Adjustable throttling control device of perfusion bioreactor

Abstract

The utility model belongs to the technical field of perfusion type bioreactors, and particularly relates to an adjustable throttling control device of a perfusion type bioreactor, which comprises a support frame, the support frame is provided with a reactor body through support ribs, the lower end of the reactor body is fixedly connected with a runner pipe, the lower end of the runner pipe is contacted with a throttling pipe, and the lower end of the throttling pipe is provided with a throttling valve. An inserting rod is fixedly connected to the inner wall of the second connecting disc of the throttling pipe and slidably connected with the first connecting disc of the runner pipe, a fixing rod is fixedly connected to the side face of the runner pipe, and the outer side of the fixing rod is slidably sleeved with a moving piece. The handle is pushed to drive the rotating shaft to rotate so as to drive the rotating disc to rotate, the rotating disc is positioned under the structures such as the positioning rod and the inserting hole, the rotating disc is stable after the position is adjusted, the opening and closing angle of the rotating disc is adjusted for use, and then the circulation amount of the throttle pipe is adjusted.

Description

Technical Field

[0001] This utility model relates to the field of perfusion bioreactor technology, specifically to an adjustable throttling control device for a perfusion bioreactor. Background Technology

[0002] Perfusion bioreactors are commonly used for the cultivation and growth of biological reaction processes. To control the flow rate and volume of the reaction solution, adjustable throttling control devices can be used. These devices can regulate the flow rate of gas or liquid entering and exiting the bioreactor.

[0003] A utility model patent with patent authorization announcement number CN212833765U discloses a bioartificial liver perfusion bioreactor, characterized by including a cylindrical shell, a plasma inlet and a plasma inlet sealing cap at the lower end of the shell, a plasma outlet and a plasma outlet sealing cap at the upper end of the shell, a cell filling port and a cell filling port sealing cap on the side, and two filters protruding outward from the center near both ends inside the reactor.

[0004] However, existing perfusion bioreactors also have certain shortcomings. Although the adjustable flow control devices of existing perfusion bioreactors use a combination of pipe structures such as flow tubes and throttling tubes to control the outflow of the reaction liquid, the straight-through nature of the throttling tubes and other pipe structures makes it difficult for operators to adjust the flow rate. Utility Model Content

[0005] The purpose of this invention is to provide an adjustable flow control device for a perfusion bioreactor, which solves the problem that existing adjustable flow control devices for perfusion bioreactors, although using a combination of flow pipes, throttling pipes, and other pipe structures to control the outflow of the reaction liquid, make it difficult for operators to adjust the flow rate due to the straight-through characteristics of the throttling pipes and other pipe structures.

[0006] To achieve the above objectives, this utility model provides the following technical solution: an adjustable throttling control device for a perfusion bioreactor, comprising a support frame, a reactor body mounted on the support frame via support ribs, a flow pipe fixedly connected to the lower end of the reactor body, a throttling pipe contacting the lower end of the flow pipe, an insert rod fixedly connected to the inner wall of the connecting plate of the throttling pipe, the insert rod being slidably connected to the connecting plate of the flow pipe, a fixing rod fixedly connected to the side of the flow pipe, and a movable piece slidably sleeved on the outer side of the fixing rod;

[0007] The movable plate is slidably connected to the reactor body. A limiting rod is fixedly connected to the inner wall of the movable plate. The limiting rod is slidably connected to the insertion rod. An auxiliary plate is fixedly connected to the upper side of the limiting rod. The auxiliary plate is slidably connected to the fixed rod. A spring is provided on the outer side of the fixed rod. An adjustment mechanism is provided on the throttling tube.

[0008] Preferably, two insertion rods are provided, and the two insertion rods are symmetrically distributed on the throttling tube. The insertion rods can be used to connect the flow tube and the throttling tube.

[0009] Preferably, one end of the spring is welded to the auxiliary plate, and the other end of the spring is welded to the flow pipe. The auxiliary plate can be connected and used by means of the spring.

[0010] Preferably, the adjusting mechanism includes an installation cylinder, with the installation cylinder fixedly connected to the upper side of the throttling tube. A rotating shaft is rotatably connected to the inner wall of the installation cylinder, and the rotating shaft is rotatably connected to the throttling tube. A rotating disk is fixedly sleeved on the outer side of the rotating shaft, and the rotating disk is rotatably connected to the throttling tube. A handle is fixedly connected to the upper end of the rotating shaft, and the handle is rotatably connected to the installation cylinder. An insertion hole is provided on the surface of the rotating shaft. A positioning rod is threadedly connected to the inner wall of the installation cylinder, and the positioning rod is movably connected to the insertion hole. Through the arrangement of the rotating shaft, handle, and other structures, the rotating disk can be driven to rotate, thereby adjusting the flow rate of the throttling tube. The insertion hole, positioning rod, and other structures can also position the rotating disk to ensure its stability after rotation.

