Fixing device for fixing rat coat and rat spinal curvature

Abstract

The utility model provides a fixing mouse cover and a rat spinal curvature fixing device.The fixing device comprises the fixing mouse cover, a perforated flat plate and a suspension table, the fixing mouse cover comprises a body and a ridge part, the body is made of non-elastic cloth, the ridge part is made of elastic cloth, the body is provided with anterior and posterior limb holes and a plurality of pairs of bandages, and the anterior and posterior limb holes are communicated with the suspension table. The perforated flat plate is provided with a plurality of pairs of perforations, and the suspension table comprises a supporting part and a top suspension frame. The rat spine bending fixing device provided by the utility model is a noninvasive device which is convenient for simulating bending stress to induce intervertebral disc degeneration, the stress influence of an operation on a rat can be avoided, and the bending stress can be applied to the chest and lumbar intervertebral disc of the rat so as to better simulate the intervertebral disc degeneration caused by human behaviors.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of intervertebral disc pathological research, and particularly relates to a fixed rat clothes and a rat spinal curvature fixing device. BACKGROUND

[0002] Establishing an animal model that can simulate human intervertebral disc degeneration is helpful for in-depth research on the pathogenesis, pathological process and treatment method of intervertebral disc degenerative diseases. At present, the intervertebral disc degeneration model mainly includes two kinds of animal in vitro intervertebral disc model and animal in vivo intervertebral disc model. The animal in vitro model includes intervertebral disc cell culture model and intervertebral disc tissue culture model, and these models are mainly aimed at obtaining related intervertebral disc degeneration tissues or cells; the animal in vivo intervertebral disc model includes spontaneous intervertebral disc degeneration model and induced intervertebral disc degeneration model, and the induced intervertebral disc degeneration model is commonly used in clinical research, such as needle puncture model, stress change model, spinal instability model, and chemical method constructed model, etc. The stress change model is considered to be the closest to the actual pathological mechanism of intervertebral disc degeneration, but in the existing model, surgical implantation of internal fixation equipment is often required, which is easy to cause perioperative stress reaction in rats, limits the intervention measures, and most of them act on the tail vertebrae, which is difficult to simulate the pathological changes of intervertebral disc in human natural activities. CONTENT OF THE UTILITY MODEL

[0003] The purpose of the present application is to provide a device for simulating the intervertebral disc degeneration in human activities such as long-term sitting or long-term bending behavior by non-invasive means to make the rat thoracic and lumbar intervertebral disc suffer from bending stress.

[0004] To achieve the above object and other related objects, the present application provides a fixed rat clothes in one aspect, which comprises a main body and a dorsal part, the main body is made of inelastic cloth, the dorsal part is made of elastic cloth, the main body comprises a head region, a back region, a tail region and separated abdominal regions located on both sides of the back region from front to back, the back region is provided with a rectangular opening, the long side of the rectangular opening extends along the center line direction of the main body, the dorsal part is connected with the main body and covers the rectangular opening, four holes are symmetrically arranged on the left and right sides of the back region, including two forelimb holes and two hindlimb holes, the abdominal regions are provided with a connecting piece capable of connecting the separated abdominal regions together, a plurality of pairs of straps are arranged on the fixed rat clothes from the head region to the tail region, one end of the strap is fixedly connected with the fixed rat clothes, and the other end is a free end.

[0005] In some embodiments, the dorsal part is rectangular.

[0006] In some embodiments, the main body is made of cotton cloth.

[0007] In some embodiments, the dorsal part is made of knitted cloth.

[0008] In some embodiments, the dorsal part is connected to the main body by sewing or pasting.

[0009] In some embodiments, the connecting part is a snap fastener.

[0010] In some embodiments, a triangular notch is formed in the middle of the front end of the head region.

[0011] The second aspect of the present application provides a rat spinal curvature fixation device, comprising any one of the aforementioned fixation rat clothes, a perforated plate provided with a plurality of pairs of perforations, and a suspension platform comprising a support part and a top suspension frame.

[0012] In some embodiments, the perforated plate is a rectangular plate.

[0013] In some embodiments, the perforated plate is a wooden plate or a plastic plate.

[0014] As described above, the present application has the following beneficial effects:

[0015] The rat spinal curvature fixation device provided by the present application is a non-invasive device that can conveniently simulate the intervertebral disc degeneration induced by bending stress, can avoid the stress impact of surgery on rats, and can apply bending stress to the intervertebral discs of rats to better simulate the intervertebral disc degeneration caused by human behavior. The device well solves the fit of the fixation rat clothes with the experimental rats, solves the problem that the rats cannot maintain a stable state in the bending experiment, and can conform to the pressure of the rats' body expansion outward in the bending state and the pressure inside the body, better and more naturally simulating the pathological changes of intervertebral discs in human natural activities. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 Fig. 1 shows a front view of a fixation rat clothes according to an embodiment of the present application.

