Combined fixing device for experimental rat knee joint injection
By using a combined fixation device with a sleeve and adjustable sliding door design, the problem of fixation during rat knee joint injection was solved, enabling safe and efficient knee joint injection, reducing mortality and improving experimental efficiency.
Patent Information
- Application Number
- CN202422527549.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-18
- Publication Date
- 2025-11-07
- Estimated Expiration
- 2034-10-18
AI Technical Summary
Existing rat restraint devices have limited functionality and cannot effectively stabilize the knee joint, leading to easy needle puncture of the articular cartilage during injection, drug spillage, increased risk of infection, high mortality rate due to multiple anesthetic injections, and cumbersome and inefficient operation.
A modular restraint device was designed, comprising two sleeves, a fixing knob, a slot module, a slide, a bottom support plate, and an adjustable sliding door. Through the combination of sleeves and the design of the adjustable sliding door, the rat is stably restrained, avoiding struggle and drug spillage. It is adaptable to rats of different sizes and facilitates knee joint injection and measurement.
It improved the safety and efficiency of knee joint injections, reduced the mortality rate of anesthetic drugs, simplified the operation process, and ensured the smooth progress of the experiment.
Smart Images
Figure CN223516488U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model belongs to the animal medical experiment instrument technical field, especially relates to a combined fixing device for experimental rat knee joint injection. BACKGROUND
[0002] Knee joint injection of papain, collagen II and the like is a common technology for constructing experimental rat knee osteoarthritis (KOA) animal models, which has the advantages of small trauma and simple operation compared with knee joint surgery and external fixation. However, due to the fact that experimental rats struggle violently during the knee joint injection operation, the knee joint structure of the experimental rat is delicate, the injected drug must be accurately injected into the joint cavity, and the needle insertion depth during injection is only 1-2 mm, the needle is very easy to injure the articular cartilage, meniscus and other tissues during the struggle of the rat, which not only causes joint infection of the animal, but also increases the interference factors of the experiment; at the same time, the struggle of the experimental rat during knee joint injection will cause the injected drug to overflow, resulting in failure of modeling; the existing experimental rat fixing device is mainly suitable for tail vein injection, blood sampling and the like, has single function, poor operability, low efficiency, is expensive, and cannot be used for rat knee joint injection, and there is still no fixing device specially suitable for experimental rat knee joint injection, so researchers need to inject anesthetic into the experimental rat before each injection, however, multiple injections are required for knee joint injection modeling, and the mortality rate of the experimental rat is high after multiple anesthetic injections, which causes waste of experimental funds, affects the experimental progress, and the operation of injecting anesthetic before knee joint drug injection is complicated and extremely low in efficiency.
[0003] Through the above analysis, the problems and defects of the prior art are as follows:
[0004] The existing experimental rat fixing device is mainly suitable for tail vein injection, blood sampling and the like, has single function, poor operability, low efficiency, is expensive, and cannot be used for rat knee joint injection, and there is still no fixing device specially suitable for experimental rat knee joint injection. UTILITY MODEL CONTENTS
[0005] In view of the problems existing in the prior art, the utility model provides a combined fixing device for experimental rat knee joint injection.
[0006] The utility model is realized in this way, a combined fixing device for experimental rat knee joint injection includes:
[0007] Two combined sleeves, a fixing knob, a clamping groove module, a sliding groove, a bottom support plate and two adjusting sliding doors are included; the front and rear sleeves can be separated and combined according to the size of the animal body, the top of the sleeve is flat, the bottom is arc-shaped, the special structure is easy to operate, the rat is easily and firmly fixed and quickly released, and the animal is prevented from being injured;
[0008] The front sleeve is a fusiform tapering at the front end, which is convenient for fixing the head of the rat and allowing air to pass through, and prevents the rat from biting the experimenter. The upper end of the rear sleeve is an opening, which accommodates the tail of the rat. The two sides of the opening are sliding grooves, which are matched with the clamping groove module. The fixing knob on the front sleeve is fixed with the rear sleeve through the clamping groove module. A support plate is arranged at the bottom of the rear sleeve, which provides stable support and anti-skid function for the device. The two sides of the bottom of the rear sleeve are openings, which are provided with two adjustable sliding doors. The sliding doors are connected with the openings through buckles. The size of the opening can be adjusted by turning the sliding handle, which is convenient for accommodating and fixing the lower limbs of rats of different sizes, and fully exposing the bilateral knee joints. The tail end of the rear sleeve is designed as a back, which is in close contact with the tail and sacrum of the rat, and can effectively prevent the rat from moving around. The middle part of the rear sleeve is a sliding groove, which can be used for tail injection and tail vein blood sampling in addition to fixing the tail of the rat. The bottom of the rear sleeve is an opening, which prevents the accumulation of rat excrement from affecting the operation, and is convenient for cleaning and disinfection.
