Sample material box cooling oscillation device

Abstract

The utility model relates to the technical field of biochemical experiment automation equipment, and discloses a sample material box cooling oscillation device which comprises a supporting frame, a rotating shaft is arranged on the supporting frame, an oscillation seat is installed on the rotating shaft on the inner side of the supporting frame, the rotating shaft on the outer side of the supporting frame is connected to a driving device, and a cooling unit is installed on the oscillation seat. A refrigeration surface is arranged above the cooling unit, a heat conduction frame is fixedly arranged above the refrigeration surface, the lower surface of the heat conduction frame is attached to the refrigeration surface, an adaptive cavity hole is formed in the heat conduction frame, a sample material box is fixedly arranged in the adaptive cavity hole, and a material box fixing frame is arranged on the supporting frame; and the material box fixing frame is used for pressing and loosening the sample material box on the heat conduction frame. According to the utility model, the refrigeration module and the sample material box are bound together for oscillation, so that the unification of refrigeration and automatic operation is realized.

Description

TECHNICAL FIELD

[0001] The utility model relates to biochemical experiment automation equipment technical field especially, relate to a sample material box cooling oscillation device. BACKGROUND

[0002] In the process of nucleic acid extraction experiment on biological samples, it should be carried out at lower temperature as far as possible, and oscillation is carried out to make it uniform, to ensure the efficiency and quality of nucleic acid extraction. Nucleic acid extraction is carried out under low temperature conditions, which maintains the stability of nucleic acid: low temperature environment can reduce the risk of nucleic acid degradation, and maintain its integrity and purity.

[0003] The existing oscillation equipment does not have cooling function, and when in use, the oscillation equipment needs to be placed in a refrigeration device to ensure the normal movement of the equipment and the stability of the refrigeration temperature. However, this method cannot integrate the oscillation equipment into the biological laboratory automation system.

[0004] In the biological laboratory automation system, the sample taking and placing during oscillation are completed automatically by robots, and the equipment cannot be placed in the refrigeration room for automatic operation.

[0005] The low-temperature oscillation instrument disclosed in Chinese patent "low-temperature oscillation instrument based on microwell plate" (publication number: CN206002376U) is cooled by the ice layer placed in the oscillation box to cool the microwell plate below, so that the temperature of the surface of the microwell plate is reduced. This physical cooling method cannot accurately control the temperature of the microwell plate, and the liquid after the ice layer melts directly affects the vibration frequency. The box is placed above the microwell plate, and the automatic operation of the microwell plate by the automatic equipment cannot be realized. UTILITY MODEL CONTENT

[0006] The utility model aims at solving the above problems, and provides a sample material box cooling oscillation device, which binds the refrigeration module with the sample material box for oscillation, and realizes the unity of refrigeration and automatic operation.

[0007] The technical scheme adopted by the utility model is:

[0008] A sample material box cooling oscillation device, characterized by comprising a support frame, a rotating shaft is arranged on the support frame, a vibrating seat is installed on the rotating shaft on the inner side of the support frame, the rotating shaft on the outer side of the support frame is connected to a driving device, a cooling unit is installed on the vibrating seat, a refrigeration surface is arranged above the cooling unit, a heat conduction frame is fixedly arranged above the refrigeration surface, the lower surface of the heat conduction frame is attached to the refrigeration surface, an adaptive cavity hole is arranged on the heat conduction frame, a sample material box is fixedly arranged in the adaptive cavity hole, a material box fixing frame is arranged on the support frame, and the material box fixing frame realizes pressing and loosening operation on the sample material box on the heat conduction frame.

[0009] Further, the cartridge fixing frame comprises a push rod motor arranged on the support frame, a rotating shaft arranged on the heat conducting frame, the rotating shaft being perpendicular to the push rod of the push rod motor, a pressing rod arranged on the rotating shaft, the lower end of the pressing rod being rotatably connected to a swing rod, a linkage head being arranged on the swing rod, a pulling force being generated between the end of the pressing rod away from the rotating shaft and the heat conducting frame through a pulling force spring, the pulling force causing the pressing rod to generate a pressing force on the cartridge on the heat conducting frame, and the push rod motor driving the linkage head of the swing rod to cause the swing rod to move forward, the pressing rod rotating with the rotating shaft to overcome the pulling force of the pulling force spring to open the cartridge.

[0010] Further, the fitting holes on the heat conducting frame are divided into several rows, each row of fitting holes being used to arrange one sample cartridge, and one cartridge fixing frame being arranged, a plurality of cartridge fixing frames sharing one swing rod, and the swing rod simultaneously driving the plurality of cartridge fixing frames to open and close the plurality of sample cartridges.

