Tear protein extraction device

Abstract

The utility model relates to the technical field of medical instruments, in particular to a tear protein extraction device which comprises a reagent storage part, a protection part, a plugging part and a flexible water absorption part, and the reagent storage part is provided with a first containing cavity used for containing protein lysate; the protection piece is provided with a second containing cavity used for providing a sterile environment. One end of the plugging piece is provided with a first plugging structure detachably connected to the open end of the reagent storage piece, and the other end of the plugging piece is provided with a second plugging structure detachably connected to the open end of the protection piece; the flexible water absorption piece is connected to the second plugging structure and is located in the second accommodating cavity; the first blocking piece is detached from the reagent storage piece, the blocking piece is reversed after tear liquid is extracted by utilizing the flexible water absorption piece, and the second blocking structure is connected to the opening end of the reagent storage piece, so that the tear liquid adsorbed in the flexible water absorption piece can be mixed into the lysis solution of the first accommodating cavity, and the lysis of tear liquid protein is realized; the operation is convenient; and the full utilization of tears is realized.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a tear protein extraction device. Background Technology

[0002] Tear protein analysis is a common test for ophthalmic diseases. The test involves first extracting the patient's tears, then dropping the tears into a reagent bottle containing protein lysis buffer to lyse the tear proteins, and finally extracting the lysed tear proteins from the reagent bottle for testing.

[0003] Currently, when collecting tears from patients, capillary tubes are often used to aspirate the tears, and then the tears in the capillary tube are dripped into a reagent bottle. However, because some patients have a small amount of tears, the small amount collected tends to stick to the capillary tube wall and is difficult to transfer completely to the container, resulting in insufficient tear collection volume to meet testing requirements. In addition, capillary tubes are highly irritating to the ocular surface, especially the cornea, leading to a poor patient experience. Utility Model Content

[0004] The technical problem to be solved by this invention is that, currently, when analyzing tear proteins, tear fluid is extracted from the patient's eye using a capillary tube. For patients with small tear volume, the amount of tear fluid extracted cannot meet the experimental requirements, and the patient experience is poor.

[0005] To address the aforementioned technical problems, the purpose of this invention is to provide a tear protein extraction device, comprising:

[0006] A reagent storage device having a first receiving cavity for receiving protein lysis buffer and a first opening communicating with the first receiving cavity;

[0007] The protective member has a second receiving cavity for providing a sterile environment and a second opening communicating with the second receiving cavity;

[0008] A sealing component, wherein one end of the sealing component has a first sealing structure, the first sealing structure being detachably connected to a first opening of the reagent storage component to seal the first opening; and the other end of the sealing component has a second sealing structure, the second sealing structure being detachably connected to a second opening of the protective component to seal the second opening.

[0009] A flexible absorbent component, wherein the flexible absorbent component is made of a porous absorbent material, one end of the flexible absorbent component is connected to the side of the second sealing structure facing the second opening, and the other end of the flexible absorbent component is inserted into the second receiving cavity;

[0010] The second sealing structure is also used to connect to the open end of the reagent storage device to place the flexible absorbent containing tears into the first receiving cavity and seal the first opening.

[0011] As a preferred embodiment, both the first opening and the second opening are bottle nipple structures with external threads, and both the first sealing structure and the second sealing structure are bottle cap structures screwed onto the outside of the bottle nipple structure.

[0012] One end of the flexible absorbent is connected to the top wall of the bottle cap structure.

[0013] As a preferred embodiment, the outer side of the bottle cap structure is provided with anti-slip protrusions.

[0014] As a preferred embodiment, both the first opening and the second opening are circular holes, and both the first sealing structure and the second sealing structure are plunger structures inserted into the circular holes;

[0015] The end of the flexible absorbent is connected to the end of the plunger structure.

[0016] As a preferred embodiment, both the protective element and the reagent storage element are tubes, and both the first receiving cavity and the second receiving cavity are cavities of the tubes.