[0009] Further, the two combined sleeves can be separated and combined according to the size of the animal. The top of the sleeve is flat, and the bottom is arc-shaped. The front and rear sleeves are matched with each other. The structure is special and the separate combination operation is simple, which is easy to fix and release the rat easily and firmly, and prevents animal injury.
[0010] Further, the diameter of the front sleeve is slightly smaller than that of the rear sleeve. The top is provided with a fixing knob and a clamping groove module, which can be pushed into the rear sleeve along the sliding groove and fixed. The front end of the front sleeve is a fusiform tapering, which is convenient for fixing the head of the rat and allowing air to pass through, and prevents the animal from biting the experimenter.
[0011] Further, the diameter of the rear sleeve is slightly larger than that of the front sleeve. The top end is an opening, which extends to the rear part for fixing the front sleeve and accommodating the tail of the rat. The two sides of the bottom of the rear sleeve are openings, which are used to accommodate and fix the lower limbs of the experimental rat, and expose the knee joints.
[0012] Further, the sliding groove is located on both sides of the top opening of the rear sleeve. The sliding groove is provided with a clamping groove, which is convenient for fixing the front sleeve with the rear sleeve through the fixing knob and the clamping groove module. The fixed position can also be adjusted according to the size of the experimental rat.
[0013] Further, the bottom support plate is fixed to the bottom of the rear sleeve at the front end, which is provided with an anti-skid groove. The device can be fixed on the operation table, which provides stable support and anti-skid function for the device.
[0014] Further, the two adjustable sliding doors are matched with the two side openings of the bottom of the rear sleeve through the two side buckles. The distance between the two sliding doors is at least 20 mm. A handle is arranged on the sliding door, which can adjust the size of the opening according to the diameter of the lower limbs of the experimental rat, fully expose and fix the bilateral knee joints of the experimental rat, and facilitate knee joint drug injection and joint diameter measurement operation.
[0015] Further, the rear sleeve bottom rear end is opened, which prevents the accumulation of rat excrement from affecting operation and facilitates cleaning and disinfection.
[0016] Further, the rear sleeve tail end top is designed to slide back, which fits the rat tail and sacrum and effectively prevents the rat from moving around.
[0017] In combination with the above technical solutions and solved technical problems, the technical solutions to be protected by the utility model have the following advantages and positive effects:
[0018] The utility model aims at solving the practical problem of improving experimental rat knee joint injection modeling efficiency, enhancing the security of knee joint injection modeling, reducing the death rate of anesthetic, and making up for the deficiency of the existing experimental rat fixing device, and provides a simple combined fixing device for experimental rat knee joint injection which is easy to make and convenient to use. The utility model discloses two combined sleeves, fixing knobs, card slot modules, sliding grooves, bottom support plates and two adjusting sliding doors. The top of the front and rear sleeves is flat, and the bottom is arc-shaped. The sleeves can be combined and separated through the fixing knobs, card slot modules and sliding groove card slots. The structure is special and the operation is simple. The fixing position can be adjusted according to the size of the animal body. The device is suitable for firmly fixing and quickly releasing the head, trunk, both lower limbs and tail of a rat and preventing the animal from being injured. The front end of the front sleeve is fixed with a rat head through a shuttle-shaped closing. The rat can ventilate and prevent the rat from biting the experimenter. A support plate is arranged at the bottom of the rear sleeve to provide stable support and anti-skid function for the device, preventing the device from rolling left and right due to the struggle of the rat during the experiment. The openings at both sides of the bottom of the rear sleeve are large, and two adjusting sliding doors are arranged. The size of the opening can be adjusted by pulling the sliding handle, which is convenient for accommodating and fixing the lower limbs of rats of different sizes, fully exposing the bilateral knee joints, and facilitating knee joint drug injection, joint