Scanning device and pathological section scanner

Abstract

The utility model belongs to the technical field of pathological scanning, and relates to a scanning device and a pathological section scanner, the scanning device comprises a base frame, an objective table assembly, a scanning assembly, a section information reading assembly and a backlight source, the base frame comprises a base, and the base is provided with a scanning channel; the base frame is provided with an access communicated with the scanning channel; the objective table assembly is located in the scanning channel and provided with a scanning station. The objective table assembly is used for loading a glass slide located on the scanning station and driving the glass slide to move in a reciprocating mode in the extending direction of the scanning channel. The scanning assembly is arranged on the base frame at the top of the objective table assembly; when the objective table assembly drives the glass slide to move back and forth, the scanning assembly is used for carrying out all-directional scanning on the passing glass slide; the slice information reading assembly is arranged on the base frame at the position corresponding to the inlet and outlet. The backlight source is arranged on the objective table assembly at the position corresponding to the scanning station. The scanning device and the pathological section scanner are small in occupied space and diversified in function, and high-definition digital pathological information can be conveniently and rapidly obtained.

Description

TECHNICAL FIELD

[0001] The utility model relates to pathological scanning technical field especially, a kind of scanning device and pathological section scanning instrument. BACKGROUND

[0002] Pathological section scanning instrument one can be whole slide full information, all-around fast scanning, make the traditional mediumization pathological information of organization sample sealed in slide is changed into digital pathological information medical equipment.Slides scanning is to carry out micro distance high-precision shooting to the pathological section of organization sample sealed in slide, to obtain digital whole section image, for staff to read film through computer screen.

[0003] Existing pathological section scanning instrument usually includes at least scanning head, loading stage and realizing the movement unit of scanning head and slide alignment, since the cell of organization sample is small, usually only several microns, to want to shoot clearly, the magnification of scanning head's microscope objective lens needs to be relatively high, the organization sample pathological section of shooting is in high-speed movement process, and movement unit needs to be stable enough, otherwise blurring condition is prone to occur in shooting.But the scanning precision of existing scanning device is difficult to control, leading to difficult to obtain high-definition digital pathological information.

[0004] In addition, in order to improve the diagnosis efficiency, pathological section scanning instrument is required to realize batch scanning, that is, the organization section on multiple slides needs to be sequentially and continuously scanned automatically, however, the source of the organization section to be scanned is different, a large amount of digital pathological information is obtained by batch scanning, which is difficult to distinguish at the moment, and is not easy for staff to find and manage. UTILITY MODEL CONTENT

[0005] The utility model aims at, solve the technical problem that existing scanning device is difficult to obtain high-definition digital pathological information and batch scanning obtained digital pathological information is difficult to distinguish.

[0006] The utility model embodiment provides a kind of scanning device, adopt the technical scheme as follows:

[0007] The scanning device includes:

[0008] Base frame, the base frame includes base, and the base is equipped with scanning channel;The base frame has access with the scanning channel entrance and exit;

[0009] Object table component, the object table component is located in the scanning channel and is equipped with scanning station;The object table component is used to load the slide located on the scanning station, and drives the slide reciprocating movement along the extension direction of the scanning channel;

[0010] a scanning assembly arranged on the base frame on top of the stage assembly, the scanning assembly being configured to scan the glass slide in a full range when the stage assembly reciprocally moves the glass slide;

[0011] a slice information reading assembly arranged on the base frame at a position corresponding to the entrance or the exit, the slice information reading assembly being configured to read slice information on the glass slide loaded on the scanning station;

[0012] a backlight arranged on the stage assembly at a position corresponding to the scanning station, the backlight being configured to provide backlight for the scanning assembly to scan the glass slide.

[0013] In some embodiments of the present application, the stage assembly comprises:

[0014] a linear driving assembly mounted on the base along a first direction, the linear driving assembly being configured to reciprocally move the glass slide on the scanning station along the first direction, the first direction being an extension direction of the scanning channel;

[0015] In some embodiments of the present application, the stage assembly comprises a carrying assembly, the carrying assembly comprising:

[0016] a focusing table located in the scanning channel, the focusing table being configured to reciprocally move in the scanning channel along the first direction under the driving of the linear driving assembly;

[0017] a carrier provided with the scanning station, the carrier being movably arranged on the focusing table to swing or move along a height direction when moved, so that a height difference between the glass slide on the scanning station and the scanning assembly is adjusted.

[0018] In some embodiments of the present application, when the stage assembly comprises a carrying assembly, the stage assembly further comprises:

[0019] a slide fixing device arranged on the carrier, the slide fixing device having an open state and a clamping state;

[0020] In the open state, the slide fixing device forms a first space for placing the glass slide at a position corresponding to the scanning station;

[0021] In the clamping state, the slide fixing device is configured to clamp the glass slide on the scanning station;

[0022] When the focusing table moves away from the entrance or the exit along the first direction, the slide fixing device can be switched from the open state to the clamping state, so that the scanning assembly scans the glass slide clamped and fixed by the slide fixing device.

[0023] When the focusing stage moves along the first direction towards the entrance, the slide fixing device can be switched from the clamping state to the open state to release the clamping of the scanned slide.

[0024] In some embodiments of the utility model, the slide fixing device comprises a first clamping piece, a second clamping piece and a clamping switch assembly, the first clamping piece and the second clamping piece are oppositely arranged on the stage, and both of them and the loading surface of the scanning station jointly enclose a clamping space for placing a slide;

[0025] Wherein, at least one first clamping part is arranged on the side of the first clamping piece facing the clamping space, and at least one second clamping part is arranged on the side of the second clamping piece facing the clamping space; in the length direction of the slide, the length ratio of the clamping area jointly formed by the first clamping part and the second clamping part to the length of the slide is greater than or equal to 1 / 2;

[0026] Under the action of the clamping switch assembly, the first clamping piece and the second clamping piece relatively approach to clamp different parts of the slide in the clamping space from the opposite sides of the slide through the corresponding clamping parts, or the first clamping piece and the second clamping piece relatively move away to release the clamping of the slide in the clamping space.

[0027] In some embodiments of the utility model, when the object table assembly comprises a carrying assembly, the carrying assembly further comprises:

[0028] The first leveling assembly is provided with at least three;

[0029] The stage is installed on the focusing stage through at least three first leveling assemblies which are not on the same straight line, so that the flatness of the slide on the scanning station relative to the preset reference plane is within the first preset range through the adjustment of the first leveling assembly;

[0030] And / or, when the object table assembly comprises a linear drive assembly and a carrying assembly, the object table assembly further comprises:

[0031] The first linear movement assembly is installed on the base and used for guiding the movement of the carrying assembly along the first direction;

[0032] The transmission member is slidingly installed on the first linear movement assembly, and the linear drive assembly and the carrying assembly are installed on the transmission member;

[0033] The driver is used for at least controlling the action of the linear drive assembly and is installed on the transmission member to move with the transmission member;

[0034] And / or, the position sensor is arranged on the object table assembly, the first travel switch and the second travel switch are arranged on the base, the first travel switch is used for cooperating with the position sensor to control the object table assembly to be located at the initial position, and the second travel switch is used for cooperating with the position sensor to control the object table assembly to be located at the maximum travel position.

[0035] In some embodiments of the utility model, the linear drive assembly is a bar-shaped linear motor;

[0036] And / or, the first linear moving assembly comprises a target guide rail, the target guide rail is arranged on the base along the first direction, and the transmission member is slidably installed on the target guide rail through a sliding block;

[0037] The width of the target guide rail is equivalent to more than twice the width of a common single-shaft guide rail;

[0038] And / or, when the object table assembly comprises a linear drive assembly and a carrying assembly, the scanning device further comprises:

[0039] A grating measurement system is arranged for measuring the moving distance of the carrying assembly in the scanning channel;

[0040] The grating measurement system comprises a grating ruler, a magnetic grating ruler or a distance sensor, and the grating ruler, the magnetic grating ruler or the distance sensor is located between the focusing table and the first linear moving assembly;

[0041] And / or, a mounting cavity is concavely arranged on the top of the focusing table, and a driving member for driving the movement of the carrier table is arranged in the mounting cavity;

[0042] And / or, the focusing table is internally provided with a driving member for driving the movement of the carrier table, and the driving member is a voice coil motor.