[0017] As a preferred embodiment, both the first sealing structure and the second sealing structure are barrel-shaped structures. The inner side wall of the barrel cavity of the barrel-shaped structure and / or the outer side wall of the open end of the tube body are provided with sealing rings, and the open end of the tube body is sealed and inserted into the barrel cavity of the barrel-shaped structure.

[0018] The end of the flexible absorbent is connected to the bottom of the barrel-shaped structure.

[0019] As a preferred embodiment, the protective element is made of a transparent material.

[0020] As a preferred embodiment, the reagent storage device is made of a transparent material.

[0021] As a preferred embodiment, the flexible absorbent element is a strip of sterile filter paper.

[0022] As a preferred embodiment, the outer side of the strip-shaped sterile filter paper is provided with scale markings distributed along the length direction of the strip-shaped sterile filter paper.

[0023] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0024] This invention discloses a tear protein extraction device, comprising a reagent storage component, a protective component, a sealing component, and a flexible absorbent component. The reagent storage component has a first receiving cavity for containing protein lysis buffer and a first opening communicating with the first receiving cavity. The protective component has a second receiving cavity for providing a sterile environment and a second opening communicating with the second receiving cavity. One end of the sealing component has a first sealing structure, which is detachably connected to the first opening to seal it, thereby facilitating the storage of protein lysis buffer in the first receiving cavity. The other end of the sealing component has a second sealing structure, which is detachably connected to the second opening to seal it. The flexible absorbent component is made of a porous absorbent material, and one end of the flexible absorbent component is connected to the second sealing structure facing the second opening. The other end of the flexible absorbent is inserted into the second receiving cavity at the middle of the end. The protective element provides a sterile storage environment for the flexible absorbent. When using it, the protective element is first removed from the sealing element, and then the flexible absorbent is used to contact the patient's conjunctival sac. The flexible absorbent extracts tears under the capillary effect of the porous material, resulting in high patient comfort, low ocular surface irritation, and no risk of scratching the cornea and conjunctiva. After tear extraction, the first sealing element is removed from the reagent storage unit. The sealing element is inverted, and the second sealing structure is connected to the open end of the reagent storage unit. The flexible absorbent with absorbed tears can be placed into the first receiving cavity and the first opening is sealed. After that, the reagent storage unit is shaken, and the tears stored in the flexible absorbent can be fully mixed into the lysis solution, so as to achieve full utilization of the tears. Attached Figure Description

[0025] Figure 1 This is an isometric view of Embodiment 1 of the tear protein extraction device of this utility model;

[0026] Figure 2 This is a cross-sectional view of Embodiment 1 of the tear protein extraction device of this utility model;

[0027] Figure 3 This is an exploded view of Embodiment 1 of the tear protein extraction device of this utility model;

[0028] Figure 4 This is an isometric view of Embodiment 2 of the tear protein extraction device of this utility model;

[0029] Figure 5 This is a cross-sectional view of Embodiment 2 of the tear protein extraction device of this utility model;

[0030] Figure 6 This is an isometric view of Embodiment 3 of the tear protein extraction device of this utility model;

[0031] Figure 7 This is a cross-sectional view of Embodiment 3 of the tear protein extraction device of this utility model;

[0032] In the figure, 1 is the reagent storage component, 11 is the first receiving cavity, 12 is the first opening, 2 is the protective component, 21 is the second receiving cavity, 22 is the second opening, 3 is the sealing component, 31 is the first sealing structure, 32 is the second sealing structure, 4 is the flexible water-absorbing component, 5 is the sealing ring, and 6 is the mounting sleeve. Detailed Implementation

[0033] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are used to illustrate this utility model, but are not intended to limit its scope.

[0034] In the description of this utility model, it should be understood that the terms "upper," "lower," "left," "right," "top," and "bottom," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. It should also be understood that the terms "first," "second," etc., are used in this utility model to describe various information, but this information should not be limited to these terms. These terms are only used to distinguish information of the same type from each other. For example, without departing from the scope of this utility model, "first" information can also be referred to as "second" information, and similarly, "second" information can also be referred to as "first" information.