diameter measurement and other operations. The top of the tail end of the rear sleeve is designed as a back, which is more suitable for the back and coccygeal part of the rat compared with a cylinder, and can effectively prevent the rat from moving around. The opening in the rear wall of the rear sleeve is extended as a sliding groove. In addition to fixing the rat tail, tail injection, tail vein blood sampling and other operations can be performed. The bottom opening prevents the rat excrement from affecting the operation and facilitates cleaning and disinfection. The utility model has simple structure and is convenient to use. The experimenter holds the proximal end of the rat tail with one hand, lifts the rat hind limbs, and the rat will have a tendency to drill a hole due to fear. The experimenter aligns the front sleeve of the device with the rat head, and the rat will quickly drill into the sleeve. The experimenter pulls the tail along the sliding groove of the rear sleeve, pulls the rat tail into the rear sleeve, combines the front and rear sleeves, tightens the knob, and the rat is completely fixed. The rat struggles slightly, and the double lower limbs will automatically extend out of the opening at the bottom of the rear sleeve. The experimenter only needs to adjust and lock the sliding door to fully expose and fix the knee joints of the rat's double lower limbs, and then the knee joint drug injection, joint diameter measurement and other operations can be performed. The whole process will not cause any harm to the rat beyond the experiment. The animal does not need to be anesthetized, which avoids the death of the animal caused by multiple anesthetics, reduces the death rate of the animal, and increases the safety of the experiment. At the same time, the device is easy to operate, and one person can operate it, which solves the problem of difficult catching and long-term fixing of the animal when the experimenter performs the rat knee joint operation, and improves the experimental efficiency. In summary, the utility model has reasonable design, is easy to realize, is convenient to operate, can improve the experimental rat knee joint injection modeling efficiency, enhance the security of knee joint injection modeling, reduce the death rate of anesthetic, make up for the deficiency of the existing experimental rat fixing device, and practically solve the practical problem of difficult rat knee joint injection modeling and other experimental operations. BRIEF DESCRIPTION OF DRAWINGS
[0019] Figure 1 is the combined fixing device structure diagram for experimental rat knee joint injection provided by the embodiment of the utility model.
[0020] Figure 2 is the bottom disassembly structure schematic view provided by the embodiment of the utility model.
[0021] Figure 3 is the disassembly structure schematic view of the fixing device provided by the embodiment of the utility model.
[0022] Figure 4 is the three-dimensional combined structure schematic view provided by the embodiment of the utility model.
[0023] In the drawing: 1, front sleeve; 2, rear sleeve; 3, air hole; 4, clamping groove module; 5, fixed knob; 6, sliding groove; 7, bottom two side openings; 8, two adjusting sliding doors; 9, sliding door handle; 10, cleaning hole; 11, bottom support plate; 12, slide clamping groove. DETAILED DESCRIPTION
[0024] In order to make the purpose, technical scheme and advantages of the utility model more clear and obvious, the following combines embodiment, and this utility model is further detailedly explained.Should understand, the specific embodiment described here is only used to explain the utility model, and is not used to limit the utility model.
[0025] As Figure 1 , Figure 3 , Figure 4 indicated, the utility model embodiment provides a kind of combined fixing device for experimental rat knee joint injection, including two combined sleeves (front sleeve 1, rear sleeve 2), air hole 3, clamping groove module 4, fixed knob 5, sliding groove 6, bottom two side openings 7, two adjusting sliding doors 8, sliding door handle 9, cleaning hole 10, bottom support plate 11, slide clamping groove 12.
[0026] Front sleeve 1 top is flat, bottom is arc, its diameter is slightly smaller than rear sleeve 2, and front end is shuttle-shaped closing.
[0027] Rear sleeve 2 top is flat and has opening as sliding groove 6, bottom is arc, is provided with bottom two side openings 7 and cleaning hole 10, rear wall is designed as back, more conform to rat tail sacrum, rear sleeve 2 diameter is slightly larger than front sleeve 1, and front sleeve 1 can be combined along sliding groove with rear sleeve 2.
[0028] Air hole 3 is connected with the shuttle-shaped closing of front sleeve 1.
