Animal fixing structure for skin phototoxicity experiment and experimental device
By fixing the test animals with a fixation plate and binding structure, the problem of animal activity affecting experimental results was solved, and a more stable and rapid skin phototoxicity experiment was achieved.
Patent Information
- Application Number
- CN202422211480.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-09
- Publication Date
- 2025-10-17
- Estimated Expiration
- 2034-09-09
AI Technical Summary
In skin phototoxicity experiments, the activity of the test animals affects the reliability of the experimental results, leading to changes in ultraviolet radiation dose and time parameters.
The system employs a fixation plate and binding structure, including a front fixation strap, a middle fixation strap, and a rear fixation strap, to secure the limbs and torso of the test animal. Combined with a breathable face mask and snap fasteners, it ensures stable fixation of the animal.
This improved the reliability of experimental results, reduced animal struggles and wriggling, and enhanced the stability and speed of the experiment.
Smart Images
Figure CN223438672U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to cosmetic testing technical field, concretely relates to a skin light poison experiment is with animal fixed structure and experimental apparatus. BACKGROUND
[0002] Light toxicity refers to a kind of skin toxicity reaction caused by exposure to ultraviolet radiation after skin contacts chemical substance, which can cause damage to skin. Therefore, before cosmetic or external drug is put into use, skin light poison experiment needs to be carried out to determine the stability of chemical substance when it contacts skin and is irradiated by ultraviolet, so as to determine whether to allow cosmetic or external drug to be put into use and confirm usage and dosage.
[0003] In prior art, guinea pigs and other animals with skin similar to human skin are usually used to carry out skin light poison experiment, the drug or cosmetic to be tested is applied to the skin of test animal, then quantitative and timed irradiation is carried out by ultraviolet equipment, the skin reaction of test animal after irradiation is observed, so as to determine the light toxicity of chemical.
[0004] However, in the experiment process, because skin tissue needs to be kept active, live animals need to be used for experiment, and in the experiment process, the activity of animal can affect the change of parameters such as the amount of ultraviolet radiation and the length of irradiation accepted by part of skin for testing, and affect the reliability of results. UTILITY MODEL CONTENT
[0005] Therefore, the utility model provides an animal fixed structure and experimental apparatus for skin light poison experiment to solve the problem of reducing the reliability of experimental results caused by the activity of test animal in the experiment process.
[0006] In the first aspect, the utility model provides an animal fixed structure for skin light poison experiment, which comprises a fixed plate, a binding structure arranged on the fixed plate, the binding structure comprising a front fixing belt, a middle fixing belt and a rear fixing belt, the front fixing belt being used for fixing the forelimbs and head of test animal, and both ends of the front fixing belt being connected with the fixed plate respectively, the middle fixing belt being used for fixing the torso of test animal and both ends of the middle fixing belt being connected with the fixed plate respectively, and the rear fixing belt being used for fixing the hind limbs of test animal and both ends of the rear fixing belt being connected with the fixed plate respectively.
[0007] Beneficial effects: By setting up the binding structure of the front fixing belt, the middle fixing belt and the rear fixing belt to fix the test animal, since the test animal will be stretched out by the staff and attached to the fixing plate during the experiment, the front fixing belt extends along the width direction of the test animal's body and tightens and presses the two front limbs and the head of the test animal towards the fixing plate, the middle fixing belt presses the middle part of the test animal's torso towards the fixing plate, thereby restraining the test animal's torso, and the rear fixing belt presses the test animal's hips and two hind limbs towards the fixing plate, thereby restraining the test animal's hind limbs and hips, so that the test animal is overall attached to the fixing plate, reducing the case that the test animal struggles and twists during the experiment to affect the reliability of the experimental results.
[0008] In an alternative embodiment, a breathable mask is fixedly connected to the front fixing belt, and the breathable mask is located at a middle position in the length direction of the front fixing belt.
[0009] Beneficial effects: By setting up the breathable mask, the head of the test animal is covered, and the eyes of the test animal are also shielded, which on the one hand prevents adverse effects of ultraviolet radiation on the eyes of the test animal, and on the other hand reduces the case that the test animal is disturbed by the external environment to cause stress behavior and causes violent struggle, so that the test animal is more stable, thereby improving the stability of the fixation of the test animal and improving the reliability of the experimental results.
