Rapid drying device for solid-phase synthesis carrier of nucleic acid medicine

Abstract

The utility model discloses a quick drying device for nucleic acid medicine solid phase synthesis carriers, which relates to the field of drying devices and comprises an argon bottle, a guide pipe is connected to the top of the argon bottle, an adjusting air valve is arranged on one side of the guide pipe, one end of the guide pipe is connected with a curved pipe, the curved pipe is fixedly mounted in a water tank, and the other end of the guide pipe is connected with a water outlet. And a set of guide pipes are fixedly installed at the other end of the curved pipe, a composite column fixing box is fixedly installed at one ends of the guide pipes, and an inclined pipe is arranged on one side of the composite column fixing box. The rapid drying device solves the problem that an existing rapid drying device for the nucleic acid medicine solid-phase carrier is poor in using effect, one side of the guide pipe is connected with the curved pipe, the curved pipe is arranged in the water tank with the water inlet and the water outlet in a sleeved mode, and when a synthetic column placed in the synthetic column fixing box needs to be dried through argon, the water inlet and the water outlet can be separated from each other. The water tank needs to be filled with high-temperature liquid through the water inlet.

Description

Technical Field

[0001] This utility model relates to the field of drying devices, specifically a rapid drying device for solid-phase synthesis carriers of nucleic acid drugs. Background Technology

[0002] Solid-phase synthesis carriers for nucleic acid drugs play a crucial role in the synthesis process. They are typically solid matrices that bind to nucleic acid molecules, providing support and stability during synthesis. These carriers are vital for the research and production of nucleic acid drugs, enabling scientists to synthesize and purify nucleic acid molecules more efficiently. However, these carriers require drying before use or storage. With technological advancements, existing drying methods are increasingly inadequate, necessitating the design of a new rapid drying device for solid-phase synthesis carriers to ensure their suitability for use.

[0003] CN221036680U discloses a rapid drying device for solid-phase carriers of nucleic acid drugs, including a regulating valve, a filtration flask, a synthesis column fixing box, a synthesis column fixing metal plate, a metal adjusting screw, a metal frame, a PE gas pipe, a metal threaded column, a PEEK connector, a 7mm inner diameter hole, and a threaded interface. The synthesis column fixing box is welded to the inside of the metal frame by the metal threaded column passing through the 7mm inner diameter holes at both ends of the synthesis column fixing metal plate. The threaded interface on the synthesis column fixing metal plate is connected to the PE gas pipe through the PEEK connector. The synthesis column to be dried is placed in the synthesis column fixing box. The adjusting screw fixes the PEEK connector. The PE gas pipes extending from both ends of the fixing box are connected to an argon gas source and a filtration flask, respectively. The regulating valve is set between the argon gas source and the synthesis column fixing box. Adjusting the valve allows argon gas to flow rapidly inside the synthesis column, thereby achieving the purpose of rapid drying. The waste liquid carried out by the argon gas is finally collected in the filtration flask to avoid splashing of waste liquid.

[0004] However, for an existing rapid drying device for solid-phase carriers of nucleic acid drugs, drying the synthesis column placed in the synthesis column holder using only argon gas requires a long time and is not very effective. Moreover, when residual reagents such as acetonitrile from the synthesis process are blown out of the synthesis column by argon gas and enter the conduit, if there are many reagents, backflow can easily occur, causing them to flow back into the synthesis column holder and affect the synthesis column. Utility Model Content

[0005] Therefore, the purpose of this invention is to provide a rapid drying device for solid-phase synthesis carriers of nucleic acid drugs, so as to solve the technical problem that the existing rapid drying devices for solid-phase carriers of nucleic acid drugs have poor performance.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a rapid drying device for solid-phase synthesis carriers of nucleic acid drugs, comprising an argon cylinder, a conduit connected to the top of the argon cylinder, a regulating valve provided on one side of the conduit, one end of the conduit connected to a curved tube, the curved tube fixedly installed inside a water tank, a set of conduits fixedly installed at the other end of the curved tube, a synthesis column fixing box fixedly installed at one end of the conduit, an inclined tube provided on one side of the synthesis column fixing box, a gourd-shaped bottle installed at one end of the inclined tube, a filtrate tube provided at the bottom of the gourd-shaped bottle, and the filtrate tube sleeved inside a suction filtration flask.