[0043] In some embodiments of the utility model, the scanning assembly comprises:

[0044] A leveling platform is hung on the base frame;

[0045] A second leveling assembly is arranged on the leveling platform;

[0046] A scanning head is installed on the side of the leveling platform facing the base through a connecting member;

[0047] The leveling platform is installed on the base frame through at least three second leveling assemblies which are not on the same straight line, so that the scanning focal plane of the scanning head is within the second preset range relative to the flatness of the slide glass on the scanning station by adjusting the second leveling assemblies.

[0048] In some embodiments of the present application, the scanning assembly further comprises:

[0049] A heat dissipation member is arranged between the scanning platform and the scanning head for dissipating heat of the scanning head;

[0050] The scanning head comprises a plurality of microscopic objectives arranged in an array to form an array objective;

[0051] The width of the effective scanning area of the array objective in the second direction is greater than or equal to the interval between two opposite corners of the slice to be scanned on the slide on the scanning station in the second direction.

[0052] To solve the above technical problems, the present application further provides a pathological slice scanner, which adopts the technical scheme as follows: the pathological slice scanner comprises the scanning device.

[0053] Compared with the prior art, the scanning device and the pathological slice scanner provided by the present application have the following beneficial effects:

[0054] The scanning device is hoisted on the base frame at the position corresponding to the scanning channel of the base, so that the scanning assembly is fixed and the object table assembly carries the slide in the scanning channel and moves in the extension direction of the scanning channel in one direction, so that the slide enters the scanning area of the scanning assembly in one direction and completes omnidirectional scanning, without the need for multi-axis linkage to drive the movement of the object table assembly and / or the scanning assembly, so that the overall structure of the scanning device is relatively compact, which is beneficial to miniaturization, and the relative movement between the object table assembly and the scanning assembly is more stable and accurate, ensuring stable and accurate carrying of the slide, and the backlight source moving together with the slide is arranged on the object table assembly, which is finally beneficial to obtaining high-definition digital pathological information.

[0055] In addition, the scanning device further comprises a slice information reading assembly arranged at the entrance and exit for reading the slice information on the slide, so as to distinguish different slides, facilitate the search and management of digital pathological information, adapt to batch scanning, realize the multifunctionalization of the scanning device, and reasonably optimize the space of the scanning device, thereby ensuring the miniaturization of the scanning device. BRIEF DESCRIPTION OF DRAWINGS

[0056] In order to more clearly illustrate the schemes in the present application, the drawings required in the embodiment description will be briefly introduced as follows. Obviously, the drawings in the following description are some embodiments or corresponding prior art of the present application, and other drawings can be obtained by those skilled in the art without creative labor. Among them:

[0057] Figure 1 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the initial position, and the slide fixing device is in the open state;

[0058] Figure 2 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the slide fixing device is in the clamping state;

[0059] Figure 3 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0060] Figure 4 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0061] Figure 5 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0062] Figure 6 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0063] Figure 7 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0064] Figure 8 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0065] Figure 9 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0066] Figure 10 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state;

[0067] Figure 11 is a schematic diagram of the scanning device in an example of the present application; in this diagram, the object table assembly is in the maximum stroke position, and the slide fixing device is in the clamping state.

[0068] The reference signs in the drawings are as follows:

[0069] 100, scanning device; 200, slide;

[0070] 1, base frame; 11, base; 12, scanning channel; 13, entrance and exit; 14, mounting frame; 15, scanning cavity; 16, supporting leg; 17, accommodating cavity; 18, first stroke switch; 19, second stroke switch;

[0071] 2, stage assembly; 21, scanning station; 22, linear drive assembly; 23, carrying assembly; 231, focusing table; 2311, mounting cavity; 2312, drive member / voice coil motor; 2313, second linear movement assembly; 2314, position sensor; 232, stage; 2321, avoiding opening; 2322, carrying surface; 233, first leveling assembly; 2331, first adjusting member; 2332, second adjusting member; 234, lifting table; 2341, positioning member; 25, slide fixing device; 251, first space; 252, clamping space; 253, first clamping member / movable clamp; 2531, first clamping part; 254, second clamping member; 2541, second clamping part; 255, clamping switch assembly; 2551, guide member; 25511, guide surface; 255111, opening retaining surface; 255112, clamping retaining surface; 25223, transition arc surface; 2552, switch member; 256, elastic buffer member; 27, first linear movement assembly; 271, target guide rail; 272, sliding block; 28, transmission member; 29, sub load;

[0072] 3, scanning assembly; 31, adjusting platform; 32, second leveling assembly; 33, scanning head; 34, sensing unit; 35, connecting member;

[0073] 4, slice information reading assembly; 41, reading member; 42, light supplement source;

[0074] 5, backlight source; 6, grating measurement system; 61, grating ruler. DETAILED DESCRIPTION

[0075] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs; the terminology used in the description herein is for describing particular embodiments only and is not intended to be limiting of the application, for example, the terms "length", "width", "upper", "lower", "left", "right", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like describe orientations or positions as shown in the figures and are used for convenience in describing the present application, and are not intended to limit the present application.

[0076] The terms "including," "having," and any variations thereof in the specification and claims of this utility model and the accompanying drawings are intended to cover non-exclusive inclusions. The terms "first," "second," and the like in the specification and claims of this utility model and the accompanying drawings are used to distinguish between different items, not to describe a particular order. "Multiple" means two or more, unless otherwise expressly specified.

[0077] In the specification and claims of this utility model and the above-mentioned description of the drawings, when an element is referred to as being “fixed to”, “mounted on”, “disposed on” or “connected to” another element, it may be directly or indirectly located on the other element. For example, when an element is referred to as being “connected to” another element, it may be directly or indirectly connected to the other element.

[0078] Furthermore, references to "embodiments" herein mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present invention. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0079] An embodiment of the present invention provides a scanning device 100 , which includes but is not limited to a pathology slice scanner.

[0080] like Figures 1 to 3 As shown, the scanning device 100 includes a base frame 1, a stage assembly 2, a scanning assembly 3 and a slice information reading assembly 4, wherein the base frame 1 includes a base 11, and the base 11 is provided with a scanning channel 12 (see Figure 3 The base frame 1 has an entrance and exit 13 communicating with the scanning channel 12. It should be noted that the entrance and exit 13 is an opening for the slide 200 to be fed into or out of the scanning device 100.

[0081] For example Figures 1 to 3 As shown, the stage assembly 2 is positioned within the scanning channel 12 and is equipped with a scanning station 21. The stage assembly 2 can be used to load a glass slide 200 positioned on the scanning station 21 and to move the glass slide 200 back and forth along the extension direction of the scanning channel 12. The scanning assembly 3 is mounted on the base frame 1 atop the stage assembly 2, eliminating the need for movement during the scanning process. As the stage assembly 2 reciprocates the glass slide 200, the scanning assembly 3 can perform an omnidirectional scan of the glass slide 200 as it passes by.

[0082] Understandably, at the position corresponding to the scanning channel 12, by fixing the scanning assembly 3 on the base frame 1 and making the slide 200 carried by the stage assembly 2 move unidirectionally within the scanning channel 12 and along the extension direction of the scanning channel 12, the scanning assembly 3 can perform an all-round scanning of the passing slide 200. In this way, there is no need for multi-axis linkage to drive the stage assembly 2 and / or the scanning assembly 3 to move. On the one hand, it is conducive to simplifying the overall structure of the stage assembly 2 and reducing its occupied space, facilitating the miniaturization of the structure and facilitating transportation. On the other hand, it can avoid multi-axis installation errors and multi-axis linkage control errors, help reduce the vibration probability of the scanning area, ensure the stable movement of the stage assembly 2, and help more accurately control the scanning accuracy, so that the scanning assembly 3 can smoothly and clearly scan the slices on the slide 200, and ultimately help to quickly obtain high-definition digital pathology information.

[0083] For example Figures 1 to 3 As shown, a slice information reading assembly 4 is disposed on the base frame 1 at a position corresponding to the entrance 13. The slice information reading assembly 4 is primarily used to read slice information on the glass slide 200 loaded on the scanning station 21. Before the stage assembly 2 drives the glass slide 200 loaded on the scanning station 21 to move, or when the stage assembly 2 drives the glass slide 200 after scanning to move out of the entrance 13, the slice information reading assembly 4 can be used to read the slice information on the glass slide 200 loaded on the scanning station 21.