[0010] In an alternative embodiment, the length of the breathable mask in the direction of the front fixing belt is less than or equal to the width of the head of the test animal.
[0011] Beneficial effects: By controlling the length of the breathable mask in the length direction of the front fixing belt, the breathable mask covers the head of the test animal as much as possible without covering the two front limbs of the test animal, thereby avoiding the case that the width of the breathable mask is greater than the width of the front fixing belt, thereby reducing the binding force on the front limbs of the test animal, and further improving the stability of the fixation of the test animal.
[0012] In an alternative embodiment, a first plug-in buckle is provided on the front fixing belt, and the plug-in buckle separates the front fixing belt into two parts that are connected to each other by plug-in connection.
[0013] Beneficial effects: By setting up the first plug-in buckle, the front fixing belt can be separated into two parts, so that the staff can separate the two parts of the front fixing belt before restraining the animal on the fixing plate, and after the animal is transferred to the fixing plate, the staff can more conveniently plug the two parts of the front fixing belt to form a whole fixing belt, thereby completing the experiment more quickly and reducing the suffering of the test animal.
[0014] In an alternative embodiment, the middle fixing belt is provided with a second plug buckle, which separates the middle fixing belt into two parts connected by plug connection.
[0015] Beneficial effects: By setting the second plug buckle, the middle fixing belt can be separated into two parts, and after the test animal is transferred to the fixing plate, the two parts are inserted by the staff to form the whole middle fixing belt, so as to quickly complete the fixation of the test animal, which helps to speed up the experiment and reduce the pain of the test animal.
[0016] In an alternative embodiment, the rear fixing belt is provided with a third plug buckle, which separates the rear fixing belt into two parts connected by plug connection.
[0017] Beneficial effects: By setting the third plug buckle, the rear fixing belt can be separated into two parts, and after the test animal is transferred to the fixing plate, the two parts are inserted by the staff to form the whole rear fixing belt, so as to quickly complete the fixation of the test animal, which helps to speed up the experiment and reduce the pain of the test animal.
[0018] In an alternative embodiment, the front fixing belt, the middle fixing belt and the rear fixing belt are respectively provided with length adjusting buckles, which are used to adjust the length of the corresponding front fixing belt, middle fixing belt or rear fixing belt.
[0019] Beneficial effects: By setting the length adjusting buckle, the staff can quickly adjust the length of the front fixing belt, the middle fixing belt and the rear fixing belt, so that the fixing structure can better adapt to test animals of different sizes, and the universality of the structure is improved.
[0020] In an alternative embodiment, the width of the front fixing belt, the middle fixing belt and the rear fixing belt is greater than 1 cm and less than 3 cm.
[0021] Beneficial effects: By limiting the width of the front fixing belt, the middle fixing belt and the rear fixing belt, it can not only reduce the excessive concentration of body pressure on the test animal caused by too small width, which causes the test animal to struggle in pain, but also avoid the weak fixation of the test animal caused by the dispersion of pressure due to too large width, which makes the test animal easy to escape.
[0022] In a second aspect, the utility model also provides an experimental device, which comprises the animal fixing structure for skin phototoxicity experiment.
[0023] Beneficial effects: the experimental device can more quickly and stably fix the test animals by using the above-mentioned skin phototoxicity experiment animal fixing structure, reduces the struggle and writhing of the test animals during the experiment, and improves the reliability of the experimental results.
[0024] In an alternative embodiment, a test piece is arranged at the middle part of the length direction of the middle fixing belt, and a plurality of test windows penetrating through the test piece in the thickness direction are arranged on the test piece.