[0029] The card slot module 4 is a fixing accessory at the top front end of the front sleeve 1, has a central opening, and has slots on both sides, which are matched with the sliding slot 6 at the top of the rear sleeve 2, can slide forward and backward along the sliding slot 6, and cooperates with the fixed knob 5 and the sliding slot card slot 12 to fix the two sleeves.
[0030] The fixed knob 5 is a fixing accessory matched with the card slot module 4, is connected with the card slot module 4 through a screw rod, can rotate left and right, and is used for fixing the combined front sleeve 1 and rear sleeve 2.
[0031] The sliding slot 6 is a central slot at the top of the rear sleeve 2, extends to the central rear wall of the rear sleeve 2, has a width matched with the card slot module 4, and has a strip-shaped card slot design on the surface, which is a non-smooth surface, can increase friction, and prevents the combined front sleeve 1 and rear sleeve 2 from being too loose.
[0032] The bottom two side openings 7 are openings at the bottom rear end of the rear sleeve 2, are each on the left and right sides, are at least 20 mm apart, are used for accommodating the two lower limbs of a rat, are matched with buckles above the adjusting sliding door 8 on the two sides, facilitate the sliding adjustment of the adjusting sliding door 8 to adjust the opening size, and are used for fixing the knee joint of the rat.
[0033] The two adjusting sliding doors 8 are each on the left and right sides, are connected with the bottom two side openings 7 through buckles, can slide forward and backward along the two side openings 7, adjust the opening size and fix the knee joint according to the size of the two lower limbs of an animal.
[0034] The sliding door handle 9 is a device near the rear 1 / 3 of the two adjusting sliding doors 8, facilitates the forward and backward sliding of the sliding door.
[0035] The cleaning hole 10 is an opening design at the bottom of the rear sleeve 2 and the junction with the rear wall, has an opening width of at least 20 mm, facilitates cleaning of rat excrement and cleaning and disinfection of the device.
[0036] The bottom support plate 11 is located at the bottom front end of the rear sleeve 2, has a width of 30 mm, plays a role in supporting the entire device when the experimental rat is fixed, has an anti-slip card slot design on the surface, prevents the device from rolling due to the struggle of the rat, and has a stabilizing effect.
[0037] The sliding slot card slot 12 is a design for increasing friction on the surface of the sliding slot 6, prevents the combined front sleeve 1 and rear sleeve 2 from being too loose, facilitates
[0038] The fixing of the combined front sleeve 1 and rear sleeve 2.
[0039] In actual use: first separate the front sleeve 1 and the rear sleeve 2, place the front sleeve 1 on the desktop, open the adjusting sliding door 8 at the bottom of the rear sleeve 2, hold the tail root of the experimental rat with one hand, lift the rear lower limbs of the rat, align the head with the front sleeve 1, and the rat will often directly drill into the front sleeve 1 due to fear, and the experimenter will directly pull the tail along the sliding groove 6 to the bottom end, so that the front sleeve 1 and the rear sleeve 2 are quickly combined, and as the front and rear sleeves gradually shrink, the rat will automatically stretch out the adjusting sliding door 8 while struggling, if not, the lower limbs of the rat can be gently pulled out with hands, and then the fixing knob 5 is locked, the adjusting sliding door 8 is clamped, and then the knee joint injection, joint diameter measurement and the like operation can be carried out, if only the tail vein injection and tail vein blood sampling are carried out, the adjusting sliding door 8 can be closed, which is more conducive to operation. After the operation is completed, the adjusting sliding door 8 is opened, the fixing knob 5 is loosened, the front sleeve 1 and the rear sleeve 2 are separated, and the rat can automatically exit the device, if not, the tail can be pulled out with hands, and then the next operation is carried out. After the operation is completed, it can be directly cleaned, disinfected and dried. It should be noted that the front end of the front sleeve 1 is a shuttle-shaped opening for fixing the head of the rat, although the mouth of the rat cannot stretch out of the air hole 3, but do not put fingers into the air hole 3 during operation, otherwise the fingers can be bitten by the sharp teeth of the rat. The combined sleeve design of the top flat and the tail back type, the front and rear shrinkable length of the utility model can be adjusted, the whole body of the rat is basically completely stretched and fixed in the device, cannot be arched and moved randomly to interfere with the experiment, even if the rats of different sizes can be firmly fixed in the straight position of the lower limbs, which greatly facilitates the experimental operation, especially suitable for experimental rat knee joint injection modeling.