[0084] It can be understood that by arranging the slice information reading component 4 at the corresponding position of the entrance and exit 13 of the base frame 1, the scanning device 100 has the function of identifying the slice information of the tissue slice in the slide 200. On the one hand, by rationally utilizing the limited space of the scanning device 100, the multifunctionality of the scanning device 100 is realized. On the other hand, it is convenient for the staff to distinguish different slides 200, which is beneficial to the classification, archiving and search of the slides 200.

[0085] For example Figures 1 to 3 As shown, a backlight source 5 is disposed on the stage assembly 2 at a position corresponding to the scanning station 21, wherein the backlight source 5 can be used to provide backlight for the scanning assembly 3 when scanning the glass slide 200. It is understood that within the base frame 1, when the stage assembly 2 carries the glass slide 200 and moves away from the entrance 13 to deliver the glass slide 200 to the bottom of the scanning assembly 3 for scanning, the backlight source 5 can move along with the glass slide 200 and the stage assembly 2, and provide backlight for the scanning assembly 3 during scanning, so that the scanning assembly 3 can obtain a high-definition slice image.

[0086] In summary, compared with the prior art, the scanning device 100 has at least the following beneficial effects:

[0087] The scanning device 100 fixes the scanning assembly 3 by hoisting the scanning assembly 3 on the base frame 1 at the corresponding position of the scanning channel 12 of the base 11, and moves the slide glass 200 in the scanning channel 12 along the extension direction of the scanning channel 12 by the stage assembly 2, so that the slide glass 200 is gradually and unidirectionally scanned into the scanning area of the scanning assembly 3, without moving the stage assembly 2 and / or the scanning assembly 3 by multi-axis linkage, so that the overall structure of the scanning device 100 is compact, which is beneficial to miniaturization, and the relative movement between the stage assembly 2 and the scanning assembly 3 can be more stable and accurate, so as to ensure that the slide glass 200 is stably and accurately carried, and the backlight source 5 moving together with the slide glass 200 is arranged on the stage assembly 2, which is finally beneficial to obtaining high-definition digital pathological information.

[0088] In addition, the scanning device 100 further comprises the slice information reading assembly 4 arranged at the entrance and exit 13 and used for reading the slice information on the slide glass 200, so as to distinguish different slide glasses 200, realize the multifunctionalization of the scanning device 100, rationally utilize the space of the scanning device 100, and ensure the miniaturization of the scanning device 100.

[0089] In order to enable personnel in the technical field to better understand the technical scheme of the present application, the following will combine the accompanying drawings to Figures 1 to 11 The technical scheme in the embodiment of the present application is clearly and completely described.

[0090] In some embodiments, as shown in Figures 1 to 3 The base frame 1 further comprises the mounting frame 14, which is arranged on the base 11 and cooperates with the base 11 to form the scanning cavity 15. The mounting frame 14 is provided with the entrance and exit 13 communicating with the scanning cavity 15 and the outside. The stage assembly 2 can drive the slide glass 200 to reciprocally move in the scanning cavity 15. The scanning assembly 3 is hoisted on the mounting frame 14 in the scanning cavity 15, and the slice information reading assembly 4 is arranged outside the scanning cavity 15.

[0091] Exemplarily, at the initial position, one end of the stage assembly 2 is exposed to the entrance 13, so as to carry the slide 200 from the outside to the scanning station 21. After the slide 200 is fixedly installed on the stage assembly 2, the slice information reading assembly 4 can read the slice information marked on the slide 200, and the stage assembly 2 can carry the slide 200 into the scanning cavity 15 in a direction away from the entrance 13 for scanning by the scanning assembly 3. After the scanning of the slide 200 is completed, the slide 200 can be moved back to the entrance 13 under the driving of the stage assembly 2. Obviously, through the reasonable arrangement of the scanning channel 12, the stage assembly 2, the scanning assembly 3 and the slice information reading assembly 4 inside and outside the scanning cavity 15, the scanning operation is not only simple and fast, but also smooth and orderly, which is beneficial to realize batch scanning and further realize the miniaturization of the scanning device 100.

[0092] Exemplarily, the slide 200 has an insertion end (not shown in the figure) and an identification end (not shown in the figure). The insertion end can be inserted into the scanning station 21 from the entrance in the length direction of the slide 200, and the identification end is exposed to the scanning station 21. The middle part of the slide 200 is sealed with pathological sections of an organization, and the identification end is marked with relevant information of the pathological sections of the organization, which includes but is not limited to a two-dimensional code, a bar code, written words, pictures, etc. When the stage assembly 2 carries the slide 200 to complete the scanning and return to the initial position, the slice information reading assembly 4 can directly take a photo of the slice information marked on the identification end, so as to realize the digitization of the information of the slide 200 for distinguishing different slides 200 by the staff.

[0093] In some embodiments, as shown in Figures 1 to 3 the slice information reading assembly 4 includes a reading piece 41 and a light supplement source 42. The reading piece 41 is used to obtain the slice information marked on the slide 200. The light supplement source 42 is installed on at least one side of the opposite sides of the reading piece 41. Exemplarily, in order to improve the photo effect, the opposite sides (specifically, the left side and the right side) of the reading piece 41 are each provided with the light supplement source 42. It should be noted that the reading piece 41 described herein includes but is not limited to a code scanner and a camera.

[0094] In some embodiments, as shown in Figures 1 to 3 in order to reduce the material and simplify the structure of the scanning device 100, the base frame 1 further includes a plurality of supporting legs 16. The plurality of supporting legs 16 which are not on the same straight line are arranged on the bottom of the base 11, and the plurality of supporting legs 16 and the base 11 jointly enclose the accommodating cavity 17. In addition, the scanning device 100 further includes a control unit (not shown in the figure), and the control unit is accommodated in the accommodating cavity 17.

[0095] Understandably, the scanning device 100 is provided with multiple supporting legs 16 at the bottom of the base 11 to form a multi-point support such as a triangle, a quadrangle, etc., so as to ensure the stable placement of the base 11 and various components mounted thereon, and to form a receiving cavity 17 below the base 11 to provide a receiving space for other components such as the control unit of the scanning device 100, so as to reasonably utilize the height space of the scanning device 100 and facilitate the further reduction of the occupied space of the scanning device 100.

[0096] In some embodiments, as shown in Figures 1 to 3 In order to further reduce the occupied space of the scanning device 100, the stage assembly 2 includes a linear drive assembly 22, wherein the linear drive assembly 22 is mounted on the base 11 along a first direction, and the linear drive assembly 22 is mainly used to drive the slide glass 200 on the scanning station 21 to reciprocate along the first direction. The first direction is the extension direction of the scanning channel 12.

[0097] In some embodiments, in order to realize the carrying of the slide glass 200, the stage assembly 2 includes a carrying assembly 23, and the carrying assembly 23 includes a focusing stage 231 and a stage 232, wherein the focusing stage 231 is located in the scanning channel 12 and can reciprocate in the scanning channel 12 along the first direction under the driving of the linear drive assembly 22. The stage 232 is provided with the scanning station 21, and the stage 232 is movably arranged on the focusing stage 231 to swing or move along the height direction when moving, so that the height difference between the slide glass 200 on the scanning station 21 and the scanning assembly 3 is adjusted, so as to facilitate the focusing between the slide glass 200 and the scanning assembly 3.

[0098] In some embodiments, the stage assembly 2 further includes a glass fixing device 25, wherein the glass fixing device 25 is arranged on the stage 232, and the glass fixing device 25 has an open state and a clamping state. In the open state of the glass fixing device 25, the glass fixing device 25 is formed with a first space 251 corresponding to the scanning station 21 for placing the slide glass 200. The first space 251 is larger than the size of the slide glass 200, so as to facilitate the placement of the slide glass 200 from the outside to the scanning station 21. In the clamping state of the glass fixing device 25, the glass fixing device 25 can be used to clamp the slide glass 200 on the scanning station 21.