[0007] By adopting the above technical solution, the problem of poor performance of existing rapid drying devices for solid-phase carriers of nucleic acid drugs is solved. By connecting a curved tube to one side of the conduit and fitting the curved tube into a water tank with an inlet and an outlet, when it is necessary to dry the synthesis column placed in the synthesis column fixing box with argon gas, a high-temperature liquid needs to be poured into the water tank through the inlet first. Then, the regulating valve is turned on to allow argon gas to enter the curved tube. The high-temperature liquid in the water tank can heat the argon gas to a certain extent. Since the solid-phase synthesis carrier of nucleic acid drugs has high chemical stability, the solid-phase synthesis carrier of nucleic acid drugs itself will not undergo chemical reaction under the heating condition, thus maintaining its chemical stability. This can enhance the drying efficiency of the synthesis column placed in the synthesis column fixing box with argon gas and achieve a better drying effect.

[0008] The present invention is further configured such that an inlet is provided on one side of the water tank and an outlet is provided on the other side of the water tank.

[0009] Preferably, by providing an inlet on one side of the water tank and an outlet on the other side, the liquid inside the water tank can maintain a certain temperature, thereby achieving the desired heating effect.

[0010] The present invention is further configured such that the diameter of the curved pipe is the same as that of the guide pipe, and the curved pipe is bent inside the water tank.

[0011] Preferably, by setting the diameter of the curved pipe to be the same as that of the conduit, it is easier to install the conduit and the curved pipe. By bending the curved pipe inside the water tank, the contact area between the curved pipe and the hot liquid in the water tank can be increased, thereby achieving a better heating effect.

[0012] The present invention is further configured such that the curved pipe does not contact the water tank, and the water outlet is located at one end of one side of the water tank.

[0013] Preferably, by setting the curved tube to not contact the water tank and setting the outlet at one end of the water tank, the liquid can cover the entire curved tube, which can increase the contact area between the curved tube and the high-temperature liquid in the water tank and enhance the heating effect of the curved tube on the argon gas.

[0014] The present invention is further configured such that PEEK connectors are provided at both ends of the synthesis column fixing box, and the conduit is connected to the synthesis column fixing box through the PEEK connectors.

[0015] Preferably, PEEK connectors are provided at both ends of the synthesis column fixing box, and the conduit is connected to the synthesis column fixing box through the PEEK connectors, so that the conduit can be sealed to the synthesis column fixing box to avoid argon leakage.

[0016] The present invention is further configured such that the gourd bottle has two sets of arc-shaped surfaces inside, and the diameter of the first arc-shaped surface is larger than the diameter of the second arc-shaped surface.

[0017] Preferably, by setting two sets of arc-shaped surfaces inside the gourd-shaped bottle, and the diameter of the first arc-shaped surface is larger than the diameter of the second arc-shaped surface, the contact area between water vapor and the wall surface can be increased, thereby achieving a better cooling effect.

[0018] The present invention is further configured such that the filtrate tube at the bottom of the gourd bottle is fitted onto the top of the suction filtration bottle through a rubber stopper, and an exhaust pipe is provided on one side of the suction filtration bottle.

[0019] Preferably, the filter tube at the bottom of the gourd-shaped bottle is fitted onto the top of the suction filtration bottle with a rubber stopper to ensure the airtightness of the device and prevent argon leakage. An exhaust pipe is provided on one side of the suction filtration bottle to facilitate the collection of argon.

[0020] In summary, the present invention has the following main advantages:

[0021] 1. This utility model, by incorporating an argon cylinder, a water tank, an inlet, an outlet, a conduit, a curved tube, a synthesis column fixing box, an inclined tube, a gourd-shaped bottle, a suction filtration flask, and an exhaust pipe, solves the problem of poor performance in existing rapid drying devices for solid-phase carriers of nucleic acid drugs. By connecting a curved tube to one side of the conduit and fitting it inside a water tank with an inlet and outlet, when drying the synthesis column placed in the synthesis column fixing box with argon gas is required, a high-temperature liquid is first poured into the water tank through the inlet. Then, the regulating valve is opened to allow argon gas to enter the curved tube. The high-temperature liquid in the water tank can raise the temperature of the argon gas. Due to the high chemical stability of the solid-phase synthesis carrier of nucleic acid drugs, the carrier itself will not undergo a chemical reaction under the heating condition, maintaining its chemical stability. This enhances the drying efficiency of the synthesis column placed in the synthesis column fixing box with argon gas, achieving a better drying effect.