[0040] The combined fixing device for experimental rat knee joint injection of the utility model embodiment realizes the effective fixation of the body of the rat through the combined design of the front sleeve 1 and the rear sleeve 2. The top of the front sleeve 1 is flat, the bottom is arc-shaped, and the front end is a shuttle-shaped opening, which can be closely combined with the body of the rat, reducing the struggle of the rat during the experiment due to discomfort. At the same time, the back type design of the rear sleeve 2 is combined with the tail and sacrum of the rat, making the device more stable, avoiding the sliding or twisting of the rat during the fixing process. The front sleeve 1 and the rear sleeve 2 are combined through the sliding groove 6, and are stabilized through the clamping groove module 4 and the fixing knob 5, ensuring that the device will not loosen during use.
[0041] The air hole 3 of the device is arranged at the shuttle-shaped opening of the front sleeve 1, ensuring the smooth breathing of the rat during the experiment, avoiding the stress reaction caused by hypoxia. The slide clamping groove 12 on the surface of the sliding groove 6 is designed to increase the friction force, ensuring that the front sleeve 1 and the rear sleeve 2 will not loosen after being combined, and facilitating the adjustment of the relative position of the two sleeves, ensuring that the knee joint of the rat is in the appropriate injection position.
[0042] The bottom two side openings 7 are used to accommodate the lower limbs of the rats, and the size of the opening is adjusted by adjusting the sliding door 8, which can be flexibly adjusted according to the size of different experimental rats, so that the knee joint is fixed more accurately, and the injection operation is facilitated. The adjusting sliding door 8 is connected with the bottom opening 7 through buckles, and the sliding door handle 9 is designed on the adjusting sliding door 8, which is convenient for the operator to adjust and lock the opening.
[0043] The cleaning hole 10 is designed at the bottom rear end of the rear sleeve 2, which is used to clean the excrement of the rats during the experiment, and is convenient for disinfection and cleaning of the device, and maintains the hygiene of the experimental environment. The bottom support plate 11 is located at the bottom of the front end of the device, which not only provides support for the whole device after fixing the rats, preventing the device from moving, but also increases the stability through the anti-skid card slot, avoiding the rolling of the device due to the struggle of the rats during operation.
[0044] The following are the main components of the embodiment of the utility model, the technical problems solved and the technical effects brought by them:
[0045] 1. The front sleeve 1 and the rear sleeve 2
[0046] Technical problem: how to effectively fix the body of the experimental rat, especially the knee joint part, to reduce the struggle of the rat during knee joint injection and improve the injection accuracy.
[0047] Technical effect: the combination design of the front sleeve 1 and the rear sleeve 2 through the sliding groove 6 and the card slot module 4 can flexibly adjust the length of the device to adapt to rats of different sizes. The back design of the rear sleeve 2 fits the tail and sacrum of the rat, further improving the stability and ensuring the posture of the rat during injection, thereby improving the efficiency and safety of the experimental operation.
[0048] 2. The card slot module 4 and the fixed knob 5
[0049] Technical problem: how to ensure that the front sleeve 1 and the rear sleeve 2 do not loosen after being combined, and maintain a stable structure to adapt to long-term experimental operation.
[0050] Technical effect: the cooperation of the card slot module 4 and the fixed knob 5 can firmly lock the combined position of the front sleeve 1 and the rear sleeve 2, preventing loosening. Through the adjustment of the screw type fixed knob 5, the sleeve combination position can be quickly and accurately fixed, ensuring the stability of the whole device during use and improving the reliability of the operation.
[0051] 3. The adjusting sliding door 8 and the bottom two side openings 7
[0052] Technical problem: how to adjust the size of the opening according to the size of the rat, accurately fix the knee joint of the rat, and prevent the displacement of the leg from affecting the injection operation.
[0053] Technical effects: The sliding door 8 and the bottom two side openings 7 are adjusted by sliding adjustment design, so that the opening size can be flexibly adjusted according to rats of different sizes, the knee joint part of the rat is accurately fixed, the leg of the experimental rat is stable during injection, experimental errors caused by leg movement are avoided, and the operation precision is improved.