[0099] When the focusing stage 231 moves along the first direction away from the entrance and exit 13, the glass fixing device 25 can be switched from the open state to the clamping state, so that the scanning assembly 3 can scan the slide glass 200 clamped and fixed by the glass fixing device 25. When the focusing stage 231 moves along the first direction towards the entrance and exit 13, the glass fixing device 25 can be switched from the clamping state to the open state to release the clamping of the scanned slide glass 200.

[0100] Exemplarily, at the initial position of the entrance and exit, the slide 200 is placed in the scanning station 21 from outside, and after being placed in the first space 251, the slide 200 is fixed and clamped by the slide fixing device 25 when the focusing stage 231 carrying the slide 200 moves away from the entrance and exit 13 along the scanning channel 12 into the scanning cavity 15 under the driving of the linear driving assembly 22. The slide 200 fixedly installed on the stage 232 is gradually and unidirectionally moved to the lower side of the scanning assembly 3, and the scanning assembly 3 can scan the passing slide 200. If the acquired image does not meet the requirements, the height difference between the stage 232 and the scanning assembly 3 can be adjusted in time to adapt to the slide 200 of different heights. After the focusing of the slide 200 and the scanning assembly 3 is completed, the focusing stage 231 can be quickly moved back to the entrance and exit 13 under the driving of the linear driving assembly 22, and when the focusing stage 231 moves to the target position, the focusing stage 231 is slowly unidirectionally moved into the scanning cavity 15 under the driving of the linear driving assembly 22, so that the slide 200 slowly passes through the scanning assembly 3 for omnidirectional scanning. After the scanning is completed, the focusing stage 231 loads the slide 200 to the initial position under the driving of the linear driving assembly 22. When the focusing stage 231 moves to the vicinity of the entrance and exit 13, the slide fixing device 25 can release the clamping of the scanned slide 200, so as to facilitate the removal of the slide 200 from the scanning device 100.

[0101] It should be noted that the first direction described herein is preferably a longitudinal direction, which can be non-parallel to the extension direction of the scanning channel 12. For example, the extension direction of the scanning channel 12 is slightly inclined relative to the first direction. Alternatively, the first direction is the length direction or the extension direction of the scanning channel 12.

[0102] In some embodiments, as shown in Figure 8 and Figure 9 To achieve clamping and fixing of the slide 200, the slide fixing device 25 includes a first clamping piece 253, a second clamping piece 254 and a clamping switch assembly 255. The first clamping piece 253 and the second clamping piece 254 are oppositely arranged on the stage 232, and together with the supporting surface 2322 of the scanning station 21, they jointly form a clamping space 252 for placing the slide 200.

[0103] It can be understood that the first clamping piece 253 can be used to clamp the slide 200 from one side (specifically, the left side) of the slide 200, and the second clamping piece 254 can be used to clamp the slide 200 from the other side (specifically, the right side) of the slide 200. It should be noted that when the slide fixing device 25 is in an open state, the clamping space 252 is the first space 251.

[0104] Further as shown in Figure 8 and Figure 9As shown, the first clamping member 253 is provided with at least one first clamping portion 2531 on the side facing the clamping space 252, and correspondingly, the second clamping member 254 is provided with at least one second clamping portion 2541 on the side facing the clamping space 252; in order to ensure stable and safe clamping of the slide 200, in the length direction of the slide 200, the length of the clamping area formed by the first clamping portion 2531 and the second clamping portion 2541 together is greater than or equal to 1 / 2 of the length of the slide 200.

[0105] Under the action of the clamping switch assembly 255, the first clamping member 253 and the second clamping member 254 are relatively close to clamp different parts of the slide 200 in the clamping space 252 from opposite sides of the slide 200 through the corresponding clamping portions, or the first clamping member 253 and the second clamping member 254 are relatively far apart to release the clamping of the slide 200 in the clamping space 252.

[0106] Understandably, when the slide 200 placed on the loading surface 2322 of the loading platform 232 needs to be clamped, the first clamping member 253 and the second clamping member 254 can be relatively close to clamp the slide 200 together. As shown in Figure 8 As shown, in the clamping state, the first clamping portion 2531 and the second clamping portion 2541 are in contact with the opposite two side walls of the slide 200 respectively, and all the first clamping portions 2531 and the second clamping portions 2541 can be arranged in a triangular shape, or in a quadrangular shape, etc. The specific arrangement form between the first clamping portion 2531 and the second clamping portion 2541 can be determined according to the actual number of the first clamping portion 2531 and the second clamping portion 2541. In addition, the size of the clamping space 252 at this time is matched with the size of the slide 200.

[0107] Or, when the slide 200 needs to be taken out from the loading surface 2322 of the loading platform 232, the first clamping member 253 and the second clamping member 254 can be relatively far apart to make the slide fixing device 25 in an open state, so as to release the clamping of the slide 200 in the clamping space 252. As shown in Figure 9 As shown, in the open state, the first clamping portion 2531 and / or the second clamping portion 2541 has a gap with the slide 200.

[0108] The slide fixing device 25 automatically controls the relative proximity or distance between the first clamping member 253 and the second clamping member 254 through the action of the mechanical clamping switch assembly 255, which is beneficial to improving the efficiency of fixing and installing the slide 200 on the one hand and reducing the energy consumption during the installation process of the slide 200 on the other hand. In addition, the first clamping portion 2531 and the second clamping portion 2541 clamp different parts of the slide 200 in the clamping space 252 from opposite sides of the slide 200, so as to achieve the desired effect. 1 together form a clamping area, and ensure that the length of the clamping area is at least 1 / 2 to 3 / 4 times the length of the glass slide 200. On the one hand, it can effectively ensure that the first clamping member 253 and the second clamping member 254 can stably clamp the glass slide 200. On the other hand, the first clamping portion 2531 and the second clamping portion 2541 can partially contact the glass slide 200, thereby reducing the contact area between the first clamping member 253 and the second clamping member 254 and the glass slide 200, which is conducive to reducing the breakage rate of the glass slide 200 and realizing safe and stable transportation of the glass slide 200.

[0109] In some embodiments, in order to realize the automatic clamping or releasing operation of the first clamping member 253 and the second clamping member 254 on the glass slide 200, at least one of the first clamping member 253 and the second clamping member 254 is a movable clamp; Figure 8 、 Figure 10 and Figure 11 As shown, the clamping switch assembly 255 includes a guide member 2551 and a switch member 2552 disposed on a movable clamp. The guide member 2551 is located near the entrance 13 in the scanning chamber 15 and has a guide surface 25511. The guide surface 25511 includes an opening and holding surface 255111 and a clamping and holding surface 255112. The opening and holding surfaces 255111 and the clamping and holding surfaces 255112 are arranged sequentially along the feeding direction of the slide 200.

[0110] When the switch member 2552 abuts the open holding surface 255111, the clamping space 252 becomes the first space 251, creating a gap between the movable clamp and the glass slide 200 in the clamping space 252, thereby releasing the grip of the glass slide 200. At this point, the slide fixture 25 is in the open state. When the switch member 2552 abuts the clamping holding surface 255112, the first clamping portion 2531 and the second clamping portion 2541 jointly clamp the glass slide 200. At this point, the slide fixture 25 is in the clamping state.

[0111] For example, Figure 8 and Figure 9 As shown, the first clamp 253 is a movable clamp 253, and the second clamp 254 is fixedly installed on the platform 232. In this way, the slide 200 can be clamped conveniently with the second clamp 254 as a reference, which is beneficial to improving the stability and accuracy of clamping the slide 200 and also beneficial to reducing the difficulty of the clamping operation.

[0112] In addition, as shown in Figure 11 , the opening retaining surface 255111 and the clamping retaining surface 255112 are arranged in front of and behind the feeding direction of the slide 200, so that, as shown in Figure 1 , when the slide fixing device 25 is in the initial position and the opening retaining surface 255111 of the guide 2551 abuts against the switch piece 2552, the slide 200 can be conveniently fed into the clamping space 252. After the slide 200 is placed on the loading surface 2322 of the stage 232, the stage 232 can be directly moved away from the entrance 13 to drive the slide 200, the first clamping piece 253, the second clamping piece 254 and the switch piece 2552 to move together with the stage 232. In this movement process, the first clamping piece 253 can gradually move towards the second clamping piece 254, and the switch piece 2552 can gradually move to the position of the clamping retaining surface 255112. When the switch piece 2552 abuts against the clamping retaining surface 255112, the first clamping piece 253 can clamp the slide 200 together with the second clamping piece 254, and ensure that the slide 200 fixing device is always in a clamped state.