[0035] Example 1

[0036] like Figures 1 to 3As shown, a first embodiment of the tear protein extraction device of this utility model includes a reagent storage component 1, a protective component 2, a sealing component 3, and a flexible absorbent component 4. The reagent storage component 1 has a first receiving cavity 11 for containing protein lysis buffer and a first opening 12 communicating with the first receiving cavity 11. The protective component 2 has a second receiving cavity 21 for providing a sterile environment and a second opening 22 communicating with the second receiving cavity 21. One end of the sealing component 3 has a first sealing structure 31, which is detachably connected to the first opening 11 and can seal the first opening 12, thereby facilitating the storage of protein lysis buffer in the first receiving cavity 11. The other end of the sealing component 3 has a second sealing structure 32, which is detachably connected to the second opening 22 to seal the second opening 22. The flexible absorbent component 4 is made of a porous absorbent material, and one end of the flexible absorbent component 4 is connected to the end of the second sealing structure 32 facing the second opening 22. The other end of the flexible absorbent 4 is inserted into the second receiving cavity 21. The protective element 2 provides a sterile storage environment for the flexible absorbent 4. When using it, the protective element 2 is first removed from the sealing element 3. Then, the flexible absorbent 4 is used to contact the patient's conjunctival sac. The flexible absorbent 4 extracts tears under the capillary effect of the porous material. The patient is comfortable during the tear extraction process, the ocular surface is less irritated, and there is no risk of scratching the cornea and conjunctiva. After the tear extraction is completed, the first sealing element 3 is removed from the reagent storage unit 1. The sealing element 3 is inverted, and the second sealing structure 32 is connected to the open end of the reagent storage unit 1. The flexible absorbent 4 with the adsorbed tears can be placed into the first receiving cavity 11 and the first opening 12 is sealed. After that, the reagent storage unit 1 is shaken. The tears stored in the flexible absorbent 4 can be fully mixed into the lysis solution, realizing the full utilization of the tears. Moreover, the process of extracting tears and the process of protein lysis are integrated, which can reduce the test time.

[0037] The protective component 2 and reagent storage component 1 can be configured in various ways. For example, both can be bottle-shaped, box-shaped, or bag-shaped. When both are bag-shaped, a rigid nozzle can be provided at the end of the bag to facilitate sealing of the first opening 12 and the second opening 22 by the sealing component 3. In this embodiment, both the protective component 2 and the reagent storage component 1 are tubes, and the first receiving cavity 11 and the second receiving cavity 21 are both cavities of the tubes. The protective component 2 provides aseptic packaging for the flexible absorbent strip, while the reagent storage component 1 ensures aseptic protection of the protein lysis buffer and provides reaction space for the reaction between the protein lysis buffer and tears.

[0038] To facilitate medical staff in distinguishing between reagent storage component 1 and protective component 2, protective component 2 is made of transparent material. In this embodiment, to facilitate medical staff in identifying the lysed liquid pores inside reagent storage component 1, reagent storage component 1 is also made of transparent material.

[0039] When the protective component 2 is removed from the second sealing structure 32, or when the first sealing structure 31 is removed from the reagent storage component 1, it is necessary to hold the sealing component 3. In order to facilitate holding the sealing component 3, in this embodiment, the outer side of the bottle cap structure is provided with anti-slip protrusions. Specifically, the sealing component 3 is processed by injection molding, and the anti-slip protrusions are formed by injection molding during injection molding.

[0040] The flexible absorbent element 4 can be configured in various ways, such as using a sterile cotton core or sterile cloth. In this embodiment, to facilitate accurate judgment of tear extraction volume by medical personnel, the flexible absorbent element 4 is a strip of sterile filter paper. The strip of filter paper has good absorbency and is relatively thin, so the amount of tear that can be absorbed per unit length of filter paper is fixed. Medical personnel can determine the tear extraction volume by judging the length of tear wetting on the strip of sterile filter paper.