[0022] 2. This utility model incorporates an inclined tube. When residual reagents such as acetonitrile from the synthesis process are blown out of the synthesis column by argon gas and enter the inclined tube, they can flow along the inclined tube into the gourd-shaped flask without backflow. Furthermore, due to the high temperature of the argon gas, in addition to the residual reagent liquid, it also carries away water vapor formed by the residual reagents. The gourd-shaped flask with a large inner cavity increases the contact area between the water vapor and the wall surface, achieving a condensation effect and preventing water vapor from entering the filtration flask and leaking out through the exhaust pipe. Attached Figure Description

[0023] Figure 1 This is a first structural schematic diagram of the present invention;

[0024] Figure 2 This is a schematic diagram of the second structure of the present invention;

[0025] Figure 3 This is a cross-sectional view of the present invention.

[0026] Explanation of reference numerals in the attached figures:

[0027] 1. Argon cylinder; 2. Regulating valve; 3. Water tank; 31. Inlet; 32. Outlet; 4. Guide tube; 5. Curved tube; 6. Synthesis column fixing box; 7. Inclined tube; 8. Gourd flask; 9. Vacuum filtration flask; 91. Exhaust pipe. Detailed Implementation

[0028] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0029] The embodiments of this utility model will be described below based on its overall structure.

[0030] Please see Figures 1-3 The system includes an argon cylinder 1, with a conduit 4 connected to the top of the argon cylinder 1. A regulating valve 2 is installed on one side of the conduit 4. One end of the conduit 4 is connected to a curved tube 5, which is fixedly installed inside a water tank 3. The water tank 3 and the curved tube 5 are connected to the argon gas to enhance the drying effect. A set of conduits 4 are fixedly installed at the other end of the curved tube 5. A synthesis column fixing box 6 is fixedly installed at one end of the conduit 4. An inclined tube 7 is installed on one side of the synthesis column fixing box 6. A gourd bottle 8 is installed at one end of the inclined tube 7. The gourd bottle 8, which has a large internal cavity, can cool the stable and high water vapor. A filter tube is installed at the bottom of the gourd bottle 8, which is fitted inside a suction filtration bottle 9.

[0031] For details regarding the above embodiments, please refer to [link / reference]. Figure 1and Figure 2 The water tank 3 has an inlet 31 on one side and an outlet 32 ​​on the other side. By having an inlet 31 on one side and an outlet 32 ​​on the other side, the liquid in the water tank 3 can maintain a certain temperature, thereby achieving the desired heating effect.

[0032] For details regarding the above embodiments, please refer to [link / reference]. Figure 3 The diameter of the curved pipe 5 is the same as that of the conduit 4, and the curved pipe 5 is bent inside the water tank 3. By setting the diameter of the curved pipe 5 to be the same as that of the conduit 4, it is easier to install the conduit 4 and the curved pipe 5. The curved pipe 5 is bent inside the water tank 3, which can increase the contact area between the curved pipe 5 and the high-temperature liquid in the water tank 3, thereby achieving a better heating effect.

[0033] For details regarding the above embodiments, please refer to [link / reference]. Figure 1 The curved tube 5 does not contact the water tank 3, and the outlet 32 ​​is located at one end of the side of the water tank 3. By setting the curved tube 5 to not contact the water tank 3 and the outlet 32 ​​to one end of the side of the water tank 3, the liquid can cover the entire curved tube 5, which can increase the contact area between the curved tube 5 and the high-temperature liquid in the water tank 3, and enhance the heating effect of the curved tube 5 on the argon gas.

[0034] For details regarding the above embodiments, please refer to [link / reference]. Figure 3 The synthesis column fixing box 6 is equipped with PEEK connectors at both ends. The conduit 4 is connected to the synthesis column fixing box 6 through the PEEK connectors. By providing PEEK connectors at both ends of the synthesis column fixing box 6 and connecting the conduit 4 to the synthesis column fixing box 6 through the PEEK connectors, the conduit 4 can be sealed to the synthesis column fixing box 6 to prevent argon gas leakage.

[0035] For details regarding the above embodiments, please refer to [link / reference]. Figure 1 and Figure 3 The gourd-shaped bottle 8 has two sets of curved surfaces inside, and the diameter of the first curved surface is larger than the diameter of the second curved surface. By setting two sets of curved surfaces inside the gourd-shaped bottle 8, and the diameter of the first curved surface is larger than the diameter of the second curved surface, the contact area between water vapor and the wall can be increased, thereby achieving a better cooling effect.

[0036] For details regarding the above embodiments, please refer to [link / reference]. Figure 3 The filter tube at the bottom of the gourd bottle 8 is fitted onto the top of the suction filtration bottle 9 with a rubber stopper. An exhaust pipe 91 is provided on one side of the suction filtration bottle 9. By fitting the filter tube at the bottom of the gourd bottle 8 onto the top of the suction filtration bottle 9 with a rubber stopper, the airtightness of the device is ensured to prevent argon leakage. The exhaust pipe 91 on one side of the suction filtration bottle 9 facilitates the collection of argon.