[0113] Conversely, when the switch piece 2552 abuts against the clamping retaining surface 255112 of the guide 2551 and the slide 200 fixing device is in a clamped state, the stage 232 can be moved towards the entrance 13 to drive the slide 200, the first clamping piece 253, the second clamping piece 254 and the switch piece 2552 to move together with the stage 232. In this movement process, the first clamping piece 253 can gradually move away from the second clamping piece 254, and the switch piece 2552 can gradually move to the position of the opening retaining surface 255111. When the switch piece 2552 abuts against the opening retaining surface 255111, the first clamping portion 2531 of the first clamping piece 253 has a predetermined gap with the slide 200 and no longer contacts, so as to ensure that the slide 200 fixing device is always in an open state.

[0114] Overall, the slide fixing device 25 has simple and reliable structure, low energy consumption, and simple and safe clamping operation.

[0115] Of course, in other embodiments, the first clamping piece 253 and the second clamping piece 254 can both be movable clamps, or the second clamping piece 254 can be a movable clamp, and the working principle is substantially the same as described above, which will not be repeated here.

[0116] Exemplarily, to enable the switch piece 2552 to smoothly transition between the opening retaining surface 255111 and the clamping retaining surface 255112 during movement, so as to ensure the smoothness of clamping and opening actions, as shown in Figure 11As shown, the guide surface 25511 of the guide member 2551 further comprises a transition arc surface 25223, wherein the transition arc surface 25223 is located between the opening retaining surface 255111 and the clamping retaining surface 255112; the opposite ends of the transition arc surface 25223 are tangent to the opening retaining surface 255111 and the clamping retaining surface 255112, respectively.

[0117] Wherein, when the switch member 2552 moves relative to the guide member 2551 along the feeding direction of the slide glass 200 (specifically, the direction of moving from front to back), and the switch member 2552 abuts against the transition arc surface 25223, the movable clamp 253 gradually approaches the slide glass 200 in the clamping space 252 to finally clamp the slide glass 200. When the switch member 2552 moves relative to the guide member 2551 along the feeding direction of the slide glass 200 (specifically, the direction of moving from back to front), and the switch member 2552 abuts against the transition arc surface 25223, the clamping force of the movable clamp 253 on the slide glass 200 in the clamping space 252 gradually decreases to finally release the clamping of the slide glass 200.

[0118] In some embodiments, in order to simplify the overall structure and reduce the wear between the switch member 2552 and the guide member 2551, the switch member 2552 is a cam, and the wheel surface of the cam abuts against the guide surface 25511 when the guide member 2551 abuts against the switch member 2552. That is, the relative motion between the guide member 2551 and the switch member 2552 is a surface contact, which is beneficial to improve the safety and stability of clamping.

[0119] In some embodiments, the clamping switch assembly 255 further comprises a resilient buffer 256, which is arranged between the carrier 232 and the first clamp 253, and is used to provide a buffer force for the opening or clamping of the first clamp 253.

[0120] For example, the resilient buffer 256 is arranged along the width direction of the slide glass 200, and one end of the resilient buffer 256 is connected to the first clamp, and the other end is connected to the carrier 232. When the first clamp 253 approaches the second clamp 254, the slide glass 200 can be gradually approached by the buffer of the resilient buffer 256, which is beneficial to the clamping safety of the slide glass 200. When the switch member 2552 moves away from the guide member 2551 and continues to move together with the carrier 232 along the length direction of the slide glass 200, the first clamp 253 can stably clamp the slide glass 200 through the resilient buffer 256, and is not easily displaced due to vibration of the carrier 232, etc., which is beneficial to ensure the clamping stability of the slide glass 200.

[0121] And / or, in some embodiments, to reduce the contact area between the slide fixing device 25 and the slide 200 as much as possible and ensure safe carrying of the slide 200, at least one point and surface contact is formed between each first clamping part 2531 and each second clamping part 2541 and the corresponding side of the slide 200. For example, the first clamping part 2531 and the second clamping part 2541 are provided with arc-shaped protrusions on the side facing the slide 200.

[0122] And / or, in some embodiments, as shown in FIG. 2, the stage 232 is provided with a clearance 2321 for the slide 200 to be transferred to the scanning station 21, and the clearance 2321 is in communication with the clamping space 252. The first clamping part 2531 and / or the second clamping part 2541 are arranged at the clearance of the stage 232, so that the slide 200 is clamped at the clearance of the slide 200 by the first clamping part 2531 and / or the second clamping part 2541, thereby preventing the slide 200 placed on the stage surface 2322 from moving out of the clamping space 252. Figure 8

[0123] And / or, in some embodiments, the first clamping part 2531 and the second clamping part 2541 are arranged in a linear gap along the length direction of the slide 200, and are arranged opposite to each other.

[0124] For example, in the present embodiment, as shown in FIG. 2, the first clamping part 2531 of the first clamping member 253 and the second clamping part 2541 of the second clamping member 254 are arranged opposite to each other at the clearance of the stage 232, so that the left and right sides of the slide 200 are clamped by the first clamping part 2531 and the second clamping part 2541, thereby improving the installation stability of the slide 200. Figure 8 Figure 9 For example, in the present embodiment, as shown in FIG. 2, the first clamping part 2531 of the first clamping member 253 and the second clamping part 2541 of the second clamping member 254 are arranged opposite to each other at the clearance of the stage 232, so that the left and right sides of the slide 200 are clamped by the first clamping part 2531 and the second clamping part 2541, thereby improving the installation stability of the slide 200.

[0125] For example, in the present embodiment, as shown in FIG. 2, the first clamping part 2531 of the first clamping member 253 and the second clamping part 2541 of the second clamping member 254 are arranged opposite to each other at the clearance of the stage 232, so that the left and right sides of the slide 200 are clamped by the first clamping part 2531 and the second clamping part 2541, thereby improving the installation stability of the slide 200.

[0126] ​​Optionally, in particular in the embodiment, to simplify the structure of the slide fixing device 25 and further ensure the safety and stability of the clamping of the slide 200, the first clamping part 2531 and the second clamping part 2541 are each provided with three, the three first clamping parts 2531 are respectively used for clamping the corresponding positions of the front end, the middle part and the avoiding opening of the slide 200, and the three second clamping parts 2541 are respectively used for clamping the corresponding positions of the front end, the middle part and the avoiding opening of the slide 200, so as to clamp the front part, the middle part and the rear part of the slide 200, so as to ensure the clamping stability, and also to ensure that the contact surface of the first clamping part 253 and the second clamping part 254 with the slide 200 is as small as possible.

[0127] In some embodiments, to improve the scanning effect and ensure the flatness of the slide 200 carried on the stage assembly 2, as shown in the embodiment, when the stage assembly 2 comprises the carrying assembly 23, the stage assembly 2 further comprises a first leveling assembly 233, and the stage assembly 2 further comprises the first leveling assembly 233. Figure 5

[0128] It can be understood that, with the preset reference plane as the reference surface, the mounting tightness of the stage 232 with the focusing table 231 is adjusted by adjusting the at least three first leveling assemblies 233 arranged in a triangular shape, so as to adjust the flatness of the loading surface 2322 on which the slide 200 is placed to be within the first preset range.

[0129] And / or, in some embodiments, as shown in the embodiment, when the stage assembly 2 comprises the linear driving assembly 22 and the carrying assembly 23, the stage assembly 2 further comprises a first linear movement assembly 27, a transmission member 28 and a driver (not shown in the figure), and the first linear movement assembly 27 is installed on the base 11 and is mainly used for guiding the carrying assembly 23 to move in the first direction. Figures 2 to 4

[0130] It should be noted that the first linear movement assembly 27 itself does not necessarily extend in the first direction, but at least ensures that the first linear movement assembly 27 has a tendency to extend in the first direction.