[0011] Preferably, the handle is in the shape of a cross and is made of rubber. The handle facilitates the rotation of the rotating shaft, and the rubber material has good skin-friendliness.

[0012] Preferably, there are multiple insertion holes arranged in a circular array on the rotating shaft. The insertion holes facilitate positioning with the positioning rod.

[0013] Preferably, the rotating disk is in the shape of a disc and is made of stainless steel. The rotating disk allows for the opening and closing of the throttling tube, and the stainless steel material has good durability.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0015] 1. This utility model pushes the throttling tube into contact with the flow tube, allowing the insertion rod to pass through the flow tube. With the help of the spring, limiting rod, moving plate and other structures, the insertion rod can be limited, so that the insertion rod drives the throttling tube to be in a stable position, which is convenient for operators to install and use quickly.

[0016] 2. This utility model drives the rotating shaft to rotate by pushing the handle, which in turn drives the rotating disk to rotate. With the positioning rod, insertion hole and other structures, the rotating disk is positioned so that the rotating disk is stable after the position is adjusted. The opening and closing angle of the rotating disk can be adjusted, thereby adjusting the flow rate of the throttling tube. Attached Figure Description

[0017] Figure 1 This is a perspective view of the overall structure of this utility model;

[0018] Figure 2 For the present utility model Figure 1 A bottom view;

[0019] Figure 3 For the present utility model Figure 1 A front sectional view;

[0020] Figure 4 For the present utility model Figure 2 Enlarged view of the moving section;

[0021] Figure 5 For the present utility model Figure 3 Enlarged view of the adjustment mechanism.

[0022] In the diagram: 1. Support frame; 2. Reactor body; 3. Flow pipe; 4. Throttling pipe; 5. Insert rod; 6. Fixing rod; 7. Moving plate; 8. Limiting rod; 9. Auxiliary plate; 10. Spring; 11. Adjustment mechanism; 111. Mounting cylinder; 112. Rotating shaft; 113. Rotating disk; 114. Handle; 115. Insertion hole; 116. Positioning rod. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Please see Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5An adjustable throttling control device for an irrigation bioreactor includes a support frame 1, a reactor body 2 mounted on the support frame 1 via support ribs, a flow pipe 3 fixedly connected to the lower end of the reactor body 2, a throttling pipe 4 in contact with the lower end of the flow pipe 3, an insertion rod 5 fixedly connected to the inner wall of the connecting plate of the throttling pipe 4, the insertion rod 5 being slidably connected to the connecting plate of the flow pipe 3, a fixing rod 6 fixedly connected to the side of the flow pipe 3, and a movable piece 7 slidably sleeved on the outer side of the fixing rod 6.

[0025] The movable plate 7 is slidably connected to the reactor body 2. A limiting rod 8 is fixedly connected to the inner wall of the movable plate 7. The limiting rod 8 is slidably connected to the insertion rod 5. An auxiliary plate 9 is fixedly connected to the upper side of the limiting rod 8. The auxiliary plate 9 is slidably connected to the fixed rod 6. A spring 10 is provided on the outer side of the fixed rod 6.

[0026] Please see Figure 1 , Figure 2 , Figure 3 , Figure 4 There are two insertion rods 5, which are symmetrically distributed on the throttling tube 4. The insertion rods 5 can be used to connect the flow tube 3 and the throttling tube 4. One end of the spring 10 is welded to the auxiliary plate 9, and the other end of the spring 10 is welded to the flow tube 3. The auxiliary plate 9 can be used to connect the spring 10.

[0027] Please see Figure 1 , Figure 2 , Figure 3 , Figure 5 An adjustment mechanism 11 is provided on the throttling tube 4. The adjustment mechanism 11 includes a mounting cylinder 111. The mounting cylinder 111 is fixedly connected to the upper side of the throttling tube 4. A rotating shaft 112 is rotatably connected to the inner wall of the mounting cylinder 111. The rotating shaft 112 is rotatably connected to the throttling tube 4. A rotating disk 113 is fixedly sleeved on the outer side of the rotating shaft 112. The rotating disk 113 is rotatably connected to the throttling tube 4. A handle 114 is fixedly connected to the upper end of the rotating shaft 112. The handle 114 rotates with the mounting cylinder 111. The rotating shaft 112 has an insertion hole 115 on its surface. The inner wall of the mounting cylinder 111 is connected to a positioning rod 116 by a thread. The positioning rod 116 is movably connected to the insertion hole 115. Through the setting of the rotating shaft 112, handle 114 and other structures, the rotating disk 113 can be driven to rotate, thereby adjusting the flow rate of the throttling tube 4. With the insertion hole 115, positioning rod 116 and other structures, the rotating disk 113 can be positioned to ensure the stability of the rotating disk 113 after rotation.

