Auxiliary training device for rat osteoarthritis modeling

Abstract

The utility model discloses an auxiliary training device for rat osteoarthritis modeling, which is characterized by comprising a running machine, the running machine comprises a base, a runway is arranged on the upper portion of the base, a supporting plate is further arranged at the tail end of the runway, and the supporting plate is mounted on the base; a supporting device is arranged on the upper portion of the base, a fixing device is further arranged on the supporting device, the fixing device comprises a fixing part, a connecting rope and an animal clamp, and the animal clamp (43) is connected with the fixing part through the connecting rope. The small animal treadmill solves the problem that the stability and accuracy of rat osteoarthritis modeling are doubted due to insufficient running training of a rat on an existing small animal treadmill.

Description

TECHNICAL FIELD

[0001] The utility model mainly relates to the biological medicine technical field, mainly relates to a kind of for the auxiliary training device of rat osteoarthritis modeling. BACKGROUND

[0002] Osteoarthritis is a common joint disease, mainly manifested as joint pain, swelling and dysfunction. In order to study the pathogenesis and treatment of osteoarthritis, researchers often need to establish animal models to simulate the symptoms of human osteoarthritis. Rats are a commonly used experimental animal, as they are small in size, easy to feed and manage, and therefore widely used in biomedical research. In the process of establishing an osteoarthritis animal model, a small animal treadmill is a commonly used device that simulates similar pathological changes to human osteoarthritis by having rats run on a runway. However, the adaptive training of rats on the treadmill is a key issue. Rats that have not been trained or have only been partially trained may not adapt well to the runway of the treadmill, often resulting in rats not wanting to run or turning around and not running. Some treadmills also have an electric shock method to encourage rats to run, which involves the rat falling behind and touching the electrified metal strip at the back if it does not voluntarily run to the front of the runway. However, the electric shock not only startles the rat but also may cause burns to its tail. In addition, after receiving electric shocks for a long time, the rat may become accustomed to the stimulus and no longer have a fear response. This situation is not conducive to the health of the animal and does not meet the ethical requirements of animal welfare, and it may also affect the accuracy of the modeling and the accuracy of the research conclusions.

[0003] Therefore, how to achieve a training device for osteoarthritis modeling that has good training results, high modeling accuracy and stability, is convenient and fast, and does not cause additional harm to rats is a technical problem that needs to be solved in the industry. CONTENT OF THE UTILITY MODEL

[0004] The utility model aims to solve the problem of insufficient training of rats on existing small animal treadmills, which affects the stability and accuracy of rat osteoarthritis modeling.

[0005] The technical solution of the utility model is as follows:

[0006] The utility model relates to a kind of auxiliary training device for rat osteoarthritis modeling, characterized by comprising treadmill, and the treadmill includes base, runway is set up on the upper portion of base, support plate is also set up at the tail end of runway, and the support plate is installed on the base;Support device is set up on the upper portion of base, and fixing device is also set up on support device, the fixing device includes fixed part, connecting rope and animal clamp, and the animal clamp (43) is connected with fixed part by connecting rope.

[0007] Further, the fixing device is movably connected with the supporting device through the upper part of the fixing part.

[0008] Further, the animal clamp is a split ring clamp, which can be equally split into two clamp pieces, the upper parts of the clamp pieces are connected through screws, and the clamp pieces are made of rubber or foam, so that the animal clamp can be adjusted in tightness, stress reaction of animals can be reduced, and animal welfare ethics requirements are met.

[0009] Further, a wire spool is arranged in the fixing part, the length of the connecting rope between the fixing part and the animal clamp can be adjusted, and the upright angle of the mouse is adjusted from 0-90 degrees.

[0010] Further, the upper part of the supporting plate is provided with a groove, and the groove is located on the central axis of the runway.

[0011] Further, the supporting device is a rod-shaped structure, and a protrusion is arranged on the supporting device, so that the fixing device can be prevented from sliding forward and backward along the supporting device during the experiment.

[0012] Further, the supporting device is fixed to the upper part of the supporting plate through the groove, so that the supporting device can be prevented from rolling on the upper part of the supporting plate during the experiment, and the rat can be ensured to be located in the middle of the runway when being fixed.

[0013] Further, the material of the runway is plywood, and the use of the plywood can increase the friction force, prevent the rat from slipping, and improve the experimental efficiency of the rat on the runway.

[0014] As described above, since the technical scheme is adopted, the beneficial effects of the utility model are as follows:

[0015] 1. The fixing device of the auxiliary training device for rat osteoarthritis modeling is designed uniquely, can accurately fix the rat, and ensures the stability and accuracy of modeling during modeling.

[0016] 2. The fixing device is provided with an adjustable pressure mechanism, allows researchers to accurately control the force of fixing the rat according to experimental requirements, so as to avoid excessive pressure or damage to the rat.