[0017] Figure 2 Fig. 2 shows a top view of a fixation rat clothes according to an embodiment of the present application.

[0018] Figure 3 Fig. 3 shows a top view of a perforated plate according to an embodiment of the present application.

[0019] Figure 4 Fig. 4 shows a perspective view of a suspension platform according to an embodiment of the present application.

[0020] REFERENCE SIGNS:

[0021] 1 - fixed rat clothes; 11 - head region; 12 - back region; 13 - tail region; 14 - abdominal region; 15 - dorsal part; 16 - forelimb hole; 17 - hindlimb hole; 18 - buckle; 19 - belt; 2 - perforated plate; 21 - perforation; 3 - suspension platform; 31 - top suspension frame. DETAILED DESCRIPTION

[0022] The advantages and effects of the present application can be easily understood by those skilled in the art from the description. The present application can also be implemented or applied by different specific embodiments, and the details in the description can be modified or changed based on different views and applications without departing from the spirit of the present application. It should be noted that the following examples and features in the examples can be combined with each other without conflict.

[0023] The technical solutions of the present application will be described in detail below with reference to the accompanying drawings. Referring to Figures 1-4 , the rat spinal curvature fixation device provided in an embodiment of the present application includes fixed rat clothes 1, a perforated plate 2, and a suspension platform 3.

[0024] The fixed rat clothes includes a main body and a dorsal part. As shown in Figure 1 and 2 , the main body can be divided into a head region 11, a back region 12, and a tail region 13 from front to back, and the back region 12 has two separated abdominal regions 14 on both sides.

[0025] The back region 12 of the main body is provided with a rectangular opening, the long side of which extends along the center line direction of the main body, i.e., in the direction from the head region 11 to the tail region 13, and the dorsal part 15 is connected at the rectangular opening. The main body is made of non-elastic cloth, such as cotton cloth, and the dorsal part 15 is made of elastic cloth, such as knitted cloth. As shown in Figure 1 and 2 , the dorsal part 15 can be connected with the main body by sewing or pasting and cover the above-mentioned rectangular opening, and the dorsal part 15 can also be rectangular, the long side and the short side of which are respectively consistent with the extension direction of the long side and the short side of the rectangular opening.

[0026] The left and right sides of the back region 12 are provided with four holes for the rat forelimbs and hindlimbs to pass through, wherein the two holes on the front side are forelimb holes 16, and the two holes on the back side are hindlimb holes 17. The positions of the forelimb holes 16 and the hindlimb holes 17 can be determined according to the size of the rat.

[0027] Two separate abdominal regions 14 are provided with snaps 18, i.e. one of the abdominal regions 14 is provided with male snaps 18 and the other abdominal region 14 is provided with female snaps 18, and the snaps 18 can be one or more, Figure 1 and 2 In the example shown, the snaps 18 are two arranged side by side. In other embodiments, the snaps 18 can also be replaced by other forms of buttons or lanyards, etc.

[0028] As shown in Figure 1 and 2 The fixed mouse coat 1 is provided with a plurality of pairs of straps 19 from the head region 11 to the tail region 13, one end of the straps 19 is fixedly connected with the fixed mouse coat 1, and the other end is a free end for connection with the perforated plate 2 and the suspension platform 3 described below. The specific arrangement position of the straps 19 can be selected according to the head region 11, the back region 12, the tail region 13 and the dorsal portion 15, and the figure is only an example.

[0029] Suitably, the head region 11 is cut into a shape suitable for covering the head of the rat, Figure 2 A specific example is shown, in which a reverse triangular notch is provided in the middle part of the front end of the head region 11.

[0030] As shown in Figure 3 The perforated plate 2 can be a rectangular plate, which can be a wooden plate or a plastic plate, etc., and a plurality of pairs of perforations 21 are provided on it for cooperation with part of the straps 19 on the fixed mouse coat 1 to achieve fixation of the rat.

[0031] As shown in Figure 4 The suspension platform 3 is of a frame structure, including a support portion and a top suspension frame 31 composed of one or more horizontal bars, and through the connection of part of the straps 19 with the top suspension frame 31, the rat that has been fixed by the fixed mouse coat 1 and the perforated plate 2 can be suspended on the suspension platform 3.

