity of the side opening 13, the thin film on the side opening 13 is pushed open by the guidewire 30 or the microcatheter 20, allowing the guidewire 30 to pass through the side opening 13. The microcatheter 20 is then guided along the guidewire 30 through the side opening 13 and into the left hepatic artery 40, and the guidewire 30 is withdrawn. Next, contrast agent is injected through the first injection port 12 and the second injection port 22, respectively, to confirm whether the main catheter 10 and microcatheter 20 have reached the required positions. After confirmation, the main catheter 10 and microcatheter 20 are fixed. Finally, the total drug dose is calculated, and the drug dose injected from the main catheter 10 and the drug dose injected from the microcatheter 20 are flexibly allocated according to treatment needs. The drugs are injected separately. The drug injected from the first injection port 22 passes through the first fluid channel 17 and then flows out of the first drug outlet 16 into the right hepatic artery. The drug injected from the second injection port 22 passes through the second through hole 21 and then flows out of the second drug outlet 23 into the left hepatic artery 40. It should be noted that the flow path of the contrast agent is the same as that of the drug.
[0024] The device is not limited to the femoral artery approach and can also be used for radial artery approach. Furthermore, the device is not limited to liver infusion and can also be used for other organ infusions.
[0025] The above description is only a specific embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformation made using the contents of the description and drawings of the present invention, or directly or indirectly applied in other related technical fields, is also included in the patent protection scope of the present invention.
Claims
1. A device for flexibly dispensing drug dosages for continuous arterial infusion, characterized by: It includes a main catheter and a microcatheter, wherein a first through hole is axially provided in the main catheter, a first injection port is provided on the rear end tube wall of the main catheter, the front end head of the main catheter is a first drug outlet, a side opening is provided on the front end tube wall of the main catheter, and the first injection port, the first drug outlet and the side opening are all connected to the first through hole; a second through hole is axially provided in the microcatheter, the microcatheter is arranged in the first through hole of the main catheter, the front end head of the microcatheter passes through the side opening, a first fluid channel is formed between the inner wall of the main catheter and the outer wall of the microcatheter, and the second through hole serves as a second fluid channel.
2. The device for flexible dispensing of drug dosages for continuous arterial infusion according to claim 1, characterized in that: A plurality of side openings are provided on the front end wall of the main conduit, and the side openings are spaced apart in the axial direction and each side opening is provided with a sealing member.
3. The device for flexible dispensing of drug dosages for continuous arterial infusion according to claim 2, characterized in that: The sealing member is a film with a cross-shaped or Y-shaped slit.
4. The device for flexible dispensing of drug dosages for continuous arterial infusion according to claim 1, characterized in that: An indicator mark is provided at the side opening.