[0131] In particular, in the embodiment of the utility model, optionally, to further ensure the compactness of the structure, the first linear movement assembly 27 is parallel to the linear driving assembly 22, that is, the first linear movement assembly 27 is arranged in the first direction. ​​

[0132] It should be noted that during the movement of the stage assembly 2 along the first direction, it is necessary to ensure that the part of the slide 200 passing through the scanning assembly 3 is completely covered by the orthographic projection of the scanning assembly 3 on the plane where the slide 200 is located, and it is not possible that the part of the slide 200 passing through the scanning assembly 3 is partly below the scanning assembly 3 and partly outside the scanning assembly 3. For example, when the stage assembly 2 moves forward, the part of the slide 200 passing through the scanning assembly 3 can be covered by the scanning assembly 3, and the part of the slide 200 below the scanning assembly 3 can be covered by the scanning assembly 3 on the left and / or right side.

[0133] As shown in Figures 2 to 4 The transmission member 28 is slidingly installed on the first linear movement assembly 27, and the linear driving assembly 22 and the carrying assembly 23 are installed on the transmission member 28. It can be understood that under the driving of the linear driving assembly 22, the transmission member 28 can drive the carrying assembly 23 to reciprocate along the first direction under the guidance of the first linear movement assembly 27.

[0134] The driver (not shown in the figure) is used to at least control the action of the linear driving assembly 22 and is installed on the transmission member 28 to move with the transmission member 28. Of course, in other embodiments, the driver can also be installed on other components to be fixed.

[0135] It should be noted that in addition to the driver and the transmission member 28, the stage assembly 2 also includes other functional components, wherein the functional components are mainly used to ensure the normal operation of the stage assembly 2 and to realize some preset functions. In the present embodiment, the driver and other functional components are installed on the components on the transmission member 28, and the transmission member 28 can be collectively referred to as a sub-load 29 (see the figure). The sub-load 29 and the carrying assembly 23, the focusing stage 231, the carrier stage 232, the lifting stage 234, and the slide fixing device 25 can be collectively referred to as the total load of the linear driving assembly 22. Under the driving of the linear driving assembly 22, the total load composed of the sub-load 29 and the carrying assembly 23, the focusing stage 231, the carrier stage 232, the lifting stage 234, and the slide fixing device 25 can move together along the first direction to reduce the movement of the electrical connection lines (not shown in the figure) between the components, thereby reducing the wear of the connection lines and improving the safety, reliability, and service life of the stage assembly 2.

[0136] Optionally, in order to further reduce the occupied space of the stage assembly 2, as shown in Figures 2 to 4 The linear driving assembly 22, the first linear movement assembly 27, the transmission member 28, and the carrying assembly 23 are located on the same side of the base 11 (specifically, the side close to the scanning assembly 3, for example, the upper side of the base 11), and the first linear movement assembly 27 is located between the linear driving assembly 22 and the carrying assembly 23.

[0137] Exemplarily, the intermediate portion of the transmission member 28 is slidingly mounted on the first linear moving assembly 27, one end of the transmission member 28 is connected with the mover of the linear driving assembly 22 (specifically, a bar-shaped linear motor), and the other end of the transmission member 28 is mounted with the carrying assembly 23.

[0138] It should be noted that the planeness of the preset reference plane can be guaranteed by the manufacturing requirements of the manufacturer, that is, the preset reference plane is the reference surface inherent to the present carrying table assembly 2. Specifically, in the embodiment, the preset reference plane can be the sliding block movement plane fitted by the sliding block 272 when moving in the first linear moving assembly 27. Understandably, the sliding block movement plane is a virtual plane. Of course, in other embodiments, the preset reference plane can also be other suitable planes, which are not listed one by one here.

[0139] And / or, in some embodiments, in order to improve the moving accuracy of the carrying table assembly 2, and the motion reliability and safety, as shown in Figure 10 and Figure 11 shown, the carrying table assembly 2 is provided with a position sensor 2314, and the base 11 is provided with a first travel switch 18 and a second travel switch 19, wherein the first travel switch 18 can be used in cooperation with the position sensor 2314 to control the carrying table assembly 2 to be located at the initial position; and the second travel switch 19 can be used in cooperation with the position sensor 2314 to control the focusing table 231 of the carrying table assembly 2 to be located at the maximum travel position.

[0140] Exemplarily, when the position sensor 2314 is located at the minimum travel switch position, the focusing table 231 of the carrying table assembly 2 is parked at the initial position; when the focusing table 231 of the carrying table assembly 2 moves away from the entrance and exit 13 (specifically, can be moved forward), if the position sensor 2314 moves to the maximum travel switch position, the controller (not shown in the figure) of the scanning device 100 will control the carrying table assembly 2 to stop moving, so that the carrying table assembly 2 is located at the maximum travel position.

[0141] In some embodiments, the linear driving assembly 22 can be selected as a bar-shaped linear motor. Because the bar-shaped linear motor has small volume, the output force is more uniform compared with ordinary motors, and the control accuracy is higher, so it is beneficial to realize the miniaturization of the overall structure of the carrying table assembly 2, and it is also beneficial to ensure that the focusing table 231 of the carrying table assembly 2 and the glass slide 200 carried thereby move more stably and accurately, thereby improving the scanning effect.

[0142] And / or, in some embodiments, in order to simplify the structure of the carrying table assembly 2 and further optimize the spatial layout of each part thereof, as shown in Figures 2 to 4 shown, the first linear moving assembly 27 includes a target guide rail 271, wherein the target guide rail 271 is arranged on the base 11 along the first direction; and the transmission member 28 is slidingly mounted on the target guide rail 271 through the sliding block 272.

[0143] Optionally, the width of the target guide rail 271 is equivalent to more than twice the width of a common single-axis guide rail, so that the base 11 is balanced in force on the opposite sides (specifically, the left and right sides) of the target guide rail 271. Understandably, because the total weight of the focusing stage 231 and the components thereon located on the left side of the first linear movement assembly 27 is greater than the weight of the linear drive assembly 22 located on the right side of the first linear movement assembly 27, by increasing the width of the common single-axis guide rail, the guide rail becomes the target guide rail 271 with a left-right balancing effect, which can simply and effectively ensure the balance of the base 11 on the left and right sides of the first linear movement assembly 27, and further ensure that the focusing stage 231 and the glass slides 200 carried thereby can move smoothly and stably.

[0144] And / or, in some embodiments, when the object table assembly 2 includes the linear drive assembly 22 and the carrying assembly 23, the scanning device 100 further includes a grating measurement system 6, which can be used to measure the movement distance of the carrying assembly 23 in the scanning channel 12. The grating measurement system 6 includes a grating ruler 61, a magnetic grating ruler, or a distance sensor, which is located between the focusing stage 231 and the first linear movement assembly 27, and the grating ruler 61 can be arranged in the first direction.

[0145] Understandably, taking the grating measurement system 6 including the grating ruler 61 as an example, measuring the movement distance of the carrying assembly 23 focusing stage 231 carrier 232 in the scanning channel 12 by the grating ruler 61 of the grating measurement system 6 can facilitate improving the motion control accuracy of the object table assembly 2; similarly, measuring the lifting height of the carrier surface 2322 of the carrier 232 by the grating ruler 61 of the grating measurement system 6 can facilitate improving the focusing accuracy between the scanning assembly 3 and the glass slides 200 on the object table assembly 2, and improving the scanning effect.

[0146] In addition, the grating ruler 61 of the grating measurement system 6 is located on the side of the first linear movement assembly 27 close to the carrier 232, so that the grating ruler 61 of the grating measurement system 6 can be relatively close to the carrying assembly 23 to more truly feedback the real-time position of the carrier 232, facilitating more accurate control.

[0147] In some embodiments, to realize that the carrier 232 can move automatically in the height direction thereof, as shown in Figure 6 The top of the focusing stage 231 is concavely provided with a mounting cavity 2311, wherein the mounting cavity 2311 is provided with a driving member 2312 and a second linear movement assembly 2313, and the driving member 2312 can be used to drive the carrier 232 to move. As shown in Figure 5 and Figure 6As shown, the carrying assembly 23 further comprises a lifting platform 234, the top of the lifting platform 234 is installed with the carrier 232 through a first leveling assembly 233, and the first leveling assembly 233 is distributed on opposite sides of the scanning station 21. In addition, the lifting platform 234 can also be installed on the top of the focusing platform 231 through a second linear moving assembly 2313, and the lifting platform 234 drives the carrier 232 to move along the height direction of the lifting platform 234 under the driving of the driving member 2312. Understandably, the second linear moving assembly 2313 is mainly used to guide the lifting platform 234 and the carrier 232 to move along the depth direction of the installation cavity 2311.