[0017] 3. The utility model is convenient to operate and use, reduces the work burden of researchers, and the surface material is selected as silica gel or sponge, so that the stress reaction of animals can be reduced, the animal welfare ethics requirements are met, the fixing device material is durable, can withstand multiple use and disinfection treatment, and the service life is prolonged. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a schematic view of the utility model for a rat osteoarthritis modeling auxiliary training device.

[0019] Figure 2 This is an enlarged view of the fixing device of this utility model.

[0020] Reference numerals: 1-Treadmill, 11-Base, 12-Running track, 2-Support plate, 21-Groove, 3-Support device, 4-Fixing device, 41-Fixing part, 42-Connecting rope, 43-Animal clamp, 431-Clamping piece, 5-Rat. Detailed Implementation

[0021] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0022] This utility model discloses an auxiliary training device for modeling osteoarthritis in rats, characterized in that it includes a treadmill 1, the treadmill including a base 11, a running track 12 provided on the upper part of the base, and a support plate 2 provided at the tail end of the running track 12, the support plate 2 being mounted on the base 11; a support device 3 is provided on the upper part of the base 11, and a fixing device 4 is provided on the support device 3, the fixing device including a fixing part 41, a connecting rope 42 and an animal clamp 43, the animal clamp 43 being connected to the fixing part 41 through the connecting rope 42.

[0023] The features and performance of this utility model will be further described in detail below with reference to the embodiments.

[0024] like Figure 1 , 2 As shown, before rat 5 was trained on a treadmill to accelerate the successful modeling of osteoarthritis, the position of the fixation device 4 was first adjusted according to the length of rat 5. The fixation device 4 was positioned using the protrusion on the support device 3. Then, each fixation device 4 was used to fix rat 5. Rats 5 were trained on the corresponding track 12 to accelerate the modeling of osteoarthritis.

[0025] The animal holder 43 is wrapped around the rat 5 under the armpit 4-5 cm, so that the forelimbs are suspended, and only the hindlimbs are on the runway 12, forcing the rat 5 to use only the hindlimbs to bear weight and move, accelerating the wear of the knee joint and promoting the completion of the osteoarthritis modeling. The other end of the animal holder 43 is connected to the connecting rope 42, and the other end of the connecting rope 42 is connected to the fixing part 41. The fixing part 41 can adjust the length of the connecting rope 42 between the fixing part 41 and the animal holder 43, so that the standing angle of the rat 5 can be adjusted between 0-90°. The rat 5 is fixed by the animal holder 43, and the rat 5 is 45° with the runway, and only the hindlimbs are on the runway 12 for running training, promoting the completion of the modeling. After the rat 5 completes the running training task, the rat 5 that has completed the modeling can be removed from the animal holder 43.

[0026] The above-described embodiments only express the specific implementation of the present application, and the description is more specific and detailed, but it cannot be understood as a limitation on the protection scope of the present application. It should be noted that for ordinary skilled persons in the art, without departing from the technical concept of the present application, a number of modifications and improvements can be made, which are within the protection scope of the present application.

Claims

1. An auxiliary trainer for rat osteoarthritis modeling, characterized by, The utility model provides a treadmill (1), the treadmill includes the base (11), is provided with the track (12) on the upper portion of base (11), is further provided with the support plate (2) on the tail end of track (12), support plate (2) is detachably installed on base (11), is provided with the support device (3) on the upper portion of support plate (2), is provided with the fixed device (4) on support device (3), and the fixed device includes fixed part (41), connecting rope (42) and animal clamp (43), and animal clamp (43) is connected with fixed part (41) through connecting rope (42).

2. The training aid for osteoarthritis modeling in rats according to claim 1, characterized in that, The fixed device (4) is connected with the support device (3) through the upper portion of the fixed part (41).

3. The training aid for osteoarthritis modeling in rats according to claim 1 or 2, characterized in that, The animal clamp (43) is a split ring clamp, which can be equally divided into two clamping pieces (431), the upper portion of the clamping piece (431) is connected by a screw, and the material of the clamping piece (431) is rubber or foam.

4. The training aid for osteoarthritis modeling in rats according to claim 1, wherein The fixed part (41) is internally provided with a wire spool.

5. The training aid for osteoarthritis modeling in rats according to claim 1, wherein The upper portion of the support plate (2) is provided with a groove (21), and the groove (21) is located on the central axis of the track (12).

6. The training aid for osteoarthritis modeling in rats according to claim 1 or 5, wherein The support device (3) is a rod-shaped structure, and a protrusion is arranged on the support device (3).

7. The training aid for use in rat osteoarthritis modeling according to claim 6, wherein The support device (3) is fixed to the upper portion of the support plate (2) through the groove (21).

8. The training aid for osteoarthritis modeling in rats according to claim 1, wherein The material of the track (12) is plywood.

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