[0025] Beneficial effects: the test piece is integrated on the middle fixing belt, after the staff completes the binding of the middle fixing belt to the test animals, the test piece is automatically attached to the skin of the animals, and the corresponding test window forms a test area for coating the tested drugs or cosmetics, without the need for additional test piece structure to be attached to the skin of the animals, and the operation is simpler. At the same time, since the test window and the test piece are closely attached to the skin of the test animals, the light irradiation position and intensity on the skin of the test animals are not easy to change due to the large irradiation range of the ultraviolet light source during the experiment, which can further improve the reliability of the experimental results. BRIEF DESCRIPTION OF DRAWINGS
[0026] In order to more clearly illustrate the specific embodiments of the present application or the technical solutions in the prior art, the drawings needed in the following specific embodiments or prior art description will be briefly introduced. Obviously, the drawings in the following description are some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained without creative labor.
[0027] Fig. 1 It is a whole structure schematic view of an experimental device of an embodiment of the present application.
[0028] Fig. 2 It is a whole structure schematic view of another experimental device of an embodiment of the present application.
[0029] Explanation of reference signs:
[0030] 100, fixing plate; 200, binding structure; 201, front fixing belt; 2011, air-permeable mask; 2012, first plug-in buckle; 202, middle fixing belt; 2021, second plug-in buckle; 203, rear fixing belt; 2031, third plug-in buckle; 300, length adjusting buckle; 400, test piece; 401, test window. DETAILED DESCRIPTION
[0031] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described in combination with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by the person skilled in the art without creative labor belong to the protection scope of the utility model.
[0032] The embodiments of the utility model will be described below in combination with Figs. 1-2 .
[0033] According to the embodiments of the utility model, on the one hand, an animal fixing structure for skin phototoxicity experiment is provided. Please refer to Fig. 1 and Fig. 2 , which comprises a fixing plate 100, a binding structure 200 arranged on the fixing plate 100, comprising a front fixing belt 201, a middle fixing belt 202 and a rear fixing belt 203, the front fixing belt 201 is used for fixing the forelimbs and head of the test animal, and the two ends of the front fixing belt 201 are respectively connected with the fixing plate 100, the middle fixing belt 202 is used for fixing the torso of the test animal and the two ends thereof are respectively connected with the fixing plate 100, and the rear fixing belt 203 is used for fixing the hind limbs of the test animal and the two ends thereof are respectively connected with the fixing plate 100.
[0034] In the embodiments, the test animal is fixed by the binding structure 200 composed of the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203. Since the test animal will be stretched by the staff and attached to the fixing plate 100 during the experiment, the front fixing belt 201 extends along the width direction of the test animal's body, tightens and presses the two forelimbs and head of the test animal towards the fixing plate 100, the middle fixing belt 202 presses the middle part of the test animal's torso towards the fixing plate 100, thereby restraining the test animal's torso, and the rear fixing belt 203 presses the hips and two hind limbs of the test animal towards the fixing plate 100, thereby restraining the test animal's hind limbs and hips, so that the test animal is overall attached to the fixing plate 100, and the situation that the test animal struggles and wriggles during the experiment to affect the reliability of the experimental results is reduced.
[0035] Specifically, in the above embodiments, the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203 all extend along the length direction of the fixing plate 100, or all extend along the width direction of the fixing plate 100. Correspondingly, the two ends of the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203 can be connected with the fixing plate 100 by means of adhesion, or can be connected to the fixing plate 100 by means of riveting, and the specific connection mode is not limited in the embodiments.
[0036] In addition, specifically, the embodiment is not limited to the width and material of the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203, as long as the corresponding forelimbs and head, the middle part of the trunk, and the hindlimbs and hips of the test animal can be fixed.
[0037] In one embodiment, the front fixing belt 201 is fixedly connected with a breathable mask 2011, and the breathable mask 2011 is located at a middle position in the length direction of the front fixing belt 201.
[0038] Specifically, the length of the breathable mask 2011 is not limited, and the breathable mask 2011 can cover only the head or face of the test animal, or can cover the head, face and forelimbs of the test animal. In addition, it should be noted that the breathable mask 2011 can be a light-blocking nylon mask, or a light-blocking mask of other materials, which can block the line of sight of the test animal.