[0037] In practical operation, this invention works as follows: A curved tube 5 is connected to one side of the conduit 4, and the curved tube 5 is fitted into a water tank 3 with an inlet 31 and an outlet 32. When it is necessary to dry the synthesis column placed in the synthesis column fixing box 6 with argon gas, a high-temperature liquid is first poured into the water tank 3 through the inlet 31. Then, the regulating valve 2 is turned on to allow argon gas from the argon cylinder 1 to enter the curved tube 5. The high-temperature liquid in the water tank 3 can raise the temperature of the argon gas. Due to the high chemical stability of the nucleic acid drug solid-phase synthesis carrier, the nucleic acid drug solid-phase synthesis carrier itself will not undergo a chemical reaction under the heating condition, thus maintaining its chemical stability. When the highly stable argon gas enters the synthesis column fixing box 6, it can enhance the drying efficiency of the synthesis column placed in the synthesis column fixing box 6, achieving... To achieve better drying, the high-temperature argon gas enters the synthesis column fixing box 6 and carries out the reagent residue and water vapor formed by the high-temperature argon gas through the PEEK connector at the other end. The reagent residue and water vapor formed by the high-temperature argon gas enter the inclined tube 7 and then enter the gourd flask 8 along the inclined tube 7. The reagent residue will enter the suction flask 9 through the filter tube at the bottom of the gourd flask 8 along the inner wall of the gourd flask 8. The water vapor formed by the high-temperature argon gas will come into contact with the wall of the gourd flask 8, thereby achieving a cooling effect on the water vapor, allowing it to condense into liquid and enter the suction flask 9 through the filter tube along the wall of the gourd flask 8, thus serving a collection function. The discharged argon gas can be discharged into the collection device through the exhaust pipe 91 to prevent leakage and ensure the safety and environmental protection of the device.

[0038] Although embodiments of the present invention have been shown and described, these specific embodiments are merely explanations of the present invention and are not intended to limit the invention. The specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. After reading this specification, those skilled in the art may make modifications, substitutions, and variations to the embodiments as needed without departing from the principles and spirit of the present invention, provided that such modifications, substitutions, and variations are within the scope of the claims of the present invention and are protected by patent law.

Claims

1. A rapid drying device for solid-phase synthesis carriers of nucleic acid drugs, comprising an argon cylinder (1), characterized in that: The top of the argon cylinder (1) is connected to a conduit (4), and a regulating valve (2) is provided on one side of the conduit (4). One end of the conduit (4) is connected to a curved tube (5), which is fixedly installed inside the water tank (3). A set of conduits (4) is fixedly installed at the other end of the curved tube (5). A synthesis column fixing box (6) is fixedly installed at one end of the conduit (4). An inclined tube (7) is provided on one side of the synthesis column fixing box (6). A gourd bottle (8) is installed at one end of the inclined tube (7). A filter tube is provided at the bottom of the gourd bottle (8), and the filter tube is fitted inside the suction filtration bottle (9).

2. The rapid drying device for solid-phase synthesis carriers of nucleic acid drugs according to claim 1, characterized in that: The water tank (3) has an inlet (31) on one side and an outlet (32) on the other side.

3. The rapid drying device for solid-phase synthesis carriers of nucleic acid drugs according to claim 1, characterized in that: The diameter of the curved pipe (5) is the same as that of the conduit (4), and the curved pipe (5) is bent inside the water tank (3).

4. The rapid drying device for solid-phase synthesis carriers of nucleic acid drugs according to claim 1, characterized in that: The curved pipe (5) does not contact the water tank (3), and the outlet (32) is located at one end of the side of the water tank (3).

5. The rapid drying device for solid-phase synthesis carriers of nucleic acid drugs according to claim 1, characterized in that: The synthesis column fixing box (6) is equipped with PEEK connectors at both ends, and the conduit (4) is connected to the synthesis column fixing box (6) through the PEEK connectors.

6. The rapid drying apparatus for solid-phase synthesis carriers of nucleic acid drugs according to claim 1, characterized in that: The gourd bottle (8) has two sets of arc-shaped surfaces inside, and the diameter of the first arc-shaped surface is larger than the diameter of the second arc-shaped surface.

7. The rapid drying apparatus for solid-phase synthesis carriers of nucleic acid drugs according to claim 1, characterized in that: The filtrate tube at the bottom of the gourd bottle (8) is fitted onto the top of the suction filtration bottle (9) via a rubber stopper, and an exhaust pipe (91) is provided on one side of the suction filtration bottle (9).

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