Antibody preparation adjuvant device for multiple animal models

Abstract

The utility model discloses an antibody preparation adjuvant device for various animal models, which belongs to the technical field of biological medicine and comprises a preparation table, the upper surface of the preparation table is fixedly connected with an ultrasonic crusher, the upper surface of the ultrasonic crusher is fixedly connected with an ultrasonic concussion seat, a preparation bottle is clamped on the inner wall of the ultrasonic concussion seat, and the upper surface of the preparation bottle is fixedly connected with the ultrasonic concussion seat. The preparation bottle is a transparent glass bottle, a Y-shaped dropper is arranged in the preparation bottle, the preparation bottle, the Y-shaped dropper and the mixing injectors are arranged, the same amount of adjuvant and antigen solution are sucked into the two mixing injectors respectively, and needle tubes are pushed alternately, so that the adjuvant and the antigen solution are mixed and injected into the Y-shaped dropper and the preparation bottle; through the arrangement of the ultrasonic crusher and the ultrasonic oscillation seat, the ultrasonic frequency and time are controlled, the auxiliary oscillation emulsification of the mixed solution of the adjuvant and the antigen solution is realized, and the emulsification effect of the adjuvant and the antigen is effectively improved, so that the preparation effect of the antibody is improved.

Description

Technical Field

[0001] This invention relates to the field of biomedical technology, specifically to an adjuvant device for antibody preparation in various animal models. Background Technology

[0002] Tumor growth and metastasis largely depend on their ability to evade host immune surveillance and overcome host defenses. Although most tumors express antigens that can be recognized by the host immune system to varying degrees, in many cases, the inefficient activation of effector T cells leads to an insufficient immune response. Therefore, external antibody supplementation is required to increase the amount of antibodies in the patient's body. In the antibody preparation process, in order to increase the surface area of ​​the antigen and prolong the retention time of the antigen in the body, so that the antigen has sufficient contact time with lymphatic system cells, it is often necessary to use adjuvants for mixing and emulsification.

[0003] Current adjuvant and antibody preparation methods generally use syringes for mixing and emulsification, but this emulsification is difficult to complete. Some antigens cannot be pushed with plastic syringes at all, while glass syringes leak, thus reducing the antibody preparation effect. Therefore, those skilled in the art provide an antibody preparation adjuvant device for various animal models to solve the problems mentioned in the background art. Utility Model Content

[0004] The purpose of this invention is to provide an antibody preparation adjuvant device for various animal models, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] An adjuvant preparation device for various animal models includes a preparation platform. An ultrasonic disruptor is fixedly connected to the upper surface of the preparation platform. An ultrasonic oscillator is fixedly connected to the upper surface of the ultrasonic disruptor. A preparation bottle, which is a transparent glass bottle, is held in place on the inner wall of the ultrasonic oscillator. A Y-shaped dropper is provided inside the preparation bottle. Both input ends of the Y-shaped dropper penetrate the preparation bottle and are fixedly connected to a clamping head. A mixing syringe is clamped to the inner wall of each clamping head. A sealing plug is clamped to the top of the preparation bottle.

[0007] As a further improvement of this utility model: a scale is provided on the front of the preparation bottle, and the scale is located in the middle of the preparation bottle.

[0008] As a further improvement of this utility model: a set of gripping grooves are provided on both the left and right sides of the preparation bottle, and the gripping grooves are located in the middle of the preparation bottle.

[0009] As a further improvement of this utility model: the back of the ultrasonic oscillation seat is threaded with a fastening screw, which is made of plastic.

[0010] As a further improvement of this utility model: a transport handle is fixedly connected to both the left and right sides of the preparation table, and the transport handle is located in the middle of the preparation table.

[0011] As a further improvement of this utility model: an operation label is fixedly connected to the front of the preparation table, and the operation label is located in the middle of the preparation table.

[0012] As a further improvement of this utility model: the bottom surface of the preparation table is fixedly connected to two sets of support legs, and the bottom surface of each support leg is fixedly connected to a damping pad, and the upper surface of the support leg is provided with mounting holes.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] This adjuvant device for antibody preparation in various animal models uses a preparation bottle, a Y-shaped dropper, and a mixing syringe. Equal volumes of adjuvant and antigen solutions are drawn into two mixing syringes, and the syringes are alternately pushed to mix the adjuvant and antigen solutions, injecting them into the Y-shaped dropper and preparation bottle to form a viscous emulsion. An ultrasonic disruptor and ultrasonic oscillator control the ultrasonic frequency and time to achieve assisted agitation and emulsification of the adjuvant and antigen solution mixture, effectively increasing the emulsification effect and thus improving antibody preparation efficiency. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall three-dimensional structure of an antibody preparation adjuvant device for various animal models;

[0016] Figure 2 Rear view of the preparation stage in an antibody preparation adjuvant apparatus used in various animal models;

[0017] Figure 3 This is a schematic diagram of the internal cross-sectional structure of a preparation bottle in an antibody preparation adjuvant device used in various animal models.

[0018] Figure 4 This is a top view of the preparation stage in an antibody preparation adjuvant apparatus used in various animal models.