[0041] Furthermore, in this embodiment, the outer side of the strip-shaped sterile filter paper is provided with scale markings distributed along the length of the strip-shaped sterile filter paper. Specifically, the zero point of the scale markings is at the end of the strip-shaped sterile filter paper away from the sealing member 3, the scale division value is 1mm, and the total length of the scale markings is 20mm. When the wetting length of the tear on the strip-shaped sterile filter paper reaches 5mm, it can meet the minimum requirement for tear protein analysis testing.

[0042] The sealing element 3 and the first opening 12 and the second opening 22 can be configured in various ways. In this embodiment, both the first sealing structure 31 and the second sealing structure 32 are barrel-shaped structures. Specifically, the sealing element 3 is a cylindrical body with a partition in the middle of the cylindrical cavity. The partition separates the cylindrical body into two barrel-shaped structures with their openings facing away from each other. The inner side wall of the barrel cavity of the barrel-shaped structure and / or the outer side wall of the opening end of the tube body are provided with sealing rings 5. The opening end of the tube body used as a reagent sealing element is sealed and inserted into the barrel cavity of the barrel-shaped structure used as the first sealing structure 31. The opening end of the tube body used as a protective element 2 is sealed and inserted into the barrel cavity of the barrel-shaped structure used as the second sealing structure 32. The end of the flexible absorbent element 4 is connected to the bottom of the barrel-shaped structure used as the first sealing structure 31, that is, the end of the flexible absorbent element 4 is connected to the partition. The flexible absorbent element 4 can be fixed to the middle of the partition by bonding or hot pressing. In this embodiment, an installation sleeve 6 is fixedly fitted on the outer side of the tube body used as reagent storage component 1 and the tube body used as protective component 2, and a sealing ring 5 is fitted on the outer side of the installation sleeve 6.

[0043] Example 2

[0044] like Figure 4 , Figure 5As shown, the difference between this embodiment and Embodiment 1 is that: both the first opening 12 and the second opening 22 are bottle mouth structures with external threads; both the first sealing structure 31 and the second sealing structure 32 are bottle cap structures screwed to the outside of the bottle mouth structure; one end of the flexible absorbent 4 is connected to the top wall of the bottle cap structure. The sealing of the first opening 12 and the second opening 22 is achieved through threaded engagement, as well as the detachable connection between the first sealing structure 31 and the first opening 12, and the detachable connection between the second sealing structure 32 and the second opening 22.

[0045] Example 3

[0046] like Figure 6 , Figure 7 As shown, the difference between this embodiment and Embodiments 1 and 2 is that: both the first opening 12 and the second opening 22 are circular holes, and both the first sealing structure 31 and the second sealing structure 32 are plunger structures inserted into the circular holes; a sterile paper strip is connected to the end of the plunger structure. In this embodiment, the plunger structure can be made of an elastic plastic material; the plunger structure can also be made of a non-elastic material, and the plunger structure seals the first opening 12 and the second opening 22 by fixing a sealing ring 5 on the outside of the plunger.

[0047] In summary, the tear protein extraction device of this invention includes a reagent storage component 1, a protective component 2, a sealing component 3, and a flexible absorbent component 4. The reagent storage component 1 has a first receiving cavity 11 for containing protein lysis buffer and a first opening 12 communicating with the first receiving cavity 11. The protective component 2 has a second receiving cavity 21 for providing a sterile environment and a second opening 22 communicating with the second receiving cavity 21. One end of the sealing component 3 has a first sealing structure 31, which is detachably connected to the opening end of the reagent storage component 1 and can seal the first opening 12, thereby facilitating the storage of protein lysis buffer in the first receiving cavity 11. The other end of the sealing component 3 has a second sealing structure 32, which is detachably connected to the opening end of the protective component 2 to seal the second opening 22. The flexible absorbent component 4 is made of porous absorbent material, and one end of the flexible absorbent component 4 is connected to the second sealing component. The flexible absorbent 4 is inserted into the second receiving cavity 21 at the middle of one end of structure 32 facing the second opening 22. The protective member 2 provides a sterile storage environment for the flexible absorbent 4. When in use, the protective member 2 is first removed from the sealing member 3. Then, the flexible absorbent 4 is used to contact the patient's conjunctival sac. The flexible absorbent 4 extracts tears under the capillary effect of the porous material. The patient is comfortable, the ocular surface is less irritated, and there is no risk of scratching the cornea and conjunctiva. After the tears are extracted, the first sealing member 3 is removed from the reagent storage unit 1. The sealing member 3 is inverted, and the second sealing structure 32 is connected to the opening end of the reagent storage unit 1. The flexible absorbent 4 with the tears adsorbed can be placed into the first receiving cavity 11 and the first opening 12 is sealed. After that, the reagent storage unit 1 is shaken. The tears stored in the flexible absorbent 4 can be fully mixed into the lysis solution to achieve full utilization of the tears.