[0032] The specific dimensions of the fixed mouse coat 1 and the perforated plate 2 can be determined according to actual conditions, and a specific application example is given below as shown in Figures 1-4

[0033] As shown in Figures 1-4 The length of the head region 11 of the fixed mouse coat 1 is 6 cm, the length of the back region 12 is 9 cm, and the corresponding length of the dorsal portion 15 can also be selected as 9 cm or less, and the length of the tail region 13 is 3.5 cm. The width of the outside of the reverse triangular notch of the head region 11 is 3.5 cm, and the width of the dorsal portion 15 is 5 cm. The length of the perforated plate 2 is 4 cm, and the width is 2.5 cm.

[0034] In combination with the above embodiments, the use of the rat spinal curvature fixation device provided by the present application is exemplarily illustrated:​

[0035] In use, first, the head region 11 of the fixed rat coat 1 is used to cover the head of the rat, the back region 12 and the tail region 13 are used to cover the rat, then the forelimbs and hindlimbs of the rat are respectively passed through the forelimb hole 16 and the hindlimb hole 17 from the inner side to the outer side of the fixed rat coat 1, and then the two separated abdominal regions 14 are overlapped on the abdomen of the rat and fixed by the snap fastener 18, thereby completing the wearing of the fixed rat coat 1. Next, the rat is fixed to the perforated plate 2 by passing the several pairs of straps 19 located in the middle through the perforations 21 on the perforated plate 2 and tightening, and at the same time, the back of the rat is bent. By adjusting the binding position and the binding force, the bending curve, position and intensity of the rat can be adjusted. Finally, the rat is hung on the hanging table 3 by the straps 19 of the head region 11 and the tail region 13 to reduce the struggle of the rat.

[0036] The rat spinal column bending and fixing device provided by the present application is a non-invasive device for conveniently simulating the intervertebral disc degeneration induced by bending stress, which can avoid the stress influence of surgery on the rat and can apply bending stress to the intervertebral discs of the thoracic and lumbar vertebrae of the rat to better simulate the intervertebral disc degeneration caused by human behavior. The device well solves the fit of the fixed rat coat with the experimental rat, solves the problem that the rat cannot maintain a stable state in the bending experiment, and can conform to the pressure of the expansion of the body of the rat outward and the compression inside the body in the bending state, better and more naturally simulating the pathological changes of the intervertebral discs in human natural activities.

[0037] The above embodiments only exemplarily illustrate the principles and effects of the present application, and are not used to limit the present application. Any person skilled in the art can modify or change the above embodiments without departing from the spirit and scope of the present application. Therefore, all equivalent modifications or changes completed by those skilled in the art without departing from the spirit and technical thought disclosed by the present application should be covered by the claims of the present application.

Claims

1. A fixing mouse coat characterized in that: it comprises a main body and a dorsal part, the main body is made of non-elastic cloth, the dorsal part is made of elastic cloth, the main body comprises a head region, a back region, a tail region and separated abdominal regions on both sides of the back region from front to back, the back region is provided with a rectangular opening, the long side of the rectangular opening extends along the direction of the center line of the main body, the dorsal part is connected with the main body and covers the rectangular opening, four holes are symmetrically arranged on the left and right sides of the back region, including two forelimb holes and two hindlimb holes, the abdominal regions are provided with connecting pieces capable of connecting the separated abdominal regions together, the fixing mouse coat is provided with a plurality of pairs of straps from the head region to the tail region, one end of the straps is fixedly connected with the fixing mouse coat, and the other end is a free end.

2. The fixing mouse coat according to claim 1 characterized in that: the dorsal part is rectangular.

3. The fixing mouse coat according to claim 1 characterized in that: the main body is made of cotton cloth.

4. The fixing mouse coat according to claim 1 characterized in that: the dorsal part is made of knitted cloth.

5. The fixing mouse coat according to claim 1 characterized in that: the dorsal part is connected with the main body by sewing or pasting.

6. The fixing mouse coat according to claim 1 characterized in that: the connecting piece is a snap fastener.

7. The fixing mouse coat according to claim 1 characterized in that: a reverse triangular notch is formed in the middle part of the front end of the head region.

8. A rat spinal curvature fixing device characterized in that: it comprises the fixing mouse coat according to any one of claims 1-7, a perforated plate and a suspension table, the perforated plate is provided with a plurality of pairs of perforations, and the suspension table comprises a supporting part and a top suspension frame.

9. The rat spinal curvature fixing device according to claim 8 characterized in that: the perforated plate is a rectangular plate.

10. The rat spinal curvature fixing device according to claim 8 characterized in that: the perforated plate is a wooden plate or a plastic plate.

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