[0148] Understandably, the carrying assembly 23 is equivalent to setting a "double hand" to lift the carrier 232 on the focusing platform 231 by installing the lifting platform 234 between the focusing platform 231 and the carrier 232, and distributing the first leveling assembly 233 on opposite sides (specifically, left and right sides) of the scanning station 21, so as to flexibly and stably adjust the height or flatness of the carrier 232.

[0149] It can also be understood that, in order to improve the scanning effect, after the slide glass 200 is placed on the carrier supporting surface 2322 of the carrier 232, the scanning assembly 3 and the slide glass 200 on the carrier 232 need to be focused to determine whether the height of the carrier 232 needs to be adjusted through the lifting of the lifting platform 234. Exemplarily, after the slide glass 200 is placed on the carrier supporting surface 2322 of the carrier 232, the linear driving assembly 22 can drive the carrier assembly 2 to move backward along the first direction at a high speed, and when the slide glass 200 on the carrying assembly 23 passes through the fixed scanning assembly 3, the scanning assembly 3 can preliminarily scan the slide glass 200, and if it is judged that the imaging picture cannot meet the requirements, the driving member 2312 in the installation cavity 2311 will automatically receive the related signal to drive the lifting platform 234 to adaptively lift, and after the imaging picture meets the requirements, the focusing operation of the slide glass 200 can be completed.

[0150] Optionally, in order to realize the miniaturization of the carrier assembly 2 and realize the large-stroke adjustment of the lifting platform 234 and the carrier 232, the driving member 2312 in the installation cavity 2311 of the focusing platform 231 is a voice coil motor 2312.

[0151] Optionally, in the case that the lifting platform 234 is slidingly installed on the focusing platform 231 and can drive the carrier 232 to move along the height direction of the lifting platform 234, one of the lifting platform 234 and the carrier 232 is provided with a positioning member 2341 (see Figure 6 ) between the lifting platform 234 and the carrier 232, and the other is provided with a positioning slot hole (not shown in the figure), and the positioning member 2341 and the positioning slot hole are matched in concave-convex mode, so as to quickly realize the installation alignment between the lifting platform 234 and the carrier 232 and ensure the structural stability of the carrier assembly 2.

[0152] and / or, in some embodiments, as Figure 5 As shown, the focusing stage 231 has a cubic structure. To improve leveling accuracy, four first leveling assemblies 233 are provided. These four first leveling assemblies 233 connect the lifting platform 234 and the carrier 232, and are arranged in a square pattern on the lifting platform 234 and the carrier 232. Specifically, the four first leveling assemblies 233 are located at the four corners of the lifting platform 234 and the carrier 232. Of course, in other embodiments, three first leveling assemblies 233 may be provided, arranged in a triangle; alternatively, more first leveling assemblies 233 may be provided, which are not listed here.

[0153] And / or, in some embodiments, in order to adjust the flatness of the supporting surface 2322 of the carrier 232 by the first leveling assembly 233, each first leveling assembly 233 includes a first adjusting member 2331 and a second adjusting member 2332, wherein the first adjusting member 2331 is used to connect the lifting platform 234 and the carrier 232, so that the corresponding part of the carrier 232 is lifted relative to the focusing stage 231 during adjustment (see Figure 5 , the dotted upward arrow represents lifting). Correspondingly, the second adjusting member 2332 is used to connect the lifting platform 234 and the carrier 232, so that the corresponding part of the carrier 232 is lowered relative to the focusing platform 231 during adjustment (see Figure 5 , the dashed downward arrow represents a decrease).

[0154] Optionally, the first adjusting member 2331 and the second adjusting member 2332 can both be screw members, where the screw members include but are not limited to screws, bolts, etc. For example, the first adjusting member 2331 and the second adjusting member 2332 can also be motors with screws, gear rack assemblies, etc.

[0155] In some embodiments, as Figure 7 As shown, the scanning assembly 3 includes an adjustment platform 31, a second leveling assembly 32, and a scanning head 33. The adjustment platform 31 is hoisted on the base 1. At least three second leveling assemblies 32 are provided. The scanning head 33 is mounted on the side of the adjustment platform 31 facing the base 11 (specifically, the bottom side) via a connector 35. The adjustment platform 31 can be mounted on the base 1 via at least three second leveling assemblies 32 that are not aligned in a straight line. The second leveling assemblies 32 can be adjusted to ensure that the scanning focal plane of the scanning head 33 is within a second predetermined flatness range relative to the glass slide 200 on the scanning station 21.

[0156] Exemplarily, four second leveling assemblies 32 are provided, and the four second leveling assemblies 32 are arranged in a quadrilateral. At the time of factory delivery or during the debugging or maintenance of the scanning device 100, the distance between the base frame 1 and the scanning head 33 connected to the adjusting platform 31 can be adjusted by adjusting the second leveling assemblies 32, and thus the height difference between the scanning head 33 and the carrier surface 2322 can be adjusted.

[0157] Optionally, to ensure the safety of the scanning assembly 3, the scanning assembly 3 further comprises a heat dissipation member (not shown in the figure), wherein the heat dissipation member is located between the adjusting platform 31 and the scanning head 33 and is used to dissipate the heat of the scanning head 33.

[0158] Exemplarily, as shown in Figure 7 the scanning assembly 3 further comprises a sensing unit 34, wherein one side (specifically, the top side) of the sensing unit 34 is connected to the adjusting platform 31 through a connecting member 35, and the other side (specifically, the bottom side) of the sensing unit 34 is connected to the top of the scanning head 33. Specifically, the heat dissipation member is located between the adjusting platform 31 and the sensing unit 34, so as to dissipate the heat of the sensing unit 34 and the scanning head 33, ensure the safe operation of the scanning assembly 3, and facilitate the service life and safety of the scanning device 100.

[0159] In some embodiments, the scanning head 33 comprises a plurality of microscopic objectives (not shown in the figure), and the plurality of microscopic objectives are arranged in an array to form an array objective (not shown in the figure). The width of the effective scanning area of the array objective in the second direction is greater than or equal to the interval size between two opposite corners of the to-be-scanned slice of the slide 200 on the scanning station 21 in the second direction. In this way, the one-way movement of the slide 200 can be realized, so that the scanning area (not shown in the figure) of the array objective can cover all to-be-scanned slice parts directly below the scanning assembly 3, regardless of whether the slide 200 is placed parallel to the first direction or slightly tilted relative to the first direction, and thus the omnidirectional scanning of the slide 200 can be realized without moving (for example, moving left and right) the scanning assembly 3.

[0160] Optionally, the second direction herein is perpendicular to the extension direction of the scanning channel 12. In addition, the scanning focal plane of the scanning head 33 is a virtual focal plane (not shown in the figure) fitted by the focal points of the plurality of microscopic objectives in the array objective.

[0161] Based on the scanning device 100 described above, the utility model embodiment further provides a pathological section scanning instrument (not shown in the figure), wherein the pathological section scanning instrument comprises the scanning device 100 described above.

[0162] It should be noted that the pathological section scanner further comprises a loading and unloading assembly (not shown in the figure), wherein the loading and unloading assembly can be used to push the slide 200 from the entrance and exit 13 to the scanning station 21 of the stage assembly 2, or remove the slide 200 from the scanning station 21 of the stage assembly 2.

[0163] In summary, compared with the prior art, the pathological section scanner has at least the following beneficial effects:

[0164] The pathological section scanner can realize miniaturization of the structure, safe and accurate carrying of the slide 200, and better scanning effect by adopting the scanning device 100.

[0165] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. For those skilled in the art, the present application can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application shall be included in the scope of the claims of the present application.