[0011] Further, the rotating shaft is divided into two parts, and the two parts are arranged in the shaft holes on the two sides of the heat conducting frame, and the two parts of the rotating shaft are coaxially connected to the two ends of the pressing rod.

[0012] Further, a pad is arranged on the side of the heat conducting frame close to the push rod motor, the shaft hole on the side is arranged on the pad, another shaft hole is arranged on the other side of the heat conducting frame, and the pulling force spring is arranged between the pad and the pressing rod.

[0013] Further, the cooling unit is a semiconductor refrigeration assembly, comprising a semiconductor refrigeration sheet and a heat dissipation frame, the semiconductor refrigeration sheet being arranged on the heat dissipation frame, the refrigeration surface of the semiconductor refrigeration sheet being attached to the bottom surface of the heat conducting frame, and the heating surface of the semiconductor refrigeration sheet being attached to the heat dissipation frame.

[0014] Further, a heat insulation fence is arranged between the heat dissipation frame and the heat conducting frame, and a positioning corner piece is arranged on the heat insulation fence at four corner positions of the heat dissipation frame, and the heat dissipation frame is fixed on the positioning corner piece.

[0015] Further, a flow guide groove is arranged on the heat insulation fence, and a water outlet of the flow guide groove is located on one side of the heat insulation fence.

[0016] Further, heat dissipation holes are arranged on the left and right sides of the heat dissipation frame, a fan and a wind pipe are arranged inside the heat dissipation frame, and the wind pipe is paired with the heat dissipation holes.

[0017] Further, the driving device is a speed reduction motor arranged on the outside of the support frame, the speed reduction motor drives the oscillation seat to swing, and the swing angle is-90° to +90°.

[0018] The beneficial effects of the utility model are:

[0019] (1) The semiconductor refrigeration module is small in size, organically combined with the sample cartridge, and convenient to integrate into an automatic system.

[0020] (2) The sample box is convenient and quick to install, and is suitable for automatic taking and placing;

[0021] (3) The temperature control is accurate, and the long-time unattended workstation is suitable. BRIEF DESCRIPTION OF DRAWINGS

[0022] Figure Figure 1 is a schematic diagram of the three-dimensional structure of the utility model;

[0023] Figure Figure 2 is a schematic diagram of the three-dimensional structure of the utility model's oscillation driving unit;

[0024] Figure Figure 3 is a schematic diagram of the three-dimensional structure of the utility model's cooling unit;

[0025] Figure Figure 4 is a schematic diagram of the three-dimensional structure of the utility model's cooling unit; Figure 3 is a schematic diagram of the internal structure of the part of the panel;

[0026] Figure Figure 5 is a schematic diagram of the structure of the heat conduction frame;

[0027] Figure Figure 6 is a schematic diagram of the structure of the sample box;

[0028] Figure Figure 7 is a local enlarged view of the position of the box fixing frame.

[0029] The reference numbers in the drawings are as follows:

[0030] 1. Box heat transfer unit; 2. Cooling unit;

[0031] 3. Oscillation driving unit; 4. Support frame;

[0032] 5. Oscillation seat; 6. Reducing motor;

[0033] 7. Heat conduction frame; 8. Sample box;

[0034] 9. Semiconductor refrigeration sheet; 10. Heat dissipation frame;

[0035] 11. Heat transfer plate; 12. Heat insulation fence;

[0036] 13. Positioning angle piece; 14. Heat dissipation hole;

[0037] 15. Fan; 16. Air pipe;

[0038] 17. Adaptation cavity hole; 18. Box fixing frame;

[0039] 19. Swing lever; 20. Push rod motor;

[0040] 21. Push rod; 22. Pressing rod;

[0041] 23. Linkage head; 24. Tension spring;

[0042] 25. Shaft hole; 26. Pad;

[0043] 27. Positioning sheet; 28. Position sensor. DETAILED DESCRIPTION

[0044] The specific embodiments of the sample box cooling and oscillation device of the utility model will be described in detail below with reference to the accompanying drawings.

[0045] Referring to the accompanying drawings Figure 1 The sample box cooling and oscillation device mainly consists of a box heat transfer unit 1, a cooling unit 2 and an oscillation driving unit 3.

[0046] Referring to the accompanying drawings Figure 2 A rotating shaft is arranged on the support frame 4 of the oscillation driving unit 3, and an oscillation seat 5 is mounted on the rotating shaft on the inner side of the support frame 4. The rotating shaft on the outer side of the support frame 4 is connected to a driving device, which is a speed reducer motor 6. The speed reducer motor 6 drives the oscillation seat 5 to swing, and the swing angle is -90° to +90°. According to the category of the sample, the system can adjust the frequency and angle of oscillation.