[0048] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and substitutions can be made without departing from the technical principles of the present utility model, and these improvements and substitutions should also be considered within the protection scope of the present utility model.

Claims

1. A tear protein extraction device, characterized in that, include: The reagent storage unit (1) has a first receiving cavity (11) for receiving protein lysis buffer and a first opening (12) communicating with the first receiving cavity (11). The protective element (2) has a second receiving cavity (21) for providing a sterile environment and a second opening (22) communicating with the second receiving cavity (21). A sealing component (3) has a first sealing structure (31) at one end, which is detachably connected to the first opening (12) to seal the first opening (12); and a second sealing structure (32) at the other end, which is detachably connected to the second opening (22) to seal the second opening (22). The flexible absorbent (4) is made of porous absorbent material. One end of the flexible absorbent (4) is connected to the side of the second sealing structure (32) facing the second opening (22), and the other end of the flexible absorbent (4) is inserted into the second receiving cavity (21). The second sealing structure (32) is also used to connect to the open end of the reagent storage device (1) to place the flexible absorbent (4) with adsorbed tears into the first receiving cavity (11) and seal the first opening (12).

2. The tear protein extraction device according to claim 1, characterized in that, The first opening (12) and the second opening (22) are both bottle mouth structures with external threads, and the first sealing structure (31) and the second sealing structure (32) are both bottle cap structures screwed to the outside of the bottle mouth structure; The end of the flexible absorbent (4) is connected to the top wall of the bottle cap structure.

3. The tear protein extraction device according to claim 2, characterized in that, The outer side of the bottle cap structure is provided with anti-slip protrusions.

4. The tear protein extraction device according to claim 1, characterized in that, Both the first opening (12) and the second opening (22) are circular holes, and both the first sealing structure (31) and the second sealing structure (32) are plunger structures inserted into the circular holes; The flexible absorbent element (4) is connected to the end of the plunger structure.

5. The tear protein extraction device according to claim 1, characterized in that, The protective component (2) and the reagent storage component (1) are both tubes, and the first receiving cavity (11) and the second receiving cavity (21) are both cavities of the tubes.

6. The tear protein extraction device according to claim 5, characterized in that, Both the first sealing structure (31) and the second sealing structure (32) are barrel-shaped structures. The inner side wall of the barrel cavity of the barrel-shaped structure and / or the outer side wall of the opening end of the tube body are provided with sealing rings (5). The opening end of the tube body is sealed and inserted into the barrel cavity of the barrel-shaped structure. The end of the flexible absorbent (4) is connected to the bottom of the barrel structure.

7. The tear protein extraction device according to claim 1, characterized in that, The protective element (2) is made of a transparent material.

8. The tear protein extraction device according to claim 1, characterized in that, The reagent storage device (1) is made of a transparent material.

9. The tear protein extraction device according to claim 1, characterized in that, The flexible absorbent element (4) is a strip of sterile filter paper.

10. The tear protein extraction device according to claim 9, characterized in that, The outer side of the strip-shaped sterile filter paper is provided with scale markings distributed along the length of the strip-shaped sterile filter paper.

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