[0054] 4. Cleaning hole 10 and bottom support plate 11
[0055] Technical problem: How to conveniently clean rat excrement and keep the device clean while providing sufficient device stability to avoid device movement or overturning during the experiment.
[0056] Technical effects: The design of the cleaning hole 10 facilitates the cleaning of rat excrement, avoids pollution of the experimental environment, facilitates subsequent cleaning and disinfection, and ensures experimental hygiene. The bottom support plate 11 is designed with a non-slip clamping groove, which increases the overall stability of the device, prevents the device from moving or rolling when the rat struggles, and ensures the continuity and safety of the experimental operation.
[0057] Through the combination design of these components, the utility model effectively solves the problems of stability, operation precision and cleaning and maintenance during the fixing of experimental rats, and brings the technical effects of improving experimental efficiency, safety and experimental environment hygiene.
[0058] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited to this. Any skilled person in the technical field can make any modification, equivalent replacement and improvement within the technical range disclosed by the utility model, as long as it is within the spirit and principles of the utility model, and it should be covered within the protection scope of the utility model.
Claims
1. A combined fixation device for experimental rat knee joint injection, characterized in that, The utility model relates to a device for exposing and fixing the bilateral knee joint of experimental rats, comprising two combined sleeves, a fixing knob, a clamping groove module, a sliding groove, a bottom support plate and two adjusting sliding doors. The front sleeve is shaped like a shuttle at the front end, and the rear sleeve is open at the upper end to accommodate the tail of a rat. The bottom of the rear sleeve is provided with a support plate to provide stable support and anti-skid function for the device.
2. The combined fixation device for experimental rat knee joint injection according to claim 1, characterized in that, The two adjusting sliding doors are connected to the openings on both sides of the bottom of the rear sleeve through buckles.
3. The combined fixation device for experimental rat knee joint injection according to claim 2, characterized in that, The top of the tail end of the rear sleeve is designed like a back, which fits the tail and sacrum of a rat to effectively prevent the rat from moving around. The middle part of the rear sleeve is extended with a sliding groove.
4. The combined fixing device for knee joint injection of experimental rats according to claim 3, characterized in that, The bottom of the rear sleeve is open.
5. The combined fixation device for experimental rat knee joint injection according to claim 4, wherein, The two combined sleeves can be separated and combined according to the size of the animal.
6. The combined fixation device for experimental rat knee joint injection according to claim 5, wherein, The top of the sleeve is flat, and the bottom is arc-shaped.
7. The combined fixation device for experimental rat knee joint injection according to claim 4, wherein, The front and rear sleeves match each other.
8. The combined fixation device for experimental rat knee joint injection according to claim 4, wherein, The diameter of the front sleeve is slightly smaller than that of the rear sleeve.
9. The combined fixation device for experimental rat knee joint injection according to claim 4, wherein, The top of the front sleeve is provided with a fixing knob and a clamping groove module. The front end of the front sleeve is shaped like a shuttle. The diameter of the rear sleeve is slightly larger than that of the front sleeve. The top of the rear sleeve is open and extends to the rear end for fixing the front sleeve and accommodating the tail of a rat. The bottom of the rear sleeve is open on both sides to accommodate and fix the bilateral lower limbs of an experimental rat and expose the knee joint. The sliding groove is located on both sides of the top opening of the rear sleeve. The sliding groove is provided with a clamping groove to facilitate the fixation of the front sleeve to the rear sleeve through the fixing knob and the clamping groove module. The bottom support plate is fixed to the bottom of the rear sleeve at the front end and is provided with an anti-skid groove to fix the device on the operating table and provide stable support and anti-skid function for the device. The two adjusting sliding doors are connected to the openings on both sides of the bottom of the rear sleeve through buckles. The distance between the two sliding doors is at least 20 mm. A handle is provided on the sliding door to adjust the size of the opening according to the diameter of the lower limbs of an experimental rat. The bottom of the rear sleeve is open at the rear end to prevent the accumulation of rat excrement from affecting the operation and facilitate cleaning and disinfection. The top of the tail end of the rear sleeve is designed like a back. The middle part of the rear sleeve is extended with a sliding groove.