[0047] The cooling unit 2 is mounted on the oscillation seat 5, and a refrigeration surface is arranged above the cooling unit 2. The box heat transfer unit 1 is fixedly arranged above the refrigeration surface, and the box heat transfer unit 1 includes a heat conduction frame 7, and the lower surface of the heat conduction frame 7 is attached to the refrigeration surface. The heat conduction frame 7 is used to place the sample box 8 and to store the sample box 8 at low temperature.

[0048] Referring to the accompanying drawings Figure 3 , 4 The cooling unit 2 is a semiconductor refrigeration assembly, which includes a semiconductor refrigeration sheet 9 and a heat dissipation frame 10. The semiconductor refrigeration sheet 9 is arranged on the heat dissipation frame 10. The refrigeration surface of the semiconductor refrigeration sheet 9 is attached to the bottom surface of the heat conduction frame 7 through a heat transfer plate 11, and the heating surface of the semiconductor refrigeration sheet 9 is attached to the heat dissipation frame 10. A heat insulation fence 12 is arranged between the heat dissipation frame 10 and the heat conduction frame 7. Positioning corner pieces 13 are arranged on the heat insulation fence 12 at four corner positions of the heat dissipation frame 10, and the heat conduction frame 7 is fixed on the positioning corner pieces 13.

[0049] The heat insulation fence 12 ensures heat transfer between the heat dissipation frame 10 and the heat conduction frame 7. A flow guide groove (not shown in the figure) is arranged on the heat insulation fence 12, and the water outlet of the flow guide groove is located on one side of the heat insulation fence 12. Because the temperature of the heat conduction frame 7 is low, condensate water will form on its surface, and the flow guide groove can guide the condensate water out.

[0050] Heat dissipation holes 14 are arranged on the left and right sides of the heat dissipation frame 10. A fan 15 and an air duct 16 are arranged inside the heat dissipation frame 10, and the air duct 16 is paired with the heat dissipation holes 14.

[0051] Referring to the drawings Figure 5 , 6 , 7, the heat conducting frame 7 is provided with an adaptive cavity hole 17, the sample box 8 is fixedly arranged in the adaptive cavity hole 17, and the box fixing frame 18 is arranged on the support frame 4, and the box fixing frame 18 realizes the pressing and loosening operation of the sample box 8 on the heat conducting frame 7.

[0052] The adaptive cavity hole 17 on the heat conducting frame 7 is divided into several rows, each row of adaptive cavity holes 17 is used to arrange one sample box 8, and one box fixing frame 18 is arranged, a plurality of box fixing frames 18 share one swing lever 19, and the swing lever 19 simultaneously drives a plurality of box fixing frames 18 to open and close a plurality of sample boxes 8.

[0053] The box fixing frame 18 comprises a push rod motor 20 arranged on the support frame 4, a rotating shaft arranged on the heat conducting frame 7, the rotating shaft being perpendicular to a push rod 21 of the push rod motor 20, a pressing rod 22 arranged on the rotating shaft, the lower end of the pressing rod 22 being rotatably connected to the swing lever 19, a linkage head 23 arranged on the swing lever 19, a tension spring 24 arranged between the end of the pressing rod 22 away from the rotating shaft and the heat conducting frame 7, the tension spring 24 generating a tension force, the tension force causing the pressing rod 22 to generate a pressing force on the sample box 8 on the heat conducting frame 7, the push rod motor 20 pushing the linkage head 23 of the swing lever 19 to cause the swing lever 19 to move forward, and the pressing rod 22 rotating with the rotating shaft to overcome the tension of the tension spring 24 to open from the sample box 8. The linkage head 23 of the swing lever 19 is arranged in the shape of a screw to facilitate linear contact with the push rod 21.

[0054] A positioning sheet 27 is arranged on the push rod 21 of the push rod motor 20, and a position sensor 28 is arranged on the support frame 4, and the two are matched to determine the position of the pressing rod 22 pushed by the push rod motor 20, so as to clearly determine whether the pressing rod 22 presses the sample box 8.

[0055] The rotating shaft is divided into two parts and arranged in the shaft holes 25 on the two sides of the heat conducting frame 7, and the two parts of the rotating shaft are coaxially connected with the two ends of the pressing rod 22. A cushion block 26 is arranged on the side of the heat conducting frame 7 close to the push rod motor 20, the shaft hole 25 on this side is arranged on the cushion block 26, another shaft hole 25 is arranged on the other side of the heat conducting frame 7, and the tension spring 24 is arranged between the cushion block and the pressing rod 22.