[0028] Please see Figure 1 , Figure 2 , Figure 3 , Figure 5The handle 114 is cross-shaped and made of rubber. The handle 114 facilitates the rotation of the rotating shaft 112, and the rubber material is skin-friendly. There are multiple sockets 115 arranged in a circular array on the rotating shaft 112. The sockets 115 facilitate positioning with the positioning rod 116. The rotating disk 113 is disc-shaped and made of stainless steel. The rotating disk 113 allows the opening and closing of the throttle tube 4, and the stainless steel material has good durability.

[0029] The specific implementation process of this utility model is as follows: In use, by pushing the movable piece 7 to move away from the flow tube 3 along the surface of the fixed rod 6, the auxiliary piece 9 is moved along the surface of the fixed rod 6. The spring 10 deforms and moves the limiting rod 8. Then, the throttling tube 4 is pushed to contact the flow tube 3, so that the insertion rod 5 passes through the connecting plate of the flow tube 3. The movable piece 7 is released so that the spring 10 returns to its original deformation, so that the auxiliary piece 9 is pulled to move closer to the flow tube 3, and the limiting rod 8 is moved. The limiting rod 8 passes through the insertion rod 5 and limits the throttling tube 4, so that the connection between the throttling tube 4 and the flow tube 3 is stable.

[0030] By pushing the positioning rod 116 to rotate in the opposite direction, under the threaded connection, the positioning rod 116 is disengaged from the insertion hole 115. Then, the handle 114 is pushed to rotate, thereby driving the rotating shaft 112 to rotate, which in turn drives the rotating disk 113 to rotate. The opening and closing angle of the rotating disk 113 is adjusted, thereby regulating the flow of the throttle tube 4. Pushing the positioning rod 116 to rotate in the forward direction allows the positioning rod 116 to be inserted into the next insertion hole 115 opened on the surface of the rotating shaft 112, positioning the rotating shaft 112 and stabilizing the rotating disk 113.

[0031] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An adjustable flow control device for an irrigation-type bioreactor, comprising a support frame (1), characterized in that: The support frame (1) is equipped with a reactor body (2) via support ribs. A flow pipe (3) is fixedly connected to the lower end of the reactor body (2). A throttling pipe (4) is in contact with the lower end of the flow pipe (3). An insert rod (5) is fixedly connected to the inner wall of the connecting plate of the throttling pipe (4). The insert rod (5) is slidably connected to the connecting plate of the flow pipe (3). A fixing rod (6) is fixedly connected to the side of the flow pipe (3). A movable piece (7) is slidably sleeved on the outer side of the fixing rod (6). The movable plate (7) is slidably connected to the reactor body (2). A limiting rod (8) is fixedly connected to the inner wall of the movable plate (7). The limiting rod (8) is slidably connected to the insertion rod (5). An auxiliary plate (9) is fixedly connected to the upper side of the limiting rod (8). The auxiliary plate (9) is slidably connected to the fixed rod (6). A spring (10) is provided on the outer side of the fixed rod (6). An adjustment mechanism (11) is provided on the throttling tube (4).

2. The adjustable flow control device for an irrigation-type bioreactor according to claim 1, characterized in that: There are two insertion rods (5), and the two insertion rods (5) are symmetrically distributed on the throttling tube (4).

3. The adjustable flow control device for an irrigation-type bioreactor according to claim 1, characterized in that: One end of the spring (10) is welded to the auxiliary plate (9), and the other end of the spring (10) is welded to the flow pipe (3).

4. The adjustable flow control device for an irrigation-type bioreactor according to claim 1, characterized in that: The adjustment mechanism (11) includes an installation cylinder (111). The installation cylinder (111) is fixedly connected to the upper side of the throttling tube (4). A rotating shaft (112) is rotatably connected to the inner wall of the installation cylinder (111). The rotating shaft (112) is rotatably connected to the throttling tube (4). A rotating disk (113) is fixedly sleeved on the outer side of the rotating shaft (112). The rotating disk (113) is rotatably connected to the throttling tube (4). A handle (114) is fixedly connected to the upper end of the rotating shaft (112). The handle (114) is rotatably connected to the installation cylinder (111). An insertion hole (115) is opened on the surface of the rotating shaft (112). A positioning rod (116) is threadedly connected to the inner wall of the installation cylinder (111). The positioning rod (116) is movably connected to the insertion hole (115).

5. The adjustable throttling control device for an irrigation-type bioreactor according to claim 4, characterized in that: The handle (114) is in the shape of a cross and is made of rubber.

6. The adjustable throttling control device for an irrigation-type bioreactor according to claim 4, characterized in that: The sockets (115) are provided in multiple ways, and the multiple sockets (115) are arranged in a ring array on the rotating shaft (112).

7. The adjustable throttling control device for an irrigation-type bioreactor according to claim 4, characterized in that: The rotating disk (113) is in the shape of a disc and is made of stainless steel.

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