[0039] In the embodiment, by setting the breathable mask 2011, the head of the test animal is covered, and the eyes of the test animal are also blocked. On the one hand, the adverse effects of ultraviolet radiation on the eyes of the test animal are prevented. On the other hand, by blocking the line of sight of the test animal, the stress behavior caused by the disturbance of the external environment is reduced, and the situation of violent struggle is avoided. The test animal can be more stable, so as to improve the stability of the fixation of the test animal and improve the reliability of the experimental results.
[0040] In one embodiment, please refer to Fig. 2 The length of the breathable mask 2011 in the length direction of the front fixing belt 201 is less than or equal to the width of the head of the test animal.
[0041] In the embodiment, by controlling the length of the breathable mask 2011 in the length direction of the front fixing belt 201, the breathable mask 2011 can cover only the head of the test animal as much as possible, and the two forelimbs of the test animal are not covered. Avoid the situation that the width of the breathable mask 2011 is greater than the width of the front fixing belt 201, so as to weaken the binding force of the forelimbs of the test animal, and further improve the stability of the fixation of the test animal.
[0042] In one embodiment, the front fixing belt 201 is provided with a first plug-in buckle 2012, and the plug-in buckle separates the front fixing belt 201 into two parts which are connected with each other by plug-in connection.
[0043] In the embodiment, the first plug-in buckle 2012 is arranged, so that the front fixing belt 201 can be separated into two parts, and the two parts of the front fixing belt 201 are in a separated state before the animal is bound on the fixing plate 100 by the worker, and after the animal is transferred to the fixing plate 100, the worker can more conveniently plug the two parts of the front fixing belt 201 to form a whole fixing belt, so that the experiment is more quickly completed, and the pain suffered by the test animal is reduced.
[0044] In one embodiment, the second plug-in buckle 2021 is arranged on the middle fixing belt 202, and the second plug-in buckle 2021 separates the middle fixing belt 202 into two parts which are connected by plug-in.
[0045] In the embodiment, the second plug-in buckle 2021 is arranged, so that the middle fixing belt 202 can be separated into two parts, and the two parts are plugged to form a whole middle fixing belt 202 by the worker after the test animal is transferred to the fixing plate 100, so that the fixation of the test animal is quickly completed, and the experiment speed is accelerated and the pain suffered by the test animal is reduced.
[0046] In one embodiment, the third plug-in buckle 2031 is arranged on the rear fixing belt 203, and the third plug-in buckle 2031 separates the rear fixing belt 203 into two parts which are connected by plug-in.
[0047] In the embodiment, the third plug-in buckle 2031 is arranged, so that the rear fixing belt 203 can be separated into two parts, and the two parts are plugged to form a whole rear fixing belt 203 by the worker after the test animal is transferred to the fixing plate 100, so that the fixation of the test animal is quickly completed, and the experiment speed is accelerated and the pain suffered by the test animal is reduced.
[0048] In some of the above embodiments, it should be noted that the first plug-in buckle 2012, the second plug-in buckle 2021 and the third plug-in buckle 2031 can be ordinary clothing buckles, and in some not shown embodiments, other forms of plug-in structures can be used, which can realize the connection and separation between the two parts of the corresponding front fixing belt 201, middle fixing belt 202 or rear fixing belt 203.
[0049] In one embodiment, the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203 are respectively provided with length adjusting buckles 300, and the adjusting buckles are used to adjust the length of the corresponding front fixing belt 201, middle fixing belt 202 or rear fixing belt 203.
[0050] In the embodiment, the length adjusting buckle 300 is arranged, so that the staff can quickly adjust the lengths of the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203, the fixing structure can better adapt to test animals of different body shapes, and the structural versatility is improved.
[0051] In one embodiment, the widths of the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203 are greater than 1 cm and less than 3 cm.
[0052] In the embodiment, by limiting the widths of the front fixing belt 201, the middle fixing belt 202 and the rear fixing belt 203, the following problems can be solved: when the width is too small, the test animal is too concentratedly pressed, and the test animal struggles in pain; and when the width is too large, the fixing force on the test animal is weak, and the test animal is easily disengaged.
[0053] According to the embodiment of the utility model, on the other hand, an experimental device is also provided, the animal fixing structure for skin phototoxicity experiment.