[0056] The working process of the patent is as follows: after starting the device, first make the cooling unit 2 work to reduce the temperature to a predetermined temperature, then the push rod motor 20 pushes out the swing lever 19 forward, at this time the pressing rod 22 is opened, the centrifuge tube with the sample arranged therein is placed in the heat conducting frame 7, after the arrangement is completed, the push rod motor 20 retracts the push rod 21, the tension spring 24 resets the swing lever 19, and at the same time the pressing rod 22 is forced to press the sample box 8. Complete the loading of the sample box 8. Then start the speed reducer motor 6 to drive the vibration seat to swing and oscillate. Realize the function of oscillating the sample in a low temperature environment.

[0057] The whole device can be integrated into an automatic system for nucleic acid detection, and the sample cartridge 8 is operated by a robot, the work of the push rod motor 20 and the reduction motor 6 is controlled by the system, and the refrigeration parameters of the cooling unit 2 are controlled.

[0058] The above is only the preferred embodiment of the present application, it should be pointed out that, for ordinary skilled in the art, without departing from the principles of the present application, can make a number of improvements and refinements, these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A sample container cooling and oscillation device, characterized in that: The device includes a support frame with a rotating shaft on it. An oscillating seat is mounted on the rotating shaft inside the support frame, and a rotating shaft on the outside of the support frame is connected to a drive device. A cooling unit is mounted on the oscillating seat, and a cooling surface is located above the cooling surface. A heat-conducting frame is fixedly mounted above the cooling surface, and its lower surface is in contact with the cooling surface. An adapter cavity is provided on the heat-conducting frame, and a sample box is fixedly mounted within the adapter cavity. A sample box fixing bracket is provided on the support frame, and the sample box fixing bracket performs pressing and releasing operations on the sample box on the heat-conducting frame.

2. The sample box cooling and oscillation device according to claim 1, characterized in that: The material box fixing frame includes a push rod motor mounted on a support frame, a rotating shaft mounted on a heat-conducting frame, the rotating shaft being perpendicular to the push rod of the push rod motor, a pressure rod mounted on the rotating shaft, the lower end of the pressure rod being rotatably connected to a swing rod, a connecting head mounted on the swing rod, and a tension spring generating tension between the end of the pressure rod away from the rotating shaft and the heat-conducting frame, the tension causing the pressure rod to exert a pressing force on the material box on the heat-conducting frame. When the push rod motor pushes the connecting head of the swing rod to move the swing rod forward, the pressure rod rotates with the rotating shaft to overcome the tension spring and open from the material box.

3. The sample box cooling and oscillation device according to claim 2, characterized in that: The adapter holes on the heat conduction frame are divided into several rows. Each row of adapter holes is used to set a sample box and is equipped with a box fixing frame. Multiple box fixing frames share a swing arm, and the swing arm simultaneously drives multiple box fixing frames to open and close multiple sample boxes.

4. The sample box cooling and oscillation device according to claim 3, characterized in that: The rotating shaft is divided into two parts, which are respectively installed in the shaft holes on both sides of the heat conduction frame. The two parts of the rotating shaft are coaxially connected to the two ends of the pressure rod.

5. The sample box cooling and oscillation device according to claim 4, characterized in that: A pad is provided on the heat conduction frame near the push rod motor, and a shaft hole is provided on the pad on this side. Another shaft hole is provided on the other side of the heat conduction frame, and the tension spring is provided between the pad and the pressure rod.

6. The sample box cooling and oscillating device according to any one of claims 1 to 5, characterized in that: The cooling unit is a semiconductor refrigeration component, including a semiconductor refrigeration chip and a heat dissipation frame. The semiconductor refrigeration chip is disposed on the heat dissipation frame, with the cooling surface of the semiconductor refrigeration chip in contact with the bottom surface of the heat dissipation frame and the heating surface of the semiconductor refrigeration chip in contact with the heat dissipation frame.

7. The sample box cooling and oscillation device according to claim 6, characterized in that: A heat insulation fence is provided between the heat dissipation frame and the heat conduction frame, and positioning corner pieces are provided on the heat insulation fence at the four corners of the heat dissipation frame, and the heat conduction frame is fixed on the positioning corner pieces.

8. The sample container cooling and oscillation device according to claim 7, characterized in that: A flow guide channel is provided on the heat insulation fence, and the outlet of the flow guide channel is located on one side of the heat insulation fence.

9. The sample box cooling and oscillation device according to claim 6, characterized in that: The heat dissipation frame is provided with heat dissipation holes on the left and right sides, and a fan and air duct are provided inside the heat dissipation frame, with the air duct paired with the heat dissipation holes.

10. The sample box cooling and oscillating device according to any one of claims 1 to 5, characterized in that: The driving device is a geared motor installed on the outside of the support frame. The geared motor drives the oscillating seat to swing, and the swing angle is from -90° to +90°.

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