[0019] In the diagram: 1. Preparation table; 2. Ultrasonic breaker; 3. Ultrasonic vibrator; 4. Preparation bottle; 5. Ruler; 6. Mixing syringe; 7. Clip-on head; 8. Sealing plug; 9. Y-shaped dropper; 10. Grip groove; 11. Handle; 12. Support leg; 13. Mounting hole; 14. Damping pad; 15. Fastening screw; 16. Operation label. Detailed Implementation

[0020] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0021] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0022] Please see Figures 1-4 In this embodiment of the present invention, an antibody preparation adjuvant device for various animal models includes a preparation platform 1. An ultrasonic disruptor 2 is fixedly connected to the upper surface of the preparation platform 1. An ultrasonic oscillator 3 is fixedly connected to the upper surface of the ultrasonic disruptor 2. A preparation bottle 4 is held in place on the inner wall of the ultrasonic oscillator 3. The preparation bottle 4 is a transparent glass bottle. A Y-shaped dropper 9 is provided inside the preparation bottle 4. Both input ends of the Y-shaped dropper 9 pass through the preparation bottle 4 and are fixedly connected to a clamping head 7. A mixing syringe 6 is clamped to the inner wall of each clamping head 7. A sealing plug 8 is clamped to the top of the preparation bottle 4.

[0023] A scale 5 is provided on the front of the preparation bottle 4, located in the middle of the preparation bottle 4, which can be used to understand the content of the mixture and facilitate the precise preparation of antibodies. A set of grip grooves 10 are provided on both the left and right sides of the preparation bottle 4, located in the middle of the preparation bottle 4, which can enable the preparation personnel to hold the preparation bottle 4 stably and facilitate the stable transfer and transportation of the prepared antibodies. A fastening screw 15 is threaded on the back of the ultrasonic oscillator 3. The fastening screw 15 is made of plastic and can lock and position the preparation bottle 4 to facilitate the stable use of the preparation bottle 4.

[0024] The left and right sides of the preparation table 1 are fixedly connected to a handling handle 11, which is located in the middle of the preparation table 1. This allows for easy movement of the preparation table 1 and facilitates the installation and operation of the device. The front of the preparation table 1 is fixedly connected to an operation label 16, which is located in the middle of the preparation table 1. This label provides instructions for the operation of the device and facilitates antibody preparation operations for the personnel. The bottom surface of the preparation table 1 is fixedly connected to two sets of support legs 12. The bottom surface of each support leg 12 is fixedly connected to a damping pad 14. The upper surface of the support leg 12 is provided with mounting holes 13, which can be used to install and fix the preparation table 1, facilitating the stable use of this antibody preparation adjuvant device.

[0025] The working principle of this utility model is as follows: In use, the preparation table 1 is installed and fixed through the support frame 12 and the mounting hole 13. Then, the device is powered on, and the preparation bottle 4 is inserted into the ultrasonic oscillation base 3. Then, different mixing syringes 6 are used to draw out a certain amount of adjuvant and antigen solution respectively. Then, the syringe is pushed alternately to mix the adjuvant and antigen solution and inject it into the Y-shaped dropper 9 and the preparation bottle 4 to form a viscous emulsion. Then, the ultrasonic disruptor 2 is controlled to work and the ultrasonic waves are penetrated into the ultrasonic oscillation base 3. At the same time, the ultrasonic frequency and time are controlled to achieve auxiliary oscillation and emulsification of the adjuvant and antigen solution mixture in the preparation bottle 4, so as to achieve effective emulsification of adjuvant and antigen, thereby increasing the antibody preparation effect.

[0026] The above description is merely a preferred embodiment of this utility model, but the scope of protection of this utility model is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the technical scope disclosed in this utility model, based on the technical solution and inventive concept of this utility model, should be included within the scope of protection of this utility model. It is obvious to those skilled in the art that this utility model is not limited to the details of the above exemplary embodiments, and that it can be implemented in other specific forms without departing from the spirit or basic characteristics of this utility model. Therefore, the embodiments should be considered exemplary and non-limiting in all respects. The scope of this utility model is defined by the appended claims rather than the foregoing description, and thus all variations falling within the meaning and scope of equivalent elements of the claims are intended to be included within this utility model. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0027] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. An antibody preparation adjuvant apparatus for various animal models, comprising a preparation stage (1), characterized in that, An ultrasonic disruptor (2) is fixedly connected to the upper surface of the preparation table (1). An ultrasonic oscillating seat (3) is fixedly connected to the upper surface of the ultrasonic disruptor (2). A preparation bottle (4) is placed on the inner wall of the ultrasonic oscillating seat (3). The preparation bottle (4) is a transparent glass bottle. A Y-shaped dropper (9) is provided inside the preparation bottle (4). Both input ends of the Y-shaped dropper (9) pass through the preparation bottle (4) and are fixedly connected to a clamping head (7). A mixing syringe (6) is clamped to the inner wall of each clamping head (7). A sealing plug (8) is clamped to the top of the preparation bottle (4).

2. The antibody preparation adjuvant device for various animal models according to claim 1, characterized in that, A scale (5) is provided on the front of the preparation bottle (4), and the scale (5) is located in the middle of the preparation bottle (4).

3. The antibody preparation adjuvant device for various animal models according to claim 1, characterized in that, The preparation bottle (4) has a set of gripping grooves (10) on both the left and right sides, and the gripping grooves (10) are located in the middle of the preparation bottle (4).

4. The antibody preparation adjuvant device for various animal models according to claim 1, characterized in that, The back of the ultrasonic oscillating seat (3) is threaded with a fastening screw (15), which is made of plastic.

5. The antibody preparation adjuvant device for various animal models according to claim 1, characterized in that, The preparation table (1) is fixedly connected to both the left and right sides with a transport handle (11), and the transport handle (11) is located in the middle of the preparation table (1).

6. The antibody preparation adjuvant device for various animal models according to claim 1, characterized in that, An operation sign (16) is fixedly connected to the front of the preparation table (1), and the operation sign (16) is located in the middle of the preparation table (1).

7. The antibody preparation adjuvant device for various animal models according to claim 1, characterized in that, The bottom surface of the preparation platform (1) is fixedly connected to two sets of support legs (12), and each support leg (12) is fixedly connected to a damping pad (14). The upper surface of the support leg (12) is provided with mounting holes (13).

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