[0054] In the embodiment, the experimental device adopts the animal fixing structure for skin phototoxicity experiment, so that the test animal can be fixed more quickly and stably, the struggle and wriggling of the test animal in the experiment are reduced, and the reliability of the experimental result is improved.
[0055] In one embodiment, the middle part of the middle fixing belt 202 in the length direction is provided with a test piece 400, and the test piece 400 is provided with a plurality of test windows 401 penetrating the test piece 400 in the thickness direction.
[0056] In the embodiment, the test piece 400 is integrated on the middle fixing belt 202, after the staff completes the restraint of the test animal by the middle fixing belt 202, the test piece 400 is automatically attached to the skin of the animal, and the corresponding test window 401 forms a test area, which is used for coating the tested medicine or cosmetic, and other test piece 400 structures do not need to be additionally attached to the skin of the animal, so that the operation is simpler. Meanwhile, since the test window 401 and the test piece 400 are closely attached to the skin of the test animal, the illumination position and intensity on the skin of the test animal are not easy to change under the condition that the animal slightly wriggles the torso, the illumination range of the ultraviolet light source is large, and the reliability of the experimental result can be further improved.
[0057] Although the embodiments of the utility model are described in combination with the drawings, various modifications and variations can be made by those skilled in the art without departing from the spirit and scope of the utility model, and such modifications and variations all fall within the scope defined by the appended claims.
Claims
1. An animal fixing structure for skin phototoxicity experiments, characterized in that: include: Fixed plate (100); A binding structure (200) is provided on the fixing plate (100), comprising a front fixing belt (201), a middle fixing belt (202) and a rear fixing belt (203), wherein the front fixing belt (201) is used to fix the forelimbs and head of the test animal, and the two ends of the front fixing belt (201) are respectively connected to the fixing plate (100), the middle fixing belt (202) is used to fix the trunk of the test animal, and the two ends are respectively connected to the fixing plate (100), and the rear fixing belt (203) is used to fix the hindlimbs of the test animal, and the two ends are respectively connected to the fixing plate (100); A breathable mask (2011) is fixedly connected to the front fixing belt (201), and the breathable mask (2011) is located in the middle of the length direction of the front fixing belt (201).
2. The animal fixing structure for skin phototoxicity experiment according to claim 1, characterized in that: The length of the breathable mask (2011) along the direction of the front fixing belt (201) is less than or equal to the width of the head of the test animal.
3. The animal fixing structure for skin phototoxicity experiment according to claim 1, characterized in that: The front fixing belt (201) is provided with a first plug-in buckle (2012), which separates the front fixing belt (201) into two parts that are plug-connected to each other.
4. The animal fixing structure for skin phototoxicity experiment according to claim 1, characterized in that: The middle fixing belt (202) is provided with a second plug-in buckle (2021), and the second plug-in buckle (2021) separates the middle fixing belt (202) into two parts that are plug-connected to each other.
5. The animal fixing structure for skin phototoxicity experiment according to claim 1, characterized in that: The rear fixing belt (203) is provided with a third plug-in buckle (2031), and the third plug-in buckle (2031) separates the rear fixing belt (203) into two parts that are plug-connected to each other.
6. The animal fixing structure for skin phototoxicity experiments according to any one of claims 1 to 5, characterized in that: The front fixing belt (201), the middle fixing belt (202) and the rear fixing belt (203) are respectively provided with length adjustment buckles (300), and the adjustment buckles are used to adjust the length of the corresponding front fixing belt (201), the middle fixing belt (202) or the rear fixing belt (203).
7. The animal fixing structure for skin phototoxicity experiment according to claim 6, characterized in that: The widths of the front fixing belt (201), the middle fixing belt (202) and the rear fixing belt (203) are greater than 1 centimeter and less than 3 centimeters.
8. An experimental device, characterized in that: include: An animal fixing structure for skin phototoxicity experiments according to any one of claims 1 to 7.
9. The experimental device according to claim 8, characterized in that A test piece (400) is provided in the middle of the length direction of the middle fixing belt (202), and a plurality of test windows (401) are provided on the test piece (400) and penetrate the test piece (400) in the thickness direction.