Claims

1. A scanning device, characterized by The scanning device comprises: a base frame comprising a base provided with a scanning channel; the base frame has an entrance and exit communicating with the scanning channel; a stage assembly located in the scanning channel and provided with a scanning station; the stage assembly is used to load a slide on the scanning station and drive the slide to reciprocate along the extension direction of the scanning channel; a scanning assembly arranged on the base frame on top of the stage assembly; when the stage assembly drives the slide to reciprocate, the scanning assembly is used to scan the passing slide in all directions; a slice information reading assembly arranged on the base frame at a position corresponding to the entrance and exit; the slice information reading assembly is used to read slice information marked on the slide loaded on the scanning station; a backlight source arranged on the stage assembly at a position corresponding to the scanning station; the backlight source is used to provide backlight for the scanning assembly when scanning the slide.

2. The scanning device of claim 1, wherein, The base frame further comprises: a mounting rack arranged on the base and jointly enclosing a scanning cavity with the base; the mounting rack is provided with the entrance and exit communicating with the scanning cavity and the outside; the stage assembly can drive the slide to reciprocate in the scanning cavity; the scanning assembly is hoisted on the mounting rack in the scanning cavity; the slice information reading assembly is located outside the scanning cavity; and / or, the slice information reading assembly comprises: a reading piece used to obtain slice information marked on the slide; a supplementary light source installed on at least one side of the reading piece; and / or, the base frame further comprises: a plurality of supporting legs; the supporting legs not on the same straight line are arranged on the bottom of the base; the supporting legs jointly enclose a containing cavity with the base; the scanning device further comprises a control unit contained in the containing cavity.

3. The scanning device of claim 1, wherein, The stage assembly comprises: a linear drive assembly mounted on the base along a first direction and used to drive the slide on the scanning station to reciprocate along the first direction; the first direction is the extension direction of the scanning channel; and / or, the stage assembly comprises a carrying assembly, which comprises: a focusing table located in the scanning channel; the focusing table reciprocates in the scanning channel along the first direction under the drive of the linear drive assembly; a stage provided with the scanning station; the stage is movably arranged on the focusing table to swing or move along its height direction when moving, so that the height difference between the slide on the scanning station and the scanning assembly is adjusted.

4. The scanning device of claim 3, wherein, When the stage assembly comprises the carrying assembly, the stage assembly further comprises: a slide fixing device arranged on the stage and having an open state and a clamping state; in the open state, the slide fixing device forms a first space for placing the slide at a position corresponding to the scanning station; In the clamping state, the slide fixing device is used to clamp the slide on the scanning station; When the focusing table moves in the first direction away from the entrance, the slide fixing device can be switched from the open state to the clamping state, so that the scanning assembly scans the slide clamped and fixed by the slide fixing device; When the focusing table moves in the first direction towards the entrance, the slide fixing device can be switched from the clamping state to the open state, so as to release the clamping of the scanned slide.

5. The scanning device of claim 4, wherein, The slide fixing device comprises a first clamping piece, a second clamping piece and a clamping switch assembly, the first clamping piece and the second clamping piece are oppositely arranged on the table, and both of them and the supporting surface of the scanning station jointly form a clamping space for placing the slide; Wherein, at least one first clamping part is arranged on one side of the first clamping piece facing the clamping space, and at least one second clamping part is arranged on one side of the second clamping piece facing the clamping space; in the length direction of the slide, the length ratio of the clamping area formed by the first clamping part and the second clamping part to the length of the slide is greater than or equal to 1 / 2; Under the action of the clamping switch assembly, the first clamping piece and the second clamping piece are relatively close to clamp different parts of the slide in the clamping space from the opposite sides of the slide through the first clamping part and the second clamping part, or the first clamping piece and the second clamping piece are relatively far away to release the clamping of the slide in the clamping space.

6. The scanning device of claim 5, wherein, At least one of the first clamping piece and the second clamping piece is a movable clamp; the clamping switch assembly comprises a guide piece and a switch piece arranged on the movable clamp; the guide piece is located near the entrance in the scanning cavity and is provided with a guide surface; The guide surface comprises an open holding surface and a clamping holding surface; the open holding surface and the clamping holding surface are arranged in sequence along the feeding direction of the slide; When the switch piece abuts against the open holding surface, the clamping space is the first space, so that the movable clamp has a gap with the slide in the clamping space; When the switch piece abuts against the clamping holding surface, the first clamping part and the second clamping part jointly clamp the slide; And / or, each first clamping part and each second clamping part has at least one point and surface contact with the corresponding side surface of the slide; And / or, the table is provided with a avoiding opening for transferring the slide to the scanning station, and the avoiding opening communicates with the clamping space; The first clamping part and / or the second clamping part correspond to the avoiding opening of the table; And / or, the first clamping part and the second clamping part are arranged in a straight gap along the length direction of the slide, and they are arranged one by one in opposition; And / or, the first clamping part and the second clamping part are each provided with three, three first clamping parts are respectively used to clamp the front end, the middle part and the part corresponding to the avoiding opening of the slide; three second clamping parts are respectively used to clamp the front end, the middle part and the part corresponding to the avoiding opening of the slide.

7. The scanning device of claim 3, wherein, When the carrier stage assembly comprises a carrier assembly, the carrier assembly further comprises: a first leveling assembly, the first leveling assembly is provided with at least three; the carrier stage is installed on the focusing stage through at least three first leveling assemblies which are not on the same straight line, so that the flatness of the slide on the scanning station relative to the preset reference plane is within the first preset range by adjusting the first leveling assemblies; and / or, when the carrier stage assembly comprises a linear drive assembly and a carrier assembly, the carrier stage assembly further comprises: a first linear moving assembly, the first linear moving assembly is installed on the base and used to guide the carrier assembly to move along the first direction; a transmission member, the transmission member is slidingly installed on the first linear moving assembly, and the linear drive assembly and the carrier assembly are installed on the transmission member; a driver, the driver is used to control the action of the linear drive assembly and is installed on the transmission member to move with the transmission member; and / or, the carrier stage assembly is provided with a position sensor, the base is provided with a first travel switch and a second travel switch, the first travel switch is used to cooperate with the position sensor to control the carrier stage assembly to be located at the initial position, and the second travel switch is used to cooperate with the position sensor to control the carrier stage assembly to be located at the maximum travel position.

8. The scanning device of claim 7, wherein, the linear drive assembly is a bar-shaped linear motor; and / or, the first linear moving assembly comprises a target guide rail, the target guide rail is arranged on the base along the first direction, and the transmission member is slidingly installed on the target guide rail through a sliding block; the width of the target guide rail is equivalent to more than twice the width of a common single-axis guide rail; and / or, when the carrier stage assembly comprises a linear drive assembly and a carrier assembly, the scanning device further comprises: a grating measurement system, the grating measurement system is used to measure the moving distance of the carrier assembly in the scanning channel; the grating measurement system comprises an optical grating ruler, a magnetic grating ruler or a distance sensor, and the optical grating ruler, the magnetic grating ruler or the distance sensor is located between the focusing stage and the first linear moving assembly; and / or, the top of the focusing stage is concavely provided with a mounting cavity, and a driving member for driving the carrier stage to move is arranged in the mounting cavity; and / or, the focusing stage is built-in with a driving member for driving the carrier stage to move, and the driving member is a voice coil motor.

9. The scanning device according to any one of claims 1 to 8, characterized in that the scanning assembly comprises: a leveling platform, the leveling platform is hung on the base frame; a second leveling assembly, the second leveling assembly is provided with at least three; a scanning head, the scanning head is installed on the side of the leveling platform facing the base through a connecting member; wherein the leveling platform is installed on the base frame through at least three second leveling assemblies which are not on the same straight line, so that the scanning focal plane of the scanning head is within the second preset range relative to the flatness of the slide on the scanning station by adjusting the second leveling assemblies.

10. The scanning device of claim 9, wherein, the scanning assembly further comprises: a heat dissipation member, the heat dissipation member is located between the leveling platform and the scanning head and used to dissipate the heat of the scanning head; and / or, the scanning head comprises a plurality of microscopic objectives, and a plurality of the microscopic objectives are arrayed to form an array objective. The effective scanning area of the array objective in the second direction is greater than or equal to the interval between two opposite corners of the slice to be scanned on the slide in the second direction; the second direction is perpendicular to the extension direction of the scanning channel.

11. A pathology slide scanner, characterized in that, The pathological slice scanner comprises the scanning device according to any one of claims